Nitrogen Containing (e.g., Ferric Chelates Of Ethylenediaminetetracetic Acid, Etc.) Patents (Class 556/148)
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Patent number: 6458981Abstract: The present invention relates to compositions and methods of preparing amino acid chelates that are essentially free of interfering ions. The composition is prepared by reacting in an aqueous solution, a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a positively charged metal amino acid chelate having a hydroxide counter-ion, and calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 1:1 to 2:1.Type: GrantFiled: October 11, 2000Date of Patent: October 1, 2002Assignee: Albion International, Inc.Inventors: Stephen D. Ashmead, David C. Wheelwright, Clayton Ericson, Mark Pedersen
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Patent number: 6451940Abstract: Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones. Suitable complexes have the following structure: wherein: R2 is hydrocarbyl or substituted hydrocarbyl, provided that R2 is attached to said nitrogen atom in (I) by an atom that has at least 2 other atoms that are not hydrogen attached to it; and R3, R4, R5, R6 and R7 are each independently hydrogen, hydrocarbyl, substituted hydrocarbyl or a functional group, provided that any two of R3, R4, R5, R6 and R7 vicinal to one another may form a ring; L1 is a monodentate monoanionic ligand and L2 is a monodentate neutral ligand or an empty coordination site, or L1 and L2 taken together are a monoanionic bidentate ligand.Type: GrantFiled: October 13, 2000Date of Patent: September 17, 2002Assignee: E. I. du Pont de Nemours and CompanyInventors: Frederick Hicks, Maurice S. Brookhart
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Patent number: 6426424Abstract: Compositions and methods of preparing amino acid chelates and complexes are disclosed and described. Specifically, by (a) blending hydrated metal sulfate salts, amino acid ligands, and reaction modifiers; (b) confining the particulate blend in an enclosed environment; and (c) applying heat to the particulate blend in the enclosed environment causing the waters of hydration of the metal sulfate salt to be released into the enclosed environment causing a reaction resulting in the formation of a granular amino acid chelate or complex by effecting the reaction between functional electron rich groups of the amino acid ligand and a metal ion of the metal sulfate salt. The waters of hydration serve to provide the water necessary to enable a bonding reaction to take place between the electron rich functional groups of the amino acid ligand and the metal ion of the hydrated metal sulfate salt.Type: GrantFiled: October 11, 2000Date of Patent: July 30, 2002Assignee: Albion International, Inc.Inventors: Stephen D. Ashmead, Mark Pedersen
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Publication number: 20020072625Abstract: The present invention relates to chelate-fluorophore conjugates and their use in monitoring binding reactions between a chelate and a macromolecular biological binding agent, such as an antibody. Such monitoring is used both to identify anti-chelate antibodies that have a desired metal selectivity and to configure immunoassays that provide a means of detecting and quantitating a given metal ion.Type: ApplicationFiled: December 9, 2000Publication date: June 13, 2002Inventor: David Kenneth Johnson
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Patent number: 6380278Abstract: A urethane (meth)acrylate metal salt obtained by reacting (A) one or more polyisocyanates, (B) one or more hydroxy functional (meth)acrylates, and (C) one or more metal salt polyols which are the reaction product of a metal oxide and a half ester containing a hydroxy group and a carboxylic acid group. Processes of preparing such salts and polymers prepared from such salts are also disclosed. The polymers are useful for coating and adhesive compositions prepared by radiation or peroxide curing processes.Type: GrantFiled: January 19, 2001Date of Patent: April 30, 2002Assignee: Sartomer Technology Co., Inc.Inventors: Mingxin Fan, Xiaoxing Chuck Dong, Jeffrey Allan Klang, James Horgan, Gary W. Ceska
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Patent number: 6372932Abstract: A solid product which is a porous chiral (10,3)-a network of 1,3,5-benzenetricarboxylate molecules of formula (I) where X is H, hydrocarbon, halide, etc, linked through metal atoms.Type: GrantFiled: May 1, 2000Date of Patent: April 16, 2002Assignee: University of LiverpoolInventors: Cameron J Kepert, Matthew J Rosseinsky
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Publication number: 20020040156Abstract: An S,S-ethylenediamine-N,N′-disuccinic acid iron alkali salt which contains a lactam compound represented by the following general formula (1): 1Type: ApplicationFiled: August 17, 2001Publication date: April 4, 2002Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Toshitake Yamakawa, Haruo Sakai
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Publication number: 20020032343Abstract: This invention provides a process for the preparation of a complex of the formula L·B·M wherein (a) L is of the formula (R1)(R2)N—(CH2)n—N(R3)(R4), wherein each of (R1)(R2)N and N(R3)(R4) is an optically active amino acid, which may be the same or different; and wherein n is an integer from 1 to 10, (b) B is a base and (c) M is a metal, the process comprising the steps of (i) providing a reaction mixture comprising L and B and having a pH of less than 7.5; (ii) contacting the reaction mixture with M to provide an first complex mixture; and (iii) contacting the first complex mixture with a further amount of B to provide a second complex mixture.Type: ApplicationFiled: May 7, 2001Publication date: March 14, 2002Inventors: Clare Evans, Peter Michael Radley, Sarah E. Worsey
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Publication number: 20020019496Abstract: The invention provides a metal chelate resin that comprises repeating units having the structure: 1Type: ApplicationFiled: August 2, 2001Publication date: February 14, 2002Inventor: Gerald Pevow
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Patent number: 6340560Abstract: An aminopolycarboxylic acid compound represented by the following formula or analogous thereof: The aminopolycarboxylic acid compound of the present invention can be used as a chelating agent for various metals, which is excellent in the biodegradability and masking effect on metals.Type: GrantFiled: October 7, 1998Date of Patent: January 22, 2002Assignee: Fuji Photo Film Co., Ltd.Inventors: Tadashi Inaba, Kiyoshi Morimoto, Shigeo Hirano
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Patent number: 6323354Abstract: A method of preparing amino acid transition metal chelates a palatable highly bioavailable source of transition metals for animal nutrition from lipoproteins and transition metal salts. The method requires strong aqueous base hydrolysis of the lipoproteins to sodium or potassium salts of alpha amino acids mixed with fatty acids. The salts are neutralized to amino acids mixed with fatty acids before the aqueous mixture is reacted with transition metal salts to form aqueous chelates. The aqueous mixture is dried and granulated to form a dry product comprising transition metal chelates homogeneously mixed with fatty acids. The new granular composition containing zinc, iron, manganese, copper, cobalt, or chromium provides a palatable and highly bioavailable source of transition metals for animal nutrition. Effective sources of lipoproteins are fractured cell walls of microbes generated in biological syntheses.Type: GrantFiled: March 16, 2001Date of Patent: November 27, 2001Assignee: Agri-Nutrients Technology Group, Inc.Inventor: William P. Moore
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Patent number: 6303761Abstract: The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).Type: GrantFiled: January 21, 2000Date of Patent: October 16, 2001Assignee: Department of Health The Executive Yuan, Republic of ChinaInventors: Yun-Ming Wang, Gin-Chung Liu, Chien-Hsun Lee, Reu-Sheng Sheu
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Patent number: 6300510Abstract: An S,S-ethylenediamine-N,N′-disuccinic acid iron alkali salt which contains a lactam compound represented by the following general formula (1): wherein M is an ammonium ion or an alkali metal ion, and an ethylenediaminemonosuccinic acid represented by the following general formula (2): wherein M is an ammonium ion or an alkali metal ion, in an amount of 7 wt % or less, respectively.Type: GrantFiled: April 28, 2000Date of Patent: October 9, 2001Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Toshitake Yamakawa, Haruo Sakai
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Patent number: 6254850Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.Type: GrantFiled: January 10, 2000Date of Patent: July 3, 2001Assignee: Schering AktiengesellschaftInventors: Werner Krause, Franz-Karl Maier, Michael Bauer, Gabriele Schuhmann-Giampieri, Wolf-Rudiger Press, Peter Muschik
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Patent number: 6193950Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: February 22, 2000Date of Patent: February 27, 2001Assignee: Schering AGInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 6177581Abstract: Mixed-metal chelates represented by the following general formula CaM(III)EDTA(OH).xH2O wherein M is a trivalent transition metal and x is 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, or 8 and a process for their preparation are disclosed. The process comprises the steps of a) reacting calcium hydroxide or calcium oxide, ethylenediaminetetraacetic acid, and a transition metal-containing material in an aqueous medium, optionally in the presence of an oxidant to convert any transition metal present in a divalent form to its trivalent form; and b) separating the formed mixed-metal chelate by filtration or evaporation. These mixed-metal chelates are useful as catalyst precursors and dietary supplements.Type: GrantFiled: October 12, 1999Date of Patent: January 23, 2001Assignee: The Dow Chemical CompanyInventor: George M. St. George
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Patent number: 6150547Abstract: This invention provides carbonic acid- and/or hydrogencarbonic acid-iron-hydrolyzates of casein complexes containing a large amount of iron, without causing precipitation after heating their aqueous solution or astringent taste and the processes for production thereof. The complexes of the present invention are prepared by (1) partial hydrolysis of carbonic acid- and/or hydrogencarbonic acid-iron-casein complexes with a protease or (2) mixing carbonic acid and/or hydrogencarbonic acid, iron and partial hydrolyzates of casein with a protease. These complexes are used favorably as food additives, raw materials of medicines or feed components due to their lack of precipitation by heating their aqueous solution, or astringent taste.Type: GrantFiled: November 20, 1998Date of Patent: November 21, 2000Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Toshio Sakurai, Akihito Ikenaga, Taishi Oda, Toshiaki Uchida, Akira Tomizawa, Hitoshi Aikawa, Ken Takahashi
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Patent number: 6124258Abstract: Iron-casein complexes and methods for preparation thereof without iron characteristic astringent taste even by heat sterilization and having high iron supplying effect.The iron-casein complexes can be obtained by mixing three components of solution A containing i) carbonic acid, ii) hydrogencarbonic acid or iii) their mixtures, solution B1 containing iron, and solution B2 containing caseins in a suitable order.The resultant iron-casein complexes contain 1-1,000 atoms of iron and one molecule or over of carbonic acid and/or hydrogencarbonic acid for one molecule of caseins without exhibiting astringent taste even by heat sterilization. The iron-casein complexes exhibit superior anemia preventive effect than those of inorganic iron salts.Type: GrantFiled: July 14, 1999Date of Patent: September 26, 2000Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Toshio Sakurai, Toshiaki Uchida, Kazumasa Hamashita, Akira Tomizawa
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Patent number: 6114379Abstract: A chelate comprised of creatine bonded to an essential mineral selected from the group consisting of Mg, Ca, Cu, Zn, Fe, Cr, Co, Mo, Se and Mn to form a heterocyclic ring. Preferably, the metal is Mg, but Ca, Zn, Fe, Cr and Mn are also preferred. The creatine chelates of the present invention are capable of being absorbed in the stomach or intestines via active transport without substantial metabolism of the chelate. In other words, the creatine ligand is protected by the metal from undergoing cyclization in the acidic environment of the stomach and the metal is made more bioavailable due to the presence of the creatine ligand.Type: GrantFiled: July 7, 1999Date of Patent: September 5, 2000Assignee: Albion Laboratories, Inc.Inventors: David C. Wheelwright, Stephen D. Ashmead
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Patent number: 6099824Abstract: Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.Type: GrantFiled: August 1, 1997Date of Patent: August 8, 2000Assignee: Dibra S.p.A.Inventors: Pier Lucio Anelli, Andrea Beltrami, Fulvio Uggeri, Mario Virtuani
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Patent number: 6060040Abstract: The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--Z--A (1) and/or C(R.sup.1 R.sup.2).dbd.CR.sup.3 --O--Z--A--Z--CO--CR.sup.3 .dbd.C(R.sup.1 R.sup.2) (2) in monomer, oligomer, homopolymer and copolymer forms, in which the R.sup.1, R.sup.2 and R.sup.3 represent H or saturated or unsaturated C.sub.1-10 aliphatic radicals optionally substituted by one or more OH groups; Z is a covalent bond or a linker spacer and A is a moiety capable of fixing a paramagnetic metal by chelation. Compounds of type (1) useful in the present invention are, for instance the polyalkylene-aminopolycaboxylic acids such as NTA, EDTA, DTPA, DOTA and like structures, possibly involving additional substituents; an example is the compound BOPTA which is a DTPA derivative carrying a benzyloxypropyl group.Type: GrantFiled: December 23, 1997Date of Patent: May 9, 2000Assignee: Bracco Research S.A.Inventors: Herve Tournier, Philippe Bussat
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Patent number: 6054117Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.Type: GrantFiled: September 17, 1998Date of Patent: April 25, 2000Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
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Patent number: 6045776Abstract: The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex carboxylic acid and at least one solubilizing substance in dimethyl sulfoxide (DMSO) is pretreated with a dehydrating reagent, optionally with the addition of a coupling adjuvant, and is then reacted with an amine of general formula IA(NH.sub.2).sub.n (I),in whichA stands for the radical of a natural or synthetic amine, andn stands for numbers 1 to 100.Type: GrantFiled: December 2, 1997Date of Patent: April 4, 2000Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Bernd Raduchel, Heribert Schmitt-Willich, Klaus-Dieter Graske
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Patent number: 6040432Abstract: The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and antidotes and process for their production.Type: GrantFiled: June 7, 1995Date of Patent: March 21, 2000Assignee: Schering AktiengesellschaftInventors: Werner Krause, Franz-Karl Maier, Michael Bauer, Gabriele Schuhmann Giampieri, Wolf-Rudiger Press, Peter Muschik
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Patent number: 6020294Abstract: Automatic dishwashing detergent compositions comprising certain cobalt catalysts are provided. More specifically, the invention relates to automatic dishwashing detergents which provide enhanced cleaning/bleaching benefits (especially tea stain removal) through the selection of cobalt chelated catalysts having the formula:[Co.sub.n L.sub.m X.sub.p ].sup.z Y.sub.z.Preferred automatic dishwashing compositions comprise amylase and/or protease enzymes. Included are methods for washing tableware in domestic automatic dishwashing appliances using the cobalt catalysts.Type: GrantFiled: May 28, 1999Date of Patent: February 1, 2000Assignee: Procter & Gamble CompanyInventors: Edward Eugene Getty, William Michael Scheper, Alan Scott Goldstein
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Patent number: 5973175Abstract: An ultrafine titanium dioxide powder is disclosed that can be produced by hydrothermal treating an amino titanium oxalate composition. Ultrafine titanium dioxide powders are useful in cosmetic and other applications for controlling exposure to ultraviolet (UV) light.Type: GrantFiled: February 17, 1998Date of Patent: October 26, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Salvatore Anthony Bruno
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Patent number: 5962717Abstract: Plant micronutrient compounds comprising N-acyl ED3A or salts thereof. The N-acyl ED3A derivatives chelate various trace metals, including iron, copper, zinc, manganese, cobalt and nickel.Type: GrantFiled: March 9, 1999Date of Patent: October 5, 1999Assignee: Hampshire Chemical Corp.Inventors: Arthur M. Nonomura, Barry A. Cullen, Joseph J. Crudden, John J. Nishio
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Patent number: 5958372Abstract: Disclosed are linear and cross-linked polymers suitable for use as a contrast agent for magnetic resonance imaging containing units comprising the residue of a poly(amine) moiety linked to a chelating agent and to one or more pendant (poly)alkylene oxides.Type: GrantFiled: June 28, 1994Date of Patent: September 28, 1999Assignee: Nycomed Imaging ASInventor: David L. Ladd
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Patent number: 5929064Abstract: Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as antiobesity agents and for the treatment of cyanide poisoning, neonatal hyperbilirubinemia, and cancer.Type: GrantFiled: February 2, 1998Date of Patent: July 27, 1999Assignee: Warner-Lambert CompanyInventors: Om P. Goel, Stephen J. Johnson, Lawrence D. Wise
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Patent number: 5925487Abstract: A toner resin composition comprising a toner resin and the metal salt or complex of a carbocyclic hydroxy caboxylic acid containing at least one methylene group optionally substituted by hydroxy or amino such as 4-(N-methyl-N-2-hydroxyethyl)aminomethyl-3-hydroxy-2-naphthoic acid. Iron and zinc salts are preferred.Type: GrantFiled: June 27, 1997Date of Patent: July 20, 1999Assignee: Zeneca LimitedInventors: David Melville Fawkes, Peter Gregory, James Stanley Campbell
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Patent number: 5914097Abstract: The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for use as intravenous contrast agents to produce enhanced contrast magnetic resonance images of the heart, liver, biliary tree or upper small intestine. The mono- and di-amino acids, their esters and amides, and catecholamine-like derivatives, of EDTA, DTPA, and the like are prepared. The paramagnetic metal (II) or (III) ion complexes are formed and produce T1-related contrast effects in MR images. The compounds and complexes also appear to have low toxicities and to be relatively rapidly and completely cleared from the tissue of a living mammal, e.g. a human being.Type: GrantFiled: June 6, 1995Date of Patent: June 22, 1999Assignee: Regents of the University of CaliforniaInventor: David L. White
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Patent number: 5914408Abstract: A novel metallocene catalyst for the polymerization of olefin (co)polymers is of the general formula:Benzothiazole--E--M--X.sub.m L.sub.nwhere,M is a transition metal of Groups 3-10 of the Periodic Table;E is sulfur or oxygen; E being bond to the transition metal and to the carbon atom between sulfur and nitrogen of the benzothiazole moiety;L is a polymerization-stable anionic ancillary ligand;X is a halogen, alkoxy from C.sub.1 to C.sub.20, siloxy from C.sub.1 to C.sub.20, N(R.sub.1).sub.2, a hydrocarbyl group containing up to about 12 carbon atoms or hydrogen or mixtures thereof; preferably X is halogen, methoxy, ethoxy or siloxy (R.sub.1).sub.3 SiO--, where R.sub.1 is alkyl from C.sub.1 to C.sub.20 ; andm+n equals the valency of the M minus 1.Type: GrantFiled: August 7, 1998Date of Patent: June 22, 1999Assignee: Equistar Chemicals, LPInventors: Ramesh Krishnamurti, Sandor Nagy, John Tyrell, Bradley P. Etherton
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Patent number: 5914095Abstract: There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a dendritic polyamine backbone molecule, e.g. a starburst dendrimer. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.Type: GrantFiled: October 7, 1991Date of Patent: June 22, 1999Assignee: Salutar, Inc.Inventor: Alan D Watson
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Patent number: 5900499Abstract: A process for producing a ferric aminopolycarboxylic acid chelate with improved long term stability is disclosed. The process involves heating a mixture of iron oxide, ammonia and aminopolycarboxylic acid chelant at an elevated temperature for a sufficient time to improve the stability of the formed chelate.Type: GrantFiled: July 8, 1997Date of Patent: May 4, 1999Assignee: The Dow Chemical CompanyInventors: George M. St. George, David A. Wilson
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Patent number: 5898078Abstract: A process for preparing a ferric chelate of an aminopolycarboxylic acid wherein an iron-containing material is reacted with an aminopolycarboxylic acid chelant in the presence of a base, which comprises employing reactants such that the molar ratio of chelant to iron is from about 0.8 to about 0.99, is disclosed. In preferred embodiments the chelate is a ferric ammonium ethylenediaminetetraacetic acid chelate. The inventive chelates show a reduced tendency to form a dark precipitate upon standing. This process is particularly suitable for use in preparing chelates for use in applications such as photographic bleaching. The corresponding ferric chelate composition and products prepared by the described process are also disclosed.Type: GrantFiled: January 22, 1998Date of Patent: April 27, 1999Assignee: The Dow Chemical CompanyInventors: George M. St. George, Stephen B. Willis, David A. Wilson
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Patent number: 5885548Abstract: The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds, their use as contrast media and antidotes, and process for the production of pharmaceutical agents.Type: GrantFiled: November 30, 1995Date of Patent: March 23, 1999Assignee: Schering AktiengesellschaftInventors: Franz-Karl Maier, Michael Bauer, Werner Krause, Ulrich Speck, Gabriele Schuhmann-Giampiere, Andreas Muhler, Thomas Balzer, Wolf-Rudiger Press
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Patent number: 5859273Abstract: Polyamino disuccinic acids are effective chelants for use in photography and gas conditioning (both applications preferably involving the polyamino disuccinic acid in the form of a metal, preferably an iron complex). The copper chelates are also useful in electroless copper plating. In photography, the invention includes a method of bleaching or bleach-fixing a photographic material which comprises contacting said material with a bleaching solution containing a bleaching agent comprising a ferric complex of a polyamino disuccinic acid and the solution so used. In electroless desposition, the invention includes a method of electroless deposition of copper upon a non-metallic surface receptive to the deposited copper including a step of contacting the non-metallic surface with an aqueous solution comprising a soluble copper salt and a polyamino disuccinic acid and plating baths appropriate for such use.Type: GrantFiled: October 23, 1996Date of Patent: January 12, 1999Assignee: The Dow Chemical CompanyInventors: David Alan Wilson, Druce Kirk Crump
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Patent number: 5859214Abstract: Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.Type: GrantFiled: April 15, 1994Date of Patent: January 12, 1999Assignee: Schering AktiengesellshaftInventors: Heinz Gries, Erich Klieger, Bernd Raduchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jurgen Conrad
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Patent number: 5850086Abstract: A bleach and oxidation catalyst is provided comprising a catalytically active iron complex which can activate hydrogen peroxide or peroxy acids, for example.Type: GrantFiled: June 21, 1996Date of Patent: December 15, 1998Assignee: Regents of the University of MinnesotaInventors: Lawrence Que, Jr., Cheal Kim, Jinheung Kim, Yan Zang
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Patent number: 5817292Abstract: This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.Type: GrantFiled: October 14, 1992Date of Patent: October 6, 1998Assignee: Nycomed Imaging ASInventors: Robert A. Snow, David L. Ladd, John L. Toner
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Patent number: 5808013Abstract: Process for the preparation of N-alkyl substituted metal carbamate solutions characterized in that a water solution of the salt of the metal of which the corresponding carbamate is to be obtained, is reacted with an organic solution, basically consisting of an aprotic solvent and a secondary amine, saturated with carbon dioxide.The above solutions can be used as catalysts in polymerization reactions of unsaturated monomers or for supporting metals on inorganic oxides.Type: GrantFiled: July 10, 1996Date of Patent: September 15, 1998Assignee: Enichem S.p.A.Inventors: Paolo Biagini, Gabriele Lugli, Fausto Calderazzo, Daniela Belli Dell'Amico, Alessandra Merigo
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Patent number: 5804163Abstract: A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include 3,6,9-tris(carboxymethyl)-1, 11-bis(dimethylamine)-3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(diethanolamino) 3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(tris(hydroymethyl) aminomethane)-3,6,9-triazaundecane; 3,6-bis(carboxymethyl-1,8-bis(N-carboxymethylglucosamino)-3,6-diazoctane; DTPA-bis(galactosamide), DTPA-Bis(glucosamide), DTPA-Bis(pyridoxamide), and poly-(DTPA-ethylenediamide).Type: GrantFiled: July 14, 1994Date of Patent: September 8, 1998Assignee: Magnetic Research, Inc.Inventors: Wendell A. Gibby, N. Rao Puttagunta
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Patent number: 5804164Abstract: The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using these contrast-enhancing agents. The water-soluble, lipophilic contrast-enhancing agents are chelates of a paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with completing acids which contain at least one short-chain fatty acyl moiety having from about 0 to about 6 carbon atoms in its structure.Type: GrantFiled: March 13, 1996Date of Patent: September 8, 1998Assignee: Research Corporation Technologies, Inc.Inventor: Gabriel A. Elgavish
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Patent number: 5798092Abstract: Compounds of general Formula I ##STR1## wherein Z.sup.1 and Z.sup.2 in each case independently mean the residue--(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,whereinm and n means the numbers 0-20,k, l, q and r means the numbers 0 and 1, andR means a hydrogen atom, an optionally OR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl residue, or a CH.sub.2 COOR.sup.1 group with R.sup.1 meaning a hydrogen atom, a C.sub.1 -C.sub.6 -alkyl residue, or a benzyl group,with the proviso that at least two substituents X stand for a metal ion equivalent; that one of the substituents Z.sup.1 and Z.sup.2 stands for a hydrogen and the other is not H; that--if n and l each means the number 0--k and r do not simultaneously mean the number 1; that --(O).sub.r --R is not --OH; and that Z.sup.1 and Z.sup.2 are not --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOCH.sub.2 C.sub.6 H.sub.5 or --CH.sub.2 --C.sub.6 H.sub.4 --O--(CH.sub.2).sub.5 --COOCH.sub.2 C.sub.6 H.sub.Type: GrantFiled: June 5, 1995Date of Patent: August 25, 1998Assignee: Schering AktiengesellschaftInventors: Heribert Schmitt-Willich, Johannes Platzek, Heinz Gries, Gabrielle Schumann-Giampieri, Hanns-Joachim Weinmann, Hubert Vogler, Julius Deutsch, Juergen Conrad
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Patent number: 5789610Abstract: Materials and methods for preparing the surface of dentin, enamel, or other natural or industrial substrates containing or capable of binding metallic ions, for adhesion of composite materials or resins, are disclosed. Preferably, the substrate is treated with an aqueous solution comprising at least one acid, acidic salt, or chelating or sequestering agent.Type: GrantFiled: January 9, 1995Date of Patent: August 4, 1998Assignee: American Dental Association Health FoundationInventor: Rafael L. Bowen
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Patent number: 5763634Abstract: A method for the preparation of concentrated, stable iron chelate solutions of alkali metal polyamino succinic acids is disclosed. The method involves the co-feeding of an alkaline alkali-metal succinate solution and a ferric salt solution into a vessel.Type: GrantFiled: December 17, 1996Date of Patent: June 9, 1998Assignee: The dow Chemical CompanyInventors: George M. St. George, David A. Wilson, S. Bennett Willis
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Patent number: 5762910Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.Type: GrantFiled: December 9, 1996Date of Patent: June 9, 1998Assignee: ImaRx Pharmaceutical Corp.Inventors: Evan C. Unger, DeKang Shen
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Patent number: 5760264Abstract: Disclosed is a novel method of producing optically active metallocenyl phosphines of the general formula shown In the formula (Ia) (Ib), M represents iron, ruthenium or nickel; R.sup.1 and R.sup.1' both represent C.sub.1 -C.sub.4 alkyl groups; R.sup.2 and R.sup.3 each represent independently of each other either hydrogen or a C.sub.1 -C.sub.4 alkyl group, or, together with the nitrogen atom, form a five- or six member saturated heterocyclic ring which may optionally contain further heteroatoms; R.sup.4 and R.sup.5 each represent independently of each other a C.sub.1 -C.sub.4 alkyl group (for example) or an aryl group which is optionally substituted with one or more methyl or methoxy groups or with one or more fluorine atoms.Type: GrantFiled: July 9, 1997Date of Patent: June 2, 1998Assignee: Lonza, AGInventor: Walter Brieden
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Patent number: 5756540Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function of the enzymes responsible for nitric oxide production is inhibited), the present invention employs a scavenging approach whereby overproduced nitric oxide is bound in vivo to a suitable nitric oxide scavenger. The resulting complex renders the nitric oxide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods. An exemplary nitric oxide scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-ferrous iron complex. The present invention relates to methods for reducing in vivo levels of .multidot.NO as a means of treating subjects afflicted with inflammatory and/or infectious disease.Type: GrantFiled: June 2, 1995Date of Patent: May 26, 1998Assignee: MCW Research Foundation, Inc.Inventor: Ching-San Lai
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Patent number: 5756688Abstract: This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.Type: GrantFiled: September 14, 1993Date of Patent: May 26, 1998Assignee: Sterling Winthrop Inc.Inventors: Robert A. Snow, David L. Ladd, John L. Toner, K. Robert Hollister