Abstract: In certain embodiments the methods of preventing or delaying the onset of a pre-Alzheimer's condition and/or cognitive dysfunction, and/or ameliorating one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or preventing or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease, and/or of promoting the processing of amyloid precursor protein (APP) by the non-amyloidogenic pathway are provided. In certain embodiments the methods involve administering, or causing to be administered, to a subject in need thereof certain formulations comprising or more active agent(s) selected from the group consisting of tropisetron disulfiram, honokiol, nimetazepam, and/or derivatives or analogs thereof.

Abstract: The present invention concerns a method for the synthesis of glycerol dithiocarbamates or bis-dithiocarbamates (GDTCs) in which a reaction medium comprising (1) a carbonate selected from diethyl carbonate, dimethyl carbonate and ethylene or propylene carbonate associated with a glycerol type polyol in the presence of a basic catalyst or (2) a cyclic carbonate comprising five ring members, in a solvent medium, is supplemented with a primary or secondary amine in the presence of carbon disulphide, and the GDTC formed is recovered. In particular, a glycerol type polyol is brought into the presence of diethyl carbonate in the presence of a catalyst, then a primary or secondary amine is added to the reaction medium in the presence of carbon disulphide, and the GDTC formed is recovered. The invention can be used for one-step synthesis of glycerol dithiocarbamates directly from glycerol as the starting material and solvent.

Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— where n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.

Abstract: The present invention concerns a method for the synthesis of glycerol dithiocarbamates or bis-dithiocarbamates (GDTCs) in which a reaction medium comprising (1) a carbonate selected from diethyl carbonate, dimethyl carbonate and ethylene or propylene carbonate associated with a glycerol type polyol in the presence of a basic catalyst or (2) a cyclic carbonate comprising five ring members, in a solvent medium, is supplemented with a primary or secondary amine in the presence of carbon disulphide, and the GDTC formed is recovered. In particular, a glycerol type polyol is brought into the presence of diethyl carbonate in the presence of a catalyst, then a primary or secondary amine is added to the reaction medium in the presence of carbon disulphide, and the GDTC formed is recovered. The invention can be used for one-step synthesis of glycerol dithiocarbamates directly from glycerol as the starting material and solvent.

Abstract: The invention relates to a method for preparing molecular imprint polymers (MIP) by radical polymerisation that uses at least one primer including at least two chemical functions capable of forming reactive radicals, thereby providing a locally high radical concentration for priming the polymerisation on or about the imprint entity or molecule. The invention also relates to molecular imprint polymers (MIP) that can be obtained by the method of the invention, and to the use thereof in the production of biomimetic biosensors, biomimetic biochips, chemical sensors, specific adsorption separation devices, as a coating, particularly for releasing active ingredients.

Abstract: Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—, —NH—, alkylene, cycloalkylene, heterocyclylene, arylene, alkarylene, and heteroarylene; Y is a substituted alkylene group having at least two contiguous carbon atoms and which can be interrupted by one or more —O—, —S—, or —NH— moieties as defined herein, wherein the alkylene group of Y has substituents independently selected from —OH, —NH2, —SH, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or two hydrogen atoms on the same carbon atom of Y are replaced by carbonyl, and wherein at least two substituents of Y are each independently selected from —OH, —NH2, and —SH, as defined herein; and (b) at least one isocyanate functional material.

Abstract: The invention relates to an immersion liquid including at least one organic compound having at least one structural element of the general formula I wherein X denotes independently of each other S or O and R denotes hydrogen or hydrocarbon. The invention further relates to a method for preparing an organic compound for an immersion liquid as well as a use of the immersion liquid and the organic compound as an immersion oil for a microscope.

Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain dithiocarbamyl ?-hydroxy fatty acid esters, a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from epoxidized fatty acid esters. The additives exhibit synergistic anti-wear activity in combination with phosphorus containing additives.

Abstract: A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-forming, hydrophilic or hydrophobic polymer and having the following in vitro dissolution rate relative to 100 wt. % of the 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol contained in the formulation: 3-35 wt. % released after 0.5 hour, 5-50 wt. % released after 1 hour, 10-75 wt. % released after 2 hours, 15-82 wt. % released after 3 hours, 30-97 wt. % released after 6 hours, more than 50 wt. % released after 12 hours, more than 70 wt. % released after 18 hours, and more than 80 wt. % released after 24 hours.

Abstract: The present invention is directed to a solid chelating resin consisting of a reactive hydrophobic backbone having pendent carbodithioic groups. Preferably the resin is a poly(dithiocarbamate) containing no tertiary nitrogen groups. The invention is also directed to a novel process for making a chelating resin involving a) reacting a nucleophilic compound with carbon disulfide in a suitable solvent, to form a carbodithioic acid, b) neutralizing the carbodithioic acid with a base to form a carbodithioic acid salt; and c) reacting said carbodithioic acid salt with a crosslinking reagent in a suitable solvent to form a solid chelating resin. The chelating resin is useful in removing metals and cationic compounds from effluent streams.

Abstract: The invention concerns the use as thermothickeners of multi-block copolymers of general formula (I) or (II): ##STR1## wherein E designates a polyoxyalkylene sequence; A designates a water-soluble polymer sequence; X is a sulphur or oxygen atom; Y is an oxygen atom or an --N--R' group, R' being a linear or branched alkyl; R is a linear or branched alkyl, aralky or alkylaryl group; and n is such that the molecular mass of the multi-block copolymers Mp is greater than 250,000 g/mol.

Abstract: Dithiocarbamic salts made from the reaction products of certain polyamines and epoxides have been found to be useful to clarify water, particularly the oil-in-water emulsions which accompany crude oil production. The water clarification may be accomplished by demulsification or flocculation. The polyamine reaction products themselves are novel and may have the structure ##STR1## where R" is selected from the group consisting of the structure --R--NH.sub.2 and ##STR2## where R is selected from the group consisting of straight, branched or cyclic alkylene moieties; arylene moieties; substituted straight, branched or cyclic alkylene moieties; substituted arylene moieties or mixtures thereof; and where R' is--(CH.sub.2).sub.m --O--R--O--(CH.sub.2).sub.m --where n and m independently range from 1 to 5 and q is 0 or 1. The dithiocarbamic salts made from these polyamines also find use as corrosion inhibitors.

Abstract: The present invention relates to improved flotation composition comprising a mixture of (A) at least one metal salt of a phosphorus acid represented by the Formula: ##STR1## wherein each R.sub.1 is independently a hydrocarbyl, hydrocarbyloxy of hydrocarbylthio group having from 1 to about 18 carbon atoms, each X is independently oxygen or sulfur, and the lowest oxidation state of the metal is plus two, and (B) at least one dithiocarbamate represented by the formula: ##STR2## wherein each R.sub.2 is independently hydrogen, a hydrocarbyl group having from 1 to about 18 carbon atoms, or R.sub.2 taken together with R.sub.3 and the nitrogen atom form a five, six or seven member heterocyclic group; each R.sub.3 is independently a hydrocarbyl group having from 1 to about 18 carbon atoms, or R.sub.3 taken together with R.sub.2 and the nitrogen atom form a five, six or seven member heterocyclic group; and R.sub.4 is a hydrocarbylene group having from 1 to about 10 carbon atoms.

Abstract: A process for the production of thiuram polysulfides substituted by aliphatic, araliphatic and/or cycloaliphatic hydrocarbon radicals is disclosed. In this process, correspondingly substituted secondary amines having a pKa value of .gtoreq.8 are reacted with carbon disulfide and sulfur in a solvent at 0.degree. to 150.degree. C. in the presence of a metal-containing catalyst and oxygen or an oxygen-containing gas.By virtue of its high purity, the thiuram polysulfide obtainable in this way may be directly used for its intended purpose, for example as a vulcanization accelerator or sulfur donor.This process is particularly desirable for the substantially quantitative yields and selectivities and also for its high economy arising from the reaction being carried out in a single stage without expensive auxiliaries and from the elimination of an additional purification step.

Abstract: A process for the production of thiuram polysulfides substituted by aliphatic, araliphatic, cycloaliphatic aromatic and/or hydrocarbon radicals is disclosed. In this process, correspondingly substituted secondary amines are reacted with carbon disulfide and sulfur in a solvent at 0.degree. to 150.degree. C. in the presence of a tertiary amine, a metal-containing catalyst and oxygen or an oxygen-containing gas.By virtue of its high purity, the product obtained by this process may be used directly, i.e., without preceeding purification, for its intended purpose, for examples as a vulcanization accelerator or sulfur donor.This process is particularly desirable for the substantially quantitative yields and selectivities and also for its high economy arising from the reaction being carried out in a single stage without expensive auxiliaries and from the elimination of an additional purification step.

Abstract: Fungicidal N,N'-diacylaminals of the formula ##STR1## in which R.sup.1 is optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl,R.sup.2 and R.sup.3 are hydrogen or various organic radicals, andX is oxygen or sulphur.

Abstract: Nitrogen-containing dithiocarbamic acids are used as reverse demulsifiers, corrosion and scale inhibitors, flocculants, biocides, flotation aids, water clarifiers, interface control agents and antifoaming agents.

Abstract: Use of nitrogen-containing tridithiocarbamic acid compositions as reverse demulsifiers.

Abstract: Use of nitrogen-containing tridithiocarbamic acid compositions as reverse demulsifiers.

Abstract: A method for alleviating cisplatin compound-induced nephrotoxicity in animals comprising administering to the animal an effective amount of a polar dithiocarbamate compound. The polar dithiocarbamate compounds have the formula: ##STR1## In the above formula, R.sup.1 and R.sup.2 are hydrocarbon groups and R.sup.1, R.sup.2, or both R.sup.1 and R.sup.2 contain a polar group substituted thereon. M is a pharmaceutically acceptable cation and n is an integer of from 1 to 3.Novel polar dithiocarbamate compounds are disclosed as well.

Abstract: The invention relates to novel O,O'-, O,S'- or S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamothioates) and S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamodithioate). The novel compounds of this invention are useful as collectors in the froth flotation of sulfide mineral ores.