Cyano Or Nitrogen And The Hetero Ring Bonded Directly To The Same Carbon Patents (Class 549/552)
  • Patent number: 10974110
    Abstract: Provided is a golf shaft comprising an element tube made of steel, a plating layer formed on an outer periphery of the element tube, an outer layer covering the plating layer, an adhesive layer interposed between the plating layer and the outer layer to bond between the plating layer and the outer layer. The outer layer is formed of a fiber reinforced plastic having a matrix resin that is an epoxy resin, and the adhesive layer is an epoxy resin composition or a carbon nano tube resin composition, the epoxy resin composition comprising an epoxy resin and a mixed curing agent in which two or more kinds of amine-based curing agents are mixed, and the carbon nano tube resin composition comprising an epoxy resin and at least one kind of curing agents as well as dispersed carbon nano tubes.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: April 13, 2021
    Assignee: NHK SPRING CO., LTD.
    Inventors: Kosuke Fujiwara, Akihisa Inoue
  • Publication number: 20140005292
    Abstract: A compound represented by the following general formula (1). In the formula, A represents a benzene ring, a naphthalene ring and the like, wherein these rings may be substituted with a halogen atom and the like, R1 represents a hydrogen atom and the like, R2 represents a C1-35 hydrocarbon group having or not having at least one group selected from an epoxy group, 4-vinylphenyl group and a (meth)acryloyloxy group, or a hydrogen atom, wherein at least one of R2 with n occurrences is a C3-35 hydrocarbon group having at least one group selected from an epoxy group, a 4-vinylphenyl group and a (meth)acryloyloxy group, n represents an integer of 1 to 6, and X represents a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom, or an n-valent organic group having 35 or less carbon atoms.
    Type: Application
    Filed: April 12, 2012
    Publication date: January 2, 2014
    Applicant: Adeka Corporation
    Inventors: Yosuke Maeda, Masaaki Shimizu, Koich Shigeno
  • Publication number: 20130203998
    Abstract: The present invention relates to drug derivatives and linkers. The invention specifically relates to compounds and methods of phosphonates and linkers, that are useful as carriers for imaging agents and useful in the treatment of various bone diseases.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 8, 2013
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: UNIVERSITY OF SOUTHERN CALIFORNIA
  • Publication number: 20130116457
    Abstract: The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.
    Type: Application
    Filed: June 7, 2012
    Publication date: May 9, 2013
    Applicant: Aerojet Fine Chemicals LLC
    Inventors: Aslam A. Malik, Todd E. Clement, Hasan Palandoken, James Robinson, III, Joy A. Stringer
  • Patent number: 8415490
    Abstract: A novel epoxy compound represented by the following formula and a method for producing the same are provided: wherein R1 and R2 are members selected from the group consisting of hydrogen, aliphatic hydrocarbon group having 1 to 4 carbon atoms, alicyclic hydrocarbon group having 3 to 6 carbon atoms, aromatic hydrocarbon group having 6 to 10 carbon atoms, halogen atom, ether group, ester group, acyl group and nitro group, n is an integer of 1 to 4, and m is an integer of 1 to 5.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: April 9, 2013
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Koutaro Ono, Michiya Ishikawa, Jiro Nakatani
  • Publication number: 20130053557
    Abstract: Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.
    Type: Application
    Filed: April 28, 2011
    Publication date: February 28, 2013
    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventor: James R. McCarthy
  • Publication number: 20120289706
    Abstract: The present invention relates to a new process for the preparation of substituted thiotriazolo groups of the general formula (I) wherein the variables have the meanings as given in the claims and the description.
    Type: Application
    Filed: December 13, 2010
    Publication date: November 15, 2012
    Applicant: BASF SE
    Inventors: Jens Renner, Jochen Dietz, Thomas Grote, Joachim Gebhardt, Markus Nett, Michael Keil
  • Patent number: 8168826
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethylamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: May 1, 2012
    Assignee: Janssen Pharamcuetica N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Patent number: 8076495
    Abstract: A process for the preparation of aromatic N-glycidylamines is described, wherein an amine which contains at least one aromatic aminehydrogen atom is heated with at least 0.7 equivalent of epichlorohydrin per aminehydrogen equivalent of the aromatic amine, using a divalent or polyvalent metal salt of nitric acid, as a catalyst, dissolved in propylene carbonate, and the product is then dehydrochiorinated.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: December 13, 2011
    Assignee: Huntsman Advanced Materials Americas LLC
    Inventors: Roger Malherbe, Jean-Marc Pfefferle
  • Publication number: 20100317515
    Abstract: The present invention relates to triazolylmethyloxiranes of the formula I in which the variables A, B and D have the meanings described in the claims and the description.
    Type: Application
    Filed: December 12, 2008
    Publication date: December 16, 2010
    Applicant: BASF SE
    Inventors: Jochen Dietz, Thomas Grote, Bernd Mueller, Jan Klaas Lohmann, Jens Renner, Sarah Ulmschneider, Alice Glaettli, Marianna Vrettou
  • Publication number: 20100099898
    Abstract: Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
    Type: Application
    Filed: December 23, 2009
    Publication date: April 22, 2010
    Inventor: Michael R. Reeder
  • Patent number: 7649055
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethylamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: January 19, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Publication number: 20090270499
    Abstract: This invention relates to a process for synthesizing Atazanvir, including novel intermediates and novel steps to various intermediates along the synthetic pathway.
    Type: Application
    Filed: April 24, 2008
    Publication date: October 29, 2009
    Applicant: OXYRANE (UK) LIMITED
    Inventor: Weiping Chen
  • Patent number: 7569699
    Abstract: This invention provides a process for producing an epoxytriazole derivative represented by formula (2): (wherein R and Ar are defined below), which comprises a step including a reaction of an epoxy derivative represented by formula (1?): (wherein R represents a hydrogen atom or C1-12 alkyl group and Ar represents an aromatic group optionally substituted by a halogen atom(s) or trifluoromethyl group(s), and X? represents a hydroxy group or leaving group), with 1,2,4-triazole in the presence of a base and water.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: August 4, 2009
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Taro Ishibahsi, Hideo Muraoka, Tadashi Mizuno
  • Patent number: 7462728
    Abstract: The present invention relates to novel diepoxides having the formulas I. and II. R*N(A)SO2RSO2N(A)R*??I R*SO2N(A)RN(A)SO2R*??II where A=2,3-epoxypropyl, R* is a monovalent hydrocarbon alkyl aryl, aryl-alkyl, alkyl-aryl radical of 1-20 carbon atoms or a monovalent inertly substituted hydrocarbon aryl, alkyl, alkyl-aryl or aryl-alkyl radical of 1-20 carbons atoms and R is a divalent hydrocarbon arylene, alkylene, alkylene-aryl, arylene-alkyl radical or combinations thereof of 2-20 carbon atoms or an inertly substituted divalent hydrocarbon alkylene, arylene, arylene-alkyl, or alkylene-aryl radical or combinations thereof of 2-20 carbon atoms. The epoxides are useful in preparing novel epoxide resins.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: December 9, 2008
    Inventor: R. Garth Pews
  • Patent number: 7408008
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: August 5, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Steve J. Coats, Dennis J. Hlasta, Mark J. Schulz
  • Patent number: 6849750
    Abstract: Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the production of pharmaceutical agents.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: February 1, 2005
    Assignee: Pharmacia & UpJohn Company LLC
    Inventor: Michael R. Reeder
  • Patent number: 6818727
    Abstract: Provided is an epoxy resin having glycidylamino group, wherein the content of hydrolyzable chlorine is 1000 ppm or less. The epoxy resin is useful for adhesives, paints and electric/electronic materials(e.g. insulation materials, laminated plate, etc.).
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: November 16, 2004
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Akira Yokota, Nobuyuki Nakajima
  • Patent number: 6570027
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: May 27, 2003
    Assignee: G. D. Searle & Co.
    Inventors: John S Ng, Claire A. Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman
  • Patent number: 6278002
    Abstract: A process for producing (2R,3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S,3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S,3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammonium salt or a carboxylic acid metal salt a quaternary ammonium salt and a quaternary ammonium salt, to give a (2S,3S)-1-acyloxy-3-amino-2-hydroxy-4-phenylbutane compound, further treating the same with a sulfonic acid halide in the presence of an organic base to give a (2S,3S)-1-acyloxy-3-amino-2-sulfonyloxy-4-phenylbutane compound, furthermore treating said compound with an inorganic base.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: August 21, 2001
    Assignee: Kaneka Corporation
    Inventors: Kazumi Okuro, Kenji Inoue
  • Patent number: 6153771
    Abstract: 5-Substituted isophthalic acid bis(allylamides) and bis(allylamide epoxides) in which said 5-substituent is --NO.sub.2, --NH.sub.2, --NHR.sup.1 or --NR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are independently optionally substituted alkyl, alkenyl, acyl, aryl, aralkyl or alkaryl groups.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: November 28, 2000
    Assignee: Nycomed Imaging AS
    Inventors: David Redick Lane, Janis Vasilevskis
  • Patent number: 6127556
    Abstract: In a method of preparing an aminoepoxide wherein a protected aminoaldehyde is reacted with a halomethyl organometallic reagent in an appropriate solvent at a temperature above -80.degree. C., wherein said halomethyl organometallic reagent is formed by reaction between an organometallic reagent and a dihalomethane, the improvement comprising flowing said protected aminoaldehyde into a mixing zone maintained at a temperature below 0.degree. C., also flowing said halomethyl organometallic reagent in said mixing zone for contacting in said mixing zone with said protected aminoaldehyde and also withdrawing from said mixing zone reaction products of said protected aminoaldehyde and said halomethyl organometallic reagent.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: October 3, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Chin Liu, John S. Ng, James R. Behling, Arthur L. Campbell
  • Patent number: 5998330
    Abstract: A method of treating vegetation by application of a microbial insecticide in which a quinone has been covalently bonded to the viral occlusion body surface of the microbial insecticide in order to improve the UV stability of the microbial insecticide by forming a protective shield around the pathogen.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: December 7, 1999
    Assignee: The Board of Trustees of the University of Arkansas
    Inventor: Gary W. Felton
  • Patent number: 5962704
    Abstract: A method for producing an amide derivative of the formula ?XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound ?XV! at high yields, which includes compound ?XVI! having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound ?XVI! but also compounds useful as X-ray contrast media.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: October 5, 1999
    Assignees: Japan Tobacco Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Takashi Inaba, Yasuki Yamada
  • Patent number: 5962683
    Abstract: A description is given of compounds of the formula I ##STR1## where r is 0 or 1 and y is a number from the range 1-3; X is a direct bond or --NR.sub.8 --, --CO--, --CONH-- or --COO-- or a divalent aliphatic or mixed aromatic-aliphatic C.sub.1 -C.sub.18 hydrocarbon radical;Z is an aromatic, aliphatic or mixed aromatic-aliphatic C.sub.3 -C.sub.18 hydrocarbon radical which is interrupted in the aliphatic moiety by one or more divalent functional groups, in each case in a carbon-carbon single bond, and/or in the aromatic or aliphatic moiety by one or more divalent functional groups, in each case in a carbon-hydrogen bond, possible functional groups being --O--, --NR.sub.8 --, --S--, --SO--, --SO.sub.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: October 5, 1999
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Alfred Steinmann, Rolf Mulhaupt
  • Patent number: 5883121
    Abstract: The invention relates an epoxysuccinamide derivative represented by the general formula (1) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different from each other and independently represent H or an aromatic hydrocarbon group or aralkyl group which may be substituted, or R.sup.1 and R.sup.2 may form a nitrogen-containing heterocyclic ring together with the adjacent nitrogen atoms, R.sup.3 is H or an acyl group, R.sup.4 is H or an aralkyl group, and R.sup.5 is an aromatic hydrocarbon group or aralkyl group which may be substituted, or R.sup.5 may form an amino acid residue, which may be protected, together with the adjacent nitrogen atom, or a salt thereof, and a medicine comprising the derivative as an active ingredient; and this compound has an inhibiting activity against cathepsin, and particularly, specifically inhibits cathepsin L and is hence useful for prevention and treatment of osteopathy such as osteoporosis.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 16, 1999
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Tomohiro Yamashita, Yoshimitsu Suda, Yukio Tada, Nobuhiko Katunuma, Tetsuji Asao
  • Patent number: 5883264
    Abstract: Process for preparing optically active trans-3-phenylglycidamide compound, which comprises subjecting racemic trans-3-phenylglycidamide compound of the formula (I) ##STR1## wherein Ring A is substituted or unsubstituted benzene, and R.sup.1 is H or lower alkyl, to optical resolution using a microorganism having ability of preferentially hydrolyzing one of (2S,3R) isomer or (2R,3S) isomer thereof, and process for preparing an optically active 1,5-benzothiazepine derivative from the thus-obtained optically active trans-3-phenylglycidamide compound.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hiroaki Matsumae, Akiko Idei, Takuo Nishida, Yasuhiko Ozaki, Takeji Shibatani
  • Patent number: 5854303
    Abstract: A polymeric material incorporating a polyvalent cation chelating agent in an amount effective to inhibit the growth of an ocular pathogen, particularly a protozoan, can be used to produce eye care products such as contact lens cases and containers for containing eye care solutions and contact lenses.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: December 29, 1998
    Assignee: Allergan Sales, Inc.
    Inventors: Charles Hayes Powell, David C. Rupp
  • Patent number: 5773468
    Abstract: The present invention relates to a novel compound of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof which is an irreversible HIV protease inhibitor; a process for the preparation thereof; and a pharmaceutical composition containing the compound as an active ingredient which is useful for treating or preventing diseases caused by HIV infection.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: June 30, 1998
    Assignee: LG Chemical Limited
    Inventors: Sung Chun Kim, Young Chan Son, Ho Il Choi, Heungsik Yoon, Chi Hyo Park, Nakyen Choy, Chang Sun Lee, Jong Sung Koh, Kwang Yul Moon, Won Hee Jung, Chung Ryeol Kim
  • Patent number: 5763631
    Abstract: Cis-epoxide compounds of formula (I-3) and pharmaceutically acceptable salts, hydrates and solvates thereof: ##STR1## wherein: R.sup.1 is a cycloalkyl, or arly-substituted lower alkyl group;K and J are independently a group having the formula of ##STR2## wherein R.sup.18 is a lower alkyl group optionally substituted with an aryl radical; X is O, NH, or N--CH.sub.3 ; and R.sup.19 is an aromatic hetercyclic sysstem containing a nitrogen atom in its ring, or a lower alkyl group optionally substituted with an aryl radical, or a hydrogen;G is an amino acid which is linked to K-- and ##STR3## by peptide bonds in formula (I-3); Q is an amino acid which is linked toby peptide bonds in formula (I-3), or a group having the formula ofwherein R.sup.20 is a lower alkyl group optionally substituted with an aromatic radical; and Y is CH.sub.2, O or NH; andr is 0 or 1, except that Q is a group having the formula ofr is 0.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: June 9, 1998
    Assignee: Lucky Limited
    Inventors: Sung Chun Kim, Nakyen Choy, Chang Sun Lee, Ho I. Choi, Jong Sung Koh, Heungsik Yoon, Chi Hyo Park, Sang Soo Kim, Young Chan Son
  • Patent number: 5739178
    Abstract: A polymeric material incorporating a polyvalent cation chelating agent in an amount effective to inhibit the growth of an ocular pathogen, particularly a protozoan, can be used to produce eye care products such as contact lens cases and containers for containing eye care solutions and contact lenses.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: April 14, 1998
    Assignee: Allergan
    Inventors: Charles Hayes Powell, David C. Rupp
  • Patent number: 5717054
    Abstract: This invention relates to flexible epoxy resins that have a structural composition comprising an oligomeric backbone of alkylene or alkyleneoxy repeat units, terminated with an aromatic moiety bearing one or more epoxy functionalities.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: February 10, 1998
    Assignee: National Starch & Chemical Investment Holding Corp.
    Inventor: Rose Ann Schultz
  • Patent number: 5693847
    Abstract: The present invention relates to functionalized ketones and novel processes for synthesizing those ketones. The processes of this invention are especially well suited for synthesizing .alpha.-methyl leaving group functionalized ketones. This invention also relates to processes for using .alpha.-methyl leaving group functionalized ketones to produce other compounds and intermediates useful in those processes.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: December 2, 1997
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Roger D. Tung, Thomas E. D'Ambra
  • Patent number: 5679687
    Abstract: The present invention relates to novel compounds of formula (I) which have inhibitory activity against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group;R.sup.2 is an amino acid residue or a C.sub.1-8 alkyl group substituted with a C.sub.1-4 alkylsulfonyl group;R.sup.3 is a C.sub.1-4 alkyl group optionally substituted with an aromatic group;R.sup.4 is hydrogen or a C.sub.1-4 alkyl group;R.sup.5 is an aromatic group, a C.sub.1-10 alkyl group or a C.sub.1-4 alkyl groups optionally substituted with an aromatic group; andn is 1 or 2.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: October 21, 1997
    Assignee: LG Chemical Limited
    Inventors: Nakyen Choy, Hoil Choi, Chi-Hyo Park, Young-Chan Son, Chang-Sun Lee, Heungsik Yoon, Sung-Chun Kim, Jong-Sung Koh, Chung-Ryeol Kim
  • Patent number: 5670517
    Abstract: The present invention relates to novel compounds of formula (I) which has inhibitory activities against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group;R.sup.2 is an amino acid residue or a C.sub.1-8 alkyl group substituted with a C.sub.1-4 alkylsulfonyl group;R.sup.3 is a C.sub.1-4 alkyl group optionally substituted with an aromatic group;R.sup.4 is hydrogen or a C.sub.1-2 alkyl group;R.sup.5 is a C.sub.1-10 alkyl group optionally substituted with an aromatic group; andn is 1 or 2.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: September 23, 1997
    Assignee: LG Chemical Limited
    Inventors: Nakyen Choy, Hoil Choi, Chi-Hyo Park, Young-Chan Son, Chang-Sun Lee, Heungsik Yoon, Sung-Chun Kim, Jong-Sung Koh, Chung-Ryeol Kim
  • Patent number: 5670675
    Abstract: A retroviral protease inhibiting compound of the formulaA-X-Bor a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group;A is(1) substituted amino,(2) substituted carbonyl,(3) functionalized imino,(4) functionalized alkyl,(5) functionalized acyl,(6) functionalized heterocyclic or(7) functionalized (heterocyclic)alkyl; andB is(1) substituted carbonyl independently defined as herein,(2) substituted amino independently defined as herein,(3) functionalized imino independently defined as herein,(4) functionalized alkyl independently defined as herein,(5) functionalized acyl independently defined as herein,(6) functionalized heterocyclic independently defined as herein or(7) functionalized (heterocyclic)alkyl independently defined as herein.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: September 23, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck
  • Patent number: 5668227
    Abstract: Novel cyclohexyl-group-containing glycidyl ethers of formulae I to IV according to claim 1, which are distinguished especially by a low chlorine content and a low viscosity and which can be used, for example, in epoxy resin formulations as reactive diluents, flexibilisers or adhesion enhancers, or can also be polymerised per se and used as coatings or casting resins, the products having only slight water absorption and having good external weather resistance.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: September 16, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Heinz Wolleb, Andreas Kramer
  • Patent number: 5650412
    Abstract: Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 22, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Byeong Moon Kim, Joseph P. Vacca
  • Patent number: 5618939
    Abstract: A process is disclosed for making a chiral compound of the formula ##STR1## comprising reacting an epoxide compound of the formula ##STR2## and an amide of the formula ##STR3## in the presence of a strong base at a low temperature.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Paul Reider, Kai Rossen, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells
  • Patent number: 5612339
    Abstract: 2-Hydroxy-3-aminopropylsulfonamides are provided along with methods for synthesizing and using such compounds, and chemical intermediates employed in the synthetic methods.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: March 18, 1997
    Assignee: Trustees Of The University Of Pennsylvania
    Inventors: Paul Sprengeler, Amos B. Smith, III, Ralph F. Hirschmann, Akihisa Yokoyama
  • Patent number: 5563168
    Abstract: O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH.sub.2, NOalkylY isO, S, NR.sup.5R.sup.1, R.sup.2, R.sup.5 are H, alkylZ.sup.1, Z.sup.2 are H, halogen, methyl, methoxy, cyanoR.sup.3, R.sup.4 are hydrogen, cyano, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkynyl, alkoxy, haloalkoxy, alkylthio, benzylthio, alkylcarbonyl, substituted or unsubstituted phenylcarbonyl, substituted or unsubstituted benzylcarbonyl, alkoxycarbonyl, substituted or unsubstituted phenoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl,N(R.sup.6).sub.2, where R.sup.6 is H, alkyl, substituted or unsubstituted phenyl,--CO--N(R.sup.7).sub.2, where R.sup.
    Type: Grant
    Filed: June 16, 1995
    Date of Patent: October 8, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Siegbert Brand, Uwe Kardorff, Reinhard Kirstgen, Bernd Mueller, Klaus Oberdorf, Hubert Sauter, Gisela Lorenz, Eberhard Ammermann, Christoph Kuenast, Albrecht Harreus
  • Patent number: 5552558
    Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: September 3, 1996
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck
  • Patent number: 5508430
    Abstract: Novel alcohols of the formula ##STR1## wherein R.sup.a is azido or phthalimido, R.sup.4 is alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, R.sup.7 and R.sup.8 together are a trimethylene or tetramethylene group which is optionally substituted by hydroxy, alkoxycarbonylamino or acylamino or in which one --CH.sub.2 -- group is replaced by --NH--, --N(alkoxycarbonyl)--, --N(acyl)-- or --S-- or which carries a fused cycloalkane, aromatic or heteroaromatic ring, and R.sup.9 is alkoxycarbonyl, monoalkylcarbamoyl, monoaralkylcarbamoyl, monoarylcarbamoyl or a group of the formula ##STR2## in which R.sup.10 and R.sup.11 each is alkyl, are described along with a process for their manufacture. These alcohols are useful as intermediates, for example in the manufacture of amino acid derivatives having antiviral activity.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: April 16, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kevin E. B. Parkes, Sally Redshaw, Gareth J. Thomas
  • Patent number: 5391552
    Abstract: A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R.sup.3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR.sup.4 - wherein R.sup.4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: February 21, 1995
    Assignee: Pola Chemical Industries, Inc.
    Inventors: Masato Inazu, Yoshiyuki Miyata, Toshihiro Morimoto, Takeshi Yamamoto, Yuji Yoshiko, Kazunori Harada, Yoshiharu Momota, Masayuki Yanagi, Ryoko Yokota, Tetsuo Katoh, Takayuki Namiki, Makoto Kimura, Nobuyuki Kawakatsu
  • Patent number: 5362849
    Abstract: The new compound N,N,N'N'-tetraglycidyl-3,3'-diethyl-4,4'-diaminodiphenylmethane and curable resin compositions containing it.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: November 8, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Bryan Dobinson, Michael R. Thoseby
  • Patent number: 5360884
    Abstract: Glycidyl amines containing mesogenic moieties result in improved properties when cured. These amines are useful in coatings, adhesives, encapsulants, moldings, laminates, and the like.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: November 1, 1994
    Assignee: The Dow Chemical Company
    Inventors: Robert E. Hefner, Jr., Jimmy D. Earls
  • Patent number: 5310956
    Abstract: The present invention is optically active epoxides and its production characterized in that the process comprises reacting alkenyl ethylene glycols with 0.5 to 2.0 equivalents of a titanium-tetraalkoxyde, a peroxide and an L-(+)- or D-(-)-dialkyl tartrate at a temperature of -78.degree. to 50.degree. C. to asymmetrically oxidize the alkenyl ethylene glycols. The production of the present invention is an excellent method for producing chiral epoxides in which steric configuration of three asymmetric points can be perfectly controlled, the reaction is performed by mild conditions and the chemical yield and the optical yield are extremely high. The optically active epoxides which can be efficiently produced by the production of the present invention are useful as stating materials of several kinds of compounds.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: May 10, 1994
    Assignee: Chisso Corporation
    Inventors: Seiichi Takano, Kunio Ogasawara
  • Patent number: 5283270
    Abstract: Disclosed are glycidyl diamines having the formulas ##STR1## where n is 1 or 2, m is 0, 1, or 2, X is Y or ##STR2## and Y is --, O, S, SO, SO.sub.2, CO, C(CH.sub.3).sub.2, or C(CF.sub.3).sub.2. An epoxy resin can be made by mixing the glycidyl diamine with an epoxy curing agent. The epoxy resins can be used as adhesives or to make composites.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: February 1, 1994
    Assignee: Occidental Chemical Corporation
    Inventors: Robert A. Buchanan, Robert L. Ostrozynski
  • Patent number: 5280069
    Abstract: The new compound N,N,N'N'-tetraglycidyl-3,3'-diethyl-4,4'-diaminodiphenylmethane and curable resin compositions containing it.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: January 18, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Bryan Dobinson, Michael R. Thoseby
  • Patent number: 5266365
    Abstract: The present invention is directed to an epoxy-containing polymeric material having nonlinear optical properties, particularly a glycidyl amine polymer, and a process for making the nonlinear optical (NLO) epoxy-containing polymeric material including poling the polymeric material under high voltage at elevated temperature for a period of time to bring about orientation of the nonlinear optical functionalities in the polymer. The polymers have enhanced thermal stability and good NLO properties.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: November 30, 1993
    Assignee: The Dow Chemical Company
    Inventors: John J. Kester, H. Craig Silvis