The Carbonyl Is Part Of A -coo- Group Patents (Class 556/437)
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Publication number: 20030044371Abstract: Compositions of matter comprising benzoate esters of hydroxyl terminated polyether polysiloxane copolyols, in particular dimethicone copolyol benzoates, and process for preparing same. The benzoate esters are useful for personal care cleansing products, such as bar and liquid soaps, skin and hair care products and textiles and fibers. The compounds are prepared by reacting benzoic acid with hydroxyl terminated polyether polysiloxane copolyols.Type: ApplicationFiled: May 14, 2001Publication date: March 6, 2003Applicant: FINETEX; INC.Inventors: Ismail I. Walele, Samad A. Syed
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Patent number: 6489498Abstract: Silanes of the general formula are prepared, wherein R1, R2 and R3 in the molecule are the same or different and represent aliphatic or aromatic hydrocarbon groups, R4 is a divalent hydrocarbon group with 4 to 12 carbon atoms and a lateral hydroxyl group, wherein the hydrocarbon group can be interrupted by an ether oxygen, R5 is a hydrophilic, ionic group. A method for synthesizing these compounds is described. The silanes greatly lower the surface tension of aqueous solutions, the surface tension being reduced to values of about 23 mN/m. The silanes are biologically degradable and have pronounced surfactant properties.Type: GrantFiled: March 27, 2001Date of Patent: December 3, 2002Assignee: Th. Goldschmidt AGInventors: Klaus-Dieter Klein, Wilfried Knott, Götz Koerner, Manfred Krakenberg
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Patent number: 6489499Abstract: Novel compounds comprising siloxane modified carboxylic acid substituted amines and salts thereof are provided. The compounds according to the invention provide many of the desirable properties of ethylenediamine tetraacetic acid and its salts in a stationary phase. A process for synthesis of the compounds according to the invention are also provided.Type: GrantFiled: March 11, 2002Date of Patent: December 3, 2002Assignee: United Chemical Technologies, Inc.Inventors: Wayne King, John H. MacMillan, Michael J. Telepchak
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Patent number: 6479674Abstract: The present invention relates to compounds which are useful for efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acids. The compounds according to the present invention comprise 2-oxobicyclo[3.1.Type: GrantFiled: September 24, 2001Date of Patent: November 12, 2002Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Toshihito Kumagai, Kazunari Sakagami, Kazuyuki Tomisawa
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Publication number: 20020161236Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive compounds and intermediates.Type: ApplicationFiled: April 2, 2002Publication date: October 31, 2002Inventors: Michael E. Deason, Kathleen R. Whitten
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Patent number: 6465673Abstract: The invention relates to a series of novel propoxylated silicone rosin esters. This class of compounds provides unique solubility in organic solvents like iso-paraffin, and despite its lack of water solubility, provides an ability to couple water into anhydrous systems like lipsticks, minimizing the incompatibility that causes syneresis.Type: GrantFiled: May 30, 2002Date of Patent: October 15, 2002Assignee: Phoenix Research CorporationInventors: John Imperante, Anthony J. O'Lenick, Jr.
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Patent number: 6455641Abstract: The invention concerns a method for preparing polyorganosiloxanes with high purity ester function (acetoxyalkyl or acetoxyalkenyl), consisting in: hydrosilylation between a hydrogenopolyorganosiloxane oil and &agr;-olefin alcohol; esterification of the resulting hydroxy-alkylated or polyorganosiloxane with an acetyl halide; elimination of &agr;-olefin derivatives and the halohydric acid formed. The resulting polyorganosiloxanes with ester function (acetoxyalkyl) have global siloxane, &agr;-olefin unit and/or &agr;-olefin impurities contents corresponding to a number of &agr;-olefin groups for 100 g of polyorganosiloxane, with ester function less than 10−3 mol.Type: GrantFiled: August 15, 2000Date of Patent: September 24, 2002Assignee: Rhodia ChimieInventors: Philippe Jost, Gérard Mignani, Philippe Olier
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Patent number: 6437015Abstract: Radiation-curable compositions containing linear organopolysiloxanes bearing (meth)acryloxy groups and a photosensitizer are useful for release coatings particularly release coatings with enhanced adhesion to the substrate onto which they are coated, for example those used for adhesives such as pressure sensitive adhesive labels.Type: GrantFiled: February 2, 2001Date of Patent: August 20, 2002Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Christian Herzig, Josef Wolferseder, Oliver Zoellner
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Patent number: 6437142Abstract: A new process prepares retiferol derivatives of formula I: wherein A is —C≡C— or —CH═CH—, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula II with compounds of formula III. A second version couples phosphinoxides of formula IV with aldehydes of formula V. Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases and for reversing the conditions associated with photodamage.Type: GrantFiled: March 26, 2001Date of Patent: August 20, 2002Assignee: Basilea Pharmaceutica AGInventors: Hans Hilpert, Beat Wirz
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Patent number: 6426428Abstract: Topically applicable, stable, UV-photoprotective cosmetic/dermatological compositions well suited for the photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, comprise (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane UV-sunscreen compound and (b) an effective dibenzoylmethane compound (a) photostabilizing amount of at least one benzalmalonate silane having the structural formula (I):Type: GrantFiled: June 14, 1999Date of Patent: July 30, 2002Assignee: Societe L′OrealInventors: Serge Forestier, Hervé Richard, Delphine Allard, Didier Candau
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Publication number: 20020099232Abstract: An organosilicon compound represented by the following general formula (1): 1Type: ApplicationFiled: October 26, 2001Publication date: July 25, 2002Applicant: Shin-Etsu Chemical Co., Ltd.Inventors: Toshiyuki Ozai, Hiroyasu Hara, Yoshifumi Inoue, Tomoyuki Goto
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Patent number: 6414139Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.Type: GrantFiled: September 3, 1996Date of Patent: July 2, 2002Assignee: Imarx Therapeutics, Inc.Inventors: Evan C. Unger, Dekang Shen, Guanli Wu
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Publication number: 20020042531Abstract: This invention relates to a monomer shown by the general formula [1] 1Type: ApplicationFiled: October 16, 2001Publication date: April 11, 2002Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.Inventor: Motoshige Sumino
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Publication number: 20020038027Abstract: HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive compounds and intermediates.Type: ApplicationFiled: June 26, 2001Publication date: March 28, 2002Inventors: Michael E. Deason, Kathleen R. Whitten
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Patent number: 6353047Abstract: Metal organic compounds comprising three or four atoms of cobalt or nickel, each linked through oxygen atoms to aluminum, silicon or titanium and comprising a combination of aliphatic and aromatic carboxylic acid residues are useful as adhesion promoters to promote the adhesion of brass coated steel to vulcanized rubber.Type: GrantFiled: June 21, 2000Date of Patent: March 5, 2002Assignee: Rhodia LimitedInventors: John Michael Hilton, Ian Michael Hawkins, Jonathan Colin Wilson
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Publication number: 20020022734Abstract: The invention relates to the preparation and use of polyfluoro-alkylsilanes of formula (I) 1Type: ApplicationFiled: June 29, 2001Publication date: February 21, 2002Inventors: Albrecht Marhold, Jurgen Wiedemann, Sebastian Bach
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Patent number: 6340734Abstract: Novel silsesquioxane polymers are formed by methods which avoid the use of BBr3. The novel silsesquioxane polymers are especially useful in negative photoresist compositions and photolithographic processes. Alternatively, improved silsesquioxane polymer-containing negative photoresist compositions are obtained by using a polymer component containing a blend of silsesquioxane polymer and non-silsesquioxane polymer. The photoresist compositions provide improved dissolution characteristics enabling the use of 0.26N TMAH developer. The photoresist compositions also provide improved thermal characteristics enabling use of higher processing temperatures. The photoresist compositions are especially useful in a multilayer photolithographic processes and are capable of producing high resolution.Type: GrantFiled: December 7, 1999Date of Patent: January 22, 2002Assignee: International Business Machines CorporationInventors: Qinghuang Lin, Marie Angelopoulos, Ahmad D. Katnani, Ratnam Sooriyakumaran
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Patent number: 6313329Abstract: This invention relates to composition of matter of certain euganol functionalized silicone polymers useful to make substantive antimicrobial agents. These compounds allow for the topical delivery of euganol to the skin surface, where it has a variety of desirable effects.Type: GrantFiled: June 4, 2001Date of Patent: November 6, 2001Inventor: Anthony J. O'Lenick, Jr.
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Patent number: 6306512Abstract: A UV-stabilizer comprising a mixture of hydroxybenzotriazole and a hydrolyzable silane containing at least one epoxy group is disclosed. The stabilizer is especially suitable as a component of a siloxane system for coating substrates, especially thermoplastic substrates and most especially polycarbonate substrates.Type: GrantFiled: December 2, 1999Date of Patent: October 23, 2001Assignee: Bayer AktiengesellschaftInventor: Peter Bier
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Publication number: 20010029239Abstract: The invention relates to aryl vinyl ether compounds of formula (I): 1Type: ApplicationFiled: December 20, 2000Publication date: October 11, 2001Inventors: Michael Colin Cramp, Stephen Robert Mack, Michael Gingell
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Patent number: 6271330Abstract: Terminally functionalized silicone polymers prepared using protected functionalized initiators and processes for preparing the same. The silicone polymers includes protected, functionalized silicone polymers, such as mono-functional, homotelechelic, heterotelechelic, macromonomer, and radial polymers. The protected functionalized polymers can be optionally deprotected to afford functionalized silicone polymers.Type: GrantFiled: August 12, 1999Date of Patent: August 7, 2001Assignee: FMC CorporationInventors: Robert James Letchford, James Anthony Schwindeman, Roderic Paul Quirk
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Patent number: 6262288Abstract: The invention describes novel malonates and a process for using said malonates for the preparation of chiral epoxides of formula having a cyclanic (1R) configuration, the group in position 2 having a transconfiguration and the epoxy group having a cis-configuration with respect to the substituent in position 1 and wherein R is an alkyl group from C1 to C4, linear or branched, and R1 is an alkyl or an alkenyl group from C2 to C8, linear or branched. The above process comprises the rearrangement of malonate (VII) to malonate (VI) and the decarboxylation reaction of into an ester of formula followed by the stereoselective epoxidation of the thus-obtained compound.Type: GrantFiled: April 20, 2000Date of Patent: July 17, 2001Assignee: Firmenich SAInventors: Charles Fehr, Eric Ohleyer, José Galindo
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Patent number: 6262287Abstract: Organosiloxane fragrance precursor compounds having at least one organosiloxane unit of the formula or a mixture thereof and if any other siloxane unit(s) in the said organosiloxanes being present this/these is/are of formula wherein R represents a substituted or unsubstituted C1-8 alkyl group or a substituted or unsubstituted aryl group; R″ represents a hydrogen atom, a monovalent C1-8 hydrocarbon group or a monovalent C1-8 halogenated hydrocarbon group; R1 represents a hydrogen atom or a substituted or unsubstituted C1-8 alkyl group or a substituted or unsubstituted aryl group or a bond connecting CR1 and CR3; R3 represents a hydrogen atom or a substituted or unsubstituted C1-8 alkyl group or a substituted or unsubstituted aryl group; represents (CR42)n whereby R4 represents a substituted or unsubstituted C1-8 alkyl group or a substituted or unsubstituted aryl group or a hydrogen atom and whereby n is from 0-20 and each R4 is the same or different; OR2 represType: GrantFiled: May 12, 1998Date of Patent: July 17, 2001Assignee: Givaudan-Roure (International) SAInventors: Denise Anderson, Georg Frater
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Publication number: 20010007909Abstract: An industrially acceptable process for preparing 2-[tris(trimethylsilyl)silyl]ethyl (meth)acrylate in high yields involves reacting 2-[tris(trimethylsilyl)silyl]ethyl acetate with an alcohol in the presence of a catalyst to form 2-[tris(trimethylsilyl)silyl]ethanol, then reacting it with a (meth)acrylate ester.Type: ApplicationFiled: January 5, 2001Publication date: July 12, 2001Inventors: Takeshi Kinsho, Koji Hasegawa, Takeru Watanabe, Tohru Kubota, Ayumu Kiyomori
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Patent number: 6222055Abstract: Hydrolysable and polymerizable or polyadditive silanes and methods of their production and the production of (hetero)silicic acid polycondensates or of polymers.Type: GrantFiled: September 17, 1999Date of Patent: April 24, 2001Assignee: Fraunhofer-Gesellschaft zur Foerderung der angwandten Forschung e.V.Inventors: Herbert Wolter, Werner Storch
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Patent number: 6221994Abstract: A terminated silane polymer is produced by reacting an organic derivative of silicon with the terminal groups of polymers that are obtained by a Michael polyaddition reaction of organic compounds that contain at least two active hydrogens to organic components that contain at least two ethylene bonds that are activated by the presence, in the alpha position with regard to each ethylene bond, of an electronegative group.Type: GrantFiled: June 29, 1999Date of Patent: April 24, 2001Assignee: Cheming, S.A. LuxembourgInventors: Paolo Galbiati, Alessandro Galbiati
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Patent number: 6218560Abstract: The invention relates to organosilicon compounds modified with mono- or polyhydroxylated hydrocarbon radicals or carbohydrate derivatives and containing units of the general formula (I) AaRbSiXcO(4-a-b-c)/2 (I), in which R is a substituted or unsubstituted hydrocarbon radical, X is chlorine, or an alkoxy radical, A is a hydroxylated hydrocarbon, preferably a mono-, oligo-, or polysaccharide, and the sum of a, b, and c≦4. The organosilicon compounds are interface-active.Type: GrantFiled: November 23, 1999Date of Patent: April 17, 2001Assignee: Wacker-Chemie GmbHInventors: Bors Cajus Abele, Thomas Koini
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Patent number: 6194596Abstract: The invention relates to polysiloxanes containing carbonate groups and modified with linear polyesters and to their use as additives for coatings, especially radiation-curing coating materials.Type: GrantFiled: March 7, 2000Date of Patent: February 27, 2001Assignee: Goldschmidt AGInventors: Wolfgang Josten, Stefan Silber
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Patent number: 6177588Abstract: Compounds of Formula 1 and of Formula 2 where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.Type: GrantFiled: May 7, 1999Date of Patent: January 23, 2001Assignee: Allergan Sales, Inc.Inventors: Richard L. Beard, Diana F. Colon, Roshantha A. Chandraratna
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Patent number: 6166236Abstract: Novel monomers of the general formula ##STR1## where b is 0 or 1, a is 1, 2, 3 or 4, R.sup.2 is a monovalent alkyl radical and R is an organic radical. The novel monomers may be employed to produce novel copolymers useful as hydrogel, soft non-hydrogel and/or rigid gas permeable contact lens materials.Type: GrantFiled: January 21, 1997Date of Patent: December 26, 2000Assignee: Bausch & Lomb IncorporatedInventors: Ronald E. Bambury, David E. Seelye
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Patent number: 6150548Abstract: The invention relates to a compound having the formula I ##STR1## wherein R.sup.1 is hydroxy, (1-6C)alkoxy or NR.sup.4 R.sup.5, R.sup.4 and R.sup.5 being independently hydrogen, (1-6C)alkyl, (3-7C)cycloalkyl, (2-6C)alkenyl, (4-6C)aryl or (5-7C)aralkyl, the aryl groups of which may be optionally substituted with halogen, (1-6C)alkyl or (1-6C)alkoxy;R.sup.2 is a halo atom, (1-8C)acyloxy, --O--C(O)--O-(1-6C)alkyl, --O--C(O)--O-(5-7C)aralkyl, --SR.sup.6, --S(O)R.sup.6, --SeR.sup.6 or --Se(O)R.sup.6, R.sup.6 being (1-6C)alkyl or (4-6C)aryl; andR.sup.3 is --Si(R.sup.7).sub.3, R.sup.7 being independently (1-6C)alkyl or (4-6C)aryl. The compounds of the invention may be used as protective groups or as linkers in solid phase organic chemistry.Type: GrantFiled: February 9, 1999Date of Patent: November 21, 2000Assignee: Akzo Nobel, N.V.Inventor: Wim-Jan Koot
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Patent number: 6133465Abstract: A surface of a semiconductor substrate of silicon is supplied with 4-trimethylsiloxy-3-penten-2-one serving as a surface treatment agent. Thus, H in OH groups existing on the surface of the semiconductor substrate is substituted with Si(CH.sub.3).sub.3 (i.e., a trimethylsilyl group), resulting in producing CH.sub.3 COCH.sub.2 COCH.sub.3 (i.e., acetylacetone). Then, the surface of the semiconductor substrate is coated with a resist, exposed by using a desired mask, and subjected successively to PEB and development, thereby forming a resist pattern thereon. Since the surface of the semiconductor substrate is treated with 4-trimethylsiloxy-3-penten-2-one, the surface of the semiconductor substrate is made to be hydrophobic, so that the adhesion of the semiconductor substrate can be improved. As a result, the resultant resist pattern has a satisfactory shape free from peeling.Type: GrantFiled: October 15, 1997Date of Patent: October 17, 2000Assignees: Matsushita Electric Industrial Co., Ltd., Shin-Etsu Chemical Co., Ltd.Inventors: Masayuki Endo, Hiromi Ohsaki
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Patent number: 6121475Abstract: In a process for preparing an optically active .beta.-hydroxyester derivative by enantioselective aldol addition reaction between an aldehyde and a ketene silylacetal, the enantioselective aldol addition reaction is performed in the presence of an organic base and a platinum-containing catalyst composed of an optically active bisphosphine-platinum complex having two P--Pt bondings which are equivalent to each other, showing in its .sup.31 P NMR spectrum a single peak assigned to P--Pt bonding.Type: GrantFiled: September 17, 1999Date of Patent: September 19, 2000Assignee: Ube Industries, Ltd.Inventors: Osamu Fujimura, Kikuo Ataka
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Patent number: 6111125Abstract: A process for preparing 4-hydroxy-1,2,2-trimethylcyclopentyl methyl ketones of the general formula I, in particular of the (1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl methyl ketone of the formula Ia ##STR1## which is required for preparing the red dye capsorubin which is in demand, starts from 2,2,6-trimethylcyclohexanones of the general formula II ##STR2## where R is hydrogen or a protective group, via the novel intermediates of the general formulae V and VI ##STR3## by diastereoselective epoxidation and reaction of the resulting 7-oxabicyclo[4.1.0]heptanes of the general formula VIII ##STR4## with Lewis acids and, where appropriate, removal of the protective group. Also claimed are the novel intermediates of the formula V and their (1S) and (1R) isomers and those of the formula VIII as well as their (1R,3S,6S), (1S,3S,6R) and (1R,3R,6S) isomers.Type: GrantFiled: March 3, 1995Date of Patent: August 29, 2000Assignee: BASF AktiengesellschaftInventors: Michael John, Udo Rheude, Joachim Paust, Joachim Meyer
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Patent number: 6087522Abstract: Lanolin eaters of silicones are prepared by reacting a carboxy silicone and lanolin alcohol to form an ester. The resultant products are useful as highly water resistant lubricating coatings for skin.Type: GrantFiled: October 12, 1999Date of Patent: July 11, 2000Assignee: Fan Tech CorporationInventor: Anthony J. O'Lenick, Jr.
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Patent number: 6060619Abstract: The invention relates to a series of novel silicone lactylates useful as emulsifiers. This class of compounds are prepared by the reaction of a carboxy functional silicone with the hydroxyl group on lactic acid. The products provide unique surfactant properties, specifically emulsification properties for many oil phases.The compounds are useful for preparation of ultra mild products for use personal care applications for skin, hair care and related applications.Type: GrantFiled: November 9, 1998Date of Patent: May 9, 2000Assignee: Lambent Technologies Inc.Inventor: Anthony J. O'Lenick, Jr.
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Patent number: 6054600Abstract: Novel metal acid salt complexes are provided comprising (1) a metal selected from Group IV and Group V metals and (2) a polyether acid, along with a process for making the salt complexes. The process comprises: (a) preparing a polyether acid anhydride from the corresponding polyether acid; and (b) combining a metal alkoxide containing the Group IV or Group V metal with the polyether acid anhydride to form the metal acid salt complex. The resulting Group IV and Group V metal acid salt complexes enable the production of improved thin film, thick film, and bulk ceramic metal oxides and mixed metal oxides for a number of applications, including ferroelectric, electrooptic, paraelectric, and piezoelectric devices, using liquid soluble precursors which are soluble in far less toxic solvents than in the prior art. The soluble ceramic precursors may also be used as reactive binders and shape-forming aids in conventional ceramic processing.Type: GrantFiled: May 7, 1999Date of Patent: April 25, 2000Assignee: Raytheon CompanyInventors: T. Kirk Dougherty, John J. Drab, O. Glenn Ramer
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Patent number: 6051731Abstract: Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.Type: GrantFiled: September 4, 1997Date of Patent: April 18, 2000Assignee: Allergan Sales, Inc.Inventors: Vidyasagar Vuligonda, Min Teng, Richard L. Beard, Alan T. Johnson, Yuan Lin, Roshantha A. Chandraratna
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Patent number: 6034087Abstract: Nucleoside derivatives represented by formula (I); ##STR1## wherein, R.sub.1 represents hydrogen, phosphate or phosphonate group, R.sub.2 represents substituted or unsubstituted pyrimidine or purine base, and Z represents S, SO, SO.sub.2, O or C; or pharmaceutically acceptable salts thereof. Compound (I) can be obtained by reacting a compound of the formula (II); ##STR2## wherein, R.sub.7 represents hydrogen or hydroxy-protecting group, L represents aromatic or nonaromatic acyl, halide or alkoxy, and Z represents S, SO, SO.sub.2, O or C, with a base.Type: GrantFiled: June 11, 1997Date of Patent: March 7, 2000Assignee: Chong Kun Dang Corp.Inventors: Jung Woo Kim, Chong Ryul Lee, Koo Hun Chung, Soon Kil Ahn, Kyung Hoi Cha, Hoe Joo Son, Sung Jo Choi, Byeong Seon Jeong, Kyeong Bok Min
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Patent number: 6031060Abstract: Terminally functionalized silicone polymers prepared using protected functionalized initiators and processes for preparing the same. The silicone polymers includes protected, functionalized silicone polymers, such as mono-functional, homotelechelic, heterotelechelic, macromonomer, and radial polymers. The protected functionalized polymers can be optionally deprotected to afford functionalized silicone polymers.Type: GrantFiled: May 20, 1998Date of Patent: February 29, 2000Assignee: FMC CorporationInventors: Robert James Letchford, James Anthony Schwindeman, Roderic Paul Quirk
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Patent number: 6008204Abstract: Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists can be administered to mammals, including humans, for the purpose of preventing or diminishing action of RAR agonists on the bound receptor sites. Specifically, the RAR agonists are administered or coadministered with retinoid drugs to prevent or ameliorate toxicity or side effects caused by retinoids or vitamin A or vitamin A precursors. The retinoid negative hormones can be used to potentiate the activities of other retinoids and nuclear receptor agonists. For example, the retinoid negative hormone called AGN 193109 effectively increased the effectiveness of other retinoids and steroid hormones in in vitro transactivation assays. Additionally, transactivation assays can be used to identify compounds having negative hormone activity.Type: GrantFiled: December 30, 1998Date of Patent: December 28, 1999Assignee: Allergan Sales, Inc.Inventors: Elliott S. Klein, Alan T. Johnson, Andrew M. Standeven, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Sunil Nagpal, Vidyasagar Vuligonda, Min Teng, Roshantha A. Chandraratna
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Patent number: 6008397Abstract: The invention discloses novel fluoro esters made by reacting (a) a carboxy silicone, and (b) the hydroxyl group of fluoro alcohol. The compounds of the invention by virtue of (i) the silicone group, (ii) the fluoro group and (iii) the polyoxyalkylene present in the compound are extremely efficient skin care compounds used in topical treatment of skin.Type: GrantFiled: June 1, 1999Date of Patent: December 28, 1999Assignee: Hansotech Inc.Inventor: Anthony J. O'Lenick, Jr.
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Patent number: 6004542Abstract: The invention discloses novel salicylate esters made by reacting (a) a carboxy silicone, and (b) the hydroxyl group of salicylic acid. The compounds of the invention by virtue of (i) the silicone group, (ii) the salicylate group group and (iii) the polyoxyalkylene present in the compound are extremely efficient skin care compounds used in topical treatment of skin.Type: GrantFiled: December 18, 1998Date of Patent: December 21, 1999Assignee: Hansotech IncInventor: Anthony J. O'Lenick, Jr.
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Patent number: 6002039Abstract: Acetylenic maleates, fumarates and related derivative compounds are new compositions of matter having the formula:R.sub.1 O.sub.2 C--CH.dbd.CH--CO.sub.2 R.sub.2wherein R.sub.1 may be an organic moiety containing at least two carbon atoms triply bonded one to the other as:--C.tbd.C--and R.sub.2 may be hydrogen, an organic moiety, or R.sub.1 ; suitable for use as liquid injection molding inhibitors either singly or in combination with themselves or other liquid injection molding inhibitors when used for the process of liquid injection molding curable compositions enabling an increase in the size of articles manufactured therefrom, which new compositions of matter cure into the polymerizable or curable resins thereby creating new compositions of matter as cured resins from which said articles of manufacture are produced.Type: GrantFiled: January 18, 1996Date of Patent: December 14, 1999Assignee: General Electric CompanyInventors: Philip J. McDermott, Michael J. O'Brien, Edward M. Jeram
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Patent number: 5990332Abstract: Metal compound of formula [I] which is excellent in charge control or charge-enhancing property, and toner for developing electrostatic images and powdery paint for electrostatic painting incorporating thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent a hydrogen, a linear or branched alkyl group, or a linear or branched unsaturated alkyl group; R.sup.1 and R.sup.2, R.sup.2 and R.sup.3, and R.sup.3 and R.sup.4 may bind together to form an aromatic or aliphatic ring which may have one or more substituents of a linear or branched alkyl group, or a linear or branched unsaturated alkyl group; M represents a metal; m represents an integer of 3 or more; n represents an integer of 2 or more.Type: GrantFiled: December 21, 1998Date of Patent: November 23, 1999Assignee: Orient Chemical Industries, Ltd.Inventors: Kazuaki Sukata, Tohru Tsuruhara, Shun-Ichiro Yamanaka, Shuji Sugawara, Masashi Yasumatsu
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Patent number: 5986122Abstract: This Invention discloses the use of ascorbic and citric acid, their salts, ethers, acid esters and mixtures thereof in a method for the prevention of peroxide formation, and/or for decomposing peroxides already formed in polyethers. Hereby, the polyethers are made reactive to hydrosilylation by silanes and hydrosiloxanes. When the polyether treatment is done with mixtures of ascorbic acid and sodium ascorbate and allyl polyethers, the hydrosilylation product contains reduced levels of propanal. The copolymers prepared using the treated polyethers are efficient stabilizers of flexible polyurethane foams and rigid polyurethane and polyisocyanurate foams.Type: GrantFiled: November 17, 1997Date of Patent: November 16, 1999Assignee: Witco CorporationInventors: Kenrick M. Lewis, Rudolph A. Cameron
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Patent number: 5985853Abstract: A subject of the invention is the products of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, identical or different, represent a linear, branched or cyclic alkyl radical, an alkenyl or alkynyl radical, containing up to 8 carbon atoms, optionally substituted by one or more halogen atoms, an aryl radical optionally substituted by one or more halogen atoms, one or more hydroxyl radicals, one or more linear or branched alkyl radicals, optionally substituted by one or more halogen atoms, one or more O-alkyl or S-alkyl radicals optionally substituted by one or more halogen atoms,X represents a hydrogen atom, a halogen atom, an alkyl, alkenyl, alkynyl, O-alkyl, O-alkenyl, O-alkynyl, S-alkyl, S-alkenyl or S-alkynyl radical, optionally substituted by one or more halogen atoms and containing up to 11 carbon atoms, an aryl radical containing up to 14 carbon atoms, a C.tbd.N, NO.sub.2, NH.sub.2, ##STR2## CO.sub.2 alk.sub.3 radical, alk.sub.1, alk.sub.2 and alk.sub.Type: GrantFiled: December 4, 1997Date of Patent: November 16, 1999Assignee: Hoechst Marion RousselInventors: Sylvain Laugraud, deceased, by Pierre Laugtaud, legal representative, by Rolande Laugraud, legal representative, by Philippe Laugraud, legal representative, by Bruno Laugraud, legal representative, by Martine Sollossi, legal representative, Nicole Reinier
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Patent number: 5973175Abstract: An ultrafine titanium dioxide powder is disclosed that can be produced by hydrothermal treating an amino titanium oxalate composition. Ultrafine titanium dioxide powders are useful in cosmetic and other applications for controlling exposure to ultraviolet (UV) light.Type: GrantFiled: February 17, 1998Date of Patent: October 26, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Salvatore Anthony Bruno
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Patent number: 5936133Abstract: This invention provides a novel class of vitamin D related compounds, namely, the 2-alkylidene-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have the formula: ##STR1## where Y.sub.1 and Y.sub.2, which may be the same or different, are each selected from the group consisting of hydrogen and a hydroxy-protecting group, R.sub.6 and R.sub.8, which may be the same or different, are each selected from hydrogen, alkyl, hydroxyalkyl and fluoroalkyl, or when taken together represent the group --(CH.sub.2).sub.x -- where x is an integer from 2 to 5, and where the group R represents any of the typical side chains known for vitamin D type compounds. These 2-substituted compounds are characterized by low intestinal calcium transport activity and high bone calcium mobilization activity resulting in novel therapeutic agents for the treatment of diseases where bone formation is desired, particularly low bone turnover osteoporosis.Type: GrantFiled: September 10, 1998Date of Patent: August 10, 1999Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. Deluca, Rafal R. Sicinski
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Patent number: RE36477Abstract: Benzoic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or lower-alkyl, R.sub.2 and R.sub.4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R.sub.3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R.sub.5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R.sub.2 and R.sub.3 being trimethylsilyl or trinethylgermyl, and R.sub.6 means hydroxy, lower-alkoxy, or a group of the formula --NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 mean hydrogen or lower-alkyl, and X represents a group of the formula --CONH--, --NHCO--, --COO--, --OCO--, --COCH.dbd.CH--, --COCH.dbd.C(OH), or --CH.dbd.CH--, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.Type: GrantFiled: June 25, 1998Date of Patent: December 28, 1999Assignee: Taiho Pharmaceutical Co., Ltd.Inventor: Koichi Shudo