Abstract: A method for preparing N,N?-bis(2-cyanoethyl-1,2-ethylenediamine involves using glycol ether as a catalyst for synthesis reaction in which ethylenediamine and acrylonitrile at a molar ratio of 1:1.9-2.1 are reactant that react at 20-70°C to prepare N,N?-bis(2-cyanoethyl)-1,2-ethylenediamine; the method improves the yield to 98.15-98.98%; and the used glycol ether may be filtered and recycled, thereby saving costs and reducing environmental pollution.

Abstract: A method for preparing N,N?-bis(2-cyanoethyl)-1,2-ethylenediamine involves using strongly acidic cation exchange resin as a catalyst for synthesis, and is advantageous for not only eliminating the need of distillation for purification and thereby reducing reaction time, but also improving the yield of N,N?-bis(2-cyanoethyl)-1,2-ethylenediamine to 97.70-98.08%; and the method benefits simplified process and reduced costs and helps to save water significantly, thereby minimizing environmental pollution.

Abstract: The present invention relates to a continuous process for the preparation of an aminonitrile comprising the stages of: a) formation of the aminonitrile by reaction between an alkenyl nitrile, mixed with aminonitrile, and a monoamine introduced in molar excess with respect to the alkenyl nitrile; b) separation of the unreacted monoamine and the aminonitrile; c) reaction between the monoamine separated during stage b) and all or part of the alkenyl nitrile in order to form a mixture of aminonitrile and of unreacted alkenyl nitrile, with the alkenyl nitrile being introduced in molar excess with respect to the said monoamine; d) transfer of the mixture of aminonitrile and alkenyl nitrile resulting from stage c) to the reaction of stage a), and e) in the case where only a portion of the alkenyl nitrile is introduced during stage c), introduction of the remaining molar amount of alkenyl nitrile into the mixture of stage d).

Abstract: The present invention relates to a process for preparing 3-dimethylaminopropylamine (DMAPA) by reacting 3-dimethylaminopropionitrile (DMAPN) with hydrogen in the presence of a catalyst, wherein the DMAPN used has a content of 2-(dimethylaminomethyl)glutaronitrile (DGN) of 300 ppm by weight or less, based on the DMAPN used. Furthermore, the present invention relates to mixtures of DMAPN and DGN, wherein the weight ratio of DMAPN to DGN is in the range from 1 000 000:5 to 1 000 000:250.

Abstract: The invention relates to a process for preparing tetraethylenepentamine (TEPA) by hydrogenation of diethylenetriaminediacetonitrile (DETDN) over a catalyst. If appropriate, DETDN can also be present as a constituent of an amino nitrile mixture which additionally comprises diethylenetriaminemonoacetonitrile (DETMN).

Abstract: A process for reacting formaldehyde cyanohydrin (FACH) with ethylenediamine (EDA) in a reactor with limited backmixing at a temperature in the range from 20 to 120° C., wherein the residence time in the reactor is 300 seconds or less.

Abstract: The present invention relates to a process for preparing 3-dimethylaminopropylamine (DMAPA) by reacting 3-dimethylaminopropionitrile (DMAPN) with hydrogen in the presence of a catalyst, wherein the DMAPN used has a content of 2-(dimethylaminomethyl)glutaronitrile (DGN) of 300 ppm by weight or less, based on the DMAPN used. Furthermore, the present invention relates to mixtures of DMAPN and DGN, wherein the weight ratio of DMAPN to DGN is in the range from 1 000 000:5 to 1 000 000:250.

Abstract: Disclosed is a method for preparing HIV reverse transcriptase inhibitors which inhibit replication of HIV in HIV infected cells, and novel intermediate compounds used therein.

Abstract: The present invention relates to a process for preparing an aminoalkyl nitrile by reaction of a corresponding monoamine with a corresponding alkenyl nitrile in a continuous mode of operation, which comprises the steps (a) introduction of the corresponding monoamine into a continuously conveyed reaction stream; (b) introduction of the corresponding alkenyl nitrite into the reaction stream, with this already comprising the aminoalkyl nitrile on addition; (c) reaction of the reaction stream in a first reaction region; and (d) at least partial transfer of the reaction stream into at least one second reaction region for further reaction. The invention further relates to a process for preparing a diamine from the aminoalkyl nitrile, suitable apparatuses for carrying out the processes and their corresponding use.

Abstract: Curative fibre components comprise one or more fibres for filaments of curative suitable to cure curable resins such as thermoset resin. In curative fibre components comprising a plurality of fibres of curative, the fibres can be commingled, such as twisting, to form a thread or yarn. Curative fibre components can be used to form a material in the form of a sheet, fabric, layer, textile or mat of woven or non-woven curative fibres. Curative fibre components can be used to produce composite materials such as fibre reinforced resinous composite materials. The curative fibre components can be commingled, including interwoven, stitched and layered with other fibres or fibrous materials, such as fibrous reinforcement, fibrous curable resin, fibrous thermoplastic, other non-reinforcing fibres to form composite materials, prepregs, preforms and articles.

Abstract: The invention relates to a process for isolating methylglycinenitrile-N,N-diacetonitrile (MGDN) from an aqueous emulsion which comprises MGDN and has an MGDN content of 3-50% by weight in a crystallizer, comprising the steps: (a) the aqueous emulsion is, starting from a temperature above the solidification point, cooled to a temperature below the solidification point, the cooling rate averaged over time not exceeding 5 K/h, until substantially the entirety of the emulsified MGDN has solidified, (b) the resulting aqueous suspension is cooled further and/or concentrated, and the cooling rate may be greater than in step (a).

Abstract: The invention relates to a process for preparing ?-aminopropionic acid derivatives by reacting a primary or secondary amine with an acrylic acid derivative, wherein comprises (i) a first primary or secondary amine is provided as an amine of value and reacted with the acrylic acid derivative, to obtain a reaction mixture comprising a first ?-aminopropionic acid derivative as a product of value and additionally unconverted acrylic acid derivative, (ii) the unconverted acrylic acid derivative present in the reaction mixture is reacted with a second secondary amine as a scavenger amine virtually fully to give a second ?-aminopropionic acid derivative to obtain a reaction mixture comprising the first ?-aminopropionic acid derivative as a product of value, the second ?-aminopropionic acid derivative and unconverted secondary amine.

Abstract: A process for making 3-aminopentanenitrile from a crude 2-pentenenitrile (“crude 2PN”) comprising 2-pentenenitrile, 2-methyl-2-butenenitrile, and 2-methyl-3-butenenitrile includes contacting the crude 2PN with an ammonia-containing fluid and water. The ammonia-containing fluid can include at least one reactant selected from the group consisting of ammonia, aqueous ammonia, and ammonium hydroxide.

Abstract: This invention relates to a method for producing sodium chloride-free compounds of formula (I), wherein R1, R2, R3 and Z are defined in the description. The method according to the invention is characterized by reacting a tertiary amine of the formula NR1R2R3 with chloroacetonitrile in an organic solvent and then adding an acid of the formula HZ.

Abstract: The present invention relates to a process for preparing an aminoalkyl nitrile by reaction of a corresponding monoamine with a corresponding alkenyl nitrile in a continuous mode of operation, which comprises the steps (a) introduction of the corresponding monoamine into a continuously conveyed reaction stream; (b) introduction of the corresponding alkenyl nitrite into the reaction stream, with this already comprising the aminoalkyl nitrile on addition; (c) reaction of the reaction stream in a first reaction region; and (d) at least partial transfer of the reaction stream into at least one second reaction region for further reaction. The invention further relates to a process for preparing a diamine from the aminoalkyl nitrile, suitable apparatuses for carrying out the processes and their corresponding use.

Abstract: The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture containing ACN, HMD, tetrahydrozaepine (THA), adiponitrile (ADN) and low boilers (LB). A method for producing a distillate stream comprising HMD is disclosed, which is suitable for the production of Nylon-6,6. The tails stream from the distillation of the mixture can be further distilled to produce a distillate containing ACN and THA, which is particularly suitable for use in the production of caprolactam and Nylon-6 from the caprolactam. Process conditions of the method of the invention disfavor the production of 2-cyanocyclopentylideneirnine (CPI).

Abstract: A method for making N,N?-bis(3-aminopropyl)-1,2-ethylenediamine which comprises reacting acrylonitrile and ethylenediamine in about a 2:1 molar ratio to make a N,N?-bis(cyanoethyl)-1,2-ethylenediamine reaction product and hydrogenating the reaction product, the improvement for improving the selectivity of the reactions to N,N?-bis(2-cyanoethyl)-ethylenediamine and to N,N?-bis(3-aminopropyl)-1,2-ethylenediamine which comprises reacting acrylonitrile and ethylenediamine in the presence of 2-30 wt % water, based on total reactants.

Abstract: The invention relates to a process for isolating methylglycinenitrile-N,N-diacetonitrile (MGDN) from an aqueous emulsion which comprises MGDN and has an MGDN content of 3-50% by weight in a crystallizer, comprising the steps: (a) the aqueous emulsion is, starting from a temperature above the solidification point, cooled to a temperature below the solidification point, the cooling rate averaged over time not exceeding 5 K/h, until substantially the entirety of the emulsified MGDN has solidified, (b) the resulting aqueous suspension is cooled further and/or concentrated, and the cooling rate may be greater than in step (a).

Abstract: A process for reducing the level of an aliphatic monounsaturated amine (IV) in a mixture (V) containing an aminonitrile (I) or a diamine (II) or a dinitrile (III) or mixtures thereof as well as said mine (IV) by a) reacting said mixture (V) with an anionic nucleophile (VI) which contains a nucleophilic atom selected from the group consisting of oxygen, nitrogen and sulfur, which is capable of taking up an H+ ion to form an acid having a pKa value in the range from 7 to 11, as measured in water at 25° C., and which has a relative nucleophilicity, as measured in methyl perchlorate/methanol at 25° C., in the range from 3.4 to 4.7 when said nucleophilic atom is oxygen, in the range from 4.5 to 5.8 when said nucleophilic atom is nitrogen, and in the range from 5.5 to 6.8 when said nucleophilic atom is sulfur, in an amount in the range from 0.01 to 10 mol per mole of said amine (IV) in said mixture (V) at a temperature in the range from 50 to 200° C.

Abstract: The invention relates to a method for separating by distillation a portion or the entirety of an azeptine derivative (III), which is selected from the group consisting of aminohexylidene imine, tetrahydroazepine, hexylhexahydroazepine and of aminohexylhexahydroazepine, out of a mixture (II) containing an azepine derivative (III) and an amine (I). The inventive method is characterized in that the distillation is carried out with a maximum bottom temperature of 150° C.

Abstract: The invention relates to a method for producing hydrolysis-stable ammonium nitriles by reacting a compound of formula (1), wherein R1, R2, and R3 are identical or different and represent linear or branched C1–C24-alkyl groups, C2–C24-alkenyl groups, substituted or non-substituted benzyl or C1–C4-alkoxy-C1–C4-alkyl groups, or wherein R1 and R2, together with the nitrogen atom to which they are bonded, form a ring with 4 to 6 C-atoms which can be substituted with C1–C5 alkyl, C1–C5 alkoxy, C1–C5 alkanoyl, phenyl, amino, ammonium, cyano, cyanamino, chlorine or bromine and which can contain in addition to the nitrogen atom, instead of the carbon atoms, one or two oxygen or nitrogen atoms, a group N—R6 or a group R3—N—R6, wherein R6 is hydrogen, C1–C5-alkyl, C2–C5-alkenyl, C2–C5-alkinyl, phenyl, C7–C9-aralkyl, C5–C7-cycloalkyl, C1–C6-alkanoyl, cyanomethyl or cyan, R4 and R5 are hydrogen, C1–C4-alkyl, C1–C4-alkenyl, C1–C4-alkoxy-C1–C4-alkyl, phenyl or C1–C3-alkylphenyl, preferably hydrogen, methyl or phenyl, R4 esp

Abstract: The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that has a hexamethylenediamine content of less than 1 wt. -%, b) removing completely or partially the 6-aminocapronitrile from mixture (I) while obtaining a mixture (II) whose content in substances that have a higher boiling point as 6-aminocapronitrile under distillation conditions and that cannot be formed by dimerization reactions when 6-aminocapronitrile is thermally treated is less than 1 wt. -%, and c) completely or partially removing from mixture (II) the hexamethylenediamine that might be present while obtaining a mixture (IV) whose hexamethylenediamine content is higher than that of mixture (II), and a mixture (V) whose hexamethylenediamine content is lower than that of mixture (II).

Abstract: The present invention comprises the simultaneous ring opening and concomitant N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitriles in presence of catalytic amount of metal triflates to afford different N-substituted ?-amino nitriles in excellent yields and selectivities.

Abstract: A process is provided for reducing the content of a monounsaturated aliphatic amine (III) in a mixture (IV) containing an aminonitrile (I) or a diamine (II), or mixtures thereof, and the amine (III), wherein a) the mixture (IV) is reacted with an anionic nucleophile (V),  which contains a nucleophilic atom selected from the group comprising oxygen, nitrogen and sulfur,  which is capable of taking up an H+ ion to form an acid with a pKa ranging from 7 to 11, measured in water at 25° C., and  which has a relative nucleophilicity, measured in methyl perchlorate/methanol at 25° C.,  ranging from 3.4 to 4.7 when oxygen is the nucleophilic atom,  ranging from 4.5 to 5.8 when nitrogen is the nucleophilic atom, and  ranging from 5.5 to 6.8 when sulfur is the nucleophilic atom,  in an amount ranging from 0.

Abstract: The present invention relates to the hemihydrogenation of dinitriles to corresponding aminonitriles.

Abstract: The present invention is to provide a 3,3-dialkoxy-2-hydroxyiminopropionitrile represented by the formula (1): 1

Abstract: Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.

Abstract: Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and an additive for improving the yield of and/or selectivity to the aminonitrile.

Abstract: The invention relates to a method for producing hydrolysis-stable ammonium nitriles by reacting a compound of formula (1), wherein R1, R2, and R3 are identical or different and represent linear or branched C1-C24-alkyl groups, C2-C24-alkenyl groups, substituted or non-substituted benzyl or C1-C4-alkoxy-C1-C4-alkyl groups, or wherein R1 and R2, together with the nitrogen atom to which they are bonded, form a ring with 4 to 6 C-atoms which can be substituted with C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkanoyl, phenyl, amino, ammonium, cyano, cyanamino, chlorine or bromine and which can contain in addition to the nitrogen atom, instead of the carbon atoms, one or two oxygen or nitrogen atoms, a group N—R6 or a group R3—N—R6, wherein R6 is hydrogen, C1-C5-alkyl. C2-C5-alkenyl, C2-C5-alkinyl, phenyl, C7-C9-aralkyl, C5-C7-cycloalkyl. C1-C6-alkanoyl, cyanomethyl or cyan, R4 and R5 are hydrogen, C1-C4-alkyl, C1-C4-alkenyl.

Abstract: The invention relates to stereoisomerically enriched diamines, to metal complexes comprising these diamines and also to their use in a process for asymmetrically reducing ketones using silanes, in particular polymethylhydrosiloxane, as reducing agents.

Abstract: The invention relates to a method for removing, by distillation, 6-aminocapronitrile from mixtures that contain 6-aminocapronitrile, adipodinitrile and hexamethylenediamine, by a) removing the hexamethylenediamine from the mixture while obtaining a mixture (I) that has a hexamethylenediamine content of less than 1 wt.-%, b) removing completely or partially the 6-aminocapronitrile from mixture (I) while obtaining a mixture (II) whose content in substances that have a higher boiling point as 6-aminocapronitrile under distillation conditions and that cannot be formed by dimerization reactions when 6-aminocapronitrile is thermally treated is less than 1 wt.-%, and c) completely or partially removing from mixture (II) the hexamethylenediamine that might be present while obtaining a mixture (IV) whose hexamethylenediamine content is higher than that of mixture (II), and a mixture (V) whose hexamethylenediamine content is lower than that of mixture (II).

Abstract: A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may further comprise a recrystalizing step, wherein an enantiomerically enriched 3-amino nitrile salt is produced. The process may further comprise a salt exchanging step, wherein another acid is added to the chiral 3-amino nitrile salt or the enantiomerically enriched 3-amino nitrile salt to produce another 3-amino nitrile salt.

Abstract: A one-pot process for the preparation of functional alkoxyamines of the general formula (I), 1

Abstract: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.

Abstract: Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and a fluoride additive.

Abstract: Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and tetraalkylammonium hydroxide and/or tetraalkylphosphonium hydroxide additive.

Abstract: Compounds of the general formula I Z—CH2—NY2−nHn  (I) where n is 0 or 1, Z is a straight-chain or branched polyalkyl radical having a number average molecular weight of from about 150 to 40,000, and Y is a radical of the formula IIa or IIb  where the radicals R, R1 and R2 independently of one another, are each hydrogen, an unsubstituted or substituted alkyl, alkenyl or alkynyl radical or an unsubstituted or substituted cycloalkyl, aryl or arylalkyl radical, which may carry one or more heteroatoms, and A is an alkyleneimine radical; or, if n is 0, one of the radicals Y may be a polyoxyalkylene radical, and processes for their preparation and fuel and lubricant compositions, and mixtures of additives, which contain the novel compounds.

Abstract: Disclosed are novel succinate derivative compounds of the formula (I)/(Ia): 1

Abstract: The present invention relates to a process for the purification of aliphatic aminonitriles and more particularly of 6-aminocapronitrile. It consists more specifically in subjecting 6-aminocapronitrile to a hydrogenation with molecular hydrogen in the presence of a catalyst comprising at least one metal chosen from palladium, platinum, ruthenium, osmium, iridium or rhodium and a promoter agent or a preconditioning in order to improve the selectivity of the hydrogenation.

Abstract: Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and an amide additive.

Abstract: The invention relates to N-unsubstituted imidic ester alkyl sulphates, N-unsubstituted amidinium alkyl sulphates and a process for their preparation, which is characterized in that carboxamides are converted with sulphuric diesters into the corresponding imidic ester alkyl sulphates, which are reacted further with ammonia to give the analogous amidinium alkyl sulphates.

Abstract: The invention concerns a method for preparing alkoxyamines in a biphasic medium. Said method consists in mixing an ionic liquid, an organic solvent, a metal salt, a metal ligand, a halogeno-carbonaceous ZX compound and a nitroxide, maintaining the reaction medium under agitation at a temperature between 20° C. and 90° C., until the nitroxide is eliminated, decanting, recuperating the organic phase, optionally washing it with water and then in isolating the alkoxyamine by evaporating the organic solvent under reduced pressure.

Abstract: The invention concerns the hydrogenation in amine function of a nitrile function of a dinitrile to obtain the corresponding aminonitrile. More precisely, the invention concerns the hemihydrogenation of a dinitrile into the corresponding aminonitrile, in a liquid medium, characterized in that it consists in operating in the presence of a Raney nickel or cobalt catalyst containing copper and/or silver and/or gold and in the presence of an alkaline or alkaline-earth metal hydroxide. The hemihydrogenation of adiponitrile provides amino-6 capronitrile, compound which can be easily transformed by cyclization hydrolysis into caprolactam, the starting product for the synthesis of polyamide-6.

Abstract: Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.

Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

Abstract: Disclosed is a process for the oxidation of sulfonamides to sulfonyl imines using chromium (IV) dioxide as the oxidant.

Abstract: The present invention is directed towards compounds of the general formula (I) 1

Abstract: A material useful as catalyst for the hydrogenation of alpha, Omega-dinitriles comprises a) iron or a compound based on iron or mixtures thereof, (b) from 0.001 to 0.3% by weight based on (a) of a promoter based on 2, 3, 4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium, (c) from 0 to 0.3% by weight based on (a) of a compound based on an alkali and/or alkaline earth metal, and also (d) from 0.001 to 1% by weight based on (a) of manganese.

Abstract: A material useful as catalyst for the hydrogenation of alpha, omega-dinitriles comprises

Abstract: A process for preparing aliphatic alpha,omega-amino nitrites by partial hydrogenation of aliphatic alpha,omega-dinitriles in the presence of a catalyst, wherein the catalyst used for the partial hydrogenation comprises (a) iron or a compound based on iron or mixtures thereof and (b) from 0.01 to 5% by weight, based on (a), of a promoter based on 2,3,4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium and (c) from 0 to 5% by weight, based on (a), of a compound based on an alkali metal or alkaline earth metal.