Having -c(=x)-, Wherein X Is Chalcogen, Attached Directly Or Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/478)
  • Patent number: 10501429
    Abstract: A method is disclosed for making an unsaturated glycitan ester by reacting intramolecular condensates of glycitols having four or more carbons with a metathesis-derived unsaturated fatty acid in the presence of an alkaline catalyst and under conditions sufficient to form the aforesaid unsaturated glycitan fatty ester. A composition is also disclosed comprising a compound of the following structure: wherein R1 is hydrogen, alkyl, aryl or (CH2)1-9—COOR5; wherein R5 is wherein R2, R3 and R4 are hydrogen, or —(O)C—(CH2)m—CH?CH—R1 or —(CH2CH2O)nH or mixtures thereof; wherein m is 1 to 9; and wherein n is 1 to 100.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: December 10, 2019
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Ryan A. Littich, Timothy Montavon
  • Patent number: 9089132
    Abstract: Ethoxylated fatty acid mono-ester(s) of sorbitan with a fatty acid chain length from 8 to 14 and an overall degree of ethoxylation from 7 to 16 are new (though related to the polysorbates). These compounds are useful as adjuvants in agrochemical formulations, particularly combination formulations of herbicides having differing weed control effects, notably of non-selective herbicide and selective herbicide; particularly selective herbicide, particularly selective broadleaf herbicide, and graminicide; and selective graminicide and non-selective herbicide, especially a combination of a glyphosate type non-selective water soluble herbicide with a clethodim type selective (graminicide) herbicide, particularly to reduce or eliminate antagonism between differing types of herbicide. Formulations including such herbicide combinations and the adjuvant compounds are particularly useful in controlling weed including volunteer glyphosate resistant maize in subsequently sown glyphosate resistant soya.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: July 28, 2015
    Assignee: Croda, Inc.
    Inventor: Gregory James Lindner
  • Publication number: 20150105460
    Abstract: Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.
    Type: Application
    Filed: June 4, 2012
    Publication date: April 16, 2015
    Inventors: Weiwei Su, Yonggang Wang, Fengyin Liang, Ning Wang, Zhong Pei, Haibin Liu
  • Patent number: 8933251
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
  • Publication number: 20140275580
    Abstract: A method is disclosed for making an unsaturated glycitan ester by reacting intramolecular condensates of glycitols having four or more carbons with a metathesis-derived unsaturated fatty acid in the presence of an alkaline catalyst and under conditions sufficient to form the aforesaid unsaturated glycitan fatty ester. A composition is also disclosed comprising a compound of the following structure: wherein R1 is hydrogen, alkyl, aryl or (CH2)1-9—COOR5; wherein R5 is wherein R2, R3 and R4 are hydrogen, or —(O)C—(CH2)m—CH?CH—R1 or —(CH2CH2O)nH or mixtures thereof; wherein m is 1 to 9; and wherein n is 1 to 100.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: ELEVANCE RENEWABLE SCIENCES, INC.
    Inventors: Ryan A. Littich, Timothy Montavon
  • Patent number: 8835467
    Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: September 16, 2014
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Anthony A. Sauve
  • Publication number: 20140228456
    Abstract: The invention relates to novel demulsifiers for use in the demulsification of oils from water and vice versa, including the demulsification of crude oil from sea water or brine. In particular, the present invention relates to novel demulsifiers which are environmentally friendly, or ‘green’, and which can be used without restriction on-site in offshore oil drilling fields, for example in the North Sea. The novel demulsifiers are based on the reaction product of alkoxylated polyols or polyol esters with dicarboxylic acids.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 14, 2014
    Applicant: CRODA INTERNATIONAL PLC
    Inventors: Hanamanthsa Shankarsa Bevinakatti, Neil Grainger, Tracey Joanne Wardell
  • Publication number: 20140213668
    Abstract: Disclosed herein are alkoxylated sorbitan ester compounds and compositions useful in emulsion breaking applications relating to the production, transportation, storage, and separation of crude oil and natural gas. Also disclosed herein are methods of using the compounds and compositions as emulsion breakers, particularly in applications relating to the production, transportation, storage, and separation of crude oil and natural gas.
    Type: Application
    Filed: January 29, 2013
    Publication date: July 31, 2014
    Applicant: Ecolab USA Inc.
    Inventor: G. Richard Meyer
  • Publication number: 20140142296
    Abstract: The invention provides methyl-2-deoxyriboside containing at most 5 wt % of methyl-2-deoxyribopyranoside, based on the combined weight of methyl-2-deoxyriboside and methyl-2-deoxyribopyranoside.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Xing Fu, Albercht Zumbrunn
  • Publication number: 20140135389
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: January 22, 2014
    Publication date: May 15, 2014
    Inventors: Gael RONSIN, Laura STORONI, Francesca BENEDINI
  • Publication number: 20130303743
    Abstract: The present invention relates to a novel 3,6-anhydro-L-galactose dehydrogenase and to a novel compound produced therefrom. More specifically, provided is a 3,6-anhydro-L-galactose dehydrogenase which can produce 3,6-anhydrogalactonic acid of a novel type by metabolizing 3,6-anhydro-L-galactose.
    Type: Application
    Filed: January 25, 2012
    Publication date: November 14, 2013
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: In-Geol Choi, Kyoung Heon Kim, Eun Ju Yun, Saeyoung LEE
  • Publication number: 20130244877
    Abstract: Ethoxylated fatty acid mono-ester(s) of sorbitan with a fatty acid chain length from 8 to 14 and an overall degree of ethoxylation from 7 to 16 are new (though related to the polysorbates). These compounds are useful as adjuvants in agrochemical formulations, particularly combination formulations of herbicides having differing weed control effects, notably of non-selective herbicide and selective herbicide; particularly selective herbicide, particularly selective broadleaf herbicide, and graminicide; and selective graminicide and non-selective herbicide, especially a combination of a glyphosate type non-selective water soluble herbicide with a clethodim type selective (graminicide) herbicide, particularly to reduce or eliminate antagonism between differing types of herbicide. Formulations including such herbicide combinations and the adjuvant compounds are particularly useful in controlling weed including volunteer glyphosate resistant maize in subsequently sown glyphosate resistant soya.
    Type: Application
    Filed: August 16, 2011
    Publication date: September 19, 2013
    Applicant: CRODA, INC.
    Inventor: Gregory James Lindner
  • Publication number: 20130231491
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Application
    Filed: March 20, 2013
    Publication date: September 5, 2013
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Shin-Etsu Chemical Co., Ltd.
  • Patent number: 8394755
    Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: March 12, 2013
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
  • Patent number: 8383653
    Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: February 26, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Vern L. Schramm, Anthony A. Sauve
  • Publication number: 20120321579
    Abstract: The present invention provides surfactant compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.
    Type: Application
    Filed: January 23, 2012
    Publication date: December 20, 2012
    Applicant: ANTERIOS, INC.
    Inventors: Jonathan EDELSON, Timothy KOTYLA, Klaus THEOBALD
  • Patent number: 8211850
    Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: July 3, 2012
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
  • Publication number: 20120122758
    Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
    Type: Application
    Filed: March 30, 2011
    Publication date: May 17, 2012
    Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
  • Publication number: 20120123103
    Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
    Type: Application
    Filed: March 30, 2011
    Publication date: May 17, 2012
    Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
  • Publication number: 20120123104
    Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.
    Type: Application
    Filed: March 30, 2011
    Publication date: May 17, 2012
    Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
  • Publication number: 20110178102
    Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
    Type: Application
    Filed: June 30, 2004
    Publication date: July 21, 2011
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Vern L Schramm, Anthony A. Suave
  • Publication number: 20110123472
    Abstract: The present invention relates to long-wearing, non-aqueous based cosmetic compositions, and related dermatological, pharmaceutical or hygiene compositions. The present invention provides a non-aqueous based composition comprising one or a mixture of two or more emulsifiers.
    Type: Application
    Filed: February 2, 2011
    Publication date: May 26, 2011
    Inventor: Balanda ATIS
  • Publication number: 20110038847
    Abstract: A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.
    Type: Application
    Filed: April 15, 2009
    Publication date: February 17, 2011
    Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Ryoichi Kawamura, Takayuki Imamura, Hitomi Owaki
  • Patent number: 7868204
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: January 11, 2011
    Assignee: MethylGene Inc.
    Inventors: Daniel Delorme, Soon Hyung Woo, Arkadii Vaisburg, Oscar Moradei, Silvana Leit, Stephane Raeppel, Sylvie Frechette, Giliane Bouchain
  • Publication number: 20100311620
    Abstract: A new class of winterizing compositions are disclosed including a winterizing agents being a compound of general formula Z(R1)m, where Z is a polyol having between 5 and 30 carbon atoms, R1 is a carbyl group having between about 10 and about 40 carbon atoms, and where m is an integer having the value of 1 or 2, when m is 2, R1 can be the same or different and one or more carbon atoms of R1 can be replaced by B, N, O, Si, P, S, Ge and/or mixtures thereof and one or more of the hydrogen atoms in R1 can be replaced by F, Cl, Br, I, CONR22, COOR2, OR2, NR22, SR2, PR22, and/or mixtures thereof and where R2 can be a hydrogen atom, alkyl, aryl, alkylaryl or arylalkyl group having between 1-20 carbon atoms where one or more carbon or hydrogen atoms can be replaced as set forth for R1.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 9, 2010
    Applicant: Clearwater International, LLC
    Inventors: Sarkis R. Kakadjian, Gabriel Monreal, Roy Perez, Joseph E. Thompson, Frank Zamora
  • Publication number: 20100311080
    Abstract: A dual-interaction ligand for rendering otherwise hydrophobic nanoparticles water soluble or suspendable has a hydrophilic base with a plurality of hydrophilic segments extending from a core of the base, where at least one segment or the core contains a hydrophobic groups capable of forming van der Waal interaction between hydrophobic groups of the dual-interaction ligand and other hydrophobic ligands, and at least one complexing functionality to complex a metal atom or ion of a nanoparticle. The dual-interaction ligands can be combined with hydrophobic nanoparticles, where the dual-interaction ligands can displace some or all of the hydrophobic ligands of the hydrophobic nanoparticles, to form a nanoparticle-dual interaction ligand complex that can be dissolved or dispersed readily in an aqueous solution. The dual interaction ligand can be functionalized to attach an antibody or other biomolecules such that the nanoparticle dual-interaction ligands complexes can contain biomolecules.
    Type: Application
    Filed: January 28, 2009
    Publication date: December 9, 2010
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Y. Charles Cao, Huimeng Wu
  • Publication number: 20100249395
    Abstract: The present invention relates to a method for preparing capecitabine and a method for preparing a ?-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be efficiently prepared with a high yield by the method of the present invention using the ?-anomer-rich trialkyl carbonate compound as an intermediate.
    Type: Application
    Filed: November 7, 2008
    Publication date: September 30, 2010
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Jaeheon Lee, Gha-Seung Park, Weon Ki Yang, Jin Hee Kim, Cheol Hyun Park, Yong-Hoon An, Yoon Ju Lee, Young-Kil Chang, Gwan Sun Lee
  • Publication number: 20100228015
    Abstract: This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.
    Type: Application
    Filed: April 23, 2010
    Publication date: September 9, 2010
    Inventors: Mitchell A. deLong, Jill M. McFadden, Susan M. Royalty, Eric J. Toone, Jeffrey D. Yingling
  • Publication number: 20100210487
    Abstract: A friction modifier composition for reducing friction in a lubricant comprising a fatty acid sorbitan ester that is solid or semi-solid. The fatty acid sorbitan ester is capable of being released into a lubricant at a rate of less than or equal to 0.15 grams per minute.
    Type: Application
    Filed: February 16, 2009
    Publication date: August 19, 2010
    Applicant: Chemtura Coproration
    Inventors: Frank J. Deblase, Cyril A. Migdal, Gerard Mulqueen, Venkatramanan K. Madabusi
  • Publication number: 20100112482
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Inventors: Takeru WATANABE, Satoshi SHINACHI, Takeshi KINSHO, Koji HASEGAWA, Yuji HARADA, Jun HATAKEYAMA, Kazunori MAEDA, Tomohiro KOBAYASHI
  • Publication number: 20100041826
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: MALLINCKRODT INC.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Publication number: 20100041827
    Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.
    Type: Application
    Filed: October 23, 2009
    Publication date: February 18, 2010
    Applicant: Mallinckrodt, Inc.
    Inventors: Gary L. Cantrell, B. Daniel Burleigh
  • Patent number: 7622598
    Abstract: A compound represented by formula (I): [wherein, for example, X is a hydrogen atom or a halogen atom; R1 is a hydrogen atom; R2 is a hydrogen atom or a C1-4 alkyl group; R3 is —CHO or —COOH; and R4 is —CH?CH—(CH2)p—CH3 (wherein p is an integer of 1 to 12), —CH(OH)—(CH2)q—CH3 (wherein q is an integer of 1 to 13), —CH(OH)—CH2—CH(CH3)—(CH2)2—CH?C(CH3)2, —CH?CH—CH(CH3)—(CH2)3—CH(CH3)2, —(CH2)2—CH(CH3)—(CH2)3—CH(CH3)2 or —(CH2)8—CH3], an optical isomer thereof and a pharmaceutically acceptable salt thereof. These compounds have antitrypanosoma activity, and accordingly are useful as drugs for preventing or treating the diseases caused by trypanosoma.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: November 24, 2009
    Assignee: aRigen Pharmaceuticals, Inc.
    Inventors: Hiroyuki Saimoto, Yoshihiro Shigemasa, Kiyoshi Kita, Yoshisada Yabu, Tomoyoshi Hosokawa, Masaichi Yamamoto
  • Publication number: 20090156614
    Abstract: This invention provides new compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, prostate cancer, muscle wasting diseases and/or disorders or a bone-related diseases and/or disorders.
    Type: Application
    Filed: July 19, 2007
    Publication date: June 18, 2009
    Inventors: James T. Dalton, Duane D. Miller, Igor Rakov, Casey Bohl, Michael L. Mohler
  • Publication number: 20090076201
    Abstract: The present invention provides a (meth)acrylate containing a heterocyclic ring, which is a structure necessary for achieving physical properties required in many fields, and a hydrophilic group in the same monomer molecule and further provides a process for producing the same from industrially easily-available starting materials by industrially feasible reactions. A (meth)acryloyloxytetrahydrofuran having a structure represented by the following general formula (1): wherein R1 and R2 each is a hydrogen atom or a (meth)acryloyl group represented by the following general formula (2) and at least one of R1 and R2 is a (meth)acryloyl group represented by the general formula (2).
    Type: Application
    Filed: March 16, 2006
    Publication date: March 19, 2009
    Applicant: Mitsubishi Chemical Corporation
    Inventors: Haruhiko Kusaka, Hiroko Takahashi, Yuji Ohgomori, Kaoru Hamashima, Gan Wen, Taketoshi Naito
  • Patent number: 7468360
    Abstract: Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: December 23, 2008
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Danny T. Dinh
  • Publication number: 20080249119
    Abstract: The invention relates to homogemcitabines of general formula (2), with the meanings for the substituents as given in claim 1, method for production thereof, use for the production of the active agent gemcitabin and the use thereof for the production of medicaments for the treatment of proliferative diseases. The invention further relates to novel intermediates, as used in the inventive method.
    Type: Application
    Filed: July 20, 2006
    Publication date: October 9, 2008
    Applicant: PHARMACON-FORSCHUNG UND BERATUNG GMBH
    Inventors: Christian R. Noe, Muhamed Jasic, Hermann Kollmann, Karmin Saadat
  • Publication number: 20080139802
    Abstract: The present process provides an improved method for converting 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactones derivatives to 3-fluoro-3-methyl-2-chlorofuran compounds which are useful for the synthesis of nucleosides and improved processes for the synthesis of the D-ribonolactone compounds.
    Type: Application
    Filed: October 10, 2007
    Publication date: June 12, 2008
    Inventors: Steven D. Axt, Byoung-Kwon Chun, Qingwu Jin, Suguna Rachakonda, Bruce Ross, Keshab Sarma, Justin Vitale, Jiang Zhu
  • Publication number: 20080008965
    Abstract: Novel ester compounds having formulae (1) to (4) wherein A1 is a polymerizable functional group having a carbon-carbon double bond, A2 is oxygen, methylene or ethylene, R1 is a monovalent hydrocarbon group, R2 is H or a monovalent hydrocarbon group, any pair of R1 and/or R2 may form an aliphatic hydrocarbon ring, R3 is a monovalent hydrocarbon group, and n is 0 to 6 are polymerizable into polymers. Resist compositions comprising the polymers as a base resin are thermally stable and sensitive to high-energy radiation, have excellent sensitivity and resolution, and lend themselves to micropatterning with electron beam or deep-UV.
    Type: Application
    Filed: July 5, 2007
    Publication date: January 10, 2008
    Inventors: Masaki Ohashi, Takeshi Kinsho, Takeru Watanabe
  • Patent number: 7132001
    Abstract: The object of the present patent application are 3-aminophenol derivatives of formula (I) or the physiologically compatible, water-soluble salts thereof and colorants based on a developer-coupler combination containing these compounds.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: November 7, 2006
    Assignee: Wella AG
    Inventors: Gisela Umbricht, Franco Jose Rosato, Hans-Juergen Braun
  • Patent number: 7128764
    Abstract: The object of the present patent application are 3-aminophenol derivatives of formula (I) or the physiologically tolerated, water-soluble salts thereof wherein R denotes a heterocyclic aromatic 5-membered ring of formula (Ia) and colorants based on a developer-coupler combination and containing these compounds.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: October 31, 2006
    Assignee: Wella AG
    Inventors: Cècile Pasquier, Patrick Wyss, Hans-Juergen Braun
  • Patent number: 7122061
    Abstract: The present invention has for an object compounds of formula (I) and colorants containing these 4-aminobiphenyl-3-ol derivatives of general formula (I) for dyeing keratin fibers, particularly hair, wherein R1 and R2 independently of each other denote hydrogen, a halogen atom, a cyano group, a hydroxyl group, a C1–C4-alkoxy group, a C2–C4-hydroxyalkoxy group, a C1–C6-alkyl group, a nitro group, a trifluoromethyl group, a —C(O)H group, a —C(O)CH3 group, a —C(O)CF3 group, an —Si(CH3)3 group or a C1–6-hydroxyalkyl group or R1 and R2 together form an —O—CH2—O— bridge.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: October 17, 2006
    Assignee: Wella AG
    Inventors: Laurent Chassot, Hans-Juergen Braun
  • Patent number: 7034167
    Abstract: A novel process is provided for the preparation of ribofuranose sugar derivatives which are useful in the synthesis of branched-chain ribonucleoside inhibitors of HCV polymerase for the treatment of HCV infection. Also provided are useful intermediates obtained from the instant process.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: April 25, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Kimberly A. Savary, Zhiguo J. Song, J. Michael Williams, Feng Xu
  • Patent number: 7019024
    Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: March 28, 2006
    Assignee: Allelix Neuroscience Inc.
    Inventors: Vassil Iliya Ognyanov, Laurence A. Borden, Stanley Charles Bell, Jing Zhang
  • Patent number: 6897324
    Abstract: For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R2 is C1-5 alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R3-R6 are independently selected from C1-6 alkyl and C6-10 aryl
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: May 24, 2005
    Assignee: Chirotech Technology Limited
    Inventors: Martin Edward Fox, Mark Jackson
  • Patent number: 6852866
    Abstract: Disclosed is an invention concerning triazolyloligosaccharides, oligosaccharides wherein the bonding between the saccharide groups is via a triazole group and methods for their preparation.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: February 8, 2005
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Subramaniam Sabesan
  • Patent number: 6840965
    Abstract: The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination containing at least one p-aminophenol derivative of formula (I).
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: January 11, 2005
    Assignee: Wella Aktiengesellschaft
    Inventors: Laurent Chassot, Hans-Juergen Braun
  • Patent number: 6689892
    Abstract: This invention concerns a process for the manufacture of anhydro- and dianhydro- hexitols, pentitols, and tetritols by the dehydration of sugar alcohols (alditols) in the presence of a dehydration catalyst and with the assistance of an inert gas sparge.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: February 10, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Mark Allen Andrews, Kamlesh Kumar Bhatia, Paul Joseph Fagan
  • Patent number: 6680392
    Abstract: A process for removing polyol impurities from a sorbitan ester solution involving: (a) providing a sorbitan ester solution containing polyol impurities; (b) adding to the sorbitan ester solution a clarifying-effective amount of a silica component; (c) adsorbing the polyol impurities from the sorbitan ester solution onto the silica to form a mixture of sorbitan ester and polyol-containing silica; and (d) removing the polyol-containing silica from the sorbitan ester solution.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: January 20, 2004
    Assignee: Cognis Corporation
    Inventors: Jeff A. Barnhorst, Dean A. Oester
  • Publication number: 20030166948
    Abstract: For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R2 is C1-5 alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R3-R6 are independently selected from C1-6 alkyl and C6-10 aryl.
    Type: Application
    Filed: May 5, 2003
    Publication date: September 4, 2003
    Inventors: Martin Edward Fox, Mark Jackson