The Two Cyclos Share At Least Three Ring Members (i.e., Bridged) Patents (Class 549/463)
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Patent number: 11897895Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I), any one of its individual enantiomers or any non-racemic mixture thereof any one of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description) with elemental sodium to form a sodium salt of the formula (III), any one of its individual enantiomers or any non-racemic mixture thereof (as defined in the description), and (b) reacting said sodium salt (III) with a 2-Methylbenzyl compound of the formula (IV) wherein X is a leaving group, wherein the steps (a) and (b) are conducted in the presence of at least one substantially anhydrous inert organic solvent.Type: GrantFiled: December 6, 2018Date of Patent: February 13, 2024Assignee: BASF AGRO B.V.Inventors: Michael Rack, Stefan Benson, Bernd Wolf, Roland Goetz
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Patent number: 11639358Abstract: The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.Type: GrantFiled: May 9, 2018Date of Patent: May 2, 2023Assignee: BASF AGRO B.V.Inventors: Klaus Ditrich, Michael Rack, Stefan Benson, Roland Goetz, Helmut Kraus
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Patent number: 10875873Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I), (I) any one of its individual enantiomers or any non-racemic mixture thereof comprising the steps of (a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.Type: GrantFiled: February 5, 2018Date of Patent: December 29, 2020Assignee: BASF AGRO B.V.Inventors: Stefan Benson, Michael Rack, Roland Goetz, Bernd Wolf, Joachim Gebhardt, Helmut Kraus
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Patent number: 10858298Abstract: This disclosure relates to the preparation of diphenyl compounds, especially dimethylbiphenyl compounds, in which there is one methyl group on each ring, and their oxidized analogues. These compounds, and particularly alkylated biphenyl compounds and biphenylcarboxylic acids, alcohols and esters, are useful intermediates in the production of a variety of commercially valuable products, including polyesters and plasticizers for PVC and other polymer compositions.Type: GrantFiled: March 27, 2019Date of Patent: December 8, 2020Assignee: ExxonMobil Research and Engineering CompanyInventors: Aaron Sattler, Victor DeFlorio, Michele L. Paccagnini, Allen W. Burton
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Patent number: 10815245Abstract: The present invention relates to the production of xylene derivatives from furfural and its derivatives. The invention describes new routes for converting furfural and its derivatives into xylene derivatives including novel intermediates.Type: GrantFiled: December 8, 2016Date of Patent: October 27, 2020Assignees: RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Didier Morvan, Olivier Back, Raphaël Wischert, Eric Muller
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Patent number: 10710969Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) any of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) wherein X is a leaving group in the presence of at least one base capable of forming water or a C1-C4 alkyl alcohol under the reaction conditions, and at least one inert organic solvent, and (b) simultaneously removing water, the C1-C4 alkyl alcohol or any mixture thereof from the reaction mixture.Type: GrantFiled: September 7, 2017Date of Patent: July 14, 2020Assignee: BASF AGRO B.V.Inventors: Stefan Benson, Michael Rack, Bernd Wolf, Roland Goetz, Joachim Gebhardt, Helmut Kraus
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Patent number: 10647584Abstract: Some embodiments are directed to a method for the preparation of defect-free nanosized synthetic zeolite materials, to the defect-free nanosized synthetic zeolite materials, to stable colloidal suspensions of the defect-free synthetic zeolite materials, and to the use of the defect-free nanosized synthetic zeolite materials and the stable colloidal suspensions in various applications.Type: GrantFiled: October 22, 2015Date of Patent: May 12, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ÉCOLE NATIONALE SUPÉRIEURE D'INGÉNIEURS DE CAEN, UNIVERSITÉ DE CAEN / UNIVERSITÉ DE BASSE-NORMANDIEInventors: Svetlana Mintova Lazarova, Siddulu Naidu Talapaneni, Julien Grand, Jean-Pierre Gilson
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Patent number: 9108982Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.Type: GrantFiled: December 5, 2014Date of Patent: August 18, 2015Assignee: California Institute of TechnologyInventors: Mark E. Davis, Joshua J. Pacheco
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Patent number: 9108979Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.Type: GrantFiled: May 20, 2014Date of Patent: August 18, 2015Assignee: California Institute of TechnologyInventors: Mark E. Davis, Joshua Pacheco
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Publication number: 20150141465Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.Type: ApplicationFiled: November 14, 2014Publication date: May 21, 2015Inventors: Calvin W. YEE, Zhe Li
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Publication number: 20150141670Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.Type: ApplicationFiled: December 5, 2014Publication date: May 21, 2015Inventors: MARK E. DAVIS, JOSHUA J. PACHECO
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Publication number: 20150125741Abstract: A secondary battery includes: a cathode; an anode; and non-aqueous electrolytic solution including a cyclic ether compound that includes a skeleton and one or more substituent groups introduced into the skeleton. The skeleton includes one or more four-or-more-membered oxygen-containing rings. The one or more substituent groups each are a monovalent group represented by Formula (1). —X—O—R??(1) (X is one of a divalent chain saturated hydrocarbon group, a halide group thereof, and nothing. R is one of a monovalent chain saturated hydrocarbon group, etc. At least one of one or more Rs includes one or more of the monovalent chain unsaturated hydrocarbon group, the monovalent cyclic unsaturated hydrocarbon group, the monovalent oxygen-containing cyclic unsaturated hydrocarbon group, the halide group thereof, and the monovalent group obtained by bonding two or more thereof, and includes a carbon-carbon multiple bond (one of —C?C— and —C?C—) bonded to an ether bond (—O—).Type: ApplicationFiled: October 24, 2014Publication date: May 7, 2015Inventors: Toru ODANI, Tadahiko KUBOTA
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Publication number: 20140364631Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.Type: ApplicationFiled: May 20, 2014Publication date: December 11, 2014Inventors: MARK E. DAVIS, JOSHUA PACHECO
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Publication number: 20140356787Abstract: A resist composition comprising a compound (m0) (wherein Rb1 represents an electron withdrawing group; Rb2 and Rb3 each independently represents an aryl group, an alkyl group or an alkenyl group, provided that Rb2 and Rb3 may be mutually bonded to form a ring with the sulfur atom; and X0? represents a monovalent counteranion).Type: ApplicationFiled: May 30, 2014Publication date: December 4, 2014Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Yoshitaka Komuro, Takaaki Kaiho, Toshiaki Hato, Akiya Kawaue, Junichi Tsuchiya, Yoshiyuki Utsumi
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Publication number: 20140342288Abstract: The present invention provides a radiation-sensitive resin composition that contains a polymer having a structural unit that includes an acid-labile group; and an acid generator, wherein the acid generator includes a compound including a sulfonate anion having SO3?, wherein a hydrogen atom or an electron-donating group bonds to an ? carbon atom with respect to SO3?, and an electron-withdrawing group bonds to a ? carbon atom with respect to SO3?; and a radiation-degradable onium cation. The compound preferably has a group represented by the following formula (1-1) or (1-2). In the following formulae (1-1) and (1-2), R1 and R2 each independently represent a hydrogen atom or a monovalent electron-donating group. R3 represent a monovalent electron-withdrawing group. R4 represents a hydrogen atom or a monovalent hydrocarbon group.Type: ApplicationFiled: May 20, 2014Publication date: November 20, 2014Applicant: JSR CORPORATIONInventors: Hiroshi TOMIOKA, Takakazu KIMOTO, Yusuke ASANO
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Publication number: 20140288169Abstract: The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions.Type: ApplicationFiled: January 5, 2012Publication date: September 25, 2014Applicant: TARGACEPT, INC.Inventors: Srinivasa Rao Akireddy, Scott R. Breining, Matt S. Melvin, Srinivasa V. Murthy, Anatoly A. Mazurov, Balwinder Singh Bhatti, Jon-Paul Strachan, Ronald Joseph Heemstra, Todd Showalter, Yunde Xiao, Philip S. Hammond, Lan Miao, David Kombo, Daniel Yohannes, Jason Speake
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Publication number: 20140187626Abstract: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogues synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.Type: ApplicationFiled: December 16, 2013Publication date: July 3, 2014Applicant: Hong Kong Baptist UniversityInventors: Zhaoxiang BIAN, Chengyuan LIN, Baomin FAN, Huaixue MU, Yongyun ZHOU, Weimin ZENG, Aiping LU, Albert Sun Chi CHAN
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Publication number: 20140161740Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: December 4, 2013Publication date: June 12, 2014Applicant: The Procter & Gamble CompanyInventors: Hugo Robert Germain DENUTTE, An PINTENS, Johan SMETS, Freek Annie Camiel VRIELYNCK, Koen VAN AKEN
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Publication number: 20140134539Abstract: To provide an alcohol compound containing fewer impurities at a high yield by conducting the following steps: a hydroboration process in which a reaction mixture is obtained by reacting in a solvent a compound represented by formula (C) and a boron agent selected from a group of diborane and borane complexes; and an oxidation process in which the pH of the reaction mixture is set at 0.5 to 4, which is conducted after treating the reaction mixture with hydrogen peroxide. In the formula, A1 to A6 are each independently a hydrogen atom, methyl group or ethyl group, and X is an oxygen atom, sulfur atom, methylene group or ethylene group.Type: ApplicationFiled: June 14, 2012Publication date: May 15, 2014Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Satoshi Sakuma, Masashi Serizawa, Atsushi Yasuda, Nobushi Yada, Shinichi Maeda
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Publication number: 20140080984Abstract: The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts.Type: ApplicationFiled: November 21, 2013Publication date: March 20, 2014Applicant: ZANNA SCITECH CO., LTD.Inventor: Zheng-Yun James ZHAN
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Publication number: 20140066637Abstract: The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The curable compound derived from biomass according to the invention comprises a bicycle structure, to which one of two epoxide functional groups are bonded.Type: ApplicationFiled: November 13, 2013Publication date: March 6, 2014Applicant: Korea Institute of Industrial TechnologyInventors: Jin Ku Cho, Sang Yong Kim, Do Hoon Lee, Bo Ra Kim, Baek Jin Kim, Jae Won Jung, Sang Hyeup Lee, Jae Soung Lee
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Publication number: 20130317101Abstract: According to the embodiments described herein, a SUMOylation inhibitor compound comprising a singleton scaffold is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a singleton SUMOylation inhibitor compound.Type: ApplicationFiled: May 9, 2013Publication date: November 28, 2013Applicants: Sanford-Burnham Medical Research Institute at Lake Nona, CITY OF HOPEInventors: Yuan Chen, Yi-Jia Li, Daniela Divlianska, Ekaterina Bobkova, Greg Roth
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Patent number: 8563779Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.Type: GrantFiled: July 19, 2011Date of Patent: October 22, 2013Assignee: Bayer CropScience AGInventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
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Publication number: 20130203688Abstract: The present document describes a nutraceutical or cosmeceutical composition for the prophylaxis of an ailment comprising a therapeutically effective amount of a sugar plant syrup filtration residue in association with a pharmaceutically acceptable carrier. The present document also describes a nutraceutical or cosmeceutical composition for improving health condition of skin. The present document describes a method of producing a sugar plant syrup-derived product; wherein the improvement is characterized in the step of: collecting a sugar plant syrup residue during the production of sugar or syrup to produce a syrup-derived by-product.Type: ApplicationFiled: August 19, 2011Publication date: August 8, 2013Applicant: FÉDÉRATION DES PRODUCTEURS ACÉRI-COLES DU QUÉBECInventors: Julie Barbeau, Geneviève Béland
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Patent number: 8501805Abstract: The present disclosure describes substituted ?-L-bicyclic nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, substituted ?-L-bicyclic nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.Type: GrantFiled: September 23, 2009Date of Patent: August 6, 2013Assignee: Isis Pharmaceuticals, Inc.Inventors: Punit P. Seth, Eric E. Swayze
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Publication number: 20120270736Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.Type: ApplicationFiled: June 30, 2011Publication date: October 25, 2012Applicant: Lixte Biotechnology, Inc.Inventors: John S. Kovach, Francis Johnson
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Publication number: 20120252996Abstract: The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The curable compound derived from biomass according to the invention comprises a bicycle structure, to which one of two epoxide functional groups are bonded.Type: ApplicationFiled: May 5, 2010Publication date: October 4, 2012Applicant: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGYInventors: Jin Ku Cho, Sang Yong Kim, Do Hoon Lee, Bo Ra Kim, Baek Jin Kim, Jae Won Jung, Sang Hyeup Lee, Jae Soung Lee
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Publication number: 20120226041Abstract: The invention provides catalysts and methods for preparing boronate esters. The methods can include the borylation of a secondary or primary C—H bond, for example, by contacting a reactant having a methylene or methyl and a diboron bis-ester in the presence of an effective catalyst. The contacting can be in the presence of an iridium complex, to effect borylation of the secondary or primary C—H bond, thereby providing the boronate ester. The boronate esters can be readily isolated and/or converted into other useful compounds and intermediates.Type: ApplicationFiled: March 5, 2012Publication date: September 6, 2012Applicant: The Board of Trustees of the University of IllinoisInventors: John F. Hartwig, Carl W. Liskey
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Patent number: 8227473Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.Type: GrantFiled: July 17, 2009Date of Patent: July 24, 2012Assignee: Lixte Biotechnology, Inc.Inventors: John S. Kovach, Francis Johnson
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Publication number: 20110144197Abstract: Compounds of the general formula (formula I) in which the meanings of the substituents R1 and R6 are as indicated in claim 1, have renin-inhibiting properties and can be used as medicines.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Stefan Stutz, Aleksandar Stojanovic, Stjepan Jelakovic, Christiane Marti
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Patent number: 7759044Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.Type: GrantFiled: January 25, 2008Date of Patent: July 20, 2010Assignee: International Business Machines CorporationInventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
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Publication number: 20100160166Abstract: A compound of formula (I): wherein: R1 is —SR10, —O—C(O)—R11, —NR12R13, where R10 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group, R11 is a thiophenenyl, furanyl or pyrrolyl group, R12 is H or a C1-4-alkyl group and R13 is a C1-8-alkyl group or a phenyl group unsubstituted or substituted by a C1-4-alkyl group; R2 is H or a C1-4-alkyl group; R3 and R4 are independently H or C1-4-alkyl groups; R5 and R6 are independently H, OH or OR14, or taken together are ?O, where R14 is a protecting group; R7 is H or a C1-4-alkyl group; and, R8 is H, R9 is OH and R15 is H, or R15 is H and R8 and R9 taken together are —O—, or R9 is OH and R8 and R15 taken together form a bond; and, R18 and R19 are both H, or R18 and R19 taken together form a bond, or a plant physiologically acceptable salt thereof is useful for inhibiting 9-cis-epoxycarotenoid dioxygenase (NCED) in a plant or seed and is therefore useful for regulating ABA biosynthesis in the plant or seed.Type: ApplicationFiled: July 22, 2009Publication date: June 24, 2010Inventors: Suzanne R. Abrams, Michele C. Loewen, Jason Boyd, Adrian John Cutler, Yuanzhu Gai, Kenneth M. Nelson
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Publication number: 20100029640Abstract: Disclosed herein are methods of treating neurodegenerative diseases comprising administering to the subject a compound having the structure: wherein ? and R1-R8 are described herein, or a compound having the structure: wherein Y, Z, and R21, R24, R25, and R31-R33 are described herein.Type: ApplicationFiled: July 29, 2009Publication date: February 4, 2010Inventor: John S. Kovach
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Patent number: 7547697Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.Type: GrantFiled: July 2, 2007Date of Patent: June 16, 2009Assignee: Hoffmann-La Roche Inc.Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Werner Neidhart, Alexander V. Mayweg
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Publication number: 20090136667Abstract: Method of forming a low dielectric k porous film on a substrate, comprising reacting at least a film matrix precursor compound having silicon, carbon, oxygen and hydrogen atoms, and either at least a pore-forming compound, of the formula (I) wherein R represents: either a linear or branched, saturated or non saturated hydrocarbon radical, or a cyclic saturated or unsaturated hydrocarbon radical, or at least one of the following pore-forming compounds: 1-methyl-4-(1-methyl ethyl)-7-oxabicyclo[2.2.1.]heptane, 1,3,3-trimethyl-2-oxabicyclo[2.2.1.]octane or 1,8-cineole, or 1-methyl-4-(1-methyl ethenyl)-7-oxabicyclo[4.1.0.]heptane; New precursor precursor mixture, and the use of a compound of formula (I), as a pore-forming compound in a chemical vapor deposition of a low dielectric k film on a substrate.Type: ApplicationFiled: March 20, 2007Publication date: May 28, 2009Inventors: Joanne Deval, Manon Vautier
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Patent number: 7524977Abstract: There is provided a process for producing a fluoroalkanesulfonamide derivative represented by the formula [3], R2—NH—SO2—Rf—R1??[3] including reacting a fluoroalkanesulfonic anhydride represented by the formula [1], with an organic primary amine represented by the formula [2], in the presence of water and in the presence of a base selected from the group consisting of (a) a hydroxide of an alkali metal or alkaline-earth metal or (b) a basic salt containing an alkali metal or alkaline-earth metal.Type: GrantFiled: July 25, 2007Date of Patent: April 28, 2009Assignee: Central Glass Company, LimitedInventors: Kei Matsunaga, Takeo Komata
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Publication number: 20090093641Abstract: The subject invention pertains to pentafluorosulfanyl (—SF5) substituted compounds and methods of their synthesis. The subject invention provides convenient methods to incorporate the —SF5 substituent into compounds such as heterocycles and alkynes.Type: ApplicationFiled: March 13, 2007Publication date: April 9, 2009Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: William R. Dolbier, JR., Akira Mitani
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Publication number: 20090082524Abstract: The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.Type: ApplicationFiled: September 19, 2008Publication date: March 26, 2009Applicant: UNIVERSITY OF MASSACHUSETTSInventors: Gregory N. Tew, Ahmad Emad-Eldin Madkour, Sterling Fitzgerald Alfred, Paralee Patten King, Semra Colak
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Publication number: 20090036309Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.Type: ApplicationFiled: February 6, 2008Publication date: February 5, 2009Inventors: John S. Kovach, Francis Johnson
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Publication number: 20080154043Abstract: The present invention relates to a process for the manufacture of the 7-oxabicyclo derivative of the formula IType: ApplicationFiled: December 14, 2007Publication date: June 26, 2008Inventors: Paul Spurr, Beat Wirz
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Patent number: 7332616Abstract: The present invention provides a polymer which has at least one or more of a repeating unit represented by a following general formula (1a), a repeating unit represented by a following general formula (2a) and a repeating unit represented by a following general formula (3b), and a repeating unit represented by a following general formula (1c), and a positive resist composition which contains as a base resin the polymer. Thereby, there can be provided a positive-resist composition having high sensitivity and high resolution in exposure with a high energy beam, wherein line edge roughness is small since swelling at the time of development is suppressed, and the residue after development is few.Type: GrantFiled: February 8, 2007Date of Patent: February 19, 2008Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Jun Hatakeyama, Yuji Harada, Yoshio Kawai
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Publication number: 20080008965Abstract: Novel ester compounds having formulae (1) to (4) wherein A1 is a polymerizable functional group having a carbon-carbon double bond, A2 is oxygen, methylene or ethylene, R1 is a monovalent hydrocarbon group, R2 is H or a monovalent hydrocarbon group, any pair of R1 and/or R2 may form an aliphatic hydrocarbon ring, R3 is a monovalent hydrocarbon group, and n is 0 to 6 are polymerizable into polymers. Resist compositions comprising the polymers as a base resin are thermally stable and sensitive to high-energy radiation, have excellent sensitivity and resolution, and lend themselves to micropatterning with electron beam or deep-UV.Type: ApplicationFiled: July 5, 2007Publication date: January 10, 2008Inventors: Masaki Ohashi, Takeshi Kinsho, Takeru Watanabe
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Patent number: 7186495Abstract: There are here disclosed a photoresist material for lithography using a light of 220 nm or less which comprises at least a polymer represented by the following formula (2) and a photo-acid generator for generating an acid by exposure: wherein R1, R2, R3 and R5 are each a hydrogen atom or a methyl group; R4 is an acid-labile group, an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has an acid labile group, an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has a carboxyl group, or a hydrocarbon group having 3 to 13 carbon atoms, which has an epoxy group; R6 is a hydrogen atom, a hydrocarbon group having 1 to 12 carbon atoms, or an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has a carboxyl group; x, y and z are optional values which meet x+y+z=1, 0<x?1, 0?y<1 and 0?z<1; and a weight-average molecular weight of the polymer is in the range of 2000 to 200000, and a resin having a (meth)acrylate unit of an alicyclic lactone structure represented by theType: GrantFiled: December 29, 2000Date of Patent: March 6, 2007Assignee: NEC CorporationInventors: Katsumi Maeda, Shigeyuki Iwasa, Kaichiro Nakano, Etsuo Hasegawa
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Patent number: 7019149Abstract: A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, wherein Y is (CH2)x; Z is selected from the group consisting of and (CR2)x, x is an integer of 1 or 2; n is 0 or 1; R2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom isType: GrantFiled: September 17, 2004Date of Patent: March 28, 2006Assignee: Allergan, Inc.Inventors: Robert M. Burk, Achim H-P Krauss, David F. Woodward
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Patent number: 6969730Abstract: Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.Type: GrantFiled: February 25, 2002Date of Patent: November 29, 2005Assignee: Abbott LaboratoriesInventors: Marlon D. Cowart, Youssef L. Bennani, Ramin Faghih, Gregory A. Gfesser, Lawrence A. Black
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Patent number: 6818779Abstract: A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, wherein Y is (CH2)x; Z is selected from the group consisting of x is an integer of 1 or 2; n is 0 or 1; R2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein tType: GrantFiled: August 5, 2002Date of Patent: November 16, 2004Assignee: Allergan, Inc.Inventors: Robert M. Burk, Achim H-P Krauss, David F. Woodward
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Publication number: 20040152905Abstract: Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.Type: ApplicationFiled: February 2, 2004Publication date: August 5, 2004Inventors: Andrei P. Guzaev, Muthiah Manoharan
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Publication number: 20040030162Abstract: A continuous process for the manufacture of dianhydro sugar alcohols by dehydration of the corresponding sugar alcohols or monoanhydro sugar alcohols in the presence of a dehydration catalyst, using evolved water vapor as a carrier for continuous separation of the product from the reaction mass.Type: ApplicationFiled: April 16, 2003Publication date: February 12, 2004Inventor: Kamlesh Kumar Bhatia
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Publication number: 20040030161Abstract: This invention concerns a process for recovering and purifying dianhydro sugar alcohols from a vapor stream comprising dianhydro sugar alcohols, such as isosorbide, and water vapor.Type: ApplicationFiled: April 16, 2003Publication date: February 12, 2004Inventor: Kamlesh Kumar Bhatia
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Patent number: 6677464Abstract: The present invention provides a method of industrially advantageously producing 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid derivatives under mild conditions in a high yield. The present invention relates to a production method of a 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid derivative of the formula (III) or the formula (IV), which comprises reacting an &agr;,&bgr;-unsaturated carboxylic acid of the formula (I) with a furan derivative of the formula (II) in the presence of a Lewis acid: wherein each symbol is as defined in the specification.Type: GrantFiled: March 14, 2003Date of Patent: January 13, 2004Assignees: Kuraray Co., Ltd., Sagami Chemical Research CenterInventors: Tomoya Kuwayama, Katsuji Ujita, Kazuya Shimizu, Shiro Terashima