Abstract: Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br or Cl; and R5, R6, R7, R8 and R9 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 4 wherein R12, R13, R14 and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
Type:
Application
Filed:
December 17, 2008
Publication date:
May 24, 2012
Inventors:
Donald J. Dumas, Albert Loren Casalnuovo
Abstract: The invention is a set of novel bisphospholane ligands that can be complexed with transition metals. These complexes are useful as catalysts in asymmetric reactions such as asymmetric hydrogenation.
Type:
Application
Filed:
April 18, 2007
Publication date:
April 16, 2009
Inventors:
Philip M. Jackson, Ian Campbell Lennon, Martin E. Fox
Abstract: A novel process for industrially producing an aromatic nitrile compound represented by the following general formula (3): characterized in that one of an aromatic hydroxymethyl compound, an aromatic alkoxymethyl compound and an aromatic aldehyde compound, all represented by the following general formula (1): or a mixture thereof is reacted with an oxidized bromine compound represented by the general formula (2) MBrOm ??(2) in the presence of an acid catalyst and either ammonia or an ammonium sat.
Abstract: The present invention comprises the simultaneous ring opening and concomitant N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitriles in presence of catalytic amount of metal triflates to afford different N-substituted ?-amino nitriles in excellent yields and selectivities.
Type:
Grant
Filed:
November 29, 2002
Date of Patent:
June 14, 2005
Assignee:
Council of Scientific and Industrial Research
Abstract: There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid crystal dopant, antipicornaviral agents, anti-inflammatory agents, anti-asthma agents, and fibringoen antagonists. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and diethers thereof, from 2,4-dihydroxybenzoic acid. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, 2,4-dihydroxybenzonitrile is condensed with (S)-2-methylcysteine.
Type:
Grant
Filed:
May 15, 2003
Date of Patent:
April 5, 2005
Assignee:
Genzyme Corporation
Inventors:
Mukund S. Chorghade, Mukund K. Gurjar, Joseph Cherian
Abstract: A nitrile compound is prepared by treating a solid supported amide to dehydrate it and cleave it from the support in one operation. The preparation involves acetylation of the amide compound in the presence of a base at a temperature of less than 100° C.
Type:
Grant
Filed:
August 13, 2002
Date of Patent:
December 16, 2003
Assignee:
Millennium Pharmaceuticals Limited
Inventors:
Ryszard Kobylecki, Neal David Hone, Lloyd James Payne
Abstract: The present invention relates to processes for the production of &agr;-aryl-&bgr;-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
Type:
Grant
Filed:
July 6, 2000
Date of Patent:
May 13, 2003
Assignee:
Bristol-Myers Squibb Pharma Company
Inventors:
Jiacheng Zhou, Lynette May Oh, Philip Ma
Abstract: The present invention provides a production method of a 5-phthalancarbonitrile compound of the formula [VI]
as well as production methods of a compound of the formula [V]
Abstract: This invention relates to a method for producing a partially oxidized organic compound, e.g., an unsaturated aldehyde/carboxylic acid having three or more carbon atoms, or an organic acid anhydride/nitrile compound having four or more carbon atoms. This method requires a catalyst prepared by treating a carrier in such a manner that water used in the treatment achieves specific resistance.
Abstract: There is disclosed a process for producing a nitrile compounds by ammoxidation of a carbocyclic or heterocyclic compound having organic substituent(s) by reacting the compound with ammonia and an oxygen-containing gas, wherein unreacted ammonia is recovered from the reaction product gas and recycled to the reaction system.
Abstract: The present invention relates to processes for the production of .alpha.-aryl-.beta.-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
Type:
Grant
Filed:
March 31, 1999
Date of Patent:
August 22, 2000
Assignee:
Dupont Pharmaceuticals Company
Inventors:
Jiacheng Zhou, Lynette May Oh, Philip Ma
Abstract: A novel process for producing .alpha.-[(dialkylamino) substituted-methylene].beta.-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R.sub.1 and R .sub.2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.
Abstract: There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.