Two Of The Cyclos Share At Least Three Ring Members (i.e., Bridged) Patents (Class 549/459)
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Patent number: 9120816Abstract: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogs synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.Type: GrantFiled: December 16, 2013Date of Patent: September 1, 2015Assignee: HONG KONG BAPTIST UNIVERSITYInventors: Zhaoxiang Bian, Chengyuan Lin, Baomin Fan, Huaixue Mu, Yongyun Zhou, Weimin Zeng, Aiping Lu, Albert Sun Chi Chan
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Patent number: 9005874Abstract: There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1): wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, and wherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic caType: GrantFiled: April 18, 2012Date of Patent: April 14, 2015Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Yoshitaka Komuro, Yoshiyuki Utsumi, Akiya Kawaue, Masatoshi Arai
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Publication number: 20150051277Abstract: The present invention describes use of compounds of formula 1 or 2 or their compositions for the treatment of leukemia and use of compound of formula 1 or its composition for treatment of infections caused due to M. tuberculosis. The invention further discloses use of compound of formula 3 for the conversion of solar energy into electric current in dye sensitized solar cells.Type: ApplicationFiled: August 6, 2012Publication date: February 19, 2015Inventors: Swati Pramod Joshi, Roshan Rajan Kulkarni, Ketaki Dilip Shurpali, Sampa Sarkar, Dhiman Sarkar
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Patent number: 8956799Abstract: A photoacid generator includes those of formula (I): wherein each Ra in formula 1 is independently H, F, a C1-10 nonfluorinated organic group, C1-10 fluorinated organic group, or a combination comprising at least one of the foregoing, provided at least one Ra is F or a C1-10 fluorinated organic group, the C1-10 fluorinated and nonfluorinated organic groups each optionally comprising O, S, N, or a combination comprising at least one of the foregoing heteroatoms; L1 is a linking group comprising a heteroatom comprising O, S, N, F, or a combination comprising at least one of the foregoing; G+ is an onium salt of the formula (II): wherein in formula (II), X is S or I, each R0 is independently C1-30 alkyl group; a polycyclic or monocyclic C3-30 cycloalkyl group; a polycyclic or monocyclic C4-30 aryl group; or a combination comprising at least one of the foregoing, provided at least one R0 is substituted where each R0 is a C6 monocyclic aryl group, and wherein when X is I, a is 2, and where X is S, a is 3,Type: GrantFiled: December 12, 2012Date of Patent: February 17, 2015Assignee: Rohm and Haas Electronic Materials LLCInventors: Emad Aqad, Cheng-Bai Xu, Mingqi Li, William Williams, III
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Publication number: 20150037734Abstract: A resist composition containing a compound represented by general formula (m0), wherein R1 and R2 each independently represents an aryl group which may have a substituent, an alkyl group which may have a substituent, or an alkenyl group which may have a substituent, provided that R1 and R2 may be mutually bonded to form a ring with the sulfur atom; R3 represents an aromatic hydrocarbon group which may have a substituent, an alkenyl group which may have a substituent, or an alkynyl group which may have a substituent; V1 represents a single bond or an alkylene group, provided that, when R3 is an aromatic hydrocarbon group which may have a substituent, V1 is an alkylene group; and X0? represents a monovalent organic anion.Type: ApplicationFiled: July 23, 2014Publication date: February 5, 2015Inventors: Takashi Nagamine, Yoshitaka Komuro, Masatoshi Arai, Yoshiyuki Utsumi
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Patent number: 8940913Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: GrantFiled: August 7, 2008Date of Patent: January 27, 2015Assignee: Syngenta Crop Protection, LLCInventors: Melloney Tyte, Stephane André Marie Jeanmart, Christopher John Mathews, Louisa Robinson
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Patent number: 8927594Abstract: The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.Type: GrantFiled: March 15, 2011Date of Patent: January 6, 2015Assignees: National Sun Yat-Sen University, National Museum of Marine Biology & AquariumInventors: Jyh-Horng Sheu, Wei-Hsien Wang, Zhi-Hong Wen, Bo-Wei Chen, Ping-Jyun Sung
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Patent number: 8916330Abstract: The present invention provides a resist composition giving a resist pattern excellent in CD uniformity and focus margin. A chemically amplified photoresist composition comprises a resin (A) and an acid generator (B), and the resin (A) contains, as a part or an entirety thereof, a copolymer (A1) which is obtained by polymerizing at least: a (meth)acrylic monomer (a1) having C5-20 alicyclic hydrocarbon group which becomes soluble in an aqueous alkali solution by the action of an acid; a (meth)acrylic monomer (a2) having a hydroxy group-containing adamantyl group; and a (meth)acrylic monomer (a3) having a lactone ring, and the copolymer (A1) has a weight-average molecular weight of 2500 or more and 5000 or less, and a content of the copolymer (A1) is not less than 50 parts by mass with respect to 100 parts by mass of the resin (A).Type: GrantFiled: June 23, 2010Date of Patent: December 23, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Koji Ichikawa, Takashi Hiraoka
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Publication number: 20140356787Abstract: A resist composition comprising a compound (m0) (wherein Rb1 represents an electron withdrawing group; Rb2 and Rb3 each independently represents an aryl group, an alkyl group or an alkenyl group, provided that Rb2 and Rb3 may be mutually bonded to form a ring with the sulfur atom; and X0? represents a monovalent counteranion).Type: ApplicationFiled: May 30, 2014Publication date: December 4, 2014Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Yoshitaka Komuro, Takaaki Kaiho, Toshiaki Hato, Akiya Kawaue, Junichi Tsuchiya, Yoshiyuki Utsumi
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Patent number: 8883394Abstract: The present invention provides a resist composition giving a resist pattern excellent in CD uniformity and focus margin. A chemically amplified photoresist composition comprises a resin (A) and an acid generator (B), and the resin (A) contains, as a part or an entirety thereof, a copolymer (A1) which is obtained by polymerizing at least: a (meth)acrylic monomer (a1) having C5-20 alicyclic hydrocarbon group which becomes soluble in an aqueous alkali solution by the action of an acid; a (meth)acrylic monomer (a2) having a hydroxy group-containing adamantyl group; and a (meth)acrylic monomer (a3) having a lactone ring, and the copolymer (A1) has a weight-average molecular weight of 2500 or more and 5000 or less, and a content of the copolymer (A1) is not less than 50 parts by mass with respect to 100 parts by mass of the resin (A).Type: GrantFiled: June 23, 2010Date of Patent: November 11, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Koji Ichikawa, Takashi Hiraoka
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Publication number: 20140323303Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is methyl or chlorine; R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluoromethoxy; and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.Type: ApplicationFiled: November 30, 2012Publication date: October 30, 2014Applicants: Syngenta Participations AG, Syngenta LimitedInventors: Alaric James Avery, Mangala Mahadev Phadte, James Nicholas Scutt, John Benjamin Taylor, Russell Colin Viner, Jeffrey Steven Wailes
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Patent number: 8835658Abstract: The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.Type: GrantFiled: December 28, 2012Date of Patent: September 16, 2014Assignees: Hong Kong Baptist University, Yunnan University of NationalitiesInventors: Albert Sun-Chi Chan, Baomin Fan, Jun Wang, Chengyuan Lin, Chao Huang, Qingjing Yang, Jianbin Xu, Zhaoxiang Bian, Aiping Lu, Jun Hu
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Patent number: 8835657Abstract: The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R3, R9, R10, R11, R12 and G have the meanings given above as insecticides and/or acaricides and/or fungicides.Type: GrantFiled: April 28, 2010Date of Patent: September 16, 2014Assignee: Bayer CropScience AGInventors: Alfred Angermann, Reiner Fischer, Stefan Lehr, Arnd Voerste
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Publication number: 20140187801Abstract: The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.Type: ApplicationFiled: December 28, 2012Publication date: July 3, 2014Applicants: YUNNAN UNIVERSITY OF NATIONALITIES, HONG KONG BAPTIST UNIVERSITYInventors: Albert Sun-Chi Chan, Baomin Fan, Jun Wang, Chengyuan Lin, Chao Huang, Qingjing Yang, Jianbin Xu, Zhaoxiang Bian, Aiping Lu, Jun Hu
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Publication number: 20140135287Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.Type: ApplicationFiled: June 1, 2012Publication date: May 15, 2014Applicant: President and Fellows of Harvard CollegeInventors: Matthew D. Shair, Brian A. Sparling, David Moebius
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Publication number: 20140120472Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) including a compound represented by (b1-1), a compound represented by (b1-1?) and/or a compound represented by (b1-1?) (R1?-R3? represents an aryl group or an alkyl group, provided that at least one of R1?-R3? represents a substituted aryl group being substituted with a group represented by (b1-1-0), and two of R1?-R3? may be mutually bonded to form a ring with the sulfur atom; X represents a C3-C30 hydrocarbon group; Q1 represents a carbonyl group-containing divalent linking group; X10 represents a C1-C30 hydrocarbon group; Q3 represents a single bond or a divalent linking group; Y10 represents —C(?O)— or —SO2—; Y11 represents a C1-C10 alkyl group or a fluorinated alkyl group: Q2 represents a single bond or an alkylene group; and W represents a C2-C10 alkylene group).Type: ApplicationFiled: January 6, 2014Publication date: May 1, 2014Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Hideo HADA, Yoshiyuki UTSUMI, Takehiro SESHIMO, Akiya KAWAUE
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Patent number: 8680339Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: GrantFiled: January 25, 2010Date of Patent: March 25, 2014Assignee: Syngenta LimitedInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Publication number: 20140066590Abstract: To provide a polyimide precursor and/or polyimide which has an excellent solubility in various organic solvents, and with which a liquid crystal alignment film can be obtained which is excellent in a rubbing resistance and which is hardly deteriorated even by irradiation with backlight. A polyimide precursor having its terminal amino group modified with at least one alicyclic epoxydicarboxylic acid anhydride selected from the group consisting of compounds of the formulae [1] and [2], or a polyimide obtained by imidizing it: wherein Y is a C1-2 alkylene or an oxygen atom, and R1 is a hydrogen atom or an organic group represented by —X1—X2—X3 , wherein X1 is a single bond or —CH2—, X2 is a single bond or -0-, and X3 is a C1-20 alkyl group, a C1-20 haloalkyl group or a C1-20 alkyl group containing a cyano group.Type: ApplicationFiled: April 27, 2012Publication date: March 6, 2014Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hideo Suzuki, Takahiro Noda
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Publication number: 20130237711Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.Type: ApplicationFiled: April 23, 2013Publication date: September 12, 2013Applicant: Eisai R&D Management Co., Ltd.Inventors: Farid BENAYOUD, Trevor Lee Calkins, Charles E. Chase, William Christ, Francis G. Fang
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Patent number: 8530667Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: GrantFiled: September 1, 2008Date of Patent: September 10, 2013Assignee: Syngenta LimitedInventors: Stephane André Marie Jeanmart, John Benjamin Taylor, Melloney Tyte, Christopher John Mathews, Stephen Christopher Smith
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Patent number: 8357810Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.Type: GrantFiled: October 8, 2010Date of Patent: January 22, 2013Assignee: International Flavors & Fragrances Inc.Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Patent number: 8357358Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.Type: GrantFiled: October 8, 2010Date of Patent: January 22, 2013Assignee: International Flavors & Fragrances Inc.Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Publication number: 20130017484Abstract: Polymerizable ester compounds having formula (1) are novel wherein R1 is H, F, methyl or trifluoromethyl, R2 is an acid labile group, Aa is a divalent hydrocarbon group which may be separated by —O— or —C(?O)—, and k1 is 0 or 1. They are useful as monomers to produce polymers which are transparent to radiation ?500 nm. Radiation-sensitive resist compositions comprising the polymers as base resin exhibit excellent developed properties.Type: ApplicationFiled: July 13, 2012Publication date: January 17, 2013Inventors: Koji HASEGAWA, Masayoshi SAGEHASHI, Yuuki SUKA, Masashi IIO
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Publication number: 20120270155Abstract: There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1): wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, and wherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic caType: ApplicationFiled: April 18, 2012Publication date: October 25, 2012Applicant: TOKYO OHKA KOGYO CO., LTD.Inventors: Yoshitaka Komuro, Yoshiyuki Utsumi, Akiya Kawaue, Masatoshi Arai
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Publication number: 20120258402Abstract: A photoresist composition includes a polymer that includes a structural unit shown by the following formula (1), and a photoacid generator. R1 in the formula (1) represents a hydrogen atom, a fluorine atom, a methyl group, or a trifluoromethyl group, Z represents a group that forms a divalent alicyclic group having 3 to 20 carbon atoms together with a carbon atom bonded to X, X represents an alkanediyl group having 1 to 6 carbon atoms, Y represents a hydrogen atom or —CR2R3(OR4), and R2 to R4 independently represent a hydrogen atom or a monovalent hydrocarbon group, provided that R3 and R4 optionally bond to each other to form a cyclic ether structure together with a carbon atom bonded to R3 and an oxygen atom bonded to R4.Type: ApplicationFiled: April 4, 2012Publication date: October 11, 2012Applicant: JSR CorporationInventors: Mitsuo SATO, Masafumi Yoshida
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Patent number: 8236971Abstract: A polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): wherein Ra represents, for example, a hydrogen atom or an alkyl group having one to six carbon atoms which may have a halogen atom; R1s each represent, for example, a halogen atom or an alkyl or haloalkyl group having one to six carbon atoms; “m” is the number of R1s; “n” is the number of cyano groups; and CH2?C(Ra)COO— group may have either of an endo conformation and an exo conformation. Accordingly, there is provided a novel polycyclic ester containing a cyano group and a lactone skeleton which is useful typically as a monomeric component for highly functional polymers. A polymer, for example, derived from this compound is highly soluble in an organic solvent while remaining stable typically to chemicals and exhibits improved hydrolyzability and/or improved solubility in water after hydrolysis.Type: GrantFiled: October 8, 2010Date of Patent: August 7, 2012Assignee: Daicel Chemical Industries, Ltd.Inventors: Keizo Inoue, Takahiro Iwahama, Masamichi Nishimura, Kiyoharu Tsutsumi
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Publication number: 20120178024Abstract: A polymer includes a repeating unit shown by a general formula (1). R1 represents a hydrogen atom, a methyl group, a fluorine atom, or a trifluoromethyl group. R2 represents a substituted or unsubstituted aryl group having 6 to 22 carbon atoms. Y represents a carbon atom. X represents —X1Z1X2— which is an atomic group which forms a cyclic structure including a heteroatom together with Y. Z1 represents —O—, —S—, —CO—, —COO—, —SO—, or —SO2—. Each of X1 and X2 individually represents a single bond, a methylene group, or an alkylene group having 2 to 25 carbon atoms. Each of X1 and X2 is unsubstituted or substituted with a substituent, and optionally a carbon atom included in X1 and a carbon atom included in X2 are bonded via a divalent group.Type: ApplicationFiled: March 22, 2012Publication date: July 12, 2012Applicant: JSR CorporationInventors: Ken MARUYAMA, Toru KIMURA
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Publication number: 20120142529Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: August 7, 2008Publication date: June 7, 2012Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Melloney Tyte, Stephane André Marie Jeanmart, Christopher John Mathews, Louisa Robinson
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Publication number: 20120094832Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: August 6, 2008Publication date: April 19, 2012Applicant: SYNGENTA LIMITEDInventors: Melloney Tyte, Christopher John Mathews, Gavin John Hall, William Guy Whittingham, Jeffrey Steven Wailes, James Nicholas Scutt, Stephane André Marie Jeanmart, Russell Viner
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Publication number: 20120088922Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.Type: ApplicationFiled: October 8, 2010Publication date: April 12, 2012Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Publication number: 20120087885Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.Type: ApplicationFiled: October 8, 2010Publication date: April 12, 2012Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Publication number: 20120087880Abstract: The present invention pertains to a method of counteracting a malodor by introducing a malodor counteracting effective amount of a novel 3.2.Type: ApplicationFiled: October 8, 2010Publication date: April 12, 2012Inventors: Benjamin Amorelli, Johan Gerwin Lodewijk Pluyter, Adam P. Closson
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Publication number: 20120028800Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: January 25, 2010Publication date: February 2, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Publication number: 20120021912Abstract: Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: January 18, 2010Publication date: January 26, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
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Publication number: 20110301233Abstract: Novel polyisoprenylated benzophenone derivatives isolated from the plant Garcinia paucinervis. Among these new compounds, paucinones A-C (Compounds 1-3) contains an unexpected cyclohexane-spiro-tetrahydrofuran moiety. A 1-methylene-3,3-dimethylcyclohexane group never reported before was found in the structure of paucinone D (Compound 4). Structures of these compounds were elucidated with spectroscopic evidence. The relative stereochemistry of 1-4 was determined by NOESY correlations. These compounds a potent ability to activate caspase-3 in HeLa-C3 cells within 72 hours at a low concentration and significant cytotoxicity against HeLa-C3 cells.Type: ApplicationFiled: June 4, 2010Publication date: December 8, 2011Inventors: XUE-MEI GAO, Ting Yu, Kathy Qian Luo, Hong Xi Xu
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Patent number: 7927780Abstract: A compound represented by formula (I); and a compound represented by formula (b1-1): wherein X represents —O—, —S—, —O—R3— or —S—R4—, wherein each of R3 and R4 independently represents an alkylene group of 1 to 5 carbon atoms; R2 represents an alkyl group of 1 to 6 carbon atoms, an alkoxy group of 1 to 6 carbon atoms, a halogenated alkyl group of 1 to 6 carbon atoms, a halogen atom, a hydroxyalkyl group of 1 to 6 carbon atoms, a hydroxyl group or a cyano group; a represents an integer of 0 to 2; Q1 represents an alkylene group of 1 to 12 carbon atoms or a single bond; Y1 represents an alkylene group of 1 to 4 carbon atoms or a fluorinated alkylene group; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: GrantFiled: September 10, 2008Date of Patent: April 19, 2011Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Akiya Kawaue, Takeshi Iwai, Hideo Hada, Shinichi Hidesaka, Tsuyoshi Kurosawa, Natsuko Maruyama, Kensuke Matsuzawa, Takehiro Seshimo, Hiroaki Shimizu, Tsuyoshi Nakamura
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Publication number: 20110028743Abstract: A polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): wherein Ra represents, for example, a hydrogen atom or an alkyl group having one to six carbon atoms which may have a halogen atom; R1s each represent, for example, a halogen atom or an alkyl or haloalkyl group having one to six carbon atoms; “m” is the number of R1s; “n” is the number of cyano groups; and CH2?C(Ra)COO— group may have either of an endo conformation and an exo conformation. Accordingly, there is provided a novel polycyclic ester containing a cyano group and a lactone skeleton which is useful typically as a monomeric component for highly functional polymers. A polymer, for example, derived from this compound is highly soluble in an organic solvent while remaining stable typically to chemicals and exhibits improved hydrolyzability and/or improved solubility in water after hydrolysis.Type: ApplicationFiled: October 8, 2010Publication date: February 3, 2011Inventors: Keizo Inoue, Takahiro Iwahama, Masamichi Nishimura, Kiyoharu Tsutsumi
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Publication number: 20100304296Abstract: A salt represented by the formula (I-CC): wherein Q1 and Q2 each independently represent a fluorine atom etc., X1 represents a single bond etc., Y1 represents a C1-C36 aliphatic hydrocarbon group etc., A1 and A2 independently each represents a C1-C20 aliphatic hydrocarbon group etc., Ar1 represents a (m4+1)-valent C6-C20 aromatic hydrocarbon group which can have one or more substituents, B1 represents a single bond etc., B2 represents a group capable of being eliminated by the action of an acid, m1 and m2 independently each represents an integer of 0 to 2, m3 represents an integer of 1 to 3, with the proviso that m1 plus m2 plus m3 equals 3, and m4 represents an integer of 1 to 3, and a photoresist composition comprising the salt represented by the formula (I-CC) and a resin comprising a structural unit having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solution by the action of an acid.Type: ApplicationFiled: May 25, 2010Publication date: December 2, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Koji Ichikawa, Masako Sugihara, Tatsuro Musuyama
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Publication number: 20100298140Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: September 1, 2008Publication date: November 25, 2010Applicant: SYNGENTA LIMITEDInventors: Stephane Andre Marie Jeanmart, John Benjamin Taylor, Melloney Tyte, Christopher John Mathews, Steve Smith
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Publication number: 20100286259Abstract: Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2?-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.Type: ApplicationFiled: December 30, 2008Publication date: November 11, 2010Applicant: The US, DHHS, NIHInventors: John A. Beutler, Ranjala Ratnayake, David Covell, Tanya R. Johnson
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Patent number: 7759492Abstract: An enantioselective route to compounds of formula I is disclosed: The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease.Type: GrantFiled: August 17, 2005Date of Patent: July 20, 2010Assignee: Merck Sharp & Dohme LimitedInventors: Stephen Philip Keen, Steven Fraser Oliver, Gavin William Stewart
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Patent number: 7652031Abstract: Compounds which mimic the chemical and/or biological activity of discodermolide are provided.Type: GrantFiled: August 6, 2002Date of Patent: January 26, 2010Assignee: The Trustees Of The University of PennsylvaniaInventors: Amos B Smith, III, Thomas Beauchamp, Matthew J. Lamarche, Paul V. Rucker
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Publication number: 20100010063Abstract: The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that the ring is not 1,2,3-triazole, the ring being substituted by groups R8, R9 and R10; X is a single or double bond; Y is O, S, N(R11) or (CR12R13)(CR14R15)m(CR16R17)n; m is 0 or 1; n is 0 or 1; and R1 to R17 each, independently, have a range of values; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient, to the preparation of the compositions mentioned and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.Type: ApplicationFiled: August 28, 2009Publication date: January 14, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Josef Ehrenfreund, Hans Tobler, Harald Walter
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Publication number: 20090247772Abstract: The invention relates to intermediates and the use thereof in a method for the preparation of escitalopram:Type: ApplicationFiled: November 14, 2006Publication date: October 1, 2009Applicant: H. Lundbeck A/SInventors: Antonio Paulon, Ottorino De Lucchi, Andrea Castellin, Fabrizio Fabris, Federico Sbrogio, Emanuele Ceron, Hans Petersen, Robert Dancer
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Publication number: 20090131498Abstract: This invention provides a method of synthesizing enantioenriched merrilactone A and enantiopure merrilactone A, as well as an improved method of synthesizing racemic merrilactone.Type: ApplicationFiled: January 18, 2006Publication date: May 21, 2009Inventors: Samuel J. Danishefsky, Zhaoyang Meng, Vladimir Birman
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Patent number: 7517904Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.Type: GrantFiled: July 7, 2005Date of Patent: April 14, 2009Assignee: Bristol-Myers Squibb CompanyInventors: Mark E. Salvati, James Aaron Balog, Dacia A. Pickering, Sören Giese, Aberra Fura, Wenying Li, Ramesh N. Patel, Ronald L. Hanson, Toomas Mitt, Jacques Y. Roberge, James R. Corte, Steven H. Spergel, Richard A. Rampulla, Raj N. Misra, Hai-Yun Xiao
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Publication number: 20090068591Abstract: A compound represented by formula (I); and a compound represented by formula (b1-1): wherein X represents —O—, —S—, —O—R3— or —S—R4—, wherein each of R3 and R4 independently represents an alkylene group of 1 to 5 carbon atoms; R2 represents an alkyl group of 1 to 6 carbon atoms, an alkoxy group of 1 to 6 carbon atoms, a halogenated alkyl group of 1 to 6 carbon atoms, a halogen atom, a hydroxyalkyl group of 1 to 6 carbon atoms, a hydroxyl group or a cyano group; a represents an integer of 0 to 2; Q1 represents an alkylene group of 1 to 12 carbon atoms or a single bond; Y1 represents an alkylene group of 1 to 4 carbon atoms or a fluorinated alkylene group; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: ApplicationFiled: September 10, 2008Publication date: March 12, 2009Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Akiya Kawaue, Takeshi Iwai, Hideo Hada, Shinichi Hidesaka, Tsuyoshi Kurosawa, Natsuko Maruyama, Kensuke Matsuzawa, Takehiro Seshimo, Hiroaki Shimizu, Tsuyoshi Nakamura
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Publication number: 20090036521Abstract: An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.Type: ApplicationFiled: September 12, 2005Publication date: February 5, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Shinichi Urayama, Eigo Mutou, Atsushi Inagaki, Takashi Okada, Shigeharu Sugisaki
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Publication number: 20080008965Abstract: Novel ester compounds having formulae (1) to (4) wherein A1 is a polymerizable functional group having a carbon-carbon double bond, A2 is oxygen, methylene or ethylene, R1 is a monovalent hydrocarbon group, R2 is H or a monovalent hydrocarbon group, any pair of R1 and/or R2 may form an aliphatic hydrocarbon ring, R3 is a monovalent hydrocarbon group, and n is 0 to 6 are polymerizable into polymers. Resist compositions comprising the polymers as a base resin are thermally stable and sensitive to high-energy radiation, have excellent sensitivity and resolution, and lend themselves to micropatterning with electron beam or deep-UV.Type: ApplicationFiled: July 5, 2007Publication date: January 10, 2008Inventors: Masaki Ohashi, Takeshi Kinsho, Takeru Watanabe
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Publication number: 20040242897Abstract: Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.Type: ApplicationFiled: December 10, 2003Publication date: December 2, 2004Inventors: Andrei P. Guzaev, Muthiah Manoharan