Processes Of Forming The Compound Patents (Class 554/82)
  • Patent number: 9403760
    Abstract: Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the production of sphingolipids. Suitable sphingolipids, include, but not limited to, sphingosine and compounds incorporating sphingosine or that may use sphingosine as an intermediate or a starting material in their synthesis (including, but not limited to, sphingosine-1-P, ceramide, gangliosides and sphingomyelin). In one contemplated use, compounds of the general formula I and II are useful in the production of sphingosine. In another contemplated use, compounds of the general formula I and II are useful in the production of a sphingofugin. Methods of manufacturing each of the above compounds are also provided.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 2, 2016
    Assignee: AVANTI POLAR LIPIDS, INC.
    Inventors: Stephen W Burgess, Walter A Shaw, Shengrong Li
  • Patent number: 9217119
    Abstract: A process for the extraction of lipids from living cells utilizing liquid carbon dioxide optionally in the presence of a porous inorganic matrix or polymer coating as well as additional solvents to improve extraction efficiency. The cells may also optionally be treated a photosensitive material to promote cellular photosynthesis.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: December 22, 2015
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Maoqi Feng, Darius D. Daruwalla, Jimell Erwin, W. Kennedy Gauger
  • Patent number: 9006472
    Abstract: A method for preparing 13C labeled plasmalogens as represented by Formula B: The method involves producing a 13C labeled cyclic plasmalogen precursor of Formula A: and conversion of the precursor to a plasmalogen of Formula B.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: April 14, 2015
    Assignee: Phenomenome Discoveries Inc.
    Inventors: M. Amin Khan, Paul L. Wood, Dayan Goodenowe
  • Publication number: 20140323749
    Abstract: A method for preparing 13C labeled plasmalogens as represented by Formula B: —The method involves producing a 13C labeled cyclic plasmalogen precursor of Formula A, and conversion of the precursor to a plasmalogen of Formula B. These plasmalogens may potentially be useful in the determination of both the mechanism of action as well as the fate of plasmalogens in the body.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 30, 2014
    Inventors: M. Amin Khan, Paul L. Wood, Dayan Goodenowe
  • Patent number: 8802875
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: August 12, 2014
    Assignee: Vascular Biogenics Ltd.
    Inventors: Gideon Halperin, Eti Kovalevski-Ishai
  • Patent number: 8759557
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: June 24, 2014
    Assignee: Vascular Biogenics Ltd.
    Inventors: Gideon Halperin, Eti Kovalevski-Ishai
  • Patent number: 8513446
    Abstract: The invention relates to stable crystal modifications of (R,S)-, (R)- and (S)-DOPC, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: August 20, 2013
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Publication number: 20130147461
    Abstract: Disclosed herein are devices and methods related to the production and measurements of amphiphilic molecule bilayers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 5, 2012
    Publication date: June 13, 2013
    Inventors: Jacob J. Schmidt, Shiva Portonovo, Jason L. Poulos
  • Patent number: 8148559
    Abstract: Disclosed are processes for development and recovery of lipids from biomass. A plant or microorganism-based biomass can be developed to encourage a desired lipid profile. Following development, ecologically friendly normally gaseous fluids such as carbon dioxide can be pressurized to a supercritical state followed by rapid expansion. The fluid is first contacted with a biomass source including oil-containing microorganisms and/or agricultural products. For instance, fungi or algae can be bioconverted from another biomass sources such as canola seed or corn syrup and then contacted with the high pressure fluid. During a contact period, the fluid can diffuse into the biomass, and in particular through the cell walls of the biomass. The fluid undergoes rapid release of pressure and opens the cell structure for improved release of oil. The fluid can optionally be utilized for extraction following the explosion process. For instance, the fluid can be re-pressurized in the same vessel for extraction processes.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: April 3, 2012
    Assignee: Clemson University Research Foundation
    Inventors: Terry H. Walker, Meidui Dong, Keri B. Cantrell, Mark C. Thies
  • Patent number: 7893286
    Abstract: Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: February 22, 2011
    Assignee: Cellectar, Inc.
    Inventors: Anatoly Pinchuk, Jamey P. Weichert, Marc Longino
  • Patent number: 7884131
    Abstract: Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: February 8, 2011
    Assignee: Martek Biosciences, Corporation
    Inventors: Linda Arterburn, William Barclay, Bindi Dangi, James Flatt, Jung Lee, Mary Van Elswyk
  • Publication number: 20100323000
    Abstract: The invention provides novel methods for preparing cardiolipin and cardiolipin analogs having varying fatty acid chain lengths, particularly 1,1?,2,2?-tetramyristoyl cardiolipin. The methods comprise reacting a starting compound, such as a 1,2-O-sn-diacylglycerol and a 2-protected glycerol, with a phosphoramidite reagent to produce a protected cardiolipin, which is deprotected to prepare cardiolipin. The cardiolipin and cardiolipin analogs may be prepared in the presence of an activator, such as pyridinium trifluororacetate. The methods of the present invention are used to prepare cardiolipin and cardiolipin analogs in large quantities. The cardiolipin prepared by the present methods can be incorporated into liposomes which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays.
    Type: Application
    Filed: February 22, 2007
    Publication date: December 23, 2010
    Applicant: NEOPHARM, INC.
    Inventors: Shoukath M. Ali, Moghis U. Ahmad, Imran Ahmad
  • Patent number: 7595411
    Abstract: The present invention relates to compositions comprising a water-insoluble pharmaceutically active ingredient or a substance having low water solubility, and a compound represented by Structural Formula (I): in which A is: The present invention further relates to methods of solubilizing substances of low water solubility, and methods of preparing compositions suitable for intravenous administration.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: September 29, 2009
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 7524981
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: April 28, 2009
    Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20090074942
    Abstract: There is disclosed a granular lecithin and the use in many applications, such as nutraceutical compositions. Also disclosed is a process for producing granular lecithins and compositions containing lecithins.
    Type: Application
    Filed: May 16, 2006
    Publication date: March 19, 2009
    Applicant: CARGILL, INCORPORATED
    Inventors: Myong Kon Ko, Heidi Schmitt, Michael Schneider, John Van De Sype
  • Patent number: 7501533
    Abstract: Process for preparing lysophosphatidylcholine by selective monoacylation of glycerophosphorylcholine (1), in the presence of an acylating agent and of a dialkyltin derivative, according to the following diagram: The process is particularly simple and has high overall yields.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: March 10, 2009
    Assignee: Chem SpA
    Inventors: Lorenzo De Ferra, Stefano Servi, Ezio Fasoli, Mauro Anibaldi, Daniele Scorretti
  • Patent number: 7495116
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 24, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20090036410
    Abstract: A method of treating a patient in need of therapy for a disease in which cyokines have become dysregulated, or are otherwise capable of modulation to provide therapeutic benefit, is provided comprising administering to that patient a therapeutically effective dose of a phospholipid comprising a phosphatidyl group esterifed with one or more fatty acyl groups, characterised in that the phospholipid has at least one fatty acyl group at the sn-1 and/or sn-2 position of the phosphatidyl group, the fatty acyl group being selected from the group consisting of ?-linolenoyl, dihomo-?-linolenoyl acid and arachidonoyl.
    Type: Application
    Filed: November 25, 2005
    Publication date: February 5, 2009
    Applicant: BTG INTERNATIONAL LIMITED
    Inventors: Laurence S. Harbige, Michael J. Leach, Mohammed Sharief, Paul Barraclough
  • Patent number: 7420071
    Abstract: There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 to 50 carbons and optionally including an ionizable or charged group (e.g., carboxyl group or quaternary amine). Thus, there are provided surfactants having Formula I: wherein the variables are as defined herein. Further provided are methods of making thermally stable surfactants and compositions, including composites and nanocomposites, using fillers coated with the surfactants.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: September 2, 2008
    Assignee: UChicago Argonne, LLC
    Inventor: David J. Chaiko
  • Patent number: 7034168
    Abstract: A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: April 25, 2006
    Assignee: Enzymotec Ltd.
    Inventors: Sobhi Basheer, Rassan Zuabi, Avidor Shulman, Neta Scheinman
  • Patent number: 6828453
    Abstract: Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R3 a can be 1,2-dihydroxypropyl or b 5 can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n≠2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y 10 is 1 for z=1 to 5 or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: December 7, 2004
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    Inventor: Hans-Jörg Eibl
  • Patent number: 6737536
    Abstract: This invention relates to inositolphospholipids, particularly to synthetic phosphatidyl-myo-inositols (PtdIns), ceramide-phosphoinositols (CerPhosIns) and their structural and stereochemical analogues. The invention specifically provides a novel approach to synthesis of inositolphospholipids which is suitable for laboratory scale preparation as well as for large scale industrial production. The synthetic approach is applicable equally well for the preparation of inositolphospholipids carrying saturated lipid chains, unsaturated lipid chains with one or more double or triple bonds, chains with hydroxyl, amino and other functional groups, or combinations of these. In addition, it provides novel high purity diastereomer molecular species of inositolphospholipids that have unequivocally defined structure and absolute stereochemistry in both the myo-inositol and the glycerol residues and are obtainable only by the present new approach.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: May 18, 2004
    Assignee: Nutrimed Biotech
    Inventor: Rajindra Aneja
  • Patent number: 6679822
    Abstract: A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: January 20, 2004
    Assignee: NOF Corporation
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi
  • Patent number: 6545169
    Abstract: Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R3 a can be 1,2-dihydroxypropyl or b can be alkyl with 1 to 3 C atoms when z is>0 or c can be alkyl with 1 to 3 carbon atoms when n≠2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y is 1 for z=1 to 5 or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: April 8, 2003
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 6486334
    Abstract: Disclosed are thiol-functionalized phospholipids that have been covalently linked to a gold and/or silver substrate, methods for making them, and intermediates useful for such purposes. The resulting material creates a biomimetic surface that can be included in a conduit containing blood.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: November 26, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hyuk Yu, Charles M. Strother, Xiqun Jiang, Sangwook Park
  • Patent number: 6344576
    Abstract: The present invention relates to phospho-lipid compounds of formula having solubilizing activity for water-insoluble or poorly water soluble active agents and their use in the delivery of active agents to cells and in the treatment of diseases, i.e., cancer and protozoal diseases. The compounds also exhibit direct therapeutic effects on some diseases. The inventive compounds can be formulated into liposomes containing phospholipids, alkylphospholipids and/or cholesterol. The compounds of the present invention may be prepared by reacting primary and secondary amines with epoxides.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: February 5, 2002
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 6297391
    Abstract: Diricinoleylphosphatidylcholine (I) in an optically active form is obtained with good yields and a high purity by means of a process which comprises: a) esterifying the terminal carboxylic group of ricinoleic acid (III) with an alcohol having from 1 to 4 carbon atoms to give the corresponding ester having formula (IV); b) protecting the hydroxylic group of the ester of ricinoleic acid (IV) with a protecting group removable under bland operating conditions and isolating the ester of ricinoleic acid of which the hydroxylic group (V) is protected; c) hydrolyzing the ester of ricinoleic acid of which the hydroxylic group (V) is protected and isolating the ricinoleic acid of which the hydroxylic group (VI) is protected; d) acylating L-&agr;-glycerophosphatidylcholine (II) with an imidazolic or triazolic derivative of the compound having formula (VI) and isolating the diricinoleylphosphatidylcholine of which the hydroxylic group (VII) is protected; e) removing the protecting group from the hydroxylic group of
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: October 2, 2001
    Assignee: Metapontum Agrobios S.c.r.l.
    Inventors: Giampietro Borsotti, Ezio Battistel, Francesco Cellini, Rina Iannacone
  • Patent number: 5677472
    Abstract: A method for extracting sphingomyelin from a phospho-lipid-containing fat concentrate is described. The method comprises the following steps:A. dissolving the fat concentrate in a solvent mixture of an essentially polar organic solvent and an essentially non-polar organic solvent,B. withdrawing a phase consisting mainly of the non-polar organic solvent and phospholipids dissolved therein,C. adding to the phase withdrawn in step B an organic solvent of intermediate polarity at a temperature of about 13.degree.-25.degree. C., thereby forming a precipitate comprising mainly sphingomyelin, together with a viscous phase and a solvent phase, and thenD. withdrawing the precipitate and the viscous phase, and separating them from one another.
    Type: Grant
    Filed: September 21, 1995
    Date of Patent: October 14, 1997
    Assignee: Svenska Mejeriernas Riksfoerening Ekonomi AB
    Inventors: Lena Nyberg, Hans Burling
  • Patent number: 5616745
    Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 1, 1997
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Behr, Jean-Philippe Loeffler
  • Patent number: 5451667
    Abstract: Fumaric acid derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a metallic cation, andR.sub.2 is a saturated or unsaturated aliphatic C.sub.6 -C.sub.24 alkyl group, psoralen-9-yl, retinyl, .alpha.-tocopheryl (vitamin E), calciferyl, corticosteroid-21-yl or monosaccharid-.omega.-yl; a group of fumaric acid derivatives based on glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the formula ##STR2## wherein n is an integer from to 30 to 260,R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group,R.sub.4 is one of the R.sub.3 groups and n is the number of molecule repetitions, processes for their production and compositions containing same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial action.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: September 19, 1995
    Inventors: Peter P. Speiser, Rajendra K. Joshi
  • Patent number: 5362892
    Abstract: A phospholipid composition which satisfies the following requirements (i) and (ii):(i) a weight ratio of a nitrogen-containing phospholipid to the sum of a phospholipid, a glycolipid and a sterol derivative of less than 0.5; and(ii) a ratio of an area of a high-polar substance on a silica gel thin-layer chromatogram to the sum of areas of a phospholipid, a glycolipid and a sterol derivative on a silica gel thin-layer chromatogram of less than 500 area/.mu.g. A fat and oil composition containing from 0.001 to 30% by weight of the phospholipid composition is also disclosed. The present invention enables the blending of phospholipids with a frying oil, which has been considered difficult since it causes heat coloration. Thus a fat and oil composition, which is excellent in mold-release characteristics during cooking, has a good smell during heating, suffers from no coloration of oil after heating and shows a good flavor, can be obtained.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: November 8, 1994
    Assignee: Kao Corporation
    Inventors: Tomoshige Umeda, Hideki Yokomichi, Hideki Mori, Takuji Yasukawa, Yoshihisa Katsuragi, Yuki Mitsui, Yasuhiro Miura
  • Patent number: 5329029
    Abstract: An efficient, technically straightforward and inexpensive process for generating conjugates of phospholipids with biologically important molecules is described.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: July 12, 1994
    Inventor: Barbara Y. Wan
  • Patent number: 5321145
    Abstract: A process of producing phosphatidylcholine derivatives by the reaction of glycerophosphatidylcholine with at least one fatty acid anhydride in the presence of a pyridine catalyst is described. The reaction is carried out in a melt of the glycerophosphatidylcholine, the at least one fatty acid anhydride and the catalyst.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: June 14, 1994
    Assignee: A. Nattermann & Cie. GmbH
    Inventor: Thomas Schafer
  • Patent number: 5220043
    Abstract: A method for making optically pure D-erythro-sphingomyelins which may be labeled for identification and testing purposes is provided.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: June 15, 1993
    Assignee: Ohio University
    Inventors: Zhengxin Dong, Jared A. Butcher, Jr.
  • Patent number: 5153125
    Abstract: Lysophospholipids-containing phospholipids with reduced neutral lipids content can be produced by a process which comprises subjecting neutral lipids- and lysophospholipids-containing phospholipids to treatment with acetone in the presence of an acid. In accordance with the present invention, it is possible to produce on a commercial scale by a simple procedure lysophospholipids-containing phospholipids wherein the neutral lipids content is reduced to 10% by weight or less of the total lipids content.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: October 6, 1992
    Assignee: Kewpie Kabushiki Kaisha
    Inventor: Hideaki Kobayashi
  • Patent number: 5149695
    Abstract: Fumaric acid derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a metallic cation, andR.sub.2 is a saturated or unsaturated aliphatic C.sub.6 -C.sub.24 alkyl group, psoralen-9-yl, retinyl, .alpha.-tocopheryl (vitamin E), calciferyl, corticosteroid-21-yl or monosaccharid-.omega.-yl; a group of fumaric acid derivatives based on glycerol, alkane diol or polyol molecules; and fumaric acid derivatives of the formula ##STR2## wherein n is an integer from to 30 to 260,R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group,R.sub.4 is one of the R.sub.3 groups and n is the number of molecule repetitions, processes for their production and compositions containing same are described. These compounds are useful as drugs for the treatment of cryptogenically-caused diseases and have antisporiatic as well as antimicrobial action.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: September 22, 1992
    Inventors: Peter P. Speiser, Rajendra K. Joshi
  • Patent number: 5137660
    Abstract: A process for the selective esterification of glycerol and 1-glyceryl derivatives to 1,3-disubstituted glycerides is disclosed. This process uses a water immiscible solvent, either a hydrocarbon or halogenated hydrocarbon, a 1,3-lipase and fatty acid anhydrides. This reaction mixture selectively esterifies the primary alcohol groups of glycerol or glycerol derivatives. The preferred derivatives of glycerol are alkyl ethers, alkyl phosphates, phospholipids, alkyl and diaklyl phosphates, and sugar glycosides.
    Type: Grant
    Filed: March 15, 1991
    Date of Patent: August 11, 1992
    Assignee: The Procter & Gamble Company
    Inventors: Adam W. Mazur, George D. Hiler, II
  • Patent number: RE40480
    Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: September 2, 2008
    Assignee: Scarista Limited
    Inventors: Sherri Clarkson, Mehar Manku, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield, Austin McMordie, David B. Horrobin
  • Patent number: RE40546
    Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: October 21, 2008
    Assignee: Scarista, Ltd.
    Inventors: Sherri Clarkson, Mehar Manku, Peter Redden, Paul Wakefield, Paul Bradley, Philip Knowles, Andrea Pitt, Austin McMordie, David Fredrick Horrobin
  • Patent number: RE43632
    Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: September 4, 2012
    Assignee: Scarista, Ltd.
    Inventors: David B. Horrobin, Sherri Clarkson, legal representative, Mehar Manku, Philip Knowles, Peter Redden, Andrea Pitt, Paul Bradley, Paul Wakefield, Austin McMordie