The Hetero Ring Is Five-membered Patents (Class 549/429)
  • Patent number: 11028062
    Abstract: In one aspect, methods of HMF production are described herein. A method of HMF production, in some embodiments, comprises providing a saccharide feedstock including glucose and bringing the saccharide feedstock into contact with a solid state catalytic structure at a temperature sufficient to effectuate dehydration of the glucose to provide HMF. The solid state catalytic structure comprises a substrate having one or more surfaces functionalized with saccharide solubilization functionalities and acid functionalities, wherein the saccharide solubilization functionalities comprise one or more imidazolium salts pendant along chains of a first polymeric species attached to the substrate surface.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: June 8, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Xianghong Qian, Ranil Wickramasinghe
  • Patent number: 10752602
    Abstract: The present invention provides a process for the production of 1,4-BDO and THF from furan, said process comprising: (i) contacting furan with hydrogen and water in a reactor in the presence of a catalytic composition, wherein the furan and water are contacted in the presence of a solvent, said solvent being selected from one or more of THF, 1,4-BDO and NBA, and converting at least a portion of said furan to 1,4-BDO and THF; (ii) producing a reactor product stream comprising gases, water, THF, 1,4-BDO and furan; (iii) separating gases from the reactor product stream; (iv) then separating at least a portion of each of the THF and 1,4-BDO from said reactor product stream; and (v) recycling the remainder of the reactor product stream, comprising water, optionally furan, and at least one of THF, 1,4-BDO and NBA, to the reactor.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: August 25, 2020
    Assignee: Shell Oil Company
    Inventors: Sipke Hidde Wadman, Jean Paul Andre Marie Joseph Ghislain Lange
  • Patent number: 10618864
    Abstract: The invention describes processes to prepare levulinic acid, formic acid and/or hydroxymethyl furfural from various biomass materials.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: April 14, 2020
    Assignee: GFBiochemicals IP Assets B.V.
    Inventors: Brian D. Mullen, Cora M. Leibig, Louis A. Kapicak, Donald L. Bunning, Steven R. Strand, Daniel Joseph Brunelle, Marc David Rodwogin, Robert Page Shirtum, Andrew J. Louwagie, Dorie Janine Yontz, Matthew John Tjosaas
  • Patent number: 10457656
    Abstract: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, especially, xylose, which can then be chemically converted to furfural and furfural-derived products.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: October 29, 2019
    Assignee: XYLECO, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Christopher Cooper, Jihan Khan
  • Patent number: 10351496
    Abstract: The present invention provides a process for the preparation of 1,4-butanediol and tetrahydrofuran said process comprising contacting furan with hydrogen and water in the presence of a supported catalytic composition comprising at least one first metal selected from those in groups 8 to 10 of the periodic table and a further metal selected from manganese, molybdenum, niobium and tungsten.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: July 16, 2019
    Assignee: SHELL OIL COMPANY
    Inventors: Sipke Hidde Wadman, Jean Paul Andre Marie Joseph Ghislan Lange
  • Patent number: 10035783
    Abstract: The present invention provides a process for the production of THF and 1,4-BDO from furan in the presence of a catalytic composition, wherein the catalytic composition contains at least one metal selected from the group consisting of Fe, Ru, Os, Co, Rh, Jr, Ni, Pd, Pt and, optionally, contains one or more additional metal on a solid support, and wherein said process comprises the steps of: i) contacting furan with hydrogen and water in a reactor in the presence of said catalytic composition for a time; ii) stopping the flow of furan and the flow of water to the reactor and removing furan and water from the reactor; iii) subjecting the catalytic composition to a gas stream comprising hydrogen at a temperature of from 200 to 600° C. in the absence of the furan and water; iv) re-starting the flow of furan and the flow of water to the reactor.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: July 31, 2018
    Assignee: SHELL OIL COMPANY
    Inventors: Jean Paul Andre Marie Joseph Ghislain Lange, Rene Johan Haan
  • Patent number: 9963437
    Abstract: The present invention provides a process for the treatment of a liquid first furan stream comprising furan and carbon monoxide, said process comprising the steps of: i) contacting said first furan stream with a CO-lean first gaseous stream; and ii) stripping at least a portion of the carbon monoxide in the first furan stream into the first gaseous stream to produce a second furan stream comprising less carbon monoxide than the first furan stream and a CO-enriched second gaseous stream.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 8, 2018
    Assignee: SHELL OIL COMPANY
    Inventors: Sipke Hidde Wadman, Jean Paul Andre Marie Joseph Ghislain Lange
  • Patent number: 9914715
    Abstract: The present invention provides a process for the production of furan, said process comprising the steps of: i) contacting furfural with a decarbonylation catalyst in a decarbonylation reactor to produce a gaseous decarbonylation reaction product stream comprising furan and carbon monoxide; ii) contacting said gaseous decarbonylation reaction product stream with a solvent stream comprising furfural; iii) absorbing at least a portion of the furan present in the gaseous decarbonylation reaction product stream into the solvent stream to provide a furan-containing solvent stream and a gaseous stream comprising carbon monoxide; iv) separating the furan from the furan containing solvent stream by distillation to provide a first furan stream; and v) using at least a portion of the remaining solvent stream comprising furfural as at least a portion of the furfural provided to the decarbonylation reactor.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: March 13, 2018
    Assignee: SHELL OIL COMPANY
    Inventors: Sipke Hidde Wadman, Jean Paul Andre Marie Joseph Ghislain Lange
  • Patent number: 9902661
    Abstract: A method for producing a linear hydrocarbon, including reacting a linear aliphatic aldehyde in the presence of at least one metal ion selected from the group consisting of a vanadium ion, a manganese ion, an iron ion, a cobalt ion, an iridium ion, a copper ion, and a thallium ion.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: February 27, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Masayoshi Muramatsu, Chikara Ohto
  • Patent number: 9765061
    Abstract: The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an N-acyl homoserine lactone analog (AHL), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) to the patient. Novel bioactive analogs of an N-acyl homoserine lactone are also provided.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 19, 2017
    Assignee: The Scripps Research Institute
    Inventors: Vladimir Kravchenko, Richard J. Ulevitch, Kim D. Janda
  • Patent number: 9730450
    Abstract: The use of one or more compounds of the formula (I) in which R is a straight-chain or branched saturated alkyl group having 5 to 11 carbon atoms or a straight-chain or branched mono- or polyunsaturated alkenyl group having 5 to 11 carbon atoms as antimicrobially active compound is described. The use is preferably in cosmetic, dermatological or pharmaceutical compositions, in crop protection formulations, in washing or cleaning compositions or in paints or coatings.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: August 15, 2017
    Assignee: CLARIANT INTERNATIONAL LTD.
    Inventors: Maurice Frederic Pilz, Peter Klug, Franz-Xaver Scherl, Joerg Grohmann
  • Patent number: 9650354
    Abstract: An efficient, hydrogen gas-free, high yielding, moderate temperature and safe-to-handle process for producing furan and its derivatives from furfural, which comprises contacting furfural and water-isopropanol mixture with a supported Pd or Pt catalyst at a temperature in the range of 200-250° C., is reported.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: May 16, 2017
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Srinivas Darbha, Bhogeswararao Seemala
  • Patent number: 9604950
    Abstract: The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an N-acyl homoserine lactone analog (AHL), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (TNF) related apoptosis inducing ligand (TRAIL) to the patient. Novel bioactive analogs of an N-acyl homoserine lactone are also provided.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: March 28, 2017
    Assignee: The Scripps Research Institute
    Inventors: Vladimir Kravchenko, Richard J. Ulevitch, Kim D. Janda
  • Patent number: 9604202
    Abstract: Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry comprising furan-2,5-dicarboxylic acid (FDCA) and compositions thereof. Also disclosed is a process to produce a dry purified carboxylic acid product by utilizing various purification methods on the crude carboxylic acid.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: March 28, 2017
    Assignee: EASTMAN CHEMICAL COMPANY
    Inventors: Kenny Parker, Mesfin Janka, Ashfaq Shaikh, Lee Partin
  • Patent number: 9598341
    Abstract: The invention describes processes to prepare levulinic acid, formic acid and/or hydroxymethyl furfural from various biomass materials.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: March 21, 2017
    Assignee: GFBiochemicals Limited
    Inventors: Brian D. Mullen, Dorie Janine Yontz, Cora M. Leibig
  • Patent number: 9403734
    Abstract: A method and integrated reactor system are provided for producing one or more organic acids, organic acid degradation compounds, and combinations thereof, from various types of biomass, including sludge from a pulp and paper mill.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: August 2, 2016
    Assignee: Georgia-Pacific LLC
    Inventors: John Patrick Kelly, Michael Eugene Carroll, Paul Topping
  • Patent number: 9328290
    Abstract: Multiple catalytic processing stations enable a method for producing volatile gas streams from biomass decomposition at discrete increasing temperatures. These catalytic processing stations can be programmed to maximize conversion of biomass to useful renewable fuel components based on input feedstock and desired outputs.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: May 3, 2016
    Assignee: Cool Planet Energy Systems, Inc.
    Inventors: Michael C. Cheiky, Rajashekharam Malyala
  • Patent number: 9284290
    Abstract: The present invention refers to a process for production of a mixture including 2,4-furandicarboxylic acid (2,4-FDCA) and 2,5 furandicarboxylic acid (2,5-FDCA) through the disproportionation route, using as base compounds oxidation products of furfural. This invention also relates to a process for production of 2,4-FDCA as a result of a disproportionation route and the use of 2,4-FDCA as a monomer or comonomer to synthesize esters or any compounds which can generate macromolecules, such as polyesters.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 15, 2016
    Assignee: Braskem S.A.
    Inventors: Jacco van Haveren, Shanmugam Thiyagarajan, Augusto Teruo Morita
  • Patent number: 9238022
    Abstract: The present invention relates to a method for the treatment or prophylaxis of a disease associated with hyperproliferative cellular division, comprising administering to a subject in need thereof a therapeutically effective dosage of the pharmaceutical composition comprising xanthanodien, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: January 19, 2016
    Inventor: Caroline Van Haaften
  • Patent number: 9186599
    Abstract: A process which isolates tetrahydrofuran from a stream of tetrahydrofuran, alkanol and high boilers, by: (a) separating off a first stream of tetrahydrofuran and alkanol as azeotrope in a first distillation stage; (b) feeding part of the first stream into a reactor for esterifying maleic anhydride, giving a second stream of tetrahydrofuran and monoalkyl maleate; (c) separating the second stream into a third stream of monoalkyl maleate and a fourth stream of tetrahydrofuran in a second distillation stage; (d) feeding the fourth stream of tetrahydrofuran from the second distillation stage and the part of the first stream from (a) which is not fed to the reactor into a third distillation stage to obtain a product stream of tetrahydrofuran and a sixth stream of tetrahydrofuran and alkanol; (e) recirculating the sixth stream from the third distillation stage into the first distillation stage or the reactor in (b).
    Type: Grant
    Filed: September 18, 2011
    Date of Patent: November 17, 2015
    Assignee: BASF SE
    Inventors: Maria Guixa Guardia, Rolf Pinkos, Nadja Pollmer, Wolf-Steffen Weissker, Hugues Vandenmersch
  • Publication number: 20150141667
    Abstract: The present invention provides catalysts, methods, and reactor systems for converting oxygenated hydrocarbons to oxygenated compounds. The invention includes methods for producing cyclic ethers, monooxygenates, dioxygenates, ketones, aldehydes, carboxylic acids, and alcohols from oxygenated hydrocarbons, such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like, using catalysts containing palladium, molybdenum, tin, and tungsten. The oxygenated compounds produced are useful in the production of liquid fuels, chemicals, and other products.
    Type: Application
    Filed: December 30, 2014
    Publication date: May 21, 2015
    Inventors: Brian Blank, Randy Cortright, Taylor Beck, Elizabeth Woods, Mike Jehring
  • Patent number: 8999197
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1) For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: April 7, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
  • Patent number: 8969404
    Abstract: A process for purifying a crude furan 2,5-dicarboxylic acid composition (cFDCA) by hydrogenation of a FDCA composition dissolved in a hydrogenation solvent such as water, and hydrogenating under mild conditions, such as at a temperature within a range of 130° C. to 225° C. by contacting the solvated FDCA composition with hydrogen in the presence of a hydrogenation catalyst under a hydrogen partial pressure within a range of 10 psi to 900 psi. A product FDCA composition is produced having a low amount of tetrahydrofuran dicarboxylic acid, a low b*, and a low amount of 5-formyl furan-2-carboxylic acid (FFCA).
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: March 3, 2015
    Assignee: Eastman Chemical Company
    Inventors: Mesfin Ejerssa Janka, Charles Edwan Sumner, Jr., Shane Kipley Kirk, Ashfaq Shahanawaz Shaikh, Kenny Randolph Parker
  • Patent number: 8957232
    Abstract: The invention relates to a method for the extraction of all unsaponifiable fraction contained in a vegetable oil, an oil originating from a micro-organism or a vegetable butter or in a co-product from the vegetable oil refining industry, such as deodorization discharge. The method includes at least: A) a step comprising the transformation of the aforementioned oils, butter or co-product from the vegetable oil refining industry or oils originating from micro-organisms into a hydro-alcoholic solution by means of, in particular, a step selected from saponification and esterification steps; B) a step comprising the extraction of the hydro-alcoholic solution in which the fatty fraction is separated from the unsaponifiable fraction by means of liquid/liquid extraction; and C) an optional step comprising the purification of the unsaponifiable fraction, selected from the group containing crystallization and liquid/liquid extraction steps.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: February 17, 2015
    Assignee: Laboratoires Expanscience
    Inventors: Alex Saunois, Jacques Legrand, Eglantine Mercier
  • Patent number: 8952056
    Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: February 10, 2015
    Assignee: Sequoia Pharmaceuticals, Inc.
    Inventors: Michael Eissenstat, Dehui Duan, Sergi Gulnik, John W. Erickson
  • Patent number: 8916564
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 23, 2014
    Assignee: Pfizer Inc.
    Inventors: Martin Youngjin Pettersson, Douglas Scott Johnson, Chakrapani Subramanyam, Christopher John O'Donnell, Christopher William am Ende, Michael Eric Green, Nandini Chaturbhai Patel, Cory Michael Stiff, Tuan Phong Tran, Gregory Wayne Kauffman, Antonia Friederike Stepan, Patrick Robert Verhoest
  • Patent number: 8912188
    Abstract: Disclosed herein are substituted quinoxaline carboxylic acids of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: December 16, 2014
    Assignee: BioEnergenix, LLC
    Inventors: John M. McCall, Donna L. Romero, Robert C. Kelly
  • Patent number: 8901326
    Abstract: Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H2, an acid catalyst and hydrogenation catalyst in the presence of an alkylamide solvent. The hydrogenation catalyst is a heterogeneous catalyst comprising a metal selected from the group consisting of Pt, Pd, and nickel. The acid catalysts may be homogeneous mineral acid or a heterogeneous acid catalyst on substrate. In a preferred practice the two catalysts are provided on a common heterogeneous bifunctional support. Using similar combinations of acid and hydrogenation catalysts, there is also described single step methods for making furandimethanol by simultaneously contacting a hexose with the two separate catalysts in the presence of H2 in an aprotic solvent, such as dimethylformamide.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 2, 2014
    Assignee: Archer Daniels Midland Company
    Inventors: Stephen Howard, Alexandra Sanborn
  • Patent number: 8901126
    Abstract: Substituted imidazo[1,5-a]quinoxalin-4-one compounds of formula (I) described herein exhibit PDE9-inhibitory action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: December 2, 2014
    Assignee: Astellas Pharma Inc.
    Inventors: Hiroyuki Kaizawa, Mari Sugita, Hirofumi Yamamoto, Kazunori Kamijo, Kazuyuki Tsuchiya, Ryushi Seo, Satoshi Yamamoto
  • Patent number: 8889734
    Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: November 18, 2014
    Assignee: SANOFI
    Inventors: Antal Friesz, Zsolt Dombrady, Mariann Csatarine Nagy
  • Patent number: 8884035
    Abstract: Disclosed herein are processes comprising contacting isosorbide with hydrogen in the presence of a first hydrogenation catalyst to form a first product mixture comprising tetrahydrofuran-2,5-dimethanol. The processes can further comprise heating the first product mixture in the presence of hydrogen and a second hydrogenation catalyst to form a second product mixture comprising 1,6-hexanediol. The first and second hydrogenation catalysts can be the same or different.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 11, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Wathudura Indika Namal de Silva, Ekaterini Korovessi, Carl Andrew Menning, Joseph E Murphy, Joachim C Ritter, Sourav Kumar Sengupta, Christina S Stauffer
  • Patent number: 8877759
    Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: November 4, 2014
    Assignee: Vertex Pharnaceuticals Incorporated
    Inventors: Jean-Damien Charrier, David Kay, Somhairle MacCormick, Pierre-Henri Storck, Joanne Pinder, Michael Edward O'Donnell, Ronald Marcellus Alphonsus Knegtel, Stephen Clinton Young, Philip Michael Reaper, Steven John Durrant, Heather Clare Twin, Christopher John Davis
  • Patent number: 8871802
    Abstract: The present invention discloses novel naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]thiophene-4,9-diones and methods of making and using the same. The present invention also discloses pharmaceutical compositions comprising novel naphtho[2,3-b]furan-4,9-dione or naphtho[2,3-b]thiophene-4,9-diones for the treatment of various indications including proliferative diseases.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: October 28, 2014
    Assignee: Zhoushan HaiZhongZhou Xinsheng Pharmaceuticals Co., Ltd.
    Inventors: Zhiwei Jiang, Aijin Wang, Xian Li, Qingrong Li, Hongwei Hu, Jiali Xu, Yuesong Hu, Yan Ye
  • Patent number: 8859599
    Abstract: The present invention concerns compounds of general formula (I): Method of preparation and uses thereof.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: October 14, 2014
    Assignees: CNR—Consiglio Nazionale delle Ricerche, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) S.r.l.
    Inventors: Greta Varchi, Andrea Guerrini, Anna Tesei, Giovanni Brigliadori
  • Patent number: 8853282
    Abstract: A topical liquid formulation is provided which contains a combination of three active ingredients for treating fleas and ticks in domestic animals. Total concentration of the active hydrophobic and hydrophilic ingredients can exceed 60 weight percent. In contrast to commonly available flea treatments, the new insecticidal composition is safe and effective for both felines and canines and a single topical application can be effective for at least several weeks.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 7, 2014
    Assignee: Sumitomo Corporation
    Inventor: Ian Cottrell
  • Patent number: 8835659
    Abstract: The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: September 16, 2014
    Assignees: Ikerchem, S.L., Universidad del Pais Vasco
    Inventors: Fernando Pedro Cossio Mora, Leire Lidia Arias Echeverría, Yosu Ion Vara Zalazar, Eneko Aldaba Arévalo, Eider San Sebastián Larzabal, Aizpea Zubia Olascoaga
  • Patent number: 8822708
    Abstract: Triphenylene containing benzo-fused thiophene compounds are provided. Additionally, triphenylene containing benzo-fused furan compounds are provided. The compounds may be useful in organic light emitting devices, particularly as hosts in the emissive layer of such devices, or as materials for enhancement layers in such devices, or both.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 2, 2014
    Assignee: Universal Display Corporation
    Inventors: Bin Ma, Yonggang Wu, Chun Lin, Raymond Kwong
  • Patent number: 8822469
    Abstract: The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: September 2, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Somhairle MacCormick, Pierre-Henri Storck, Michael Paul Mortimore, Jean-Damien Charrier, Ronald Knegtel, Stephen Clinton Young, Joanne Pinder, Steven John Durrant
  • Patent number: 8815999
    Abstract: Disclosed are novel cross-linkable end-cappers for oligo- and polyimides. End-capped oligo- and polyimides comprising such an end-capper may be cured at a lower temperature compared to oligo- and polyimides end-capped with PEPA.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: August 26, 2014
    Assignee: Nexam Chemical AB
    Inventors: Jan-Erik Rosenberg, Daniel Röme, David Persson, Erik Lager, Malin Knutsson, Dane Momcilovic
  • Patent number: 8809491
    Abstract: The present invention provides a method for depolymerization of a mixture comprising oligomeric cyclic ethers resulting from copolymerization of at least one tetrahydrofuran and at least one other cyclic ether to recover tetrahydrofuran monomer.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 19, 2014
    Assignee: INVISTA North America S.à r.l.
    Inventors: Robert B. Osborne, Paul S. Pearlman, Yanhui Sun
  • Patent number: 8809319
    Abstract: Nitromethylene analogues of imidacloprid and divalent and oxabridged heterocyclic neonicotinoid compounds constructed by dialdehydes, preparation methods and uses thereof are disclosed. Compounds represented by formula (A) or (B), their optical isomers or agrochemically acceptable salts are provided. Agrochemical compositions comprising the said compounds, their optical isomers or agrochemically acceptable salts, the uses of the said agrochemical compositions and the preparation methods of the said compounds, their optical isomers or agrochemically acceptable salts are also disclosed. The compounds and their derivatives have high insecticidal activities to several farming and forestry pests including homoptera and lepidoptera pests, such as aphis, fulgorid, whitefly, leafhopper, common thrips, cotton bollworm, cabbage caterpillar, cabbage moth, cotton leafworm and armyworm.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: August 19, 2014
    Assignee: East China University of Science and Technology
    Inventors: Xuhong Qian, Zhong Li, Xusheng Shao, Xiaoyong Xu, Zhiping Xu, Gonghua Song
  • Patent number: 8791118
    Abstract: The invention provides new pyridopyrazine compounds according to formula (I) which are highly selective as Ras-Raf-Mek-Erk signal transduction pathway inhibitors and in particular are highly selective Erk inhibitors.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: July 29, 2014
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Lars Blumenstein, Gilbert Mueller, Eckhard Guenther, Tilmann Schuster, Michael Teifel
  • Patent number: 8791119
    Abstract: Compounds corresponding to the general formula (I) wherein R2 represents a group C1-10-alkyl, C3-10-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl-C3-7-cycloalkyl, C3-7-cycloalkyl-C3-7-cycloalkyl, C1-6-alkylthio-C-1-10-alkyl, C1-6-alkoxy-C1-10-alkyl, hydroxy-C1-10-alkyl, hydroxy-C1-6-alkyl-C3-7-cycloalkyl-C1-6-alkyl, hydroxy-C3-10-cycloalkyl, C1-10-fluoroalkyl or C3-10-fluorocycloalkyl; an optionally substituted heterocyclic group; a group C1-10-alkyl substituted with an optionally substituted heterocyclic group; X6 represents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-fluoroalkyl or cyano; and R7 represents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents, in the form of the base or of an acid-addition salt, and the therapeutic use thereof.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: July 29, 2014
    Assignee: Sanofi
    Inventors: Sylvain Cote Des Combes, Jacques Froissant, Jean-Francois Gibert, Frank Marguet, Christophe Pacaud, Frédéric Puech, Antoine Ravet
  • Patent number: 8772515
    Abstract: Described is a process to produce hydroxymethyl furfural (HMF) from biomass-derived sugars. The process includes the steps of reacting a C5 and/or C6 sugar-containing reactant derived from biomass in a monophasic or biphasic reaction solution comprising water and a co-solvent. The co-solvent can be beta-, gamma-, and/or delta-lactones derived from biomass, tetrahydrofuran (THF) derived from biomass, and/or methyltetrahydrofuran (MTHF) derived from biomass. The reaction takes place in the presence of an acid catalyst and a dehydration catalyst for a time and under conditions such that at least a portion of glucose or fructose present in the reactant is converted to HMF.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: July 8, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Jean Marcel Ribeiro Gallo, David Alonso
  • Patent number: 8772323
    Abstract: The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: July 8, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Grauert, Remko Bakker, Steffen Breitfelder, Frank Buettner, Peter Eickelmann, Thomas Fox, Marc Grundl, Thorsten Lehmann-Lintz, Wolfgang Rist
  • Publication number: 20140187740
    Abstract: The present invention is aimed to provide a 1,4-butanediol-containing composition having high thermal stability as compared with conventional 1,4BG, and the present invention is concerned with a 1,4-butanediol-containing composition having a concentration of 1,4-butanediol of 99.00% by weight or more and not more than 99.99% by weight and containing an amide compound in a concentration, as converted into a nitrogen atom, of from 1.0 to 50 ppm by weight.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 3, 2014
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yusuke IZAWA, Masaru Utsunomiya, Norikazu Konishi, Kouta Tanaka, Takayuki Suzuki, Shinichirou Matsuzono
  • Patent number: 8765804
    Abstract: The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl) -2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: July 1, 2014
    Assignee: Universität Innsbruck
    Inventors: Hermann Stuppner, Stefan Schwaiger, David Bernhard, Günther Laufer
  • Patent number: 8748479
    Abstract: A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: June 10, 2014
    Assignee: Eastman Chemical Company
    Inventors: Ashfaq Shaikh, Kenny Randolph Parker, Mesfin Ejerssa Janka, Lee Reynolds Partin
  • Patent number: 8722910
    Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.
    Type: Grant
    Filed: January 6, 2012
    Date of Patent: May 13, 2014
    Assignee: Evolva AG
    Inventors: Jean-Philippe Meyer, Philipp Knechtle, Katrine Buch Greve, Alexandre M P Santana Sørenson
  • Publication number: 20140128583
    Abstract: Disclosed is an anti-infective drug-macrolide derivate, preparation and uses thereof. Macrolide derivate, namely erythromycin ethylsuccinate crystalline hydrate, which has less moisture absorption and good storage stability, can be used in the preparation of medicaments for the treatment and prevention of human or animal infectious diseases caused by Gram-positive or negative bacteria.
    Type: Application
    Filed: April 20, 2012
    Publication date: May 8, 2014
    Inventor: Li Liu