Phosphorus Containing Patents (Class 554/78)
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Patent number: 10787470Abstract: A method of preparing a solid-supported phospholipid bilayer is provided. The method includes a) a first step of providing a solution comprising a bicellar mixture of a long-chain phospholipid and a short-chain phospholipid; b) at least one second step of decreasing the temperature of the solution to below 0° C., increasing the temperature to above room temperature and causing the solution to be blended; and c) a third step of depositing the solution obtained after the second step on a surface of a support, wherein the concentration of the long-chain phospholipid in the solution is at most 0.1 mg/mL, for obtaining a solid-supported phospholipid bilayer. A solid-supported phospholipid layer obtained by the method as defined above is also provided.Type: GrantFiled: February 14, 2018Date of Patent: September 29, 2020Assignee: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Nam-Joon Cho, Joshua Alexander Jackman
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Patent number: 9187713Abstract: Methods of producing fatty acid ethyl esters (FAEE) using a direct transesterification process are described. The direct transesterification process uses low levels of chemical solvents, acid catalysts, and heating energy to produce the FAEE in a method with increased efficiency in a co-solvent system. The FAEE produced may be used in a variety of products including health, beauty, nutraceutical, and cosmetic products.Type: GrantFiled: July 21, 2015Date of Patent: November 17, 2015Assignee: Heliae Development LLCInventor: Sandip Shinde
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Publication number: 20150110866Abstract: A complex is provided, including a phospholipid and curcumin, wherein some or all of the phospholipid is a marine phospholipid. In addition, a composition is provided including a complex with a phospholipid and curcumin, wherein some or all of the phospholipid in the complex is a marine phospholipid. In addition, a method is provided of preparing a complex or composition including the steps of: a) forming a first solution by dissolving a quantity of curcumin in a solvent; b) forming a further solution by adding slowly to the first solution a suitable quantity of a marine phospholipid; c) processing the further solution to form the complex; and d) separating the complex from the solvent by distillation.Type: ApplicationFiled: December 24, 2014Publication date: April 23, 2015Inventor: Harold Gordon Cave
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Patent number: 8895040Abstract: The present invention relates to cosmetic and/or personal care formulations and/or compounds. In one embodiment, the present invention relates to ester compounds that can be used in various personal care formulations and/or compounds. In another embodiment, the present invention relates to branced ester compounds having a molecular weight of at least about 1,500 daltons that can be used in various personal care formulations and/or compounds.Type: GrantFiled: June 4, 2009Date of Patent: November 25, 2014Assignee: Lubrizol Advanced Materials, Inc.Inventors: Brian J. Vondruska, Peter Frank, Anchuu Wu
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Publication number: 20140308360Abstract: The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.Type: ApplicationFiled: June 26, 2014Publication date: October 16, 2014Inventor: Yan Zhao
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Patent number: 8846880Abstract: The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.Type: GrantFiled: May 20, 2009Date of Patent: September 30, 2014Assignees: Centre National de la Recherche Scientifique—CNRS—, Universite d'OrleansInventors: Valérie Quesniaux Ryffel, Olivier Martin, Sophie Front
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Patent number: 8822712Abstract: Chemically-modified triglycerides are prepared by reacting epoxidized triglyceride oils with phosphorus-based acid hydroxide or esters. The phosphorus-containing triglyceride derivatives are of the formula: wherein R1?, R2? and R3? are independently selected from C3 to C29 aliphatic fatty acid residues, at least one of which comprising one or both of the derivatized methylene groups of the formula: wherein m is 0, 1 or 2, n is 0 or 1, q is 1, 2 or 3, and R and R? are independently selected from the group consisting of H, straight, branched or cyclic hydrocarbons and substituted hydrocarbons, and aryl groups. The phosphorus-containing triglyceride derivatives so produced have utility as antiwear/antifriction additives for industrial oils and automotive applications.Type: GrantFiled: August 30, 2011Date of Patent: September 2, 2014Assignees: The United States of America, as represented by the Secretary of Agriculture, The Penn State Research FoundationInventors: Kenneth M. Doll, Brajendra K. Sharma, Paulo A. Suarez
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Publication number: 20140242252Abstract: A method for extraction from Lesquerella seeds having an acid value of less than 6 mg KOH/g, said method including the following steps: a seed-processing step i) that includes a single operation of flattening the seeds and at least one operation of drying the seeds; and a step ii) of placing the processed seeds into contact with a mixture of light anhydrous alcohol and co-solvent under temperature and time conditions that are sufficient for extracting a raw oil including phospholipids and gums, as well as obtaining a de-oiled cake.Type: ApplicationFiled: September 24, 2012Publication date: August 28, 2014Inventors: Jean-Luc Dubois, Antoine Piccirilli, Julien Magne
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Patent number: 8802875Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: December 10, 2012Date of Patent: August 12, 2014Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Patent number: 8772516Abstract: Organic solvent-free processes for obtaining krill oil compositions are disclosed. The processes include a) cooking krill in a cooker vessel for a time and at a temperature sufficient to denature the protein content of the krill and cause a first solid krill fraction and a first liquid krill fraction to be formed while substantially avoiding emulsification of the first solid and first liquid krill fractions; b) removing the first solid and first liquid krill fractions from the cooker vessel at a temperature of at least about 90° C.; c) separating the first solid fraction and the first liquid fraction; and d) obtaining krill oil with neutral enriched from the first liquid fraction, and e) by pressing of first solid fraction to obtain press liquid or a second liquid krill fraction for obtaining krill oil with phospholipids enriched krill oil, the separating and the obtaining steps being carried out without the use of organic solvents. Krill oil compositions made by the process are also disclosed.Type: GrantFiled: April 28, 2011Date of Patent: July 8, 2014Assignees: Tharos. Ltd., Lonza, Ltd.Inventors: Dimitri Sclabos Katevas, Raul R. Toro Guerra, Mario M. Chiong Lay
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Patent number: 8759557Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: March 12, 2013Date of Patent: June 24, 2014Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Publication number: 20140100175Abstract: The present invention provides insecticidal lipids and lipid fractions from fungi of the phylum Ascomycota, together with compositions comprising such lipids and lipid fractions and methods of preparing same. Methods for the biological control of insects, such as phytopathogenic insects, using the lipids and lipid fractions or compositions comprising said lipids optionally together with one or more insecticidal or entomopathogenic agents including entomopathogenic fungi, are also provided.Type: ApplicationFiled: March 26, 2012Publication date: April 10, 2014Applicant: BIOTELLIGA HOLDINGS LIMITEDInventors: Stephen Reynold Ford, Travis Robert Glare
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Patent number: 8686167Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: GrantFiled: October 1, 2010Date of Patent: April 1, 2014Assignee: Complexa, Inc.Inventor: Raymond A. Miller
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Publication number: 20140046080Abstract: Generally, a method of pressure regulated supercritical fluid fractionation of oil seed extraction materials which can be utilized to refine oil seed extraction material established in an amount of supercritical fluid. Specifically, a method of pressure regulated supercritical fluid fractionation of corn germ extraction material to produce a refined corn oil extraction material.Type: ApplicationFiled: October 15, 2013Publication date: February 13, 2014Applicant: MOR Supercritical, LLCInventor: Rodger T. Marentis
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Publication number: 20140031569Abstract: The present invention relates to processes for the isolation of a phospholipid and for producing a polyunsaturated, long-chain fatty acids (PUFA)-enriched fraction from a fish oil comprising the steps of -providing a fish oil containing lipids and phospholipids; -mixing the fish oil with a polar solvent; -centrifuging the mixture of the fish oil and the polar solvent to separate a polar fraction from a lipid fraction; -isolating a phospholipid from the polar fraction or isolating a PUFA-enriched fraction from the polar fraction. The fish oil may be provided by -extracting a fish material with an extractant solvent; -removing the extractant solvent to provide the fish oil; -optionally subjecting the fish oil to a solid-liquid separation. The isolated phospholipids and PUFA's may be used as additives for functional foods, as a dietary supplement and for pharmaceutical application.Type: ApplicationFiled: April 13, 2012Publication date: January 30, 2014Applicant: POLAR OMEGA A/SInventors: Hans Otto Soerensen, Nils Christian Jensen
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Patent number: 8603568Abstract: A specific lecithin composition comprising phospholipids and lysophospholipids is described that can be used as an animal feed additive for the improvement of digestibility parameters and consequently gut health and animal performance. In addition, the mixture possesses useful biological and chemical properties that can be utilized in the animal feed and human food industries. The composition is chemically characterized by means of HPLC-ELSD, HPLC-MS/MS and 31P-NMR and its biological functionalities are fully described.Type: GrantFiled: January 14, 2011Date of Patent: December 10, 2013Assignee: Kemin Industries, Inc.Inventors: Stefaan M. O. Van Dyck, Bart Vennekens, Bruno Coppens, Filip Nuyens
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Patent number: 8568771Abstract: The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CD1 33+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).Type: GrantFiled: October 29, 2007Date of Patent: October 29, 2013Assignee: Fresenius Medical Care Deutschland G.m.b.H.Inventors: Vincenzo Cantaluppi, Maria Chiara Deregibus, Giovanni Camussi
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Publication number: 20130225794Abstract: The present invention contemplates the creation of a low fluoride oil processed from a phospholipid-protein complex (PPC) formed immediately upon a crustacean (i.e., for example, krill) catch. The process comprises disintegrating the crustaceans into smaller particles, adding water, heating the result, adding enzyme(s) to hydrolyze the disintegrated material, deactivating the enzyme(s), removing solids from the enzymatically processed material to reduce fluoride content of the material, separating and drying the PPC material. Then, using extraction with supercritical CO2 and ethanol as solvents, inter alia krill oil is separated from the PPC. In the extraction the krill oil can be separated almost wholly from the feed material. The products have low fluoride content. The manufacturing costs in the extraction process are relatively low.Type: ApplicationFiled: April 4, 2013Publication date: August 29, 2013Applicant: Olympic Seafood ASInventor: Olympic Seafood AS
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Publication number: 20130225533Abstract: Medicaments and therapeutic compositions contain (1) phospholipids having 4,7,10,13,16,19-docosahexaenoic acid covalently bound thereto and (2) at least one omega-3 polyunsaturated fatty acid, or at least one pharmaceutically acceptable omega-3 polyunsaturated fatty acid derivative or mixtures thereof, wherein about 25% of the total 4,7,10,13,16,19-docosahexaenoic acid moieties in the composition are covalently bound to phospholipids, and wherein components (1) and (2) are present in amounts effective to support overall neurological health in a subject.Type: ApplicationFiled: April 2, 2013Publication date: August 29, 2013Applicant: Nordic Naturals, Inc.Inventor: Nordic Naturals, Inc.
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Patent number: 8512971Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.Type: GrantFiled: May 12, 2010Date of Patent: August 20, 2013Assignee: Echelon Biosciences, Inc.Inventors: Colin Ferguson, Glenn Prestwich, Damian Madan
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Patent number: 8481770Abstract: A method of selectively separating a phospholipid from a sample solution containing the phospholipid is provided. The method comprises: adsorbing calcium ions to a filler, at least a surface of the filler being constituted of a calcium phosphate-based compound; supplying the sample solution into an apparatus having a filling space, wherein the filling space being filled with the filler so that the phospholipid contained in the sample solution is adsorbed to the filler through the calcium ions; supplying an organic solvent-based eluate into the filling space of the apparatus to obtain a liquid containing the phospholipid and discharged from the apparatus; and fractionating the obtained liquid per a predetermined amount to thereby separate the phospholipid from the sample solution.Type: GrantFiled: September 17, 2010Date of Patent: July 9, 2013Assignee: Hoya CorporationInventor: Ken Sugo
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Publication number: 20130052237Abstract: A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: INTARCIA THERAPEUTICS, INC.Inventors: Rom Ezer Eliaz, Yuanpeng Zhang, Catherine Manya Rohloff, Eric William Weeks, Gunjan Junnarkar
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Patent number: 8378131Abstract: A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets.Type: GrantFiled: January 19, 2012Date of Patent: February 19, 2013Assignee: Jost Chemical CompanyInventors: John Gleason, Douglas Jost, Philip H. Merrell, Doug Caskey
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Publication number: 20120302777Abstract: The present invention provides a novel glycerol 3-phosphateacyltransferase gene and use thereof. The object of the present invention can be solved by providing a nucleic acid having a nucleotide sequence set forth in SEQ ID NO: 1, 4, or 8, SEQ ID NO: 3, 6, or 11, or SEQ ID NO: 7 or 12 and a mutant thereof. The present invention also provides a protein having an amino acid sequence set forth in SEQ ID NO: 2, 5, or 9 and a mutant thereof.Type: ApplicationFiled: February 3, 2011Publication date: November 29, 2012Applicant: SUNTORY HOLDINGS LIMITEDInventor: Misa Ochiai
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Publication number: 20120264713Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.Type: ApplicationFiled: January 15, 2011Publication date: October 18, 2012Inventors: Charles N. Serhan, Bruce D. Levy
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Patent number: 8273727Abstract: The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.Type: GrantFiled: September 2, 2009Date of Patent: September 25, 2012Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventor: Hansjörg Eibl
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Publication number: 20120237589Abstract: The invention concerns lipid assemblies, liposomes having an outer surface comprising a mixture of anionic and cationic moieties; wherein at least a portion of the cationic moieties are imino moieties that are essentially charged under physiological conditions, and their use for serum resistant transfection of cells.Type: ApplicationFiled: July 2, 2010Publication date: September 20, 2012Applicant: MARINA BIOTECH, INC.Inventors: Steffen Panzner, Evgenios Siepi
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Publication number: 20120184757Abstract: Generally, a method of pressure regulated supercritical fluid fractionation of oil seed extraction materials which can be utilized to refine oil seed extraction material established in an amount of supercritical fluid. Specifically, a method of pressure regulated supercritical fluid fractionation of corn germ extraction material to produce a refined corn oil extraction material.Type: ApplicationFiled: March 23, 2012Publication date: July 19, 2012Inventor: Rodger T. Marentis
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Patent number: 8178707Abstract: A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets.Type: GrantFiled: March 25, 2010Date of Patent: May 15, 2012Assignee: Jost Chemical CompanyInventors: John Gleason, Douglas Jost, Philip H. Merrell, Doug Caskey
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Publication number: 20120115963Abstract: A process for the preparation of a polymer nanoparticle by a photoinduced emulsion polymerization includes preparing an emulsion comprising at least one surfactant, a dispersed phase and a continuous phase. The dispersed phase comprises at least one polymerizable monomer and the continuous phase comprises water and at least one photoinitiator. The at least one polymerizable monomer is polymerized by exposing the emulsion to an electromagnetic radiation having a wavelength so as to induce a generation of radicals from the at least one photoinitiator.Type: ApplicationFiled: April 16, 2010Publication date: May 10, 2012Applicant: ETH ZUERICHInventors: Hansjoerg Gruetzmacher, Timo Ott
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Publication number: 20120116106Abstract: A co-salt of a polyunsaturated fatty acid and a non-fatty acid is formed as a precipitate. The co-salt formed is free flowing and does not tend to agglomerate (cake) in storage. The resultant co-salt product will be easy to blend with other products to produce dietary supplements. These novel co-salt products may also tablet very well and may be added to current dietary supplement tablets.Type: ApplicationFiled: January 19, 2012Publication date: May 10, 2012Applicant: JOST CHEMICAL CO.Inventors: John Gleason, Douglas Jost, Philip H. Merrell, Doug Caskey
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Publication number: 20120108550Abstract: Use of polyunsaturated fatty acid derivatives as medicaments or functional foods. The present invention relates to the use of 1,2-fatty acid derivatives in the treatment or prevention of common diseases whose etiology is based on alterations (of any type) of the cell membrane lipids, for example, changes in levels, in the composition or in the structure of these lipids. In addition, for diseases in which the regulation of lipid composition and of the structure of the membranes (or proteins that interact with membranes) causes the reversion of pathological state.Type: ApplicationFiled: March 15, 2010Publication date: May 3, 2012Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO VKInventors: Pablo Vicente Escriba Ruiz, Xavier Busquets Xaubet, Silvia Teres Jimenez, Gwendolyn Barcelo Coblijn, Victoria Llado Canellas, Amaia Marcilla Etxenike, Maria Laura Martin, Monica Higuera Urbano, Rafael Alvarez Martinez, Daniel Horacio Lopez
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Publication number: 20120065416Abstract: The present invention relates to methods useful for converting microbial lipids from an oleaginous microbial biomass into fatty acid alcohol esters, without prior extraction of the lipids from the biomass. The present invention also relates to fatty acid alcohol esters produced by the methods described herein. The fatty acid alcohol esters produced by the methods described herein may be useful as biodiesel, or a component thereof. In embodiments, the converting of microbial lipids to fatty acid alcohol esters may be accomplished by contacting an acid catalyst, an alcohol and an oleaginous microbial biomass containing microbial lipids under sufficient conditions and for a sufficient period of time for in situ transesterification reaction of at least some microbial lipids to their corresponding fatty acid alcohol ester.Type: ApplicationFiled: September 15, 2011Publication date: March 15, 2012Applicant: Utah State UniversityInventors: Lance Seefeldt, Bradley Wahlen, Robert Willis, Alexander McCurdy
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Patent number: 8129552Abstract: The invention relates to phospholipid-like compounds having defined apolar constituents and to the use of such compounds as liposomes, active ingredients, and solubilizers.Type: GrantFiled: August 29, 2007Date of Patent: March 6, 2012Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.v.Inventors: Eibl Hansjörg, Thomas Hottkowitz
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Patent number: 8124800Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: August 24, 2010Date of Patent: February 28, 2012Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Publication number: 20120045802Abstract: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, sequentially adding solvent sets to the algal biomass, and sequentially separating solid biomass fractions from liquid fractions to arrive at a liquid fraction comprising neutral lipids. The method also includes esterifying the neutral lipids, separating a water miscible fraction comprising glycerin from a water immiscible fraction comprising fuel esters, carotenoids, and omega-3 fatty acids. The method also includes obtaining a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising carotenoids and omega-3 fatty acids. The method includes hydrogenating and deoxygenating at least one of (i) the C16 or shorter fuel esters to obtain a jet fuel blend stock and (ii) the C16 or longer fuel esters to obtain a diesel blend stock.Type: ApplicationFiled: October 7, 2011Publication date: February 23, 2012Applicant: Heliae Development, LLC.Inventor: Aniket Kale
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Patent number: 8052992Abstract: Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease. The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.Type: GrantFiled: April 28, 2006Date of Patent: November 8, 2011Assignee: Enzymotec Ltd.Inventors: Gai Ben Dror, Dorit Plat, Orly Farkash, Rassan Zuabi, Zohar Bar-On, Avidor Shulman, Dori Pelled
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Publication number: 20110262548Abstract: A PGE1 derivative is provided which has an excellent sustained, slow-release PGE1 action. In addition, a PGE1-derivative-containing nanoparticle produced using this PGE1 derivative is provided, which effectively targets an affected site, has excellent drug slow-release properties, and has reduced side effects. This PGE1-derivative-containing nanoparticle is a nanoparticle containing a prostaglandin E1 derivative represented by the following formula (1) (wherein n denotes an integer of 1 to 12), obtained by hydrophobicizing the prostaglandin E1 derivative with a metal ion, and reacting the hydrophobicized prostaglandin E1 derivative with poly L-lactic acid or a poly(L-lactic acid/glycolic acid) copolymer and a poly DL- or L-lactic acid-polyethylene glycol block copolymer or a poly(DL- or L-lactic acid/glycolic acid)-polyethylene glycol block copolymer.Type: ApplicationFiled: October 16, 2009Publication date: October 27, 2011Applicant: LTT Bio-Pharma Co., Ltd.Inventors: Toru Mizushima, Masami Ohtsuka, Yoshinari Okamoto
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Publication number: 20110224450Abstract: Organic solvent-free processes for obtaining krill oil compositions are disclosed. The processes include a) cooking krill in a cooker vessel for a time and at a temperature sufficient to denature the protein content of the krill and cause a first solid krill fraction and a first liquid krill fraction to be formed while substantially avoiding emulsification of the first solid and first liquid hill fractions; b) removing the first solid and first liquid krill fractions from the cooker vessel at a temperature of at least about 90° C.; c) separating the first solid fraction and the first liquid fraction; and d) obtaining krill oil with neutral enriched from the first liquid fraction, and e) by pressing of first solid fraction to obtain press liquid or a second liquid krill fraction for obtaining hill oil with phospholipids enriched krill oil, the separating and the obtaining steps being carried out without the use of organic solvents. Krill oil compositions made by the process are also disclosed.Type: ApplicationFiled: April 28, 2011Publication date: September 15, 2011Applicants: THAROS LTD., LONZA LTD.Inventors: Dimitri Sclabos Katevas, Raul R. Toro Guerra, Mario M. Chiong Lay
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Patent number: 7989663Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.Type: GrantFiled: October 28, 2008Date of Patent: August 2, 2011Assignee: Echelon Biosciences IncorporatedInventors: Colin Ferguson, Glenn Prestwich
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Patent number: 7968737Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: GrantFiled: August 4, 2010Date of Patent: June 28, 2011Assignee: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Patent number: 7955525Abstract: Disclosed is an oil composition wherein the oil contains measurable amounts of peroxide resulting from peroxidation, and also includes an effective amount of a peroxide-reducing phosphorous compound, preferably an alkyl/aryl substituted phosphite compound or phosphinic acid (H3PO2) and its derivatives.Type: GrantFiled: August 19, 2010Date of Patent: June 7, 2011Assignee: Galata Chemicals, LLCInventors: Michael G. Denoux, Ritchie Tregre, Garrett Mineo
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Patent number: 7923052Abstract: A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a permeate stream having a decreased weight percent of phospholipids compared with the weight percent of phospholipids provided in the miscella. The retentate stream can be further processed for the recovery of lecithin. The polymeric microfiltration membrane can be conditioned for the selective separation of phospholipids in the miscella. A method for conditioning a membrane for selective separation of phospholipids from vegetable oil miscella, and the resulting membrane, are provided. The membrane which can be conditioned can be characterized as having an average pore size of between about 0.1? and about 2?.Type: GrantFiled: January 13, 2009Date of Patent: April 12, 2011Assignee: Cargill, IncorporatedInventors: Bassam Jirjis, Harapanahalli S. Muralidhara, Dennis D. Otten
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Publication number: 20110033523Abstract: The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CD1 33+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).Type: ApplicationFiled: October 29, 2007Publication date: February 10, 2011Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND G.m.b.H.Inventors: Vincenzo Cantaluppi, Maria Chiara Deregibus, Giovanni Camussi
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Patent number: 7880024Abstract: Provided are an ionic liquid and a method of preparing the same. The ionic liquid includes at least one type of compound represented by (Cat+)(R?COO?). Here, the Cat+ is a cation selected from the group consisting of quaternary ammonium, quaternary phosphonium, sulfonium, imidazolium, pyridinium, pyrazolium, piperidinium, pyrrolium, pyrrolidinium, triazolium, and a mixture of two or more thereof, and R? is a hydrocarbon comprising at least one unsaturated bond, and having 4 to 30 carbon atoms. The ionic liquid is partially or completely miscible with various polar and/or non-polar solvents, and may be used as a solvent, a solvent additive, an electrolyte, a heat carrier, a charge carrier, a heat carrier additive, a charge career additive, or a phase transfer catalyst, at room temperatures and below. Furthermore, the cost of manufacturing the ionic liquid can be reduced.Type: GrantFiled: April 25, 2008Date of Patent: February 1, 2011Assignee: Samsung Engineering Co., Ltd.Inventors: Myong Hoon Lim, Young Mi Kim, Jae Eun Rho, Jae Hoi Gu, Yong Ho Yu
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Publication number: 20100317622Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: ApplicationFiled: August 4, 2010Publication date: December 16, 2010Applicant: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Patent number: 7847113Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: GrantFiled: February 28, 2005Date of Patent: December 7, 2010Assignee: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Publication number: 20100297768Abstract: A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers can be used in a variety of applications including the formation of nanofibrillar structures for cell culture and tissue engineering.Type: ApplicationFiled: April 26, 2010Publication date: November 25, 2010Applicant: Michigan State UniversityInventors: Melvin S. Schindler, Hoo Young Chung
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Patent number: 7825270Abstract: Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives and analogues, and a process for their production starting from natural IPL. The embodiments further provide functional derivatives of PI for biomedical applications including a platform for drug design and delivery to therapeutic targets in the phosphoinositide mediated cellular signaling and allied cascades. The embodiments pertain to IPL having absolute stereo-structure. The embodiments further pertain to unique IPL and PI product compositions for defined applications, particularly pharmaceutical compositions for prophylaxis and treatment of diseases related to aberrant cellular and nuclear signaling mediated by PI and PI derived phosphates, and associated phosphoinositide specific enzymes including PI-PLC and PI 3-kinase.Type: GrantFiled: December 20, 2006Date of Patent: November 2, 2010Assignee: Nutrimed BiotechInventor: Raijindra Aneja
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Patent number: 7807847Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: January 9, 2007Date of Patent: October 5, 2010Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai