Abstract: A keratin hydrolysate including at least 94% by weight of free amino acids relative to the total weight of the amino acids of the hydrolysate. The keratin hydrolysate includes at least 93% of free valine relative to the total weight of valine in the hydrolysate, at least 90% free isoleucine relative to the total weight of isoleucine in the hydrolysate, and at least 95% of free leucine relative to the total weight of leucine in the hydrolysate. A method for producing the keratin hydrolysate, a composition comprising the hydrolysate and an animal feed containing the hydrolysate are also disclosed.

Abstract: The present invention relates to a new class of chemical admixtures for hydraulic cement compositions and methods of preparing same. The admixtures, which include complexes of metals with one or more hydroxycarboxylic acids and/or derivatives of hydroxycarboxylic acids, improve at least the following properties of cement compositions: hardness, compressive strength, shrinkage, and freeze-thaw resistance. Hydraulic cement compositions that may be improved with the chemical admixtures include pastes, mortars, grouts and concretes, all of which may be made from ordinary Portland cement, blended cements, or non-Portland cements made with Supplementary Cementitious Materials.

Abstract: The invention relates to an organometallic complex of the amino acid/metal type. The complex is a crystalline pluri-metal complex that can be obtained in the form of a homogeneous powder that can be used to optimise animal feed. More specifically, the invention relates to an organometallic complex that is characterised in that it is formed by at least one amino acid or amino acid derivative with at least two different metals. The invention also relates to a powder comprising the organometallic complex of the invention, as well as to methods for preparing such a powder.

Abstract: Disclosed are a compound including an oxalate, a carbon dioxide absorbent including the same, a method of preparing the carbon dioxide absorbent and a method of removing carbon dioxide, which may overcome issues of high recycling energy and low absorptivity of a conventional carbon dioxide absorbent to considerably reduce recycling energy and absorb a greater amount of carbon dioxide per unit absorbent, so that a size of a carbon dioxide absorption tower may be reduced and a less amount of recycling energy may be used, contributing to a substantial decrease in device manufacture costs and management costs.

Abstract: A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).

Abstract: Stable complexes are described, formed by mono- and di-functional compounds bound to nanoparticles composed of various types of transition metal oxides and of metals useful in the production processes of different types of new materials (such as for example some types of hydrophile plastics, fibers); processes for the production of the complexes are also described.

Abstract: A contrast marker having a casing and a novel MRI contrast agent comprising metal complexes disposed around, within, or abuting the casing is provided. Such contrast markers may be placed in a strand, with or without a therapy seed, to produce a seeded strand useful for imaging and in connection with brachytherapy.

Abstract: A composition includes a first chelating agent, a second chelating agent, and a plurality of metal ions. In one embodiment, the second chelating agent includes citric acid and is different than the first chelating agent. A method for forming a composition includes mixing a first chelating agent, a second chelating agent, and a metal salt together to form a mixture and processing the mixture to form at least one of a granulated composition and a powdered composition. In some embodiments, the second chelating agent includes citric acid and is different than the first chelating agent.

Abstract: A chelating agent, a metal-chelate, and a contrast agent are provided, wherein the chelating agent comprises a compound of structure (I) wherein R1, R2, R3, R8, R7, R?7 R?1, R?2, R?3 and R8? are selected from a hydrogen, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; R4 and R?4 are selected from a hydrogen, a hydroxyl group, a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5 and R?5 are selected from a hydrogen, a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals; R9 and R?9 are selected form a hydrogen or a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 0 and 10; and at least one of R7 and R?7 is acidic group or a protected acidic group.

Abstract: The invention relates to the process for the preparation of iron(III) chelates of N,N?-di(2-hydroxybenzyl)ethylenediamine-N,N?-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C1-C4 alkyl, CH2OH, SO3M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.

Abstract: A contrast marker having a casing and a novel MRI contrast agent comprising metal complexes disposed around, within, or abuting the casing is provided. Such contrast markers may be placed in a strand, with or without a therapy seed, to produce a seeded strand useful for imaging and in connection with brachytherapy.

Abstract: This invention relates to supplementation of the diets of domesticated animals (livestock and poultry) with iodine in an enhanced bioavailable manner, that is to say the iodine is more available to the animal than when using conventional sources of iodine, such as calcium iodate. The supplementary compound are alpha amino acid metal iodide complexes.

Abstract: In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.

Abstract: A mixed amino acid metal salt complex of the mixed amino acids, lysine and glutamic acid associated with trace metals selected from the group consisting of iron, manganese, copper and zinc to provide highly bioavailable sources of the iron, manganese, copper and zinc and as well to take advantage of the different amino acid transport pathways of lysine and glutamic acid.

Abstract: The invention relates to the process for the preparation of iron(III) chelates of N,N-di(2-hydroxybenzyl)ethylenediamine-N,N?-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C1-C4 alkyl, CH2OH, SO3M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.

Abstract: This invention relates to supplementation of the diets of domesticated animals (livestock and poultry) with iodine in an enhanced bioavailable manner, that is to say the iodine is more available to the animal than when using conventional sources of iodine, such as calcium iodate. The supplementary compound are alpha amino acid metal iodide complexes.

Abstract: Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.

Abstract: The invention relates to the process for the preparation of iron(III) chelates of N,N-di(2-hydroxybenzyl)ethylenediamine-N,N?-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C1-C4 alkyl, CH2OH, SO3M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.

Abstract: A composition useful for crosslinking phosphate esters in hydrocarbon gels used in formation fracturing performs especially well in cold temperatures, such as temperatures lower than (?)20° C. Methods of making the crosslinking composition and the gel are described; also methods of fracturing subterranean formations. Specific forms of ferric sulfate and ferric ammonium citrate are useful as ingredients of the crosslinking composition.

Abstract: In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.

Abstract: In one aspect, the present invention provides a protected ligand precursor having structure XXI wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence acid sensitive protecting groups.

Abstract: A metal hydride complex of the invention is a hydride complex of a metal selected from the group consisting of ruthenium, rhodium, osmium and iridium and has one or more aromatic carboxylic acid residues. According to the invention, there is provided a new metal hydride complex which is dissolved in an organic solvent having a low polarity such as a hydrocarbon solvent at a high concentration and has a high catalytic activity of hydrogenating carbon-carbon double bonds. The metal hydride complex relating to the invention is especially suitable as a catalyst in the hydrogenation reaction of a cycloolefin ring-opening polymer.

Abstract: Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailablity relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormally increased calcium resorption is desired, including cancer, hypercalcemia, osteoporosis, osteopenia and Paget's disease. Methods for preparation and treatment are also provided.

Abstract: The present invention is drawn to compositions and methods that include iron (II) amino acid chelate having a reducing agent bonded thereto. The reducing agent can be configured to substantially maintain the iron (II) in its ferrous oxidation state. The iron (II) amino acid chelate can have an amino acid ligand to iron (II) molar ratio from 1:1 to 2:1 and a reducing agent ligand to iron (II) molar ratio from 1:1 to 4:1, with a proviso that the combination of the amino acid ligands and the reducing agent ligands satisfies from 3 to 6 of the coordination sites of the iron (II).

Abstract: A novel coordination complex formed by dinuclear metal complexation is provided. The complex is a dinuclear metal complex of a compound, wherein the compound comprises a conjugation ring system substituted with: a) an electron donating group selected from —OH, —SH and —NH2; b) an indicating group selected from a chromogenic group, a fluorescent group and an electrochemical group; and c) two binding auxiliary groups, in combination with the electron donating group each of which being coordinated with the metal to provide an anion bonding site, wherein as the complex binds to a anion, the coordination of the electron donating group with the metal is weakened and electron donation of the electron donating group to the conjugation ring system is reinforced such that the reinforced electron donation by the electron donating group is transferred through the conjugation ring system to the indicating group to produce an indicating signal concomitant with the change of its electronic density.

Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).

Abstract: The invention pertains to an aqueous solution of a sodium salt xNa+ yH+ of the chelating compound of formula I: wherein x=2.1–2.7, y=0.9–0.3, and x+y=3. The invention further pertains to a container comprising at least 0.5 kg of said aqueous solution and to a method of preparing an aqueous solution comprising at least 45 wt % of the sodium salt xNa+ yH+ of the chelating compound of formula I from Na3-HEDTA, comprising the steps of electrodialysing an aqueous solution containing less than 42 wt % of Na3-HEDTA using a bipolar membrane, thereby converting the trisodium salt solution to the solution of the sodium salt of formula I with x=2.1–2.7, y=0.9–0.3, and x+y=3.

Abstract: A method for the preparation of organic chelates utilized as ingredients of animal feedstuffs. The organic chelates are passed to the intestines of livestock without decomposition in the stomach, and thereby have a high absorption rate. The present invention provides a preparation method of perfect chelate minerals having a high yield and containing copper, zinc, iron, manganese, or cobalt. The organic chelate mineral is prepared by precipitating metal sulfates or chlorides with sodium hydroxide or potassium hydroxide in a solution of two equivalents of an amino acid completely dissolved at above 70° C., collecting metal hydroxide by removing sodium sulfate, potassium sulfate, sodium chloride or potassium chloride through filtering, dissolving the metal hydroxide by adding the equivalent weights of hydrochloric acid, and then neutralizing the hydrochloric acid added for dissolving metal hydroxide.

Abstract: A ferric and acid complex includes the reaction product of a chelant, iron oxide, a base, and a reaction promoter. The chelant has at least one carboxylic acid functionality. The reaction promoter has an Fe3+ ion. A process for preparing the ferric and acid complex in a vessel includes charging solvent, the chelant, the base, the iron oxide, and the reaction promoter into the vessel. The solvent, chelant, base, iron oxide, and reaction promoter are heated to a temperature of at least 170° F. for a period of at least about 3 hours to form the ferric and acid complex. Due to the use of the reaction promoter having the Fe3+ ion, the process for preparing the ferric and acid complex results in reduced degradation of the chelant during processing and, thus, a high quality ferric and acid complex.

Abstract: A method is disclosed for the formation of metal chelates which are able to remain stable in high alkaline environments when compared to metal chelates produced from a reaction with amino acids. The method involves the reaction of sugars, amino groups, and metal components for a sufficient period of time and temperature in a water solution. Additionally, the stability of metal chelates can be enhanced by oxidation of the sugars with an oxidizing agent such as hydrogen peroxide which form an MRP which will react with the metal component to form a more stable metal chelate than if oxidation were not utilized.

Abstract: Metal L-seleno-alpha-amino acids salts and their use as a bioavailable feed and water ration supplement for domesticated animals such as cattle, pigs and poultry.

Abstract: Disclosed are novel phosphine-phosphoramidite compounds which may be employed in combination with a catalytically-active metal to effect a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. Also disclosed are a process for the preparation of the phosphine-phosphoramidite compounds, metal complex compounds comprising at least one of the phosphine-phosphoramidite compounds and a catalytically-active metal and hydrogenation processes utilizing the metal complex compounds.

Abstract: Disclosed is a process for the preparation of phosphine-aminophosphines that are useful in the formation of catalysts useful in carrying out a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. The process comprises the steps of (1) contacting a compound of formula 2 R2P—L—NHR3??2 with phosphorus trihalide PX3 in the presence of an inert, organic solvent and an acid acceptor to produce intermediate compound having formula 3 (2) contacting intermediate compound 3 with a reactant having the formula R1—M1, R2—M1 or a mixture thereof.

Abstract: There is provided a powdery S,S-EDDS iron complex improved in its caking property. An S,S-ethylenediamine-N,N?-disuccinic acid iron complex, which is crystalline and has an average particle diameter of from 10 to 1000 ?m and a water content of not more than 7% by weight, a powdery S,S-ethylene-N,N?-disuccinic acid (S,S-EDDS) iron complex having a compressive strength of not more than 1 kg/cm2, the compressive strength being measured according to JIS A 1108 after a lapse of 2 months under conditions of a temperature of 50° C. and a load of 300 g/cm2, and a process for producing the same.

Abstract: A process is described for the catalytic removal of H2S gas from a sour gas stream in the presence of a chelate ligand of the formula (I) 1

Abstract: A hydrochloride salt of ferrous bisglycinate having the formula Fe(C2H4NO2.HCl)2, which is highly soluble in water, making the compound beneficial as a dietary supplement. One form of the commercial product of the compound has the ferrous bisglycinate hydrochloride dissolved in water.

Abstract: A molecule for labeling a target material is provided including two transition-metal chelates and a detectable group.

Abstract: A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into existing iron amino acid chelates or iron proteinates. The iron amino acid chelates and iron proteinates may have a ligand to metal molar ratio from about 1:1 to 4:1, preferably 2:1 to 3:1.

Abstract: A composition and method of preparing amino acid chelates and complexes free of interfering ions by blending an amino acid ligand, a calcium oxide and/or hydroxide, and a hydrated metal sulfate salt, placing the blend in a closed environment, heating the blend, and allowing the blend to react is disclosed and described. By heating at low to moderate temperatures in an enclosed environment, the waters of hydration of the metal salt are retained in the enclosed environment and serve to provide the moisture necessary to enable a bonding reaction to take place between the electron rich functional groups of the ligand and the metal ion of the hydrated metal sulfate salt. Additionally, calcium sulfate is formed which can be maintained in the final product.

Abstract: A method is disclosed where organic acid chelates can be made by reacting an organic acid ligand with a metal compound in a non aqueous environment. The chelate is thereafter recovered by means of filtration or evaporation.

Abstract: The present invention relates to methods useful for processing a color photographic material. A method of manufacturing a ferric 1,3-PDTA complex is provided. The method includes reacting ferrous bromide with unchelated 1,3-PDTA, thereby forming a ferrous 1,3-PDTA complex; and conducting an oxidation process wherein the ferrous 1,3-PDTA complex is converted to the ferric 1,3-PDTA complex. Also provided is a method of processing a silver halide color photographic material.

Abstract: Disclosed are substantially enantiomerically pure bis-phosphine compounds comprising a substantially enantiomerically pure chiral backbone linking two phosphine residues wherein one of the phosphine residues has three phosphorus-carbon bonds and the other phosphine residue has two phosphorus-carbon bonds and one phosphorus-nitrogen bond wherein the nitrogen is part of the chiral backbone. The compounds, which have exhibited surprising air stability, are useful as ligands for metal catalysts for asymmetric reactions and have demonstrated excellent results, in particular as rhodium complexes for asymmetric hydrogenation of enamide, itaconate, and &agr;-ketoester compounds. Also disclosed are novel processes for the preparation of the bis-phosphine compounds and novel intermediate compounds useful in the preparation of the bis-phosphine compounds.

Abstract: Betaine transition metal complexes are formed by: a) reacting a solution including an alkali metal salt of chloroacetic acid with a solution including the transition metal salt to give a solution including a chloroacetate transition metal complex; and b) reacting the solution including the chloroacetate transition metal complex with trimethylamine to give a solution including the betaine transition metal complex. Such betaine transition metal complexes may be used as a feed supplement for animals in the process of preparing such animals for market.

Abstract: A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into existing iron amino acid chelates or iron proteinates. The iron amino acid chelates and iron proteinates may have a ligand to metal molar ratio from about 1:1 to 4:1, preferably 2:1 to 3:1.

Abstract: Large cobalt and nickel complexes that may be linked to antibodies and other molecules are described. These may be useful in applications benefiting from their magnetic properties.

Abstract: Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones.

Abstract: An S,S-ethylenediamine-N,N′-disuccinic acid iron alkali salt which contains a lactam compound represented by the following general formula (1): wherein M is an ammonium ion or an alkali metal ion, and an ethylenediaminemonosuccinic acid represented by the following general formula (2): wherein M is an ammonium ion or an alkali metal ion, in an amount of 7 wt % or less, respectively.

Abstract: The present invention provides a process for the preparation of a chelant or chelating agent complex of the formula L•B•M. L is an amino acid derivative including two optically active amino acids are linked via a (CH2)n group, wherein the (CH2)n group is attached to a nitrogen of each optically active amino acid, the optically active amino acid may be the same or different; and wherein n is an integer from 1 to 10; B is a base; and M is a metal. The process comprises the steps of (i) providing a reaction mixture comprising L and B and having a pH of less than 7.5; (ii) contacting the reaction mixture with M to provide a first complex mixture; and (iii) contacting the first complex mixture with a further amount of B to provide a second complex mixture. The second complex mixture can further be sequentially contacted with further amounts of M and further amounts of B. Alternatively, the second complex mixture can be heated.

Abstract: A process for synthesizing complexes of platinum(II) with iminoethers having the formula: [PtIIX2(L)(L′)], where X is a monoanionic ligand, L is an iminoether ligand and L′ is an amine group or, exclusively for the case of cyclic iminoethers, a second iminoether ligand. The platinum(II) complexes according to the present invention are suitable for the production of medical remedies having a broad antitumoral spectrum. The complexes of platinum(II) with iminoethers according to the invention are furthermore suitable as agents for modifying nucleotide bases into antisense and/or antigene oligonucleotides.