Cyano Or Carbonyl Bonded Directly To An Acyclic Carbon Which Is Double Bonded To Another Carbon Patents (Class 558/395)
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Publication number: 20130344165Abstract: This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.Type: ApplicationFiled: February 23, 2012Publication date: December 26, 2013Applicant: EMORY UNIVERSITYInventors: Scott D. Boden, Sreedhara Sangadala
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Publication number: 20080193793Abstract: The present invention relates to materials useful as an electron or hole transport or injection layer in organic electrooptic devices. The material can form or be part of an electrically conductive organic layer, suitable for the transport of so-called positive charges or holes. The inventive HTL compounds are intrinsically doped HTLs which allows their deposition with greater homogeneity and reproducibility than matrix compositions consisting of a matrix material and an admixed p-dopant.Type: ApplicationFiled: December 23, 2004Publication date: August 14, 2008Applicants: Technische Universitaet Braunschweig, BASF AktiengesellschaftInventors: Hans-Hermann Johannes, Wolfgang Kowalsky, Guergana Dobreva, Martin Duemeland, Ulf Lawrentz
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Patent number: 7094510Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula X-Z-X? where X and X? are, each independently, a (9-fluorenylidene)malononitrile group, and Z is a linking group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.Type: GrantFiled: December 30, 2003Date of Patent: August 22, 2006Assignee: Samsung Electric Co., Ltd.Inventors: Nusrallah Jubran, Zbigniew Tokarski, Kam W. Law, Eric Morrison, Vytautas Getautis, Vygintas Jankauskas
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Publication number: 20040170909Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising:Type: ApplicationFiled: December 30, 2003Publication date: September 2, 2004Inventors: Nusrallah Jubran, Zbigniew Tokarski, Kam W. Law, Eric Morrison, Vytautas Getautis, Vygintas Jankauskas
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Patent number: 6737436Abstract: Compounds of the formula I in which R1 and R2, independently of one another, each denote H, A, OA, SA or HaI, R3 denotes H or A, R4 denotes A or NH2, R5 denotes H, NH2, NHA or NA2, A denotes alkyl having 1 to 10 carbon atoms, alkenyl, cycloalkyl or alkylenecycloalkyl, Hal denotes F, Cl, Br or I, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors.Type: GrantFiled: May 3, 2002Date of Patent: May 18, 2004Assignee: Merck Patent GmbHInventors: Hans-Michael Eggenweiler, Rochus Jonas, Michael Wolf, Michael Gassen, Thomas Welge
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Patent number: 6362205Abstract: Described are substituted cyanoenamines of formula I wherein Z, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing these compounds. These compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.Type: GrantFiled: March 16, 2001Date of Patent: March 26, 2002Assignee: Novo Nordisk A/SInventors: John Bondo Hansen, Tina Moller Tagmose, John Patrick Mogensen, Florencio Zaragoza Dorwald, Anker Steen Jorgensen
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Patent number: 6248785Abstract: This invention relates to novel compounds, pharmaceutical compositions comprising these compounds and their use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).Type: GrantFiled: January 22, 1999Date of Patent: June 19, 2001Assignee: SmithKline Beecham CorporationInventors: Katherine L. Widdowson, John Gerald Gleason
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Patent number: 6121479Abstract: A compound of the formula ##STR1## where R.sup.1 is the radical of the formula II or III ##STR2## is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV ##STR3## is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.Type: GrantFiled: April 22, 1999Date of Patent: September 19, 2000Assignee: Hoechst AktiengesellschaftInventors: Stefan Mullner, Bernd Kirschbaum, Wilfried Schwab
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Patent number: 5460927Abstract: The invention provides a novel and economic method for the production of an activated propene from a malonitrile dimer which comprises reacting a compound of the formula (I) ##STR1## with a nucleophile D to provide a compound of the formula (II) ##STR2## wherein substituents A, B and E each individually represent hydrogen, a substituted or unsubstituted alkyl acyl carboxyl or aryl group or an electron withdrawing group, and X is a group capable of displacement via a substitution reaction.Type: GrantFiled: January 3, 1994Date of Patent: October 24, 1995Assignee: Eastman Kodak CompanyInventor: Hugh M. Williamson
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Patent number: 5443820Abstract: Esters and amides of aminomethylenecyanoacetic acid I ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, phenyl, naphthyl, biphenylyl or five- or six-membered hetaryl with one, two or three nitrogens or one oxygen or one sulfur or one nitrogen and one oxygen or one nitrogen and one sulfur, which can be benzo-fused, it being possible for these radicals to be substituted by one to three C.sub.1 -C.sub.12 -alkyl groups, C.sub.1 -C.sub.12 -alkoxy groups, halogen atoms, cyano groups, hydroxyl groups or groups of the formulae COOR.sup.3, COR.sup.3, CONHR.sup.3, OCOR.sup.3 or NHCOR.sup.3, and whereR.sup.3 is C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.8 -cycloalkyl or phenyl,X is C.sub.2 -C.sub.30 -alkylene which can be interrupted by non-adjacent oxygens, or is C.sub.4 -C.sub.12 -alkenylene or C.sub.4 -C.sub.12 -alkynylene where the unsaturated bonds are not adjacent to the ester oxygens, or is C.sub.5 -C.sub.8 -cycloalkylene or phenylene, andY is O or NH.Type: GrantFiled: January 5, 1994Date of Patent: August 22, 1995Assignee: Basf AktiengesellschaftInventors: Martin Holderbaum, Alexander Aumueller, Hubert Trauth
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Patent number: 5399690Abstract: Solid particle dispersions of dyes according to the formula: ##STR1## wherein D is selected from the group consisting of ##STR2## and ketomethylene nuclei are disclosed as filter dyes for photographic elements.In this formula, E.sup.1 and E.sup.2 are each independently electron withdrawing groups. R.sup.1 and R.sup.6 are each independently R or NHR, where R is aryl. R.sup.2 and R.sup.3 are each independently alkyl or aryl, or represent the carbon atoms necessary to form a fused ring with the phenyl ring to which the N atom is attached. R.sup.4 and R.sup.7 are each independently hydrogen, alkyl or aryl. R.sup.5 is alkyl. Z represents the atoms necessary to complete a 5 or 6 memebered heterocyclic nucleus. M.sup.+ is a cation. L.sup.1 through L.sup.7 are each independently methine groups. m is 0, 1, 2, or 3. n is 0 or 1. p is 0, 1, 2, 3, or 4. q is 0, 1, 2, or 3. At least one of R.sup.1 or D includes an aryl ring substituted with a carboxy or sulfonamido substituent.Type: GrantFiled: February 10, 1993Date of Patent: March 21, 1995Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Glenn M. Brown, Margaret J. Helber
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Patent number: 5395853Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, orPh(CH.sub.2).sub.n -- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C.sub.1-4 alkoxy and C.sub.1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, orR.sup.1 NHCO-- where R.sup.1 is hydrogen or a C.sub.1-6 alkyl group, orR.sup.2 CONH-- where R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; ##STR2## Y is --(CH.sub.2).sub.q, where q is an integer of from 1 to 3, or --CH.dbd.CH-- (E or Z);Z is a C.sub.Type: GrantFiled: November 24, 1993Date of Patent: March 7, 1995Assignee: Burroughs Wellcome Co.Inventors: William P. Jackson, Clifford J. Harris, Richard J. Arrowsmith, John G. Dann, Kevin J. O'Connor, Robert F. G. Booth
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Patent number: 5354777Abstract: New cyanoalkene derivatives of the formula (I) ##STR1## are described, in which R and R.sup.1 have the meaning given in the description, and a process for their preparation.The new cyanoalkene derivatives are used for combating microorganisms for the protection of industrial materials.Type: GrantFiled: February 23, 1993Date of Patent: October 11, 1994Assignee: Bayer AktiengesellschaftInventors: Peter Wachtler, Wilfried Paulus, Georg-Wilhelm Ludwig
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Patent number: 5312956Abstract: A non-functional liquid rubber is prepared by the solution polymerization of vinyl monomers. The polymer may be a homopolymer or a copolymer. As a copolymer the preferred monomers are a conjugated diene and a vinyl substituted nitrile such as acrylonitrile or methacrylonitrile. A non-functional initiator is employed that is either an azo initiator or a peroxide initiator.Type: GrantFiled: November 17, 1992Date of Patent: May 17, 1994Assignee: The B. F. Goodrich CompanyInventor: Robert J. Bertsch
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Patent number: 5290814Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph(CH.sub.2).sub.n -- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C.sub.1-4 alkoxy and C.sub.1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, or R.sup.1 NHCO-- where R.sup.1 is hydrogen or a C.sub.1-6 alkyl group, or R.sup.2 CONH-- where R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; X is ##STR2## where A is halogen; Y is --(CH.sub.2).sub.q, where q is an integer of from 1 to 3, or --CH.dbd.CH-- (E or Z);Z is a C.sub.Type: GrantFiled: November 5, 1992Date of Patent: March 1, 1994Assignee: Burroughs Wellcome Co.Inventors: William P. Jackson, Clifford J. Harris, Richard J. Arrowsmith, John G. Dann, Kevin J. O'Connor, Robert F. G. Booth
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Patent number: 4803223Abstract: A substituted aminophenylurea derivative represented by the general formula ##STR1## wherein X.sup.1 and X.sup.2 are identical or different and each represents a halogen atom, andR represents a substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbon group,and an acid addition salt thereof, and a process for preparation thereof, the compound of formula (I) being useful as antitumor agent.Type: GrantFiled: February 20, 1986Date of Patent: February 7, 1989Assignee: Tokuyama Soda Kabushiki KaishaInventor: Shozo Kato
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Patent number: 4716243Abstract: .alpha.-(o-Chlorophenyl)-aminomethylene-.beta.-formylaminopropionitrile, process for its preparation by reacting a metal salt of .alpha.-formyl-.beta.-formylaminopropionitrile with a salt of o-chloroaniline in an aqueous medium, and use of the product to prepare the compound of the formula ##STR1## by reaction with acetamidine. The pyrimidine thus obtained is an intermediate for the preparation of vitamin B.sub.1.Type: GrantFiled: August 15, 1985Date of Patent: December 29, 1987Assignee: BASF AktiengesellschaftInventors: Hansgeorg Ernst, Wolfgang Littmann, Joachim Paust
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Patent number: 4586954Abstract: A compound having the structural formula ##STR1## wherein R is C.sub.1 -C.sub.8 aliphatic and cycloaliphatic, C.sub.2 -C.sub.3 haloaliphatic, C.sub.2 -C.sub.4 alkoxyalkyl, --CH.sub.2 CN, --CH(CH.sub.3)CN or --C(CH.sub.3).sub.2 CN;R.sub.1 is hydrogen or C.sub.1 -C.sub.3 alkyl, provided that R and R.sub.1 cannot both equal hydrogen at the same time; orR and R.sub.1 taken together form a C.sub.4 -C.sub.6 alkyl or heteroalkyl ring which may be lower alkyl substituted wherein the hetero atom is oxygen or nitrogen, and the herbicidal use of the compound.Type: GrantFiled: June 3, 1985Date of Patent: May 6, 1986Assignee: Stauffer Chemical Co.Inventors: William J. Michaely, Jeff K. Curtis