Nitrogen Attached Directly Or Indirectly To The Hetero Ring By Acyclic Nonionic Bonding Patents (Class 549/467)
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Patent number: 4605740Abstract: The present invention relates to a process for the production of N-substituted acrylic acid amides by conversion of 2-carboalkoxy-t-oxabicyclo(2,2,1)hept-5-enes with primary or secondary amines to 2-carboxamide-7-oxabicyclo(2,2,1)hept-5-enes and the thermal decomposition of the latter, preferably in the presence of Lewis acids and in a vacuum, to furane and N-substituted acrylic acid amides. The process according to the invention results in high purity N-substituted acrylic acid amides that are, in the main, free of bifunctional monomers which would disrupt the subsequent polymerization of the N-substituted acrylic acid amides by undesired cross-linking.Type: GrantFiled: September 22, 1983Date of Patent: August 12, 1986Assignee: Chemische Fabrik Stockhausen GmbHInventor: Alfons Landscheidt
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Patent number: 4603211Abstract: A novel process for the preparation of 3,4-dihydro-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of the formula I ##STR1## reacting a 5-halo-2,3-dihydro-2-methylbenzo[b]furan of the formula II ##STR2## wherein Hal is chlorine or bromine, with chlorosulfonic acid to give a 6-halo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonyl chloride of formula III ##STR3## wherein Hal is chlorine or bromine, converting this sulfonyl chloride with ammonia into a 6-halo-2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of formula IV ##STR4## wherein Hal is chlorine or bromine, dehalogenating this sulfonamide with hydrogen in the presence of a tertiary amine and a noble metal catalyst, and hydrogenating the resultant 2,2-dioxo-3-methyl-1,2-benzoxathiin-8-ylsulfonamide of formula V ##STR5## with hydrogen in the presence of a noble metal catalyst.Type: GrantFiled: October 1, 1984Date of Patent: July 29, 1986Assignee: Ciba-Geigy CorporationInventor: Werner Fory
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Patent number: 4602035Abstract: There are described compounds of the formula ##STR1## where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl, or halogen, and R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethyoxycarbonyl, cyclopropylmethyl, phenethyl, or cyanoethyl, but at least one of the two is loweralkyl, which are useful as antidepressant and analgesic agents; novel intermediate compounds for preparing said compounds; and methods for synthesizing the foregoing compounds.Type: GrantFiled: December 7, 1983Date of Patent: July 22, 1986Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: John J. Tegeler, Craig J. Diamond, Grover C. Helsley
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Patent number: 4593109Abstract: Miticidal 1-(2-alkyl-4-(or 5)-bromo (or (chloro)-2,3-dihydrobenzofuran-7-yl)-4-alkoxy-4-alkylsemicarbazides.Type: GrantFiled: August 22, 1984Date of Patent: June 3, 1986Assignee: Shell Oil CompanyInventors: Kurt H. Pilgram, Richard D. Skiles
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Patent number: 4590271Abstract: Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is linked to the pyrimidinylmethyl moiety at the 1 or 7-position and is optionally substituted at the 2, 3, 4 or 6-position or at the 7-position when the linkage to the pyrimidinylmethyl moiety is at the 1-position wherein X is an oxygen or sulphur atom, a group CH.sub.2, a group S(O).sub.n where n=1 or 2, a group NR.sup.1 wherein R.sup.1 is hydrogen C.sub.1-4 alkyl or a group COR.sup.2 where R.sup.2 is hydrogen, C.sub.1-4 alkoxy or amino and the dotted line represents a single or double bond, have antimicrobial activity. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.Type: GrantFiled: April 29, 1983Date of Patent: May 20, 1986Assignee: Burroughs Wellcome Co.Inventors: Susan M. Daluge, Paul M. Skonezny, Barbara Roth, Barbara S. Rauckman
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Patent number: 4581178Abstract: Low valent transition metal complexes containing small cone angle phosphine or arsine ligands efficiently catalyze addition of aldehydes to compounds or groups having a C--H bond activated by a nitro or nitrile group, to provide nitroalcohols or cyanohydrins, respectively.Type: GrantFiled: February 28, 1985Date of Patent: April 8, 1986Assignee: E. I. Du Pont de Nemours and CompanyInventor: David Milstein
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Patent number: 4577011Abstract: Miticidal 2-(2-alkyl-4-(or 5)-bromo (or chloro)-2,3-dihydrobenzofuran-7-yl)-N-alkoxy-N-alkyldiazenecarboxamides.Type: GrantFiled: August 22, 1984Date of Patent: March 18, 1986Assignee: Shell Oil CompanyInventors: Kurt H. Pilgram, Richard D. Skiles
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Patent number: 4568691Abstract: The invention concerns novel esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl)phenols of the formula: ##STR1## and salts thereof, wherein R.sup.1 and R.sup.2 are (3-5C)alkyl, R.sup.3 and R.sup.4 are hydrogen or methyl, A is a direct bond or methylene, and Q is various heteroaromatic containing groups. The esters possess topical anti-inflammatory properties and the invention provides pharmaceutical compositions containing the esters and processes for their chemical manufacture.Type: GrantFiled: December 20, 1984Date of Patent: February 4, 1986Assignee: Imperial Chemical Industries, PLCInventors: Peter R. Marsham, David S. Thomson
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Patent number: 4562267Abstract: Variously substituted alkyl 2-(furyl or thienyl)-2-hydroxyacetates and 2-(furyl or thienyl)-2-hydroxyacetamides are useful as intermediates for hypoglycemic oxazolidine-2,4-diones.Type: GrantFiled: October 14, 1983Date of Patent: December 31, 1985Assignee: Pfizer Inc.Inventor: Rodney C. Schnur
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Patent number: 4560771Abstract: 1,2-Benzoxathiine derivatives of the formula I ##STR1## wherein Hal is chlorine, bromine or iodine,R is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, cyano or a --X--R.sup.1, --CO--X--R.sup.2, --CO--NR.sup.3 R.sup.4, --SO--R.sup.5 or --SO.sub.2 --R.sup.6 group, whereR.sup.1 is C.sub.3 -C.sub.5 alkynyl, or is C.sub.1 -C.sub.4 alkyl, unsubstituted or substituted by halogen or C.sub.1 -C.sub.4 alkoxy, or is C.sub.3 -C.sub.5 alkenyl, unsubstituted or substituted by halogen or C.sub.1 -C.sub.4 alkoxy,R.sup.2 and R.sup.5 are each independently of the other C.sub.1 -C.sub.4 alkyl,-C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, phenyl or benzyl,R.sup.3 and R.sup.4 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, phenyl or benzyl, R.sup.6 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.Type: GrantFiled: October 1, 1984Date of Patent: December 24, 1985Assignee: Ciba Geigy CorporationInventor: Werner Fory
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Patent number: 4551472Abstract: Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.Type: GrantFiled: January 9, 1984Date of Patent: November 5, 1985Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4532256Abstract: N-Methyl-carbamic acid esters of the formula ##STR1## wherein R.sub.1 is unsubstituted or substituted 2,3-dihydrobenzofuranyl, phenyl, naphthyl or ##STR2## R.sub.2 is hydroxyl, halogen, --OR.sub.1, C.sub.1 -C.sub.10 -alkoxy, C.sub.2 -C.sub.10 -alkenyloxy, C.sub.1 -C.sub.10 -dialkylamino or ##STR3## R.sub.3 is hydrogen, C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.3 -alkenyl, R.sub.4 is C.sub.1 -C.sub.6 -alkyl, --SR.sub.5, ##STR4## R.sub.5 is C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.3 -alkenyl, R.sub.6 and R.sub.7 are each hydrogen or C.sub.1 -C.sub.6 -alkyl, andn is zero or 1.A process for producing these compounds and their use for combating pests are described.Type: GrantFiled: December 12, 1983Date of Patent: July 30, 1985Assignee: Ciba-Geigy CorporationInventor: Jozef Drabek
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Patent number: 4526896Abstract: Antimicrobial 2-nitro-3-phenylbenzofurans wherein the benzo or the 3-phenyl portion of the molecule is bonded to an alkylene or an oxyalkylene group which is in turn bonded to a basic nitrogen atom or to the nitrogen atom of an (N-lower alkanoyl)amino group.Type: GrantFiled: March 5, 1981Date of Patent: July 2, 1985Assignee: Riker Laboratories, Inc.Inventors: Robert A. Scherrer, Richard M. Stern, Walton J. Hammar
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Patent number: 4521607Abstract: New bicyclic compounds, inclusive of salts thereof, of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen, halogen, lower alkyl, hydroxyl, lower alkyloxy or aralkyloxy, or R.sup.1 and R.sup.2 jointly represent lower alkylenedioxy; R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl; R.sup.5 represents hydrogen, lower alkyl or --CH.sub.2 SR.sup.7 (R.sup.7 represents hydrogen or acyl); R.sup.6 represents hydrogen or acyl, or R.sup.6 and R.sup.7 jointly represent a single bond; X represents --CH.sub.2 --, --O-- or >N--R.sup.8 (R.sup.8 represents hydrogen, acyl or lower alkyl); and n represents 2, 3 or 4, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.Type: GrantFiled: April 2, 1982Date of Patent: June 4, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshikazu Oka, Kohei Nishikawa, Akio Miyake
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Patent number: 4518609Abstract: Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthaldehyde, methyl 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoate, 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoic acid, (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, (E)-1-(5-carboxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene, (E)-1-(5-carbethoxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, and (E)-1-(5-carboxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.Type: GrantFiled: April 12, 1984Date of Patent: May 21, 1985Assignee: SRI InternationalInventors: Marcia I. Dawson, Rebecca L. S. Chan
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Patent number: 4500543Abstract: Disclosed herein are 1-aminomethyl-phthalans represented by the formula ##STR1## wherein R, R.sub.1, and R.sub.2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, thiomethyl, halo, or ##STR2## wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula ##STR3## wherein R.sub.7 is loweralkyl of 1 to 4 carbon atoms; or R and R.sub.1, or R.sub.1 and R.sub.2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R.sub.1 or R.sub.2 must be other than hydrogen; and R.sub.3 and R.sub.4 are independently selected from hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula ##STR4## wherein m is 0, 1 or 2, p is 0 or 1, R.sub.8 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R.sub.9 and R.sub.Type: GrantFiled: June 1, 1982Date of Patent: February 19, 1985Assignee: Abbott LaboratoriesInventors: John F. Debernardis, David L. Arendsen
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Patent number: 4496542Abstract: Compounds of the formula ##STR1## wherein R and R.sub.9 are independently hydroxy and lower alkoxy,R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms,R.sub.3, R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are hydrogen or lower alkyl,R.sub.6 is heterocyclic and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R.sub.9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts, possess antihypertensive activity.Type: GrantFiled: April 13, 1983Date of Patent: January 29, 1985Assignee: USV Pharmaceutical CorporationInventors: Jerry W. Skiles, Raymond D. Youssefyeh, John T. Suh, Howard Jones
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Patent number: 4486447Abstract: Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.Type: GrantFiled: June 24, 1983Date of Patent: December 4, 1984Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4485112Abstract: A 2-substituted benzofuran derivative of general formula I or II ##STR1## in which R.sub.1 and R.sub.2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NH(CO-alkyl), NH(CO-aryl) or NO.sub.2 group, or R.sub.1 and R.sub.2 can together form a ring of 5-8 carbon atoms; R.sub.3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R.sub.4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R.sub.5 is a hydroxyl group, an alkoxy group, an OCO-aryl an OCO-alkyl, OCONH-alkyl or OCONH-aryl group, ##STR2## where n is a number between 1 and 4, R.sub.7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R.sub.8 and R.sub.Type: GrantFiled: February 22, 1983Date of Patent: November 27, 1984Assignee: A. Menarini S.A.S.Inventors: Vittorio Pestellini, Mario Ghelardoni, Carlo Alberto Maggi, Gabrio Roncucci, Alberto Meli
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Patent number: 4482737Abstract: N-substituted N-isocyanatocarbonyl-carbamates, some of which are new, of the general formula ##STR1## are prepared by reacting an N-substituted carbamic acid ester of the general formulaR--NH--COOR.sup.1 (II)with chlorocarbonyl isocyanate of the formulaCl--CO--NCO (III)in a diluent, at a temperature between 50.degree. and 200.degree. C. The compounds (I) can be used as intermediate products for the preparation of new pest-combating agents.Type: GrantFiled: November 3, 1982Date of Patent: November 13, 1984Assignee: Bayer AktiengesellschaftInventors: Engelbert Kuhle, Hermann Hagemann
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Patent number: 4480110Abstract: A process for the preparation of N,O-disubstituted urethanes. A substituted urea, an alcohol and a compound taken from the group consisting of N-unsubstituted urethanes, urea, polyurets and mixtures thereof at a temperature of 120.degree.-350.degree. C. The urethanes prepared by this process are particularly suitable for the preparation of isocyanates.Type: GrantFiled: January 9, 1984Date of Patent: October 30, 1984Assignee: Bayer AktiengesellschaftInventors: Peter Heitk/a/ mper, Rudolf Fauss, Kurt Findeisen, Stefan Penninger, Hans-Joachim Scholl
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Patent number: 4456618Abstract: Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthaldehyde, methyl 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoate, 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoic acid, (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, (E)-1-(5-carboxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene, (E)-1-(5-carbethoxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, and (E)-1-(5-carboxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.Type: GrantFiled: October 15, 1982Date of Patent: June 26, 1984Assignee: SRI InternationalInventors: Marcia I. Dawson, Rebecca L. S. Chan
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Patent number: 4455436Abstract: The invention relates to N-acyl-o-phenylenediamines of the formula ##STR1## wherein A is a colorless carbocyclic or heterocyclic aromatic radical and each of R.sub.1 and R.sub.2 independently is an alkyl, alkenyl or phenyl radical which is unsubstituted or substituted by non-chromophoric groups, but only one of R.sub.1 and R.sub.2 can be phenyl, and the ring B can also be substituted by non-chromophoric groups. The invention also relates to processes for the manufacture of these compounds, their use for whitening man-made organic material their conversion into benzimidazolium compounds as well as stable, concentrated aqueous solutions of such compounds, processes for their manufacture and their use for whitening manmade organic material.Type: GrantFiled: August 14, 1981Date of Patent: June 19, 1984Assignee: Ciba-Geigy CorporationInventors: Hans R. Meyer, Max Siegrist
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Patent number: 4435422Abstract: Described are compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently of one another denote hydrogen or loweralkyl; A is CO, CH.sub.2, O, S, SO or CHOH; X is hydrogen, halo, loweralkyl, or --CH.sub.2 NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are as defined above; W is COOR wherein R is hydrogen or alkyl of 1-10 carbon atoms, CH.sub.2 OH, CONR.sub.1 R.sub.2 or CH.sub.2 NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are as defined above; Z.sub.1 and Z.sub.2 independently of one another denote hydrogen, halo or loweralkyl; and pharmaceutically acceptable salts thereof.The compounds are effective as diuretic agents.Type: GrantFiled: September 15, 1982Date of Patent: March 6, 1984Assignee: Abbott LaboratoriesInventors: Cheuk M. Lee, James A. Parks
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Patent number: 4432993Abstract: A compound of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or methyl,R.sup.3 is hydroxy, hydroxyalkoxy, benzyloxy orX--Y--Zwherein (i)X is a bond or oxygen,Y is C.sub.1-6 straight or branched alkylene, andZ is hydrogen or carboxy;or (ii)X is a bond or moiety --O--CH.sub.2 --,Y is C.sub.2-6 straight or branched alkenylene, andZ is carboxy; andR.sup.4 is an optional substituent, and n is 1, 2 or 3,their esters, amides and salts, are anti-obesity, hypoglycaemic, anti-inflammatory and platelet aggregation inhibiting agents.Type: GrantFiled: September 24, 1981Date of Patent: February 21, 1984Assignee: Beecham Group LimitedInventor: Michael J. Ferris
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Patent number: 4431668Abstract: Cyclopropane carboxylic acid ester derivatives and optical and geometrical isomers thereof expressed by the general formula: ##STR1## wherein R.sub.1 represents hydrogen atom or methyl group, R.sub.2 represents alkyl group, alkenyl group, haloalkyl group, haloalkenyl group having 1-6 carbon atoms and a group selected from the groups of the general formulae (II), (III) and (IV): ##STR2## in which n is an integer of 2-5, R.sub.4 represents methyl group, chlorine atom or methoxy group, and R.sub.3 represents a group selected from the groups of the general formulae (V), (VI), (VII), (VIII), (IX) and (X): ##STR3## in which X represents oxygen atom or vinylene group, R.sub.5 represents allyl group, propargyl group, benzyl group, phenoxy group or 2,2-dichlorovinyloxy group, R.sub.6 represents hydrogen atom, methyl group or halogen atom, R.sub.7 represents hydrogen atom, cyano group, ethynyl group or trifluoromethyl group and m is an integer of 1-2, R.sub.Type: GrantFiled: November 14, 1978Date of Patent: February 14, 1984Assignee: Dainippon Jochugiku Kabushiki KaishaInventors: Yoshio Katsuda, Yoshihiro Minamite
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Process for the preparation of N,O-disubstituted urethanes useful for the preparation of isocyanates
Patent number: 4430505Abstract: A process for the preparation of N,O-disubstituted urethanes. Urea or polyurets, primary amines and alcohols are reacted at 120.degree.-350.degree. C. in the presence of N-substituted urethanes and/or N-mono- or N,N'-disubstituted ureas or polyureas. In a preferred embodiment, the reactants further include catalysts known to be useful in esterification of carboxylic acids. The urethanes produced in accordance with this process are particularly useful as starting materials for preparation of isocyanates.Type: GrantFiled: October 15, 1980Date of Patent: February 7, 1984Assignee: Bayer AktiengesellschaftInventors: Peter Heitkamper, Klaus Konig, Kurt Findeisen, Rudolf Fauss, Rudolf Sundermann -
Patent number: 4423233Abstract: Hypoglycemic 5-furyl and 5-thienyl derivatives of oxazolidine-2,4-dione and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; and intermediates useful in the preparation of said compounds.Type: GrantFiled: March 1, 1982Date of Patent: December 27, 1983Assignee: Pfizer Inc.Inventor: Rodney C. Schnur
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Patent number: 4411910Abstract: Benzofuran derivatives of the formula ##STR1## wherein V is hydrogen or acetyl,X is oxo or two hydrogen atoms,R.sub.1 and R.sub.2 each independently is hydrogen, fluorine, or chlorine, and--A--B-- is --O--CH.sub.2 -- or --CH.sub.2 --O--,possess valuable pharmacological properties.Type: GrantFiled: March 11, 1982Date of Patent: October 25, 1983Assignee: Schering AktiengesellschaftInventors: Eberhard Schroeder, deceased, Manfred Lehman, Clemens Rufer
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Patent number: 4411908Abstract: Imidazoline derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen or alkyl C.sub.1-6 ;R.sup.2 is hydrogen, methyl, chloro, bromo or fluoro;R.sup.3 is hydrogen, methyl, hydroxy, methoxy, fluoro, chloro or bromo; and their non-toxic salts.Processes for their preparation and pharmaceutical compositions thereof. The compounds exhibit presynaptic .alpha..sub.2 -adrenoreceptor antagonist activity.Type: GrantFiled: July 13, 1982Date of Patent: October 25, 1983Assignee: Reckitt & Colman Products LimitedInventors: Christopher B. Chapleo, Peter L. Myers
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Patent number: 4400389Abstract: Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.Type: GrantFiled: May 8, 1978Date of Patent: August 23, 1983Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4381398Abstract: New amino-alcohol derivatives and processes for production thereof are disclosed. These compounds exhibit .alpha. and .beta.-adrenergic receptor blocking activity or they act to increase the flow of blood of certain organs.Type: GrantFiled: March 18, 1980Date of Patent: April 26, 1983Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiroshi Takizawa, Yoshimasa Oiji, Kazuhiro Kubo
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Patent number: 4344883Abstract: N-chlorosulfinylcarbamate esters are produced by the reaction of thionyl chloride with carbamate esters having one unsubstituted hydrogen on the carbamate nitrogen atom, preferably in the presence of a hydrogen chloride acceptor. The resulting N-chlorosulfinylcarbamate esters are useful intermediates in the preparation of pesticides having relatively low mammalian toxicity.Type: GrantFiled: October 6, 1980Date of Patent: August 17, 1982Assignee: The Regents of the University of CaliforniaInventors: Mohamed A. H. Fahmy, Tetsuo R. Fukuto
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Patent number: 4342778Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.2 -alkoxy-C.sub.1 -C.sub.2 -alkyl or cyclohexyl and R.sub.2 is C.sub.1 -C.sub.4 -alkyl possessing valuable insecticidal properties.Type: GrantFiled: May 1, 1979Date of Patent: August 3, 1982Assignee: Ciba-Geigy CorporationInventors: Jozef Drabek, Manfred Boger
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Patent number: 4341793Abstract: Compounds of formula (III): ##STR1## and esters, amides and pharmaceutically acceptable salts thereof, wherein A.sup.1 is hydrogen or methyl;A.sup.2 is hydrogen or methyl;n is 1, 2 or 3; andR is hydrogen, chlorine, bromine, hydroxy, nitro, amino or trifluoromethyl,are useful as anti-hyperglycaemic agents and/or anti-obesity agents.Type: GrantFiled: November 7, 1980Date of Patent: July 27, 1982Assignee: Beecham Group LimitedInventor: Michael J. Ferris
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Patent number: 4332952Abstract: Hypoglycemic 5-furyl and 5-thienyl derivatives of oxazolidine-2,4-dione and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; and intermediates useful in the preparation of said compounds.Type: GrantFiled: April 23, 1981Date of Patent: June 1, 1982Assignee: Pfizer Inc.Inventor: Rodney C. Schnur