Nitrogen Or Chalcogen Attached Indirectly To The -o-c(=o)o- Group By Acyclic Nonionic Bonding Patents (Class 558/276)
  • Patent number: 10975016
    Abstract: The present disclosure provides, in part, a solvent compound for use as a substitute for a glycol ether, an alkyl ether of diethylene glycol, ethylene glycol or propylene glycol.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: April 13, 2021
    Inventors: David A. Pasin, Joseph Mitchell Clarkson, Laurel L. Schafer
  • Patent number: 10040901
    Abstract: The invention relates to a method for producing polyether carbonate polyols by binding alkylene oxides and carbon dioxide to one or more H-functional starter substance/s in the presence of a double metal cyanide (DMC) catalyst, characterized in that (y) one or more H-functional starter substance/s and DMC catalyst are continuously metered into the reactor during the binding process, and the free alkylene oxide concentration in the reaction mixture amounts to 1.5 to 5.0 wt %, and the obtained reaction mixture is continuously discharged from the reactor.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: August 7, 2018
    Assignee: COVESTRO DEUTSCHLAND AG
    Inventors: Jörg Hofmann, Stefanie Braun, Kai Laemmerhold, Aurel Wolf, Michael Traving
  • Patent number: 9062156
    Abstract: The present invention relates to a process for the production of polyether carbonate polyols from one or more H-functional starter substances, one or more alkylene oxides (epoxides) and carbon dioxide in the presence of at least one double metal cyanide catalyst, wherein the production of the polyether carbonate polyols is carried out in a tubular reactor.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 23, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Christoph Gürtler, Stefan Grasser, Aurel Wolf
  • Publication number: 20150125760
    Abstract: There is provided an improvement for capacitors having activated carbon electrodes by the use of an electrolyte solution containing a carbonate of the formula RO(C?O)OR1 and a conductive salt such as a lithium salt or a quaternary ammonium salt at a concentration of from 0.6 to 3 mol/l.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 7, 2015
    Inventors: W. Novis Smith, Joel R. McCloskey
  • Patent number: 8999323
    Abstract: The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ?2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ?O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ?O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a)
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 7, 2015
    Assignee: Technische Universität Wien
    Inventors: Robert Liska, Jürgen Stampfl, Franz Varga, Heinrich Gruber, Stefan Baudis, Christian Heller, Monika Schuster, Helga Bergmeister, Günter Weigel, Claudia Dworak
  • Publication number: 20150051365
    Abstract: The present invention suggests 2-oxo-1,3-dioxolane-4-carboxamides of formula (I), in which R2 can be, inter alia, an n-valent radical (n>1) which is substituted with n?1 further 2-oxo-1,3-dioxolane-4-carboxamide groups of general formula (II), to processes for the preparation of these 2-oxo-1,3-dioxolane-4-carboxamides, to processes for the preparation of the 2-oxo-1,3-dioxolane-4-carboxylic acids of formula (III), which are suitable starting materials for the above processes, and to the use of said 2-oxo-1,3-dioxolane-4-carboxamides for the preparation of (poly)hydroxyurethanes, -hydroxycarbonates and -hydroxysulfanylformates, and also as end groups for the blocking of amines.
    Type: Application
    Filed: November 14, 2012
    Publication date: February 19, 2015
    Inventors: Heimo Woelfle, Burkhard Walther, Maximilian Köhler, Sophie Putzien
  • Patent number: 8916509
    Abstract: A bearing lubricant of the present invention contains a compound represented by the following general formula: CfH2f+1—R1a—O—(C?O)—O—R2b—CgH2g+1 wherein O represents an oxygen atom; C represents a carbon atom; H represents a hydrogen atom; R1 and R2 independently represent a C2-C48 oxaalkylene group having 1 to 6 oxygen atoms; a and b independently represent an integer of 0 or 1 and satisfy a+b?1; and f and g independently represent an integer of 1 to 12.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: December 23, 2014
    Assignee: Moresco Corporation
    Inventors: Shingo Maruyama, Yoshifumi Nakacho
  • Publication number: 20140288142
    Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Inventors: Nicoletta ALMIRANTE, Stefano BIONDI, Ennio ONGINI, Laura STORONI, Alessia NICOTRA
  • Publication number: 20140275064
    Abstract: The present invention relates to novel thiazolo[5,4-f]quinazoline compounds and methods that are useful in the amelioration, treatment or control of Down's syndrome or early Alzheimer's disease or in the amelioration, treatment or control of cancers, especially solid tumors. More specifically, the invention relates to DYRK1A and/or DYRK1B inhibitors and to methods for preparing such compounds.
    Type: Application
    Filed: August 17, 2012
    Publication date: September 18, 2014
    Applicant: DIAXONHIT
    Inventors: Bertrand Leblond, Anne-Sophie Casagrande, Laurent Desire, Alicia Foucourt, Thierry Besson
  • Publication number: 20140243527
    Abstract: The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a Jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a Boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying Boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity Boc-lysinated betulonic acid monomer ester.
    Type: Application
    Filed: June 29, 2012
    Publication date: August 28, 2014
    Applicant: KOREA INSTITUTE OF ENERGY RESEARCH
    Inventors: Kuck-Tack Chue, Tae-Hwan Kim, Leonid Ten
  • Patent number: 8779180
    Abstract: The invention relates to a process for removing an alkanol impurity from a stream containing an organic carbonate and the alkanol impurity, comprising contacting the stream with a catalyst to effect reaction of the alkanol impurity with the organic carbonate.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: July 15, 2014
    Assignee: Shell Oil Company
    Inventors: Evert Van Der Heide, Garo Garbis Vaporciyan, Cornelis Leonardus Maria Vrouwenvelder
  • Publication number: 20140194610
    Abstract: Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 10, 2014
    Inventors: Gregory L. Verdine, Meena Meena, Naoki Iwamoto, David Charles Donnell Butler
  • Patent number: 8664247
    Abstract: The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: March 4, 2014
    Assignees: RadioRx, Inc., Alliant Techsystems Inc.
    Inventors: Jan Scicinski, Bryan T. Oronsky, Robert Wardle, Louis Cannizzo, Nicholas A. Straessler
  • Patent number: 8663564
    Abstract: Embodiments of the present invention relate to carbon dioxide sequestration systems and methods. In an embodiment, the invention includes a method of sequestering carbon dioxide. The method can include mixing carbon dioxide with an alcohol to form a reaction mixture and contacting the reaction mixture with a metal oxide catalyst under reaction conditions sufficient to produce a carbonate as a reaction product. In an embodiment, the invention includes a carbon dioxide sequestration system. The system can include a carbon dioxide supply source, an alcohol supply source, and a reaction vessel. A metal oxide catalyst can be disposed within the reaction vessel. The system can be configured to mix carbon dioxide from the carbon dioxide supply source with an alcohol from the alcohol supply source to form a reaction mixture and contact the reaction mixture with the metal oxide catalyst. Other embodiments are also described herein.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: March 4, 2014
    Assignee: Sartec Corporation
    Inventors: Daniel Thomas Nowlan, Clayton V. McNeff
  • Publication number: 20140024827
    Abstract: Provided are a linezolid intermediate and the preparation method thereof and a method for synthesizing linezolid. The structure of the intermediate is shown as formula F2, wherein the compound is prepared by a condensation reaction of (S)—N—(3-chloro-2-hydroxy-1-propyl) acetamide and the compound shown in formula F4. In the preparation methods of the compound shown in formula F2 and linezolid, the reaction system is mild, side reactions are few and the product yield is high.
    Type: Application
    Filed: April 12, 2012
    Publication date: January 23, 2014
    Applicant: ZHEJIANG MEDICINE CO., LTD XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Xiaoyue Jiang, Guofeng Wu, Weidong Ye, Runpu Shen, Xiaohua Song
  • Patent number: 8632792
    Abstract: A cooling sensation agent composition with a prolonged cool sensation effect is provided comprising at least one compound selected from the group consisting of aceia or ketal derivatives of 3-(1-menthoxy)propan-1,2-diol represented by Formula (1), single or mixed carbonic esters ol one or two kinds ol alcohols represented by Formula (2), and carboxylic esters represented by Formula (4). A sensory stimulation agoni composition, a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent; and new compounds are also provided.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: January 21, 2014
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Takashi Aida, Tetsuya Yamamoto
  • Publication number: 20130313931
    Abstract: A bearing lubricant of the present invention contains a compound represented by the following general formula: CfH2f+1—R1a—O—(C?O)—O—R2b—CgH2g+1 wherein O represents an oxygen atom; C represents a carbon atom; H represents a hydrogen atom; R1 and R2 independently represent a C2-C48 oxaalkylene group having 1 to 6 oxygen atoms; a and b independently represent an integer of 0 or 1 and satisfy a+b?1; and f and g independently represent an integer of 1 to 12.
    Type: Application
    Filed: January 20, 2012
    Publication date: November 28, 2013
    Applicant: MORESCO CORPORATION
    Inventors: Shingo Maruyama, Yoshifumi Nakacho
  • Publication number: 20130299338
    Abstract: Provided is a new photochemical process for preparing artemisinin. Also provided are certain dihydroartemisinic acid derivatives useful for preparing artemisinin.
    Type: Application
    Filed: July 12, 2013
    Publication date: November 14, 2013
    Inventors: Jildaz DHAINAUT, Alain Dlubala, Ronan Guevel, Alain Medard, Gilles Oddon, Nicolas Raymond, Joel Turconi
  • Publication number: 20130295448
    Abstract: Provided are an electrolyte which may prevent the degradation of the battery performance by including a functional group which can react with a side reaction site which is responsible for decomposition of negative electrode material components and a functional group which can react with moisture which is responsible for decomposition of positive electrode material components in an electrolyte of the battery to ensure the stability of the battery at high temperatures, and a secondary battery manufactured by adding the same. The present invention may employ a compound including a functional group which can react with a side reaction site of a negative electrode material and a functional group which can react with moisture to maximize the improvement of the storage performance of a secondary battery at high temperatures.
    Type: Application
    Filed: July 1, 2013
    Publication date: November 7, 2013
    Inventors: Yo Jin KIM, Han Ho LEE, Seung Don CHOI
  • Patent number: 8557500
    Abstract: The present invention provides a salt represented by the formula (I): wherein Q1 and Q2 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, L2 represents a single bond or a C1-C6 alkanediyl group in which one or more —CH2— can be replaced by —O— or —CO—, Y represents a C3-C18 alicyclic hydrocarbon group which can have one or more substituents, and one or more —CH2— in the alicyclic hydrocarbon group can be replaced by —O—, —CO— or —SO2—, and Z+ represents an organic counter ion.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: October 15, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Hiromu Sakamoto, Takahiro Yasue
  • Publication number: 20130261036
    Abstract: The present invention relates to perfumes of general formula (A) It further relates to the use of the compounds of formula (A) for imparting or intensifying particular odor notes and/or particular odor impressions and a method of producing a perfume mixture or a perfumed product.
    Type: Application
    Filed: October 25, 2011
    Publication date: October 3, 2013
    Applicant: SYMRISE AG
    Inventor: Bernd Hölscher
  • Publication number: 20130059973
    Abstract: The invention provides polyisocyanate prepolymers, characterised in that they contain polyether carbonate polyols as structural component, their preparation and their use as isocyanate component in 1- and 2-component systems for surface-coating compositions, adhesives and sealing materials.
    Type: Application
    Filed: May 2, 2011
    Publication date: March 7, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Christian Wamprecht, Christos Karafilidis, Christoph Gürtler, Beate Baumbach
  • Publication number: 20130053418
    Abstract: The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 28, 2013
    Inventors: Jan Scicinski, Bryan T. Oronsky, Robert Wardle, Louis Cannizzo, Nicholas A. Straessler
  • Patent number: 8324419
    Abstract: The invention relates to a process for preparing polyether carbonate polyols by addition of alkylene oxides and carbon dioxide onto H-functional starter substances using DMC catalysts, wherein one or more starter substances are initially placed in the reactor and one or more starter substances are metered continuously into the reactor during the reaction.
    Type: Grant
    Filed: January 21, 2008
    Date of Patent: December 4, 2012
    Assignee: BASF SE
    Inventors: Darijo Mijolovic, Markus Kummeter, Michael Stoesser, Stephan Bauer, Stephan Goettke
  • Publication number: 20120296101
    Abstract: The present invention relates to a process for the preparation of darunavir, a nonpeptide protease inhibitor (PI), useful for the treatment of HIV/AIDS patients harboring multidrug-resistant HIV-1 variants that do not respond to previously existing HAART regimens. The present invention further relates to processes for the stereo-directed preparation of darunavir intermediates, in particular (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol and to certain novel intermediates obtained by such processes.
    Type: Application
    Filed: January 24, 2011
    Publication date: November 22, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Michael Mizhiritskii, Ehud Marom
  • Publication number: 20120225385
    Abstract: The present invention provides a salt represented by the formula (I): wherein Q1 and Q2 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, L2 represents a single bond or a C1-C6 alkanediyl group in which one or more —CH2— can be replaced by —O— or —CO—, Y represents a C3-C18 alicyclic hydrocarbon group which can have one or more substituents, and one or more —CH2— in the alicyclic hydrocarbon group can be replaced by —O—, —CO— or —SO2—, and Z+ represents an organic counter ion.
    Type: Application
    Filed: February 28, 2012
    Publication date: September 6, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji ICHIKAWA, Hiromu SAKAMOTO, Takahiro YASUE
  • Publication number: 20120095122
    Abstract: The present invention relates to polyurethane, and specifically relates to a polyurethane microcellular elastomer, a method for preparing the same, and the use thereof. The polyurethane microcellular elastomer is the reaction product of (1) an isocyanate-terminated prepolymer obtained by reacting an isocyanate with a first polyol, (2) a second polyol, (3) a chain extender and (4) a catalyst, wherein the first polyol and/or second polyol comprise at least one polycarbonate polyol obtained by reacting carbon dioxide with an alkene oxide. This method of preparing polyurethane microcellular elastomer can not only reduce the demand for raw materials derived from petrochemicals, but also realize the utilization of the “greenhouse gas” carbon dioxide.
    Type: Application
    Filed: March 31, 2010
    Publication date: April 19, 2012
    Applicant: Bayer MaterialScience AG
    Inventors: Zhiping Zhou, Zhong Cao, Yide Liang, Yuedong Zhang, Jen Chieh Roy Lin
  • Publication number: 20120071640
    Abstract: An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH2, X and Y are independently selected from S and O, and R0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof.
    Type: Application
    Filed: June 22, 2011
    Publication date: March 22, 2012
    Applicant: GIRINDUS AMERICA, INC.
    Inventors: Wieslaw Adam MAZUR, Yigang HE, Victor D. SOROKIN
  • Publication number: 20120046441
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Application
    Filed: August 26, 2011
    Publication date: February 23, 2012
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan
  • Publication number: 20110288309
    Abstract: Embodiments of the present invention relate to carbon dioxide sequestration systems and methods. In an embodiment, the invention includes a method of sequestering carbon dioxide. The method can include mixing carbon dioxide with an alcohol to form a reaction mixture and contacting the reaction mixture with a metal oxide catalyst under reaction conditions sufficient to produce a carbonate as a reaction product. In an embodiment, the invention includes a carbon dioxide sequestration system. The system can include a carbon dioxide supply source, an alcohol supply source, and a reaction vessel. A metal oxide catalyst can be disposed within the reaction vessel. The system can be configured to mix carbon dioxide from the carbon dioxide supply source with an alcohol from the alcohol supply source to form a reaction mixture and contact the reaction mixture with the metal oxide catalyst. Other embodiments are also described herein.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 24, 2011
    Inventors: Daniel Thomas Nowlan, Clayton V. McNeff
  • Publication number: 20110237785
    Abstract: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 29, 2011
    Inventors: Éric Marsault, Kamel Benakli, Hamid R. Hoveyda, Mark L. Peterson, Sylvie Beaubien, Luc Ouellet, Carl St-Louis, Sophie Beauchemin
  • Publication number: 20110217654
    Abstract: The invention pertains to a compound generating an acid of the formula I or II, for instance corresponding sulfonium and iodonium salts, as well as corresponding sulfonyloximes wherein X is CH2 or CO; Y is O, NR4, S, O(CO), O(CO)O, O(CO)NR4, OSO2, O(CS), or O(CS)NR4; R1 is for example C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, interrupted C2-C18alkyl, interrupted C3-C30cycloalkyl, interrupted C3-C30cycloalkyl-C1-C18alkyl, interrupted C4-C30cycloalkenyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or heteroaryl, all unsubstituted or are substituted; or R1 is NR12R13; R2 and R3 are for example C3-C30cycloalkylene, C3-C30cycloalkyl-C1-C18alkylene, C1-C18alkylene, C1-C10haloalkylene, C2-C12alkenylene, C4-C30cycloalkenylene, phenylene, naphthylene, anthracylene, phenanthrylene, biphenylene or heteroarylene; all unsubstituted or substituted; R4 is for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18al
    Type: Application
    Filed: February 16, 2011
    Publication date: September 8, 2011
    Applicant: BASF SE
    Inventors: Hitoshi Yamato, Toshikage Asakura, Akira Matsumoto, Keita Tanaka, Yuichi Nishimae
  • Publication number: 20110218176
    Abstract: The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.
    Type: Application
    Filed: May 6, 2011
    Publication date: September 8, 2011
    Inventor: Barbara Brooke Jennings-Spring
  • Publication number: 20110213173
    Abstract: The invention relates to a process for removing an alkanol impurity from a stream containing an organic carbonate and the alkanol impurity, comprising contacting the stream with a catalyst to effect reaction of the alkanol impurity with the organic carbonate.
    Type: Application
    Filed: October 16, 2009
    Publication date: September 1, 2011
    Inventors: Evert Van Der Heide, Garo Garbis Vaporciyan, Cornelis Leonardus Maria Vrouwenvelder
  • Publication number: 20110190527
    Abstract: The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an “alanine ester”) with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.
    Type: Application
    Filed: May 19, 2008
    Publication date: August 4, 2011
    Applicant: Nagase & Co., Ltd.
    Inventors: Jun Matsumoto, Toru Inoue
  • Publication number: 20110065933
    Abstract: Provided is a new photochemical process for preparing artemisinin. Also provided are certain dihydroartemisinic acid derivatives useful for preparing artemisinin.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 17, 2011
    Inventors: Jildaz DHAINAUT, Alain Dlubala, Ronan Guevel, Alain Medard, Gilles Oddon, Nicolas Raymond, Joel Turconi
  • Publication number: 20110021624
    Abstract: Disclosed are a series of ?-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The ?-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
    Type: Application
    Filed: December 11, 2008
    Publication date: January 27, 2011
    Inventors: Fajun Nan, Jia Li, Jian Ding, Gang Liu, Chuanming Xie, Zehong Miao, Wanyi Tai
  • Publication number: 20100303804
    Abstract: The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ?2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ?O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ?O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a)
    Type: Application
    Filed: November 21, 2008
    Publication date: December 2, 2010
    Applicant: TECHNISCHE UNIVERSITAT WIEN
    Inventors: Robert Liska, Jürgen Stampfl, Franz Varga, Heinrich Gruber, Stefan Baudis, Christian Heller, Monika Schuster, Helga Bergmeister, Günter Weigel, Claudia Dworak
  • Publication number: 20100179343
    Abstract: The present invention relates to a method of producing an optically active cyanohydrin derivative, which comprises reacting an aldehyde or an asymmetrical ketone with a cyanating agent in the presence of a Lewis base and a titanium compound produced from a partial hydrolysate of titanium tetraalkoxide and an optically active ligand represented by formula (II) or a titanium oxoalkoxide compound represented by formula (I) [TixOy](OR1)4x-2y, and an optically active ligand represented by formula (II), wherein R1 is an optionally substituted alkyl group or an optionally substituted aryl group; x is an integer of not less than 2; y is an integer of not less than 1; and y/x satisfies 0.1<y/x?1.
    Type: Application
    Filed: March 29, 2007
    Publication date: July 15, 2010
    Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, MITSUI CHEMICALS, INC.
    Inventors: Wee Chuan Yeo, L. L. Christina Chai, Selvasothi Selvaratnam, Takushi Nagata, Kasuhiko Yoshinaga
  • Publication number: 20100069643
    Abstract: The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.
    Type: Application
    Filed: December 21, 2006
    Publication date: March 18, 2010
    Inventors: James D. McChesney, John T. Henri, Sylesh K. Venkataraman, Rodger L. Lamb, Jonathan E. Foster, Christian M. Summer, Shangping Ye
  • Patent number: 7671228
    Abstract: A method of forming a polyethercarbonate polyol enhances incorporation of CO2 into the polyethercarbonate polyol. The method provides a catalyst including a multimetal cyanide compound. An H-functional initiator, an alkylene oxide, and CO2 are reacted in the presence of the multimetal cyanide compound in a reactor. The method further provides a CO2-philic compound or a CO2-philic substituent. The CO2-philic compound and substituent enhance incorporation of the CO2 into the polyethercarbonate polyol and reduce formation of cyclic alkylene carbonates, such as cyclic propylene carbonate, which are undesirable byproducts.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: March 2, 2010
    Assignee: BASF Corporation
    Inventors: Werner Hinz, Jacob Wildeson, Edward M. Dexheimer
  • Publication number: 20100048935
    Abstract: The invention relates to a process for preparing polyether carbonate polyols by addition of alkylene oxides and carbon dioxide onto H-functional starter substances using DMC catalysts, wherein one or more starter substances are initially placed in the reactor and one or more starter substances are metered continuously into the reactor during the reaction.
    Type: Application
    Filed: January 21, 2008
    Publication date: February 25, 2010
    Applicant: BASF SE
    Inventors: Darijo Mijolovic, Markus Kummeter, Michael Stoesser, Stephan Bauer, Stephan Goettke
  • Patent number: 7619110
    Abstract: The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: November 17, 2009
    Assignee: XenoPort, Inc.
    Inventors: Feng Xu, Mark A. Gallop, Vivek Sasikumar, Usha Dilip
  • Publication number: 20090280245
    Abstract: A printing or coating composition has a non-volatile liquid vehicle carrying a conductive polymer to be deposited on a substrate and is cleavable by heat or acidification without decomposition of said material, cleavage of said vehicle producing decomposition products that are more volatile than said vehicle and which can be evaporated to dry the composition. Suitably, that vehicle is a carbonic acid diester or a malonic acid diester, e.g. of the formula: wherein R2 is an organic substituent such that R2—OH is a volatile alcohol; R1 is an aliphatic or aromatic substituent of more than three carbon atoms such that is volatile; and R3 is C1-3 alkyl.
    Type: Application
    Filed: April 13, 2007
    Publication date: November 12, 2009
    Applicant: The Technical University of Denmark
    Inventors: Frederik Krebs, Mikkel Joergensen
  • Publication number: 20090263726
    Abstract: A secondary battery capable of improving the cycle characteristics is provided. The secondary battery includes a cathode and an anode oppositely arranged with a separator in between, and an electrolytic solution. At least one of the cathode, the anode, the separator, and the electrolytic solution contains a sulfone compound having a carbonate group and a sulfonyl group.
    Type: Application
    Filed: December 16, 2008
    Publication date: October 22, 2009
    Applicant: SONY CORPORATION
    Inventors: Hiroyuki Yamaguchi, Masayuki Ihara, Tadahiko Kubota
  • Publication number: 20090192325
    Abstract: Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamate prodrugs are disclosed.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 30, 2009
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Ge Peng, Steven P. Raillard
  • Publication number: 20090104322
    Abstract: By using protonic acids, diesters of dicarbonic acid may be stabilized against thermal and chemical decomposition over a relatively long period. Mixtures of diesters of dicarbonic acid and protonic acids are outstandingly suitable for preserving foods.
    Type: Application
    Filed: April 11, 2007
    Publication date: April 23, 2009
    Applicant: LANXESS DEUTSCHLAND GMBH
    Inventors: Steffen Kahlert, Johannes Kaulen, Erasmus Vogl
  • Patent number: 7420077
    Abstract: The present invention relates to an improved process for preparing aliphatic oligocarbonate diols by transesterifying dimethyl carbonate (DMC) with aliphatic diols.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: September 2, 2008
    Assignee: Bayer MaterialScience AG
    Inventors: Steffen Hofacker, Rolf Bachmann, Lothar Bäcker, Herbert Witossek
  • Patent number: 7420076
    Abstract: The novel process for preparing dialkyl dicarbonates by reacting the corresponding alkyl haloformates with alkali metal hydroxides, alkaline earth metal hydroxides and/or carbonates in the presence of water-immiscible organic solvents and in the presence of a catalyst is characterized in that the catalyst used is at least one tertiary alkylamine of the formula (I) NR1R2R3,??(I) where the substituents are each as defined in the description.
    Type: Grant
    Filed: April 30, 2005
    Date of Patent: September 2, 2008
    Assignee: Lanxess Deutschland GmbH
    Inventors: Thomas Prinz, Markus Eckert, Hans-Ulrich Buschhaus, Steffen Kahlert
  • Publication number: 20080125483
    Abstract: The invention provides novel compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof.
    Type: Application
    Filed: November 21, 2007
    Publication date: May 29, 2008
    Inventors: Jenn-Tsang Hwang, Chrong-Shiong Hwang, Yow-Lone Chang, Chung-Niang Yao