Benzene Ring Attached Indirectly To The Cyano Group By Nonionic Bonding (i.e., Alicyclic Ring Between The Benzene Ring And The Cyano Group) Patents (Class 558/426)
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Patent number: 9796668Abstract: This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: GrantFiled: November 24, 2015Date of Patent: October 24, 2017Assignee: REATA PHARMACEUTICALS, INC.Inventors: Eric Anderson, Gary L. Bolton, Deborah A. Ferguson, Xin Jiang, Robert M. Kral, Jr., Patrick M. O'Brien, Melean Visnick
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Publication number: 20150097146Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.Type: ApplicationFiled: December 15, 2014Publication date: April 9, 2015Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
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Patent number: 9000188Abstract: The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.Type: GrantFiled: October 4, 2012Date of Patent: April 7, 2015Assignee: Trustees of Dartmouth CollegeInventors: Tadashi Honda, Emilie David, Dale Mierke
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Publication number: 20150087833Abstract: An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.Type: ApplicationFiled: April 11, 2013Publication date: March 26, 2015Applicants: IHARA CHEMICAL INDUSTRY CO., LTD., KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Kei Domon, Keiji Toriyabe, Yutaka Ogawa, Junichiro Bessho, Kei Kawamoto, Akira Watanabe, Masaaki Komatsu, Takeshi Matsuda, Seisuke Ito
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Publication number: 20150001505Abstract: A cyclobutane group-containing compound and an organic EL device, the compound being represented by following Formula 1:Type: ApplicationFiled: June 26, 2014Publication date: January 1, 2015Inventor: Hisayuki KAWAMURA
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Patent number: 8853449Abstract: Process for the industrial synthesis of the compound of formula (I)Type: GrantFiled: January 4, 2012Date of Patent: October 7, 2014Assignee: Les Laboratoires ServierInventors: Samir Zard, Béatrice Sire, Mehdi Boumediene
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Publication number: 20140296544Abstract: The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C—H bonds and one or more activated C—H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C—H bonds; oxidizing selectively one of the one or more aromatic C—H bonds in preference to the one or more activated C—H bonds; adding a hydroxyl group to the one of the one or more aromatic C—H bonds to form one or more phenols; and purifying the one or more phenols.Type: ApplicationFiled: August 14, 2013Publication date: October 2, 2014Inventors: Dionicio Siegel, Andrew M. Camelio, Anders Eliasen, Trevor C. Johnson, Abram Axelrod, Changxia Yuan
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Patent number: 8846969Abstract: The invention concerns Phenolic Configurationally Locked Polyene Single Crystals, which are especially suited as highly efficient nonlinear optical organic material. The invention also concerns methods for growth of crystalline thin films or bulk crystals from melt and/or solution. The compounds are suited and the methods may be used for manufacturing optical elements for several bulk and integrated applications, e.g. electro-Optics and THz-Wave applications.Type: GrantFiled: May 5, 2009Date of Patent: September 30, 2014Assignee: Rainbow Photonics AGInventors: Peter Gunter, Mojca Jazbinsek, O-Pil Kwon, Seong-Ji Kwon, Christoph Hunziker, Harry Figi
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Publication number: 20140256698Abstract: The present invention is directed to inhibitors of cathepsins and the methods for using and making such inhibitors.Type: ApplicationFiled: March 11, 2014Publication date: September 11, 2014Inventors: Robert Booth, Jeff Dener, Michael Green
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Publication number: 20140221478Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: ViroBay, Inc.Inventors: John O. Link, Craig J. Mossman, Jie Liu, Soon Hyung Woo
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Patent number: 8791162Abstract: This invention relates to deuterated compounds which are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: GrantFiled: February 9, 2012Date of Patent: July 29, 2014Assignee: Merck Sharp & Dohme Corp.Inventors: Kelem Kassahun, Christine Fandozzi, Donald R. Gauthier, Jr., Lisa A. Shipley
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Publication number: 20140186471Abstract: The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a pharmaceutically acceptable salt thereof, or a mixture thereof, according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.Type: ApplicationFiled: March 5, 2014Publication date: July 3, 2014Inventors: Anastasia Daifotis, Selwyn Aubrey Stoch, Basil Avery Ince, Cameron Black
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Publication number: 20140163240Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: July 18, 2013Publication date: June 12, 2014Inventors: Jerry A. Murry, Edwin G. Corley, Feng Xu, Bryon Simmons
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Patent number: 8748649Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: GrantFiled: December 18, 2012Date of Patent: June 10, 2014Assignee: Virobay, Inc.Inventors: John O. Link, Craig J. Mossman, Jie Liu, Soon Hyung Woo
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Publication number: 20140094613Abstract: A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, which includes converting a compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof.Type: ApplicationFiled: December 5, 2013Publication date: April 3, 2014Applicant: TAISHO PHARMACEUTICAL CO., LTD.Inventors: Noriaki MURASE, Toshihito KUMAGAI, Hisaya WADA, Hisahide TANIMOTO, Koumei OHTA, Yoshihiro KIMURA
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Publication number: 20140018421Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: ApplicationFiled: December 18, 2012Publication date: January 16, 2014Applicant: ViroBay, Inc.Inventors: John O. Link, Craig J. Mossman, Jie Liu, Soon Hyung Woo
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Publication number: 20130331597Abstract: This invention describes an amidation process whereby perfluorinated amino acids can be activated and treated with an amine in the presence of a coupling agent and a pyridine derivative to yield amides, without loss of optical purity.Type: ApplicationFiled: February 27, 2012Publication date: December 12, 2013Inventors: Guy Humphrey, Kelvin Yong
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Publication number: 20130324610Abstract: This invention relates to deuterated compounds which are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: ApplicationFiled: February 9, 2012Publication date: December 5, 2013Applicant: MERCK SHARP & DOHME CORP.Inventors: Kelem Kassahun, Christne Fandozzi, Donald R. Gauthier, Lisa A. Shipley
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Publication number: 20130316906Abstract: The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, Y, Q and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as herbicides and/or pesticides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as pesticides and/or for preventing unwanted plant growth.Type: ApplicationFiled: October 28, 2011Publication date: November 28, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Alfred Angermann, Stefan Lehr, Guido Bojack, Reiner Fischer, Isolde Häuser-hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Arnd Voerste, Dieter Feucht
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Patent number: 8575213Abstract: An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and R5 represents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.Type: GrantFiled: March 18, 2011Date of Patent: November 5, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Noritada Matsuo, Tatsuya Mori
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Publication number: 20130274480Abstract: The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.Type: ApplicationFiled: October 4, 2012Publication date: October 17, 2013Inventors: Tadashi Honda, Emilie David, Dale Mierke
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Patent number: 8546293Abstract: A process for producing geometric shaped catalyst bodies K whose active material is a multielement oxide which comprises the element Mo, the elements Bi and/or V and one or more of the elements Co, Ni, Fe, Cu and alkali metals, in which sources of the different elements are used to obtain a finely divided mixture which is coarsened to a powder by press agglomeration, the coarsened powder is used to form, by press agglomeration, shaped bodies V which are separated into undamaged shaped bodies V+ and into damaged shaped bodies V?, the undamaged shaped bodies V+ are converted by thermal treatment to the shaped catalyst bodies K, and the damaged shaped bodies V? are comminuted and recycled into the obtaining of the finely divided mixture.Type: GrantFiled: September 10, 2012Date of Patent: October 1, 2013Assignee: BASF SEInventors: Andreas Raichle, Holger Borchert, Klaus Joachim Mueller-Engel, Catharina Horstmann, Josef Macht
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Publication number: 20130252890Abstract: The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.Type: ApplicationFiled: June 21, 2011Publication date: September 26, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Tim Wintermantel, Carsten Möller, Ulrich Bothe, Reinhard Nubbemeyer, Ludwig Zorn, Dirk Kosemund, Antonius Ter Laak, Rolf Bohlmann, Lars Wortmann, Donald Bierer
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Publication number: 20130204032Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.Type: ApplicationFiled: March 26, 2013Publication date: August 8, 2013Applicant: Les Laboratoires ServierInventor: Les Laboratoires Servier
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Publication number: 20130172409Abstract: Disclosed is a composition containing an ester compound represented by formula (1), which composition is electrostatically sprayed to pests or to a place where the pests inhabit.Type: ApplicationFiled: September 6, 2011Publication date: July 4, 2013Applicant: Sumitomo Chemical Company, LimitedInventors: Akiko Harada, Yoshito Tanaka, Timothy C. Hadingham
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Patent number: 8367724Abstract: An ester compound represented by the formula (1): wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single bond or an oxygen atom, has an excellent pest controlling efficacy, and it is useful as an active ingredient of a pest controlling agent.Type: GrantFiled: November 17, 2010Date of Patent: February 5, 2013Assignee: Sumitomo Chemical Company, LimitedInventor: Tatsuya Mori
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Publication number: 20130018098Abstract: An ester compound represented by formula (1): wherein R1 represents hydrogen, fluorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxymethyl, or C1-C4 alkylthiomethyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and R5 represents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.Type: ApplicationFiled: March 18, 2011Publication date: January 17, 2013Applicant: Sumitomo Chemical Company, LimitedInventors: Noritada Matsuo, Tatsuya Mori
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Patent number: 8338454Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.Type: GrantFiled: May 14, 2010Date of Patent: December 25, 2012Assignee: Cellceutix CorporationInventor: Krishna Menon
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Patent number: 8314270Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.Type: GrantFiled: September 9, 2010Date of Patent: November 20, 2012Assignee: Abbott LaboratoriesInventors: James T. Link, Qi Shuai, Martin Winn, Hong Yong
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Publication number: 20120283450Abstract: This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: ApplicationFiled: July 18, 2012Publication date: November 8, 2012Inventors: Eric Anderson, Gary L. Bolton, Deborah A. Ferguson, Xin Jiang, Robert M. Kral, JR., Patrick M. O'Brien, Melean Visnick
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Publication number: 20120238763Abstract: A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, which includes converting a compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof.Type: ApplicationFiled: November 18, 2010Publication date: September 20, 2012Applicant: TAISHO PHARMACEUTICAL CO., LTD.Inventors: Noriaki Murase, Toshihito Kumagai, Hisaya Wada, Hisahide Tanimoto, Koumei Ohta, Yoshihiro Kimura
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Publication number: 20120142940Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: February 3, 2012Publication date: June 7, 2012Inventors: Jerry A. MURRY, Edward G. Corley, Feng Xu, Bryon Simmons
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Publication number: 20120116112Abstract: Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: ApplicationFiled: December 30, 2011Publication date: May 10, 2012Applicants: LES LABORATOIRES SERVIER, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Jean-Louis PEGLION, Olivier Baudoin, Nicolas Audic, Manon Chaumontet, Riccardo Piccardi
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Publication number: 20120046455Abstract: A process for the preparation of a 1,1-cyclopropane(nitrile)(electron-acceptor), the process comprising treating an olefin with an acceptor/acceptor-substituted ?-cyanodiazo reagent in the presence of a catalytic amount of a metal porphyrin catalyst.Type: ApplicationFiled: August 16, 2011Publication date: February 23, 2012Inventors: X. Peter Zhang, Shifa Zhu
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Publication number: 20120016150Abstract: A process for producing comprising reacting a 3-formyl-2,2-dimethylcyclopropanecarboxylate and propionitrile in the presence of a base to obtain 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid or its salt.Type: ApplicationFiled: April 5, 2010Publication date: January 19, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Toru Uekawa, Jun Ohshita, Ichiro Komoto, Kouji Yoshikawa
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Publication number: 20110295020Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Inventors: Jerry A. MURRY, Edward G. CORLEY, Feng XU, Bryon SIMMONS
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Publication number: 20110281879Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: ApplicationFiled: January 12, 2011Publication date: November 17, 2011Applicant: ViroBay, Inc.Inventor: Craig Mossman
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Patent number: 8044224Abstract: The invention relates to a chiral iridium aqua complex of formula (1): wherein R1 and R2 are the same or different and each is an aryl group optionally having at least one substituent selected from the group consisting of a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, a nitro group, a carboxyl group and a cyano group, or the like; and wherein R3 and R4 are the same or different and each is an alkyl group or the like, as well as the use of such a chiral iridium aqua complex for asymmetric transfer hydrogenation.Type: GrantFiled: January 29, 2008Date of Patent: October 25, 2011Assignees: Sumitomo Chemical Company, LimitedInventor: Erick M. Carreira
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Patent number: 7968598Abstract: An ester compound represented by the formula (1): wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single bond or an oxygen atom, has an excellent pest controlling efficacy, and it is useful as an active ingredient of a pest controlling agent.Type: GrantFiled: February 27, 2008Date of Patent: June 28, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Tatsuya Mori
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Publication number: 20110128610Abstract: The invention concerns Phenolic Configurationally Locked Polyene Single Crystals, which are especially suited as highly efficient nonlinear optical organic material. The invention also concerns methods for growth of crystalline thin films or bulk crystals from melt and/or solution. The compounds are suited and the methods may be used for manufacturing optical elements for several bulk and integrated applications, e.g. electro-Optics and THz-Wave applications.Type: ApplicationFiled: May 5, 2009Publication date: June 2, 2011Inventors: Peter Gunter, Mojca Jazbinsek, O-Pil Kwon, Seong-Ji Kwon, Christoph Hunziker, Harry Figi
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Publication number: 20110065789Abstract: An ester compound represented by the formula (1): wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single bond or an oxygen atom, has an excellent pest controlling efficacy, and it is useful as an active ingredient of a pest controlling agent.Type: ApplicationFiled: November 17, 2010Publication date: March 17, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Tatsuya MORI
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Publication number: 20100298374Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.Type: ApplicationFiled: May 14, 2010Publication date: November 25, 2010Applicant: CELLCEUTIX CORPORATIONInventor: Krishna MENON
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Publication number: 20100261608Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides. The invention also provides selective herbicidal compositions comprising, firstly, geminally alkoxy/alkylspirocyclically substituted tetramic acid derivatives and, secondly, a crop plant compatibility-improving compound. The invention furthermore relates to the boosting of the action of crop protection compositions comprising compounds of the formula (I) through the addition of ammonium salts or phosphonium salts and optionally penetrants.Type: ApplicationFiled: November 19, 2009Publication date: October 14, 2010Applicant: Bayer CropScience AGInventors: Reiner Fischer, Stefan Lehr, Jan Dittgen, Dieter Feucht, Ulrich Görgens, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Arnd Voerste, Eva-Maria Franken, Olga Malsam
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Publication number: 20100234622Abstract: A process is described for the preparation on an industrial scale of N-[2-(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propionamide, ramelteon, having the structure illustrated below:Type: ApplicationFiled: October 16, 2009Publication date: September 16, 2010Inventors: Roberto Lenna, Cristina Ghidoli, Luigi Panza
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Publication number: 20100210524Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are as defined in the specification. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.Type: ApplicationFiled: July 21, 2008Publication date: August 19, 2010Inventors: Theresa Apelqvist, Joakim Löfstedt, Thomas Norin, Mattias Wennerstål, Xiongyu Wu, Lars Hagberg
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Publication number: 20100191475Abstract: Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.Type: ApplicationFiled: March 4, 2010Publication date: July 29, 2010Inventors: Scott Perschke, Ming Liu
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Publication number: 20100174104Abstract: Asymmetric cyclopropanation of olefins with diazosulfones.Type: ApplicationFiled: March 16, 2009Publication date: July 8, 2010Inventors: X. Peter Zhang, Shifa Zhu
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Patent number: 7741323Abstract: An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or C3-6 cycloalkyl, each of which is unsubstituted or substituted with one or more phenyl groups; R2 is H, CN, CO2Ra, CH2CO2Ra, CONRbRc, or phenyl; R3 is C1-6 alkyl, C3-6 cycloalkyl, naphthyl, phenyl, being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH2, NO2, ORa, phenyloxy, C1-6 alkyl, and C3-6 cycloalkyl; and R4, R5, R6, and R7 are each independently H, OH, OSO2CH3, O(CH2)mRe, CH2Rf, OCOCH2ORg, OCH2CH2ORg, OCH2CH?CHRg, or pyridine-2-yloxy, or R5 and R6 together form OCH2O.Type: GrantFiled: April 13, 2005Date of Patent: June 22, 2010Assignees: Korea Research Institute of Chemical Technology, Jeil Pharm. Co., Ltd., Korea Research Institute of Bioscience and Biotechnology, CJ Corp.Inventors: Hyae Gyeong Cheon, Sung-Eun Yoo, Sung Soo Kim, Sung-Don Yang, Kwang-Rok Kim, Sang Dal Rhee, Jin Hee Ahn, Seung Kyu Kang, Won Hoon Jung, Sung Dae Park, Nam Gee Kim, Jang Hyuk Lee, Sun Chul Huh, Jae Mok Lee, Seog Beom Song, Soon Ji Kwon, Jong Hoon Kim, Jeong-Hyung Lee, Seung Jun Kim
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Publication number: 20100137178Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.Type: ApplicationFiled: December 1, 2009Publication date: June 3, 2010Inventors: Johan Smets, Hugo Robert Germain Denutte, An Pintens, David Thomas Stanton, Koen Van Aken, Inge Helena Hubert Laureyn, Bram Denolf, Freek Annie Camiel Vrielynck
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Publication number: 20100113763Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.Type: ApplicationFiled: October 26, 2009Publication date: May 6, 2010Applicants: FUTURECHEM CO., LTD., THE ASAN FOUNDATIONInventors: Dae Hyuk MOON, Dae Yoon CHI, Dong Wook KIM, Seung Jun OH, Jin-sook RYU