Polycyclo Ring System Having At Least Three Cyclos, At Least One Of Which Is A Benzene Ring Patents (Class 558/427)
-
Patent number: 10196471Abstract: The invention relates to a curable composition having an electron deficient olefin.Type: GrantFiled: October 22, 2009Date of Patent: February 5, 2019Assignees: Henkel IP & Holding GmbH, Henkel AG & Co. KGaAInventors: Stefano Gherardi, Ciaran B. McArdle, Ligang Zhao
-
Patent number: 9750841Abstract: A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.Type: GrantFiled: October 31, 2012Date of Patent: September 5, 2017Assignees: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHENGDU YIPING MEDICAL SCIENCE & TECHNOLOGY CO. LTDInventors: Keliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
-
Patent number: 8748015Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.Type: GrantFiled: September 3, 2013Date of Patent: June 10, 2014Assignee: Idemitsu Kosan Co., Ltd.Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
-
Publication number: 20140144509Abstract: The present invention relates to an organic solar cell comprising new truxequinone derivatives used as acceptor, electron transport material, and doped electron transport materials.Type: ApplicationFiled: September 5, 2011Publication date: May 29, 2014Applicant: Novaled AGInventors: Omrane Fadhel, Sascha Dorok, Horst Hartmann, Ramona Pretsch
-
Publication number: 20140001461Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
-
Publication number: 20130239661Abstract: The invention relates to the use of diazonium salts for the formation of thick layers on at least one surface of a substrate. The diazonium salts used in the invention have the following formula (I): wherein R is a group that can be electrochemically reduced in a reversible manner to a cathodic potential between 0 and ?1.5 V, E is a spacer chain consisting of at least one aromatic cyclic group having between 5 and 6 links, optionally containing at least one heteroatom preferably selected from N, S, O or P and optionally substituted by at least one group selected from the C1-C5 alkyls and the halogens, r is 1 or 2, m is a whole number between 1 and 5 inclusive, p is a whole number between 1 and 5, and B is a counter-ion. The invention can be especially applied to the field of gas sensors.Type: ApplicationFiled: August 31, 2011Publication date: September 19, 2013Applicant: Commissariat a L'Energie Atomique et aux Energies AlternativesInventors: Fabien Lefloch, Muriel Matheron
-
Publication number: 20130165684Abstract: The present invention relates to a process for obtaining a compound of formula (1), (2) or (3) by means of a electrocarboxylation with CO2. The present invention also relates to the new intermediates (1) and (2). The present invention further relates to the use of intermediates (1) and (2) as starting materials for the synthesis of SPAN derivatives.Type: ApplicationFiled: December 6, 2012Publication date: June 27, 2013Applicant: AIR PRODUCTS AND CHEMICALS, INC.Inventor: Air Products and Chemicals, Inc.
-
Publication number: 20130096336Abstract: Indenofluorenes that include at least two alkynyl-containing substituents.Type: ApplicationFiled: June 15, 2011Publication date: April 18, 2013Inventors: Michael M. Haley, Daniel T. Chase, Brad Rose, Aaron G. Fix
-
Publication number: 20120322717Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: December 20, 2012Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
-
Publication number: 20120289734Abstract: A three-stage method for synthesizing 1,1-disubstituted olefins is provided.Type: ApplicationFiled: April 27, 2012Publication date: November 15, 2012Applicant: Henkel AG & Co. KGaAInventors: Carsten Friese, Dieter Kaufmann, Vasu Govardhana Reddy Peddiahgari
-
Patent number: 8299247Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: GrantFiled: July 18, 2011Date of Patent: October 30, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventor: Hironobu Morishita
-
Publication number: 20120171103Abstract: The invention relates to a method of modifying electrical properties of carbon nanotubes by subjecting a composition of carbon nanotubes to one or more radical initiator(s). The invention also relates to an electronic component such as field-effect transistor comprising a carbon nanotube obtained using the method of the invention. The invention also relates to the use of the modified carbon nanotubes in conductive and high-strength nanotube/polymer composites, transparent electrodes, sensors and nanoelectromechanical devices, additives for batteries, radiation sources, semiconductor devices (e.g. transistors) or interconnects.Type: ApplicationFiled: June 28, 2010Publication date: July 5, 2012Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventors: Jianwen Zhao, Lain-Jong Li, Peng Chen, Bee Eng Mary Chan
-
Patent number: 8119828Abstract: A material for an organic electroluminescence device represented by the following formula (I): wherein X1 is one of divalent groups represented by the following (a) to (e); Y1 to Y4 are independently a carbon atom or a nitrogen atom; and R1 to R4 are independently a hydrogen atom, an alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocycle, a halogen atom, a fluoroalkyl group or a cyano group, or R1 and R2, and R3 and R4 are independently bonded to form a substituted or unsubstituted aromatic ring or a substituted or unsubstituted heterocycle.Type: GrantFiled: December 10, 2007Date of Patent: February 21, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventor: Hironobu Morishita
-
Publication number: 20110284827Abstract: An indenofluorenedione derivative having a specific structure, which is useful as a material for organic electroluminescence devices because the derivative is excellent in heat resistance and can be vapor-deposited on a substrate at moderate temperature. An organic electroluminescence device including an anode, a cathode, and an organic thin layer between the anode and the cathode, which contains the material for organic electroluminescence devices in the organic thin layer, is driven at a low driving voltage and has a long lifetime.Type: ApplicationFiled: December 2, 2009Publication date: November 24, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hironobu Morishita, Yuichiro Kawamura, Jun Endo
-
Publication number: 20110275814Abstract: A material for an organic electroluminescence device including an indenofluorenedione derivative shown by the following formula (I): wherein X1 and X2, which may be the same or different, are any of specific divalent groups; R1 to R10, which may be the same or different, are a hydrogen atom, an alkyl group, an aryl group, a heterocycle, a halogen atom, a fluoroalkyl group, an alkoxy group, an aryloxy group or a cyano group; and R3 to R6 or R7 to R10 may be bonded to each other to form a ring.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventor: Hironobu MORISHITA
-
Patent number: 8039194Abstract: A photoacid generator P+ A? comprises (a) an antenna group P+ comprising atoms with high EUV photoabsorption cross-sections according to FIG. 1 and A? anions; or (b) an antenna group P+ and A? comprising anions with low photoabsorption cross-sections for EUV; or (c) an antenna group P+, comprising atoms with high EUV photoabsorption cross-sections according to FIG. 1 and A? comprising anions with low photoabsorption cross-sections for EUV. Novel compounds comprise DTFPIO PFBuS, and DTBPIO CN5.Type: GrantFiled: January 8, 2008Date of Patent: October 18, 2011Assignee: Internatinal Business Machines CorporationInventor: Martin Glodde
-
Publication number: 20110147732Abstract: A benzofluoranthene derivative represented by the following formula (1): wherein at least one pair of “R1 and R2” and “R3 and R4” is bonded together to form a ring represented by the following formula (2):Type: ApplicationFiled: August 12, 2009Publication date: June 23, 2011Inventor: Yumiko Mizuki
-
Patent number: 7847092Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.Type: GrantFiled: December 9, 2005Date of Patent: December 7, 2010Assignees: FutureChem Co., Ltd., The Asan FoundationInventors: Dae Hyuk Moon, Dae Yoon Chi, Dong Wook Kim, Seung Jun Oh, Jin-sook Ryu
-
Publication number: 20100298200Abstract: The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.Type: ApplicationFiled: May 22, 2009Publication date: November 25, 2010Inventors: Dakai Liu, Xiaofeng Li, Richard Jin, Yuaxin Liang, Wei Cheng, Riddhi Bhattacharyya, Guangrong Zhang
-
Patent number: 7655379Abstract: A photoacid generator compound P+A?, comprises an antenna group P+ comprising a cation that generates protons upon interaction with light, and A? comprising a weakly coordinating peracceptor-substituted aromatic anion that does not contain fluorine or semi-metallic elements such as boron. In one embodiment, such anions comprise the following compounds 4, 5, 6 and 7, wherein E comprises an electron-withdrawing group and the removal of one proton generates aromaticity. P+ comprises an onium cation that decomposes into a proton and other components upon interaction with photons. P+ may comprise an organic chalcogen onium cation or a halonium cation, wherein the chalcogen onium cation in another embodiment may comprises an oxonium, sulfonium, selenium, tellurium, or onium cation, and the halonium cation may comprise an iodonium, chlorine or bromine onium cation. A novel compound comprises TPS CN5.Type: GrantFiled: January 8, 2008Date of Patent: February 2, 2010Assignee: International Business Machines CorporationInventors: Martin Glodde, Sen Liu, Irene Y. Popova
-
Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications
Patent number: 6379590Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solventType: GrantFiled: December 2, 1994Date of Patent: April 30, 2002Assignee: AlliedSignal Inc.Inventors: Chengjiu Wu, Jianhui Shan -
Patent number: 6153175Abstract: Compounds of the formula I according to claim 1 are excellently suitable as UV absorbers for use in cosmetic products, in particular sunscreen compositions, daytime care products and hair care products. They are furthermore suitable for protection of products.Type: GrantFiled: January 28, 1999Date of Patent: November 28, 2000Assignee: Haarmann & Reimer GmbHInventors: Oskar Koch, Horst Surburg, Roland Langner, Horst Sommer
-
Patent number: 5993700Abstract: This invention provides an aggregate of a compound capable of forming helical structures such that the aggregate is capable of achieving a specific rotation of at least 100,000.degree. for plane polarized light having a wavelength of 589 nm.Type: GrantFiled: July 18, 1997Date of Patent: November 30, 1999Assignee: The Trustees of Columbia University in the City of New YorkInventors: Thomas J. Katz, Colin P. Nuckolls
-
Patent number: 5478862Abstract: The invention is drawn to 17-oxo-15,16-seco-19-nor steroids which are useful as intermediates in the production of various 15,16-seco-19-nor progestins. These progestins display elevated progestational activity with a minimum of ancillary hormonal activity and are thus useful in the suppression of ovulation in the human female.Type: GrantFiled: May 13, 1994Date of Patent: December 26, 1995Assignee: SRI InternationalInventors: Richard H. Peters, Masato Tanabe
-
Patent number: 5354511Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.Type: GrantFiled: November 27, 1992Date of Patent: October 11, 1994Assignee: AlliedSignal Inc.Inventors: Chengjiu Wu, Jianhui Shan, Ajay Nahata
-
Patent number: 5245028Abstract: Processes for the preparation of a series of tetracyclic amines useful in the treatment and/or prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: September 3, 1991Date of Patent: September 14, 1993Assignee: Warner-Lambert CompanyInventor: Thomas C. Malone
-
Patent number: 5169991Abstract: A compound is a condensate of 1,2,3-trihydroxybenzene with an aldehyde. The condensate is a macrocyclic compound such as a cyclic tetramer. The aldehyde is preferably a long-chain aldehyde such as hexanal, dodecanal or tetradecanal. The condensate can be used as an anti-wear additive in hydrocarbon liquids such as liquid paraffin or as an anti-corrosion additive. The condensate can be prepared by reacting 1,2,3-trihydroxybenzene with an equimolar quantity of an aldehyde in the presence of an acid.Type: GrantFiled: February 28, 1990Date of Patent: December 8, 1992Assignee: Imperial Chemicals Industries PLCInventors: Jeremy M. Holmes, Peter A. Tasker
-
Patent number: 5140044Abstract: A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.Type: GrantFiled: March 27, 1990Date of Patent: August 18, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Teruo Kishi, Hiromitsu Saito, Hiroshi Sano, Isami Takahashi, Tatsuya Tamaoki
-
Patent number: 5116865Abstract: 15,16-Seco-19-nor progestins are provided which display elevated progestational activity with a minimum of ancillary hormonal activity. Processes for the preparation of the novel progestins are provided as are methods of use. A preferred method of use is in the suppression of ovulation in the human female.Type: GrantFiled: January 28, 1991Date of Patent: May 26, 1992Inventors: Richard H. Peters, Masato Tanabe
-
Patent number: 5068394Abstract: Herbicidal (hetero)aryloxynaphthalene derivatives of the formula ##STR1## in which X is N or --C--R.sup.5,R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are hydrogen or halogen or R.sup.1 may be cyano or trifluoromethyl,R.sup.3 is halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or trifluoromethylsulphonyl,Y is optionally halogen-substituted alkanediyl or alkenediyl, andZ is CN or --CC--Z', whereZ' is halogen, hydroxyl, amine, alkoxy, or the like.Intermediates of the formula ##STR2## are also new.Type: GrantFiled: October 19, 1989Date of Patent: November 26, 1991Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Michael Haug, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
-
Patent number: 4948911Abstract: New chemical compounds are derivatives of fluorenones and are useful as electron-transport agents in electrophotographic elements.Type: GrantFiled: December 18, 1989Date of Patent: August 14, 1990Assignee: Eastman Kodak CompanyInventors: Douglas E. Bugner, Teh-Ming Kung, Louis J. Rossi
-
Patent number: 4904409Abstract: An optically active compound having characteristics necessary for realizing liquid crystal compositions provided with suitable characteristics, particularly a negative temperature characteristic and a very high twistability, and a liquid crystal composition containing the compound are provided, which optically active compound is expressed by the formula ##STR1## wherein R.sup.1 and R.sup.2 are 1-20 C alkyl or alkoxy or H; l, m and n are 0 or 1; X is F, Cl, Br or CN; and ##STR2## each independently represent ##STR3## wherein Y is H, halogen or CN.Type: GrantFiled: September 1, 1988Date of Patent: February 27, 1990Assignee: Chisso CorporationInventors: Kazutoshi Miyazawa, Ohno Kouji, Naoyuki Yoshida, Masakazu Kaneoya
-
Patent number: 4883898Abstract: A new class of chemiluminescent compounds is described which has the ability to emit light which corresponds to the fluorescence of the compounds' breakdown products. This chemiluminescence is stimulated by the energetic decomposition of the chemiluminescent compound. These chemiluminescent compounds have the following structure: ##STR1## wherein X is hydrogen or an electron-withdrawing group; and Y is hydrogen or an electron-withdrawing group and both X and Y are not hydrogen.Type: GrantFiled: December 10, 1987Date of Patent: November 28, 1989Assignee: University of ChicagoInventor: Nien-chu C. Yang
-
Patent number: 4845263Abstract: Disclosed are photoresponsive imaging members comprised of sulfur incorporated dicyanomethylenefluorene carboxylate electron transporting compounds of the formula: ##STR1## wherein S is sulfur, A is a spacer group selected from the group consisting of alkylene groups, arylene groups, substituted alkylene groups, and substituted arylene groups, and B is selected from the group consisting of alkyl groups, aryl groups, substituted alkyl groups, and substituted aryl groups.Type: GrantFiled: August 9, 1985Date of Patent: July 4, 1989Assignee: Xerox CorporationInventors: Beng S. Ong, Dasarao K. Murti
-
Patent number: 4834905Abstract: Compounds of the formulaR.sup.1 --Q.sup.1 --(CH.sub.2).sub.m --(COO).sub.n --(CH.sub.2).sub.p --Q.sup.2 --R.sup.2whereinR.sup.1 and R.sup.2 are each independently alkyl or alkoxy each of 1-12 C atoms, F, Cl, Br, CN or --Q.sup.3 --R.sup.3, or one of R.sup.1 and R.sup.2 can also be H;Q.sup.1, Q.sup.2 and Q.sup.3 are each independently 1,4-phenylene, 1,4-cyclohexylene, 1,4-bicyclo(2,2,2)-octylene or 1,3-dioxane-2,5-diyl, each of which is unsubstituted or substituted by 1-4 fluorine, chlorine or bromine atoms;R.sup.3 is alkyl or alkoxy each of 1-8 C atoms, H, F, Cl, Br or CN;m is 1, 2, 3, 4, 5 or 6; n is 0 or 1; and p is 0, 1, 2, 3, 4 or 5; the sum of (m+p) being 2, 4 or 6 and the sum of (m+n+p) being at least 3;but with the proviso that Q.sup.3 is unsubstituted 1,4-phenylene or 1,4-phenylene substituted by a fluorine, chlorine or bromine atom, only when n=1 or (m+p)=6 or at least one of R.sup.1 to R.sup.3 is F, Cl or Br or none of R.sup.1 to R.sup.3 is CN or two of the radicals R.sup.1 to R.sup.Type: GrantFiled: October 3, 1986Date of Patent: May 30, 1989Assignees: Merck Patent Gesellschaft mit beschrankter Haftung, The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Rudolf Eidenschink, Joachim Krause, Beatrice M. Andrews, George W. Gray, Neil Carr
-
Patent number: 4826996Abstract: The invention concerns 1,8-dihydroxy-9-anthrones substituted in the 10-position of the formula: ##STR1## in which R.sub.1 represents a group taken from the set constituted by: ##STR2## wherein R.sub.2 represents H, C.sub.1-8 alkyl, C.sub.1-3 mono- or poly-hydroxyalkyl, carbamoyl or phenyl,R.sub.3, R.sub.4, and R.sub.5 represent H, C.sub.1-8 alkyl, C.sub.3-8 mono- or poly-hydroxyalkyl, possibly interrupted by an oxygen, C.sub.3-6 cycloalkyl, or R.sub.3 and R.sub.4 form a divalent group: --(CH.sub.2).sub.(4 or 5) --, --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --, or --(CH.sub.2).sub.2 --N(R.sub.8)--(CH.sub.2).sub.2 --, R.sub.8 being H, --CH.sub.3, or --CH.sub.2 CH.sub.2 OH,R.sub.6 represents --CO.sub.2 R.sub.5, --CN, CHO, --CONH.sub.2, or --CONH--CH.sub.2 OH,and R.sub.7 and R'.sub.7 are H or --CH.sub.3, and their optical isomers.Utilization of the compounds (I) in human or veterinary medicine, in particular in the treatment of psoriasis and of warts, in cosmetics.Type: GrantFiled: December 9, 1985Date of Patent: May 2, 1989Assignee: Groupement d'Interet Economique dit Centre International De Recherches Dermatologioues C.I.R.D.Inventors: Braham Shroot, Jean Maignan, Gerard Lang
-
Patent number: 4803222Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fluoranthene or substituted fluoranthene ring system; R.sup.1 contains not more than eight carbon carbon atoms and is a group ##STR1## wherein m is 0 or 1;R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-3 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl;--C--C-- is a five- or six-membered saturated carbocyclic ring;R.sup.10 is hydrogen, methyl or hydroxymethyl;R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl;R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.Type: GrantFiled: August 28, 1987Date of Patent: February 7, 1989Assignee: Burroughs Wellcome Co.Inventor: Kenneth W. Bair
-
Patent number: 4708966Abstract: The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C.tbd.CH, C.dbd.CH.sub.2, C.dbd.C.dbd.CH.sub.2, and aldehydes in the form of their acetals.The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier.Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals.Type: GrantFiled: June 27, 1986Date of Patent: November 24, 1987Assignee: The Procter & Gamble CompanyInventors: Maurice E. Loomans, Randall S. Matthews, Joseph A. Miller