The -c(=x)x- Is -c(=s)s- Patents (Class 558/235)
  • Patent number: 8445610
    Abstract: A transition metal mediated chain transfer agent controlled polymerization process is described. The process combines the advantages of atom transfer radical polymerization (ATRP) and reversible addition fragmentation transfer (RAFT) polymerization. Synthesis of chain transfer agents useful in the disclosed processes is also disclosed. Other improvements on ATRP RAFT processes are also described.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: May 21, 2013
    Assignee: Carnegie Mellon University
    Inventors: Yungwan Kwak, Renaud Nicolay, Krzysztof Matyjaszewski
  • Publication number: 20120100358
    Abstract: The invention relates to a method for preparing molecular imprint polymers (MIP) by radical polymerisation that uses at least one primer including at least two chemical functions capable of forming reactive radicals, thereby providing a locally high radical concentration for priming the polymerisation on or about the imprint entity or molecule. The invention also relates to molecular imprint polymers (MIP) that can be obtained by the method of the invention, and to the use thereof in the production of biomimetic biosensors, biomimetic biochips, chemical sensors, specific adsorption separation devices, as a coating, particularly for releasing active ingredients.
    Type: Application
    Filed: September 1, 2009
    Publication date: April 26, 2012
    Applicant: Universite De Technologie De Compiegne - UTC
    Inventors: Karsten Haupt, Arnaud Cutivet, Jeanne Bernadette Tse Sum Bui, Pinar Cakir
  • Patent number: 8123982
    Abstract: Alternative inhibitors that offer an improvement over tolyltriazole in inhibiting yellow metal corrosion. The dithiocarbamate compounds and their salts were compared to that of tolyltriazole under identical conditions. These comparative tests were conducted in common corrosion testing systems, using both electrochemical corrosion cells and pilot cooling rigs, using various water conditions. The test methods included electrochemical studies such as linear polarization resistance, open circuit potential versus time, Tafel and cyclic polarization.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: February 28, 2012
    Assignee: Akzo Nobel N.V.
    Inventors: Eric C. Ward, Alvie L. Foster, Jr., Michael L. Standish, Ivonne C. Weidner
  • Publication number: 20120004381
    Abstract: A method of preparing polymer, the method comprising polymerising one or more ethylenically unsaturated monomers of formula (I) where U is selected from H, C1-C4 alkyl or halogen; V is halogen or of the form O-G where G is selected from —C(O)R1 and —R1, or V is of the form NGGa where G is as defined above and Ga is selected from H and R1, G and Ga form together with N a heterocyclic ring, or V is of the form CH2Gb where Gb is selected from H, R1, OH, OR1, NR12, PR12, P(O)R12, P(OR1)2, SR1, SOR1, and SO2R1; and where the or each R1 is independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, and an optionally substituted polymer chain, under the control of a RA
    Type: Application
    Filed: January 22, 2010
    Publication date: January 5, 2012
    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Ezio Rizzardo, John Chiefari, Massimo Benaglia, San Thang, Graeme Moad
  • Publication number: 20110053941
    Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer compris
    Type: Application
    Filed: December 1, 2008
    Publication date: March 3, 2011
    Applicant: NEWLINK GENETICS
    Inventors: Mario Mautino, Firoz Jaipuri, Agnieszka Marcinowicz-Flick, Tanay Kesharwani, Jesse Waldo, Steven James Collier
  • Publication number: 20110046324
    Abstract: A transition metal mediated chain transfer agent controlled polymerization process is described. The process combines the advantages of atom transfer radical polymerization (ATRP) and reversible addition fragmentation transfer (RAFT) polymerization. Synthesis of chain transfer agents useful in the disclosed processes is also disclosed. Other improvements on ATRP RAFT processes are also described.
    Type: Application
    Filed: March 6, 2009
    Publication date: February 24, 2011
    Inventors: Krzysztof Matyjaszewski, Yungwan Kwak, Renaud Nicolay
  • Patent number: 7851582
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initiators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: December 14, 2010
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventor: John Ta-Yuan Lai
  • Patent number: 7589226
    Abstract: A novel hydroxyalkyldithiocarbamate borate ester compound is presented according to the formula: where R=alkyl C1 to C25; R?=H or CO2R; R?=(CH2)mOH where m=1 to 8, or alkyl C1 to C25; n=1 to 8. The borate ester compound is prepared by reacting boric acid with a novel hydroxyalkyldithiocarbamate ester compound according to the formula, and optionally with an alcohol: where R, R?, R? and n are as above. The hydroxyalkyldithiocarbamate ester is prepared by reacting a hydroxyalkylamine with CS2, and an acrylate or maleate compound. A lubricating composition is based on a major amount of lubricating oil and a minor amount of the hydroxyalkyldithiocarbamate borate ester.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: September 15, 2009
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Kevin J. Chase, Ronald Tepper
  • Patent number: 7521401
    Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain dithiocarbamyl ?-hydroxy fatty acid esters, a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from epoxidized fatty acid esters. The additives exhibit synergistic anti-wear activity in combination with phosphorus containing additives.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: April 21, 2009
    Assignee: ChemTura Corporation
    Inventor: Robert G. Rowland
  • Patent number: 7495128
    Abstract: A s,s?-bis-(?, ??-disubstituted-??-acetic acid)-trithiocarbonate and derivatives thereof can be used as an initiator, chain transfer agent, or terminator for polymerization of monomers such as free radical polymerizable monomers. Homopolymers, copolymers, and the like as well as block copolymers can be made utilizing the trithiocarbonate compound such as in a living free radical polymerization as well as to form telechelic polymers.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: February 24, 2009
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventor: John Ta-Yuan Lai
  • Patent number: 7439266
    Abstract: The present invention relates to a novel malononitrile compound represented by the formula (A): wherein, R1 represents C1 to C6 alkyl that may be substituted with halogen, C2 to C6 alkenyl that may be substituted with halogen, etc; R2 represents hydrogen atom or C1 to C6 alkyl that may be substituted with halogen; R3 represents hydrogen atom or C1 to C6 alkyl; R4 represents hydrogen atom or C1 to C6 alkyl; R5 represents C1 to C6 alkyl that may be substituted with halogen, C3 to C6 alkenyl that may be substituted with halogen, etc, or R4 and R5 may be combined at their terminal and represent ethylene that may be substituted with C1 to C3 alkyl or trimethylene that may be substituted with C1 to C3 alkyl; and Z1 and Z2, which are the same or different, represent oxygen atom or sulfur atom. The malononitrile compound has an efficient pesticidal activity and can control effectively pests such as insect pests, acarine pests, nematode pests and the like.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: October 21, 2008
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Okada, Daisuke Oohira, Ken Otaka
  • Publication number: 20080214773
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Application
    Filed: February 25, 2008
    Publication date: September 4, 2008
    Inventor: John Ta-Yuan Lai
  • Patent number: 7335788
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 26, 2008
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventor: John Ta-Yuan Lai
  • Patent number: 7332552
    Abstract: The present invention relates to low odor ?-cyano-dithiocarboxylic ester compounds of formula I for use as chain transfer agents in free radical polymerizations, and polymerization processes employing them: wherein R1 is selected from alkyl, substituted alkyl, heteroaryl, substituted heteroaryl, alkylaryl, substituted alkylaryl, aryl, substituted aryl, alkoxy, aryloxy, thioalkyl, thioaryl, substituted thioalkyl, substituted thioaryl, secondary amino and tertiary amino; R2 is selected from alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and COOR3; and R3 is alkyl.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: February 19, 2008
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Brian Benicewicz, Chunzhao Li
  • Patent number: 7160845
    Abstract: Dithiocarbamate derivative compounds, useful as multifunctional additives for lubricating oils and fuels, are provided and are derived from a reaction product obtained from (a) a di(hydrocarbyl)thiocarbamate intermediate derived from the reaction of a dihydrocarbylamine and carbon disulfide; (b) an amide of the general formula R7CONH2 wherein R7 is an alkylene group having 2 to about 30 carbon atoms; and (c) an effective amount of a carbonyl-containing compound.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: January 9, 2007
    Assignee: Crompton Corporation
    Inventors: John R. Baranski, Theodore E. Nalesnik
  • Patent number: 7030205
    Abstract: The present invention is directed to a solid chelating resin consisting of a reactive hydrophobic backbone having pendent carbodithioic groups. Preferably the resin is a poly(dithiocarbamate) containing no tertiary nitrogen groups. The invention is also directed to a novel process for making a chelating resin involving a) reacting a nucleophilic compound with carbon disulfide in a suitable solvent, to form a carbodithioic acid, b) neutralizing the carbodithioic acid with a base to form a carbodithioic acid salt; and c) reacting said carbodithioic acid salt with a crosslinking reagent in a suitable solvent to form a solid chelating resin. The chelating resin is useful in removing metals and cationic compounds from effluent streams.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: April 18, 2006
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Alvie L. Foster, Jr., Ivonne C. Weidner, Maurice R. Smith
  • Patent number: 6962961
    Abstract: A s,s?-bis-(?, ??-disubstituted-??-acetic acid)-trithiocarbonate and derivatives thereof can be used as an initiator, chain transfer agent, or terminator for polymerization of monomers such as free radical polymerizable monomers. Homopolymers, copolymers, and the like as well as block copolymers can be made utilizing the trithio carbonate compound such as in a living free radical polymerization as well as to form telechelic polymers.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: November 8, 2005
    Assignee: Noveon IP Holdings Corp.
    Inventor: John T. Lai
  • Patent number: 6888020
    Abstract: Disclosed are water soluble dithioesters capable of acting as chain transfer agents in preparing a vinyl-based polymer to control molecular weight and molecular weight distribution thereof as well as being capable of living polymerization even in an aqueous solution, and a method for polymerization thereof.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: May 3, 2005
    Assignee: LG Chem, Ltd.
    Inventors: Hee-Jung Kim, Dong-Ryul Kim
  • Patent number: 6844407
    Abstract: Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: January 18, 2005
    Assignee: Symyx Technologies, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, Wenyue Wang
  • Publication number: 20040186302
    Abstract: The present invention relates to a process for preparing dithioesters in which a dithiocarboxylic acid and/or a dithiocarboxylic salt is reacted with a vinyl compound and/or an alkyl compound which includes a leaving group, the reaction being carried out in a biphasic system in which one of the phases comprises water and the weight ratio of the aqueous phase to the organic phase lies in the range from 95:5 to 5:95.
    Type: Application
    Filed: March 18, 2003
    Publication date: September 23, 2004
    Applicant: RohMax Additives GmbH
    Inventors: Joseph Martin Bollinger, Jen-Lung Wang
  • Publication number: 20040138492
    Abstract: Disclosed are water soluble dithioesters capable of acting as chain transfer agents in preparing a vinyl-based polymer to control molecular weight and molecular weight distribution thereof as well as being capable of living polymerization even in an aqueous solution, and a method for polymerization thereof.
    Type: Application
    Filed: October 27, 2003
    Publication date: July 15, 2004
    Inventors: Hee-Jung Kim, Dong-Ryul Kim
  • Publication number: 20040110964
    Abstract: The present invention relates to dithiocarbamic esters, their preparation and their use for regulating the degree of polymerization during the polymerization of monomers, such as during the polymerization of chloroprene to give polychloroprene, and during the polymerization of 2,3-dichlorobutadiene to give poly-2,3-dichlorobutadiene, and during the copolymerization of chloroprene with 2,3-dichlorobutadiene. The present invention further relates to polymers which are obtainable via the polymerization of monomers in the presence of the dithiocarbamic esters of the invention. The present invention also relates to polymers which contain end groups derived from the dithiocarbamic esters of the present invention.
    Type: Application
    Filed: September 15, 2003
    Publication date: June 10, 2004
    Inventors: Dirk Achten, Michael Klimpel, Emilie Barriau, Lothar Reif, Renke Mottweiler, Heinrich Berg, Zsolt Szentivanyi, Stefan Glander
  • Publication number: 20040073056
    Abstract: Dithiocarbonate derivatives are disclosed, along with a process for preparing the same. The dithiocarbonate compounds can be utilized as initators, chain transfer agents and/or terminators in controlled free radical polymerizations. The dithiocarbonates can be used to produce polymers having narrow molecular weight distribution. Advantageously, the compounds of the present invention can also introduce functional groups into the resulting polymers. The dithiocarbonate compounds have low odor and are substantially colorless.
    Type: Application
    Filed: October 8, 2003
    Publication date: April 15, 2004
    Inventor: John Ta-Yuan Lai
  • Publication number: 20040063985
    Abstract: The invention relates to bis(alkylthio)carbenium salts of the formula I 1
    Type: Application
    Filed: August 13, 2003
    Publication date: April 1, 2004
    Inventors: Peer Kirsch, Andreas Ruhl, Gerd-Volker Roschenthaler, Dmitrii Sevenard
  • Patent number: 6710086
    Abstract: In accordance with the present invention, there are provided conjugates of dithiocarbamates “DC”) and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: March 23, 2004
    Assignee: Medinox, Inc.
    Inventors: Ching-San Lai, Tingmin Wang, Vassil P. Vassilev
  • Publication number: 20030233006
    Abstract: A s,s′-bis-(&agr;,&agr;′-disubstituted-&agr;″-acetic acid)-trithiocarbonate and derivatives thereof can be used as an initiator, chain transfer agent, or terminator for polymerization of monomers such as free radical polymerizable monomers. Homopolymers, copolymers, and the like as well as block copolymers can be made utilizing the trithio carbonate compound such as in a living free radical polymerization as well as to form telechelic polymers.
    Type: Application
    Filed: May 5, 2003
    Publication date: December 18, 2003
    Applicant: Noveon IP Holdings Corp.
    Inventor: John T. Lai
  • Patent number: 6518448
    Abstract: Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. In some embodiments, a bulky group is pendant off the activated thiocarbonyl portion of the control agents. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: February 11, 2003
    Assignee: Symyx Technologies, Inc.
    Inventors: Han Ting Chang, Dominique Charmot, Yunxiao Li
  • Patent number: 6518364
    Abstract: Heterogeneous (e.g., emulsion) polymerization systems include a control agent that has a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polymerization and/or the properties of the polymers obtained and/or the monomers that may be polymerized. Multifunctional control agents provide the opportunity for a variety of structurally unique polymers, including block copolymers, stars and hyper-branched polymers.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: February 11, 2003
    Assignee: Symyx Technologies, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, Peter Huefner, Yunxiao Li
  • Publication number: 20020137775
    Abstract: Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, sulfur or nitrogen attached to a methylene group, to which is further attached a sulfur, nitrogen or CH2 group. Methods of treating illnesses and conditions, such as cancer, hemological disorders, inherited metabolic disorders and others, using these compounds are also disclosed.
    Type: Application
    Filed: May 17, 2001
    Publication date: September 26, 2002
    Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
  • Publication number: 20020019554
    Abstract: A process the preparation of a dithiocarboxylic esters comprises reacting a carboxylic acid compound of formula R1(COOH)m, a compound of formula R2AH and phosphorus pentasulfide to produce a compound of structure I.
    Type: Application
    Filed: June 8, 2001
    Publication date: February 14, 2002
    Inventors: Brian C. Benicewicz, Subbareddiar Kanagasabapathy, Arumugam Sudalai
  • Patent number: 6124382
    Abstract: The invention concerns the use as thermothickeners of multi-block copolymers of general formula (I) or (II): ##STR1## wherein E designates a polyoxyalkylene sequence; A designates a water-soluble polymer sequence; X is a sulphur or oxygen atom; Y is an oxygen atom or an --N--R' group, R' being a linear or branched alkyl; R is a linear or branched alkyl, aralky or alkylaryl group; and n is such that the molecular mass of the multi-block copolymers Mp is greater than 250,000 g/mol.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: September 26, 2000
    Assignee: Rhodia Chimie
    Inventors: Pascale Corpart, Herve Adam, Dominique Charmot
  • Patent number: 5916910
    Abstract: In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or "DC") and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e.g., dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: June 29, 1999
    Assignee: Medinox, Inc.
    Inventor: Ching-San Lai
  • Patent number: 5821260
    Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 13, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
  • Patent number: 5811449
    Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
  • Patent number: 5792787
    Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 11, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, R. Wayne Alexander, Margaret K. Offermann
  • Patent number: 5783596
    Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 21, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
  • Patent number: 5773231
    Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 30, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
  • Patent number: 5773209
    Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 30, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
  • Patent number: 5750351
    Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 12, 1998
    Assignee: Emory University
    Inventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
  • Patent number: 5726339
    Abstract: The instant invention relates to novel compounds of formula (II) ##STR1## wherein R, R.sup.2 and x are as defined in the Specification. These compounds retard oxidation of, confer protection under extreme pressures to and reduce frictional wear of lubricants and hydraulic fluids.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: March 10, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hugo Camenzind, Peter Nesvadba
  • Patent number: 5702850
    Abstract: A thermosensitive reversible color-developing and disappearing agent includes an aromatic compound having at least one group of the formula, --SO.sub.2 NHCXNH--, wherein X.dbd.O or S atom, and at least one straight chain alkyl group with 11 or more carbon atoms, and is reactive with a dye precursor in a thermosensitive recording material to thereby record colored images on the recording material upon heating imagewise, and make the colored images disappear upon heating to a temperature lower than the colored image-forming temperature.
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: December 30, 1997
    Assignee: New Oji Paper Co., Ltd.
    Inventors: Makoto Nishioka, Kazuo Yamane, Masaki Nishimura, Yoshiyuki Takahashi
  • Patent number: 5656615
    Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains a 10:1 to 1:10 mixture of (1) N-chlorophenyl carbamates and N-chlorophenylthiocarbamates and (2) N-phosphonoglycine derivatives which are systemic herbicides. This composition can also be used to treat viral infections.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: August 12, 1997
    Assignee: The Procter & Gamble Company
    Inventor: James Berger Camden
  • Patent number: 5629341
    Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition is also effective against viruses. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates which are systemic herbicides.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: May 13, 1997
    Assignee: The Procter & Gamble Company
    Inventor: James B. Camden
  • Patent number: 5629440
    Abstract: A composition comprisinga) a lubricant or a hydraulic fluid andb) at least one compound of the general formula I ##STR1## in which x=1 or 2 and,if x=1,R is as defined for R.sup.1 or R.sup.3 --O-- or,if x=2,R is as defined for R.sup.8, andR.sup.1 and R.sup.3 are, for example, alkyl, cycloalkyl, alkenyl, phenyl, naphthyl, aralkyl or alkaryl, or alkyl, cycloalkyl, alkenyl, phenyl, naphthyl, aralkyl or alkaryl, which are monosubstituted or polysubstituted by groups from the series comprising halogen, cyano, nitro, e.g. --OCH.sub.3 or e.g. --COOCH.sub.3, or alkyl, cycloalkyl, alkenyl, aralkyl or alkaryl which are interrupted by one or more groups from the series comprising --O--, --S--, --NH--, ##STR2## or alkyl, cycloalkyl, alkenyl, aralkyl or alkaryl which are monosubstituted or polysubstituted by groups from the series comprising halogen, cyano, nitro, e.g. --OCH.sub.3 or e.g. --COOCH.sub.3 and interrupted by one or more groups from the series comprising --O--, --S--, --NH--, ##STR3## and R.sup.2 is NR.sup.4 R.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 13, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Hugo Camenzind, Peter Nesvadba
  • Patent number: 5506263
    Abstract: Benzyl derivatives of the formula I ##STR1## where A is CH.sub.2, CHCl, CH-alkyl, CH-alkoxy, CH-alkylthio or N-alkoxy,B is OH, alkylthio, alkoxy or alkylamino,U, V, W are hydrogen, halogen, alkyl or alkoxy,D is ##STR2## where R' is hydrogen or alkyl andR is hydrogen, alkyl, cycloalkyl, haloalkyl, halocycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, aryloxyalkyl, aryl, arylalkyl, hetaryl, hetaryl-alkyl, hetaryloxyalkyl or heterocyclyl, and fungicides containing these compounds.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: April 9, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Wingert, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5476957
    Abstract: The heat-sensitive recording material disclosed comprises a colorless or pale colored dyestuff precursor, one or more salicylic acid derivative of the formula (1) or metal salt of the derivative and an aliphatic amide compound having 18.about.60 carbon atoms in molecular structure, and is excellent in thermal response and preservation stability of white portions and images. ##STR1## wherein X.sub.1 and X.sub.2 are a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aralkyl group or an aryl group, Y.sub.1 and Y.sub.2 are an oxygen atom or a sulfur atom, R.sub.1 is a hydrogen atom, an alkyl group, an aralkyl group or an aryl group, and R.sub.2 is an alkyl group, an alkenyl group, an aralkyl group or an aryl group.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: December 19, 1995
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Yoshimitsu Tanabe, Yuki Kobayashi, Atsuo Otsuji, Masakatsu Nakatsuka, Akihiro Yamaguchi
  • Patent number: 5468870
    Abstract: Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR.sup.1 or CONR.sup.2 R.sup.3 ;R.sup.1, R.sup.2 and R.sup.3 each independently represent hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or R.sup.2 and R.sup.3 together represent the necessary atoms to close a heterocyclic nucleus or substituted heterocyclic nucleus;Y represents OR.sup.4 or NR.sup.5 R.sup.6 or CN;R.sup.4 represents hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, SO.sub.2 R.sup.7, COR.sup.7, CSR.sup.7, POR.sup.7 R.sup.8 ;R.sup.5 and R.sup.6 each independently has one of the significances given to R.sup.4 or represent substituted or unsubstituted amino, or R.sup.5 and R.sup.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: November 21, 1995
    Assignee: AGFA-GAVAERT, N.V.
    Inventor: Luc J. Vanmaele
  • Patent number: 5449812
    Abstract: The compounds of the formula (I) ##STR1## in which R.sup.1 -R.sup.4, W, X, Y and Z are as defined in claim 1 are suitable for controlling harmful plants in crops.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: September 12, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Schnabel, Lothar Willms, Klaus Bauer, Hermann Bieringer
  • Patent number: 5416110
    Abstract: Benzyl derivatives of the formula I ##STR1## where A isCH.sub.2, CHCl, CH-alkyl, CH-alkoxy, CH-alkylthio or N-alkoxy,B isOH, alkylthio, alkoxy or alkylamino,U, V, W arehydrogen, halogen, alkyl or alkoxy,D is ##STR2## where R' ishydrogen or alkyl andR ishydrogen, alkyl, cycloalkyl, haloalkyl, halocycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, aryloxyalkyl, aryl, arylalkyl, hetaryl, hetaryl-alkyl, hetaryloxyalkyl or heterocyclyl, and fungicides containing these compounds.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: May 16, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Wingert, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5391806
    Abstract: Heat-sensitive recording materials contain an electron-donating chromogenic compound and an electron-attracting compound. The recording materials also contain at least one compound represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.3 mean a hydrogen atom or an alkyl, aralkyl or aryl group, R.sub.2 and R.sub.4 denote an alkyl, alkenyl, aralkyl or aryl group, X.sub.1, X.sub.2, Y.sub.1 and Y.sub.2 stand for an oxygen or a sulfur atom, and --Z.sub.1 -- and --Z.sub.2 -- are a specific aromatic group. Also provided are phenol compounds represented by the following formula: ##STR2## wherein R.sub.1, R.sub.2, X.sub.1 and Y.sub.1 have the same meanings as defined above; R.sub.5 and R.sub.6 are a hydrogen or halogen atom or an alkyl, alkoxy, aralkyl, aryl or hydroxyl group; p and q stand for an integer of 1-4; R.sub.5 and R.sub.6 may be either the same or different when p and q represent an integer of 2 or greater; and --Z.sub.3 -- means a specific divalent group.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: February 21, 1995
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Atsuo Otsuji, Toshihiro Motoshima, Yoshimitsu Tanabe, Kiyoharu Hasegawa, Kazuyoshi Kikkawa, Masakatsu Nakatsuka, Akihiro Yamaguchi