Polycyclo Ring System Having At Least Three Cyclos, At Least One Of Which Is A Benzene Ring Patents (Class 558/427)
  • Patent number: 10196471
    Abstract: The invention relates to a curable composition having an electron deficient olefin.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: February 5, 2019
    Assignees: Henkel IP & Holding GmbH, Henkel AG & Co. KGaA
    Inventors: Stefano Gherardi, Ciaran B. McArdle, Ligang Zhao
  • Patent number: 9750841
    Abstract: A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: September 5, 2017
    Assignees: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHENGDU YIPING MEDICAL SCIENCE & TECHNOLOGY CO. LTD
    Inventors: Keliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
  • Patent number: 8748015
    Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: June 10, 2014
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
  • Publication number: 20140144509
    Abstract: The present invention relates to an organic solar cell comprising new truxequinone derivatives used as acceptor, electron transport material, and doped electron transport materials.
    Type: Application
    Filed: September 5, 2011
    Publication date: May 29, 2014
    Applicant: Novaled AG
    Inventors: Omrane Fadhel, Sascha Dorok, Horst Hartmann, Ramona Pretsch
  • Publication number: 20140001461
    Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
  • Publication number: 20130239661
    Abstract: The invention relates to the use of diazonium salts for the formation of thick layers on at least one surface of a substrate. The diazonium salts used in the invention have the following formula (I): wherein R is a group that can be electrochemically reduced in a reversible manner to a cathodic potential between 0 and ?1.5 V, E is a spacer chain consisting of at least one aromatic cyclic group having between 5 and 6 links, optionally containing at least one heteroatom preferably selected from N, S, O or P and optionally substituted by at least one group selected from the C1-C5 alkyls and the halogens, r is 1 or 2, m is a whole number between 1 and 5 inclusive, p is a whole number between 1 and 5, and B is a counter-ion. The invention can be especially applied to the field of gas sensors.
    Type: Application
    Filed: August 31, 2011
    Publication date: September 19, 2013
    Applicant: Commissariat a L'Energie Atomique et aux Energies Alternatives
    Inventors: Fabien Lefloch, Muriel Matheron
  • Publication number: 20130165684
    Abstract: The present invention relates to a process for obtaining a compound of formula (1), (2) or (3) by means of a electrocarboxylation with CO2. The present invention also relates to the new intermediates (1) and (2). The present invention further relates to the use of intermediates (1) and (2) as starting materials for the synthesis of SPAN derivatives.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 27, 2013
    Applicant: AIR PRODUCTS AND CHEMICALS, INC.
    Inventor: Air Products and Chemicals, Inc.
  • Publication number: 20130096336
    Abstract: Indenofluorenes that include at least two alkynyl-containing substituents.
    Type: Application
    Filed: June 15, 2011
    Publication date: April 18, 2013
    Inventors: Michael M. Haley, Daniel T. Chase, Brad Rose, Aaron G. Fix
  • Publication number: 20120322717
    Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.
    Type: Application
    Filed: May 22, 2009
    Publication date: December 20, 2012
    Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
  • Publication number: 20120289734
    Abstract: A three-stage method for synthesizing 1,1-disubstituted olefins is provided.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 15, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Carsten Friese, Dieter Kaufmann, Vasu Govardhana Reddy Peddiahgari
  • Patent number: 8299247
    Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: October 30, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Hironobu Morishita
  • Publication number: 20120171103
    Abstract: The invention relates to a method of modifying electrical properties of carbon nanotubes by subjecting a composition of carbon nanotubes to one or more radical initiator(s). The invention also relates to an electronic component such as field-effect transistor comprising a carbon nanotube obtained using the method of the invention. The invention also relates to the use of the modified carbon nanotubes in conductive and high-strength nanotube/polymer composites, transparent electrodes, sensors and nanoelectromechanical devices, additives for batteries, radiation sources, semiconductor devices (e.g. transistors) or interconnects.
    Type: Application
    Filed: June 28, 2010
    Publication date: July 5, 2012
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Jianwen Zhao, Lain-Jong Li, Peng Chen, Bee Eng Mary Chan
  • Patent number: 8119828
    Abstract: A material for an organic electroluminescence device represented by the following formula (I): wherein X1 is one of divalent groups represented by the following (a) to (e); Y1 to Y4 are independently a carbon atom or a nitrogen atom; and R1 to R4 are independently a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocycle, a halogen atom, a fluoroalkyl group or a cyano group, or R1 and R2, and R3 and R4 are independently bonded to form a substituted or unsubstituted aromatic ring or a substituted or unsubstituted heterocycle.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: February 21, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Hironobu Morishita
  • Publication number: 20110284827
    Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.
    Type: Application
    Filed: December 2, 2009
    Publication date: November 24, 2011
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
  • Publication number: 20110275814
    Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 10, 2011
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventor: Hironobu MORISHITA
  • Patent number: 8039194
    Abstract: A photoacid generator P+ A? comprises (a) an antenna group P+ comprising atoms with high EUV photoabsorption cross-sections according to FIG. 1 and A? anions; or (b) an antenna group P+ and A? comprising anions with low photoabsorption cross-sections for EUV; or (c) an antenna group P+, comprising atoms with high EUV photoabsorption cross-sections according to FIG. 1 and A? comprising anions with low photoabsorption cross-sections for EUV. Novel compounds comprise DTFPIO PFBuS, and DTBPIO CN5.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: October 18, 2011
    Assignee: Internatinal Business Machines Corporation
    Inventor: Martin Glodde
  • Publication number: 20110147732
    Abstract: A benzofluoranthene derivative represented by the following formula (1): wherein at least one pair of “R1 and R2” and “R3 and R4” is bonded together to form a ring represented by the following formula (2):
    Type: Application
    Filed: August 12, 2009
    Publication date: June 23, 2011
    Inventor: Yumiko Mizuki
  • Patent number: 7847092
    Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: December 7, 2010
    Assignees: FutureChem Co., Ltd., The Asan Foundation
    Inventors: Dae Hyuk Moon, Dae Yoon Chi, Dong Wook Kim, Seung Jun Oh, Jin-sook Ryu
  • Publication number: 20100298200
    Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.
    Type: Application
    Filed: May 22, 2009
    Publication date: November 25, 2010
    Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
  • Patent number: 7655379
    Abstract: A photoacid generator compound P+A?, comprises an antenna group P+ comprising a cation that generates protons upon interaction with light, and A? comprising a weakly coordinating peracceptor-substituted aromatic anion that does not contain fluorine or semi-metallic elements such as boron. In one embodiment, such anions comprise the following compounds 4, 5, 6 and 7, wherein E comprises an electron-withdrawing group and the removal of one proton generates aromaticity. P+ comprises an onium cation that decomposes into a proton and other components upon interaction with photons. P+ may comprise an organic chalcogen onium cation or a halonium cation, wherein the chalcogen onium cation in another embodiment may comprises an oxonium, sulfonium, selenium, tellurium, or onium cation, and the halonium cation may comprise an iodonium, chlorine or bromine onium cation. A novel compound comprises TPS CN5.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: February 2, 2010
    Assignee: International Business Machines Corporation
    Inventors: Martin Glodde, Sen Liu, Irene Y. Popova
  • Patent number: 6379590
    Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solvent
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: April 30, 2002
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan
  • Patent number: 6153175
    Abstract: Compounds of the formula I according to claim 1 are excellently suitable as UV absorbers for use in cosmetic products, in particular sunscreen compositions, daytime care products and hair care products. They are furthermore suitable for protection of products.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: November 28, 2000
    Assignee: Haarmann & Reimer GmbH
    Inventors: Oskar Koch, Horst Surburg, Roland Langner, Horst Sommer
  • Patent number: 5993700
    Abstract: This invention provides an aggregate of a compound capable of forming helical structures such that the aggregate is capable of achieving a specific rotation of at least 100,000.degree. for plane polarized light having a wavelength of 589 nm.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: November 30, 1999
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas J. Katz, Colin P. Nuckolls
  • Patent number: 5478862
    Abstract: The invention is drawn to 17-oxo-15,16-seco-19-nor steroids which are useful as intermediates in the production of various 15,16-seco-19-nor progestins. These progestins display elevated progestational activity with a minimum of ancillary hormonal activity and are thus useful in the suppression of ovulation in the human female.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: December 26, 1995
    Assignee: SRI International
    Inventors: Richard H. Peters, Masato Tanabe
  • Patent number: 5354511
    Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.
    Type: Grant
    Filed: November 27, 1992
    Date of Patent: October 11, 1994
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan, Ajay Nahata
  • Patent number: 5245028
    Abstract: Processes for the preparation of a series of tetracyclic amines useful in the treatment and/or prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: September 14, 1993
    Assignee: Warner-Lambert Company
    Inventor: Thomas C. Malone
  • Patent number: 5169991
    Abstract: A compound is a condensate of 1,2,3-trihydroxybenzene with an aldehyde. The condensate is a macrocyclic compound such as a cyclic tetramer. The aldehyde is preferably a long-chain aldehyde such as hexanal, dodecanal or tetradecanal. The condensate can be used as an anti-wear additive in hydrocarbon liquids such as liquid paraffin or as an anti-corrosion additive. The condensate can be prepared by reacting 1,2,3-trihydroxybenzene with an equimolar quantity of an aldehyde in the presence of an acid.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: December 8, 1992
    Assignee: Imperial Chemicals Industries PLC
    Inventors: Jeremy M. Holmes, Peter A. Tasker
  • Patent number: 5140044
    Abstract: A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.
    Type: Grant
    Filed: March 27, 1990
    Date of Patent: August 18, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Teruo Kishi, Hiromitsu Saito, Hiroshi Sano, Isami Takahashi, Tatsuya Tamaoki
  • Patent number: 5116865
    Abstract: 15,16-Seco-19-nor progestins are provided which display elevated progestational activity with a minimum of ancillary hormonal activity. Processes for the preparation of the novel progestins are provided as are methods of use. A preferred method of use is in the suppression of ovulation in the human female.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: May 26, 1992
    Inventors: Richard H. Peters, Masato Tanabe
  • Patent number: 5068394
    Abstract: Herbicidal (hetero)aryloxynaphthalene derivatives of the formula ##STR1## in which X is N or --C--R.sup.5,R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are hydrogen or halogen or R.sup.1 may be cyano or trifluoromethyl,R.sup.3 is halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or trifluoromethylsulphonyl,Y is optionally halogen-substituted alkanediyl or alkenediyl, andZ is CN or --CC--Z', whereZ' is halogen, hydroxyl, amine, alkoxy, or the like.Intermediates of the formula ##STR2## are also new.
    Type: Grant
    Filed: October 19, 1989
    Date of Patent: November 26, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roland Andree, Michael Haug, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
  • Patent number: 4948911
    Abstract: New chemical compounds are derivatives of fluorenones and are useful as electron-transport agents in electrophotographic elements.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: August 14, 1990
    Assignee: Eastman Kodak Company
    Inventors: Douglas E. Bugner, Teh-Ming Kung, Louis J. Rossi
  • Patent number: 4904409
    Abstract: An optically active compound having characteristics necessary for realizing liquid crystal compositions provided with suitable characteristics, particularly a negative temperature characteristic and a very high twistability, and a liquid crystal composition containing the compound are provided, which optically active compound is expressed by the formula ##STR1## wherein R.sup.1 and R.sup.2 are 1-20 C alkyl or alkoxy or H; l, m and n are 0 or 1; X is F, Cl, Br or CN; and ##STR2## each independently represent ##STR3## wherein Y is H, halogen or CN.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: February 27, 1990
    Assignee: Chisso Corporation
    Inventors: Kazutoshi Miyazawa, Ohno Kouji, Naoyuki Yoshida, Masakazu Kaneoya
  • Patent number: 4883898
    Abstract: A new class of chemiluminescent compounds is described which has the ability to emit light which corresponds to the fluorescence of the compounds' breakdown products. This chemiluminescence is stimulated by the energetic decomposition of the chemiluminescent compound. These chemiluminescent compounds have the following structure: ##STR1## wherein X is hydrogen or an electron-withdrawing group; and Y is hydrogen or an electron-withdrawing group and both X and Y are not hydrogen.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: November 28, 1989
    Assignee: University of Chicago
    Inventor: Nien-chu C. Yang
  • Patent number: 4845263
    Abstract: Disclosed are photoresponsive imaging members comprised of sulfur incorporated dicyanomethylenefluorene carboxylate electron transporting compounds of the formula: ##STR1## wherein S is sulfur, A is a spacer group selected from the group consisting of alkylene groups, arylene groups, substituted alkylene groups, and substituted arylene groups, and B is selected from the group consisting of alkyl groups, aryl groups, substituted alkyl groups, and substituted aryl groups.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: July 4, 1989
    Assignee: Xerox Corporation
    Inventors: Beng S. Ong, Dasarao K. Murti
  • Patent number: 4834905
    Abstract: Compounds of the formulaR.sup.1 --Q.sup.1 --(CH.sub.2).sub.m --(COO).sub.n --(CH.sub.2).sub.p --Q.sup.2 --R.sup.2whereinR.sup.1 and R.sup.2 are each independently alkyl or alkoxy each of 1-12 C atoms, F, Cl, Br, CN or --Q.sup.3 --R.sup.3, or one of R.sup.1 and R.sup.2 can also be H;Q.sup.1, Q.sup.2 and Q.sup.3 are each independently 1,4-phenylene, 1,4-cyclohexylene, 1,4-bicyclo(2,2,2)-octylene or 1,3-dioxane-2,5-diyl, each of which is unsubstituted or substituted by 1-4 fluorine, chlorine or bromine atoms;R.sup.3 is alkyl or alkoxy each of 1-8 C atoms, H, F, Cl, Br or CN;m is 1, 2, 3, 4, 5 or 6; n is 0 or 1; and p is 0, 1, 2, 3, 4 or 5; the sum of (m+p) being 2, 4 or 6 and the sum of (m+n+p) being at least 3;but with the proviso that Q.sup.3 is unsubstituted 1,4-phenylene or 1,4-phenylene substituted by a fluorine, chlorine or bromine atom, only when n=1 or (m+p)=6 or at least one of R.sup.1 to R.sup.3 is F, Cl or Br or none of R.sup.1 to R.sup.3 is CN or two of the radicals R.sup.1 to R.sup.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: May 30, 1989
    Assignees: Merck Patent Gesellschaft mit beschrankter Haftung, The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Rudolf Eidenschink, Joachim Krause, Beatrice M. Andrews, George W. Gray, Neil Carr
  • Patent number: 4826996
    Abstract: The invention concerns 1,8-dihydroxy-9-anthrones substituted in the 10-position of the formula: ##STR1## in which R.sub.1 represents a group taken from the set constituted by: ##STR2## wherein R.sub.2 represents H, C.sub.1-8 alkyl, C.sub.1-3 mono- or poly-hydroxyalkyl, carbamoyl or phenyl,R.sub.3, R.sub.4, and R.sub.5 represent H, C.sub.1-8 alkyl, C.sub.3-8 mono- or poly-hydroxyalkyl, possibly interrupted by an oxygen, C.sub.3-6 cycloalkyl, or R.sub.3 and R.sub.4 form a divalent group: --(CH.sub.2).sub.(4 or 5) --, --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --, or --(CH.sub.2).sub.2 --N(R.sub.8)--(CH.sub.2).sub.2 --, R.sub.8 being H, --CH.sub.3, or --CH.sub.2 CH.sub.2 OH,R.sub.6 represents --CO.sub.2 R.sub.5, --CN, CHO, --CONH.sub.2, or --CONH--CH.sub.2 OH,and R.sub.7 and R'.sub.7 are H or --CH.sub.3, and their optical isomers.Utilization of the compounds (I) in human or veterinary medicine, in particular in the treatment of psoriasis and of warts, in cosmetics.
    Type: Grant
    Filed: December 9, 1985
    Date of Patent: May 2, 1989
    Assignee: Groupement d'Interet Economique dit Centre International De Recherches Dermatologioues C.I.R.D.
    Inventors: Braham Shroot, Jean Maignan, Gerard Lang
  • Patent number: 4803222
    Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fluoranthene or substituted fluoranthene ring system; R.sup.1 contains not more than eight carbon carbon atoms and is a group ##STR1## wherein m is 0 or 1;R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-3 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl;--C--C-- is a five- or six-membered saturated carbocyclic ring;R.sup.10 is hydrogen, methyl or hydroxymethyl;R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl;R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: February 7, 1989
    Assignee: Burroughs Wellcome Co.
    Inventor: Kenneth W. Bair
  • Patent number: 4708966
    Abstract: The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C.tbd.CH, C.dbd.CH.sub.2, C.dbd.C.dbd.CH.sub.2, and aldehydes in the form of their acetals.The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier.Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: November 24, 1987
    Assignee: The Procter & Gamble Company
    Inventors: Maurice E. Loomans, Randall S. Matthews, Joseph A. Miller