Sulfoxy In Acid Moiety Patents (Class 560/11)
  • Patent number: 4178460
    Abstract: The invention is 2-haloalkyl(oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids which are useful intermediates in the preparation of insecticides of m-phenoxybenzyl and .alpha.-cyano-m-phenoxybenzyl esters.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: December 11, 1979
    Assignee: American Cyanamid Co.
    Inventors: Gerald Berkelhammer, Venkataraman Kameswaran
  • Patent number: 4163106
    Abstract: 6-Alkenyl-bicyclo[3.1.0]hexanone compounds represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, and R.sup.2 represents a substituted or unsubstituted alkyl group having 1 to 8 carbon atoms;Cyclopentanone compounds represented by the formula (II) ##STR2## wherein R.sup.2 is as defined above, R.sup.3 represents a hydrogen atom or a --COOR.sup.1 group wherein R.sup.1 is as defined above, R.sup.4 represents a hydrogen atom or a --CH.sub.2 --Y--(CH.sub.2).sub.n --COOR.sup.6 wherein Y represents a --CH.sub.2 CH.sub.2 -- group or a --CH.dbd.CH-- group, R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and n is an integer of 0 to 6, R.sup.5 represents a --S--R.sup.7 group or a --SO--R.sup.7 group wherein R.sup.7 represents an alkyl group having 1 to 4 carbon atoms or an aryl group, with the proviso that R.sup.3 and R.sup.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: July 31, 1979
    Assignee: Sagami Chemical Research Center
    Inventors: Kiyosi Kondo, Daiei Tunemoto
  • Patent number: 4159991
    Abstract: .alpha.-Acyloxy-N,N'-diacylmalonamides of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different and are hydrogen, straight chain or branched alkyl radicals having from one to eleven carbon atoms, or hydrocarbon radicals with six to twelve carbon atoms and comprising at least one aromatic ring, are novel compounds prepared by the action of a mixture of carboxylic acids R.sub.3 COOH and R.sub.4 COOH upon an .alpha.-acyloxymalononitrile, R.sub.1 COO--C(CN).sub.2 --R.sub.2, in the presence of an acid catalyst and are useful as intermediates in organic synthesis and low temperature activators in bleaching or scouring compositions.
    Type: Grant
    Filed: August 22, 1977
    Date of Patent: July 3, 1979
    Assignee: Produits Chimiques Ugine Kuhlmann
    Inventors: Bernard Dubreux, Serve Y. Delavarenne, Jean-Pierre Schirmann
  • Patent number: 4156011
    Abstract: The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2,Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.
    Type: Grant
    Filed: April 5, 1977
    Date of Patent: May 22, 1979
    Assignee: Societe Anonyme dite: Laboratoire L. Lafon
    Inventors: Victor Lafon, Louis Lafon
  • Patent number: 4152457
    Abstract: Tropone derivatives substituted with an amino-, thio- or oxy-derivative of oxalic acid or acetic acid are disclosed. In addition, the tropone nucleus can be optionally further substituted. The foregoing compounds are useful for preventing or treating allergic conditions in a mammal. Methods for the preparation and use of the compounds are disclosed.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: May 1, 1979
    Assignee: Ayerst, McKenna and Harrison Limited
    Inventors: Jehan F. Bagli, Tibor Bogri
  • Patent number: 4152511
    Abstract: The invention relates to halogenous polyesters with the recurrent general formula ##STR1## in which at least part of the R's, e.g.
    Type: Grant
    Filed: October 19, 1976
    Date of Patent: May 1, 1979
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Gerhard Bier, Dagmar Kottek, Egon N. Petersen, Hermann Richtzenhain, Norbert Vollkommer
  • Patent number: 4148915
    Abstract: Bis (2-phenoxyalkane carboxylic acids) and their esters and salts, as well as a method for their preparation. These compounds are useful for the treatment of hyperlipemia and arteriosclerosis.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: April 10, 1979
    Assignee: Albert Rolland, S.A.
    Inventors: Germaine Thuillier, Sylviane S. J. Mignonac, Pierre A. R. Bessin
  • Patent number: 4127728
    Abstract: A process for the preparation of a substituted 1-phenyl-2,2,2-trihalo-ethanol ester of the formula ##STR1## in which R is alkyl, halogenoalkyl, alkoxy, cycloalkyl or optionally substituted phenyl, benzyl, phenoxy, or phenylsulfonyl,X is halogenoalkyl with 1-3 carbon atoms and 1-3 halogen atoms,Y is halogen, cyano, nitro, alkyl, alkoxy, alkylmercapto, sulfoalkoxy or optionally substituted methylenedioxy, andn is an integer from 0 to 3,Comprising reacting a compound of the formula ##STR2## WITH A HALOGENATED ALDEHYDE OF THE FORMULAX CHOin the presence of a Friedel-Crafts catalyst at a temperature of about -70 to +100.degree. C thereby to form a complex alcoholate, and reacting the complex alcoholate with an acid halide of the formula ##STR3## OR WITH A CORRESPONDING ACID ANHYDRIDE AT A TEMPERATURE OF ABOUT -70 TO +100.degree. C.
    Type: Grant
    Filed: August 24, 1976
    Date of Patent: November 28, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Schmidt, Wolfgang Kramer, Eckart Kranz
  • Patent number: 4125729
    Abstract: This invention discloses .alpha.-aryloxy para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: November 14, 1978
    Assignee: American Cyanamid Company
    Inventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
  • Patent number: 4122026
    Abstract: A nematic liquid crystal mixture comprises at least one nematic liquid crystal compound and an amount, sufficient to impart a positive DC anisotropy of at least about 15 to said mixture, of at least one liquid crystalline or potentially liquid crystalline compound having a positive DC anisotropy of above about 25, of the formula (1) ##STR1## wherein X is a monovalent radical of the formula --NR.sup.3 R.sup.4 or --N(R.sup.5)(CHO); Y is a bivalent radical of the formula --CH.dbd.N--, --N.dbd.CH--, --N.dbd.N--, --CH.dbd.CH--, --C(O)O--, --O(O)C--, --C(O)S--, --S(O)C--, --C.tbd.C-- or ##STR2## Z is a monovalent radical of the formula --CN, --NO.sub.2, --SO.sub.2 CH.sub.3, --SO.sub.2 CF.sub.3 or --NHCOR.sup.5 ; R.sup.1 and R.sup.2 are the same or different and each is fluorine, chlorine, bromine, methyl or hydroxy; R.sup.3 and R.sup.4 are the same or different and each is hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R.sup.
    Type: Grant
    Filed: May 4, 1977
    Date of Patent: October 24, 1978
    Assignee: BBC Brown, Boveri & Company Limited
    Inventor: Maged A. Osman
  • Patent number: 4110538
    Abstract: Acetal sulphones useful as intermediates in the preparation of vitamin A and other terpene compounds are made by reacting a sulphone of the formula: ##STR1## with an .omega.-halogeno-acetal of an ethylenically unsaturated aldehyde of the formula: ##STR2## in which m and n each represent zero or 1 and are such that m+n=1, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen or straight or branched alkyl radical of 1 to 6 carbon atoms, R.sub.6 represents straight or branched alkyl of 1 to 6 carbon atoms, R represents straight or branched alkyl of 1 to 6 carbon atoms or arylalkyl containing a straight or branched alkyl of from 1 to 6 carbon atoms or aryl, unsubstituted or substituted by alkyl, alkoxy, alkylthio, alkoxycarbonyl, hydroxyl or halogen, and R' represents hydrogen or, if m is zero, straight or branched alkyl of 1 to 6 carbon atoms.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: August 29, 1978
    Assignee: Rhone-Poulenc Industries
    Inventor: Jean-Pierre Decor
  • Patent number: 4108887
    Abstract: Disclosed are compounds of formula I ##STR1## in which R.sub.1 and R.sub.4, independently, are hydrogen, a non-chromophoric second order substituent, or alkyl or alkenyl unsubstituted or substituted by a non-chromophoric group,R.sub.2 and R.sub.5, independently, are hydrogen or alkyl or alkenyl, unsubstituted or substituted by a non-chromophoric group,R.sub.3 and R.sub.6, independently, are hydrogen, alkyl, carboxyl or a non-chromophoric esterified carboxyl group, orR.sub.2, together with R.sub.3, and/or R.sub.5 together with R.sub.6, signify an alkylene bridge,R.sub.7 and R.sub.8, independently, signify hydrogen or a non-chromophoric substituent, or, whenR.sub.7 is in the 3-position and/or R.sub.8 in the 3' position, R.sub.7 together with R.sub.2, and/or R.sub.8 together with R.sub.5 signify an alkylene bridge,With the proviso that no more than one of R.sub.1 and R.sub.2 and no more than one of R.sub.4 and R.sub.5 signify hydrogen, their production and use as optical brightening agents.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: August 22, 1978
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Juerg Heller
  • Patent number: 4083863
    Abstract: Certain derivatives of cyclopropane carboxylic acid and their esters are useful and valuable intermediates for the preparation of broad spectrum pyrethroid type pesticides. The invention provides a novel method for the preparation of the derivatives of cyclopropane carboxylic acid and esters from stable sulfonium ylides.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: April 11, 1978
    Assignee: American Cyanamid Corporation
    Inventor: William Wayne Brand
  • Patent number: 4070178
    Abstract: Diphenyl ethers of the formula ##STR1## whereinR.sup.1 is hydrogen or halogen,R.sup.2 is hydrogen, halogen, or cyano,R is ##STR2## wherein R.sup.3 is hydrogen, halogen, nitro, alkyl, or alkoxy,R.sup.4 is a divalent alkylene radical, andR.sup.5 is cyano or -COR.sup.6, wherein R.sup.6 is alkoxy, hydroxy or salt thereof, allyloxy, alkoxyalkoxy, amino, alkyl or dialkyl amino, aminoalkoxy, or alkyl or dialkylaminoalkoxy,And diphenyl sulfides, sulfoxides, and sulfones of the formula ##STR3## wherein R.sup.8 is hydrogen, halogen, cyano, nitro, alkyl, alkoxy, or trifluoromethyl,R.sup.2 is hydrogen, halogen or cyano,X is sulfur, sulfinyl, or sulfonyl, andR is as defined above,And compositions containing these compounds exhibit herbicidal activity.
    Type: Grant
    Filed: July 30, 1976
    Date of Patent: January 24, 1978
    Assignee: Rohm and Haas Company
    Inventors: Wayne O. Johnson, Roy Y. Yih
  • Patent number: 4066686
    Abstract: The invention provides the benzhydrylsulphinyl derivatives of the formula:(C.sub.6 H.sub.5).sub.2 CH--SO--(CH.sub.2).sub.n --R Iwhere n is 1, 2 or 3 and R is C(.dbd.O)NHOH, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, 2-.DELTA..sup.2 -imidazolinyl or NR.sub.1 R.sub.2 (where R.sub.1 is H or C.sub.1 -C.sub.3 -alkyl and R.sub.2 is H, C.sub.1 -C.sub.3 -alkyl, or CH.sub.2 CH.sub.2 OH, and R.sub.1 and R.sub.2 considered together can form, with the nitrogen atom to which they are bonded, a N-heterocyclic group of 5 to 7 ring members, which can be substituted and can contain a second hetero-atom such as O and N), and their addition salts. These products are useful in therapy for treating disturbances of the central nervous system.
    Type: Grant
    Filed: September 30, 1976
    Date of Patent: January 3, 1978
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4065437
    Abstract: New thermoplastic polymers based on aromatic polyether-sulfones, which have molecular weights of from about 15,000 to 35,000 and contain units of the formula ##STR1## and a process for their manufacture.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: December 27, 1977
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Blinne, Claus Cordes
  • Patent number: 4062973
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen,R.sub.2 is hydroxyl, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 10 carbon atoms, amino, (alkyl of 1 to 3 carbon atoms)-amino, piperidino or morpholino, andn is 0, 1 or 2,Diastereoisomers thereof and, when R.sub.2 is hydroxyl, non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds, their diastereoisomers and the salts are useful as antithrombotics, anti-hypercholesteremics and anti-hyperglyceridemics.
    Type: Grant
    Filed: October 6, 1976
    Date of Patent: December 13, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Josef Nickl, Berthold Narr, Erich Muller, Josef Roch, Walter Haarmann
  • Patent number: 4058552
    Abstract: This invention is concerned with esters of p-carbonylphenoxy-isobutyric acids of the general formulae: ##STR1## WHEREIN R is a phenyl group substituted by one or two halogen atoms;R' is H, CH.sub.3, C.sub.6 H.sub.5, SCH.sub.3, OCH.sub.3, or, SO.sub.2 CH.sub.3 ;R" is CH.sub.3 or C.sub.2 H.sub.5 ;Y is C.sub.1 -C.sub.4 alkoxy, phenoxy, phenoxy substituted by one or two halogen atoms, or, OCH.sub.2 O--CO--C(CH.sub.3).sub.3 ;Z is C.sub.1 -C.sub.4 alkyl, phenyl or R;Nr.sub.1 r.sub.2 is N(CH.sub.3).sub.2 N(C.sub.2 H.sub.5).sub.2, morpholino, piperidino, azepino, pyrrolidino.This invention is also concerned with acid addition salts obtained from formula Ia compounds with acids.Compounds of formulae I and Ia are useful as hypocholesterolemiant and hypolipidemiant agents.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: November 15, 1977
    Assignee: Orchimed SA
    Inventor: Andre Mieville
  • Patent number: RE29608
    Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclizing an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
    Type: Grant
    Filed: February 1, 1977
    Date of Patent: April 11, 1978
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, David William Dunwell, Terence Alan Hicks