Carbamic Acid Patents (Class 560/132)
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Patent number: 9580383Abstract: The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing multiple sclerosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurodegenerative diseases and other neuro-inflammatory diseases.Type: GrantFiled: November 5, 2014Date of Patent: February 28, 2017Assignee: CELLIX BIO PRIVATE LIMITEDInventor: Mahesh Kandula
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Patent number: 9126924Abstract: Chemical compositions, lubricant compositions, and methods of using the same are provided. The lubricant composition may comprise at least on carrier. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces a coefficient of friction of the at least one surface. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces wear of the at least one surface.Type: GrantFiled: June 7, 2012Date of Patent: September 8, 2015Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Henry Raczkowski, D. Andrew Dineen, Jr., Daniel D'Auge
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Patent number: 8859805Abstract: The invention relates to a multistage process for the continuous preparation of organic, distillable polyisocyanates, preferably diisocyanates, particularly preferably aliphatic or cycloaliphatic diisocyanates, by reaction of the corresponding organic polyamines with carbonic acid derivatives and alcohols to form low molecular weight monomeric polyurethanes and thermal dissociation of the latter, in which the polyisocyanates produced and unusable residues are separated off at particular stages of the reaction and reusable by-products and intermediates are recirculated to preceding stages.Type: GrantFiled: September 9, 2010Date of Patent: October 14, 2014Assignee: BASF SEInventors: Torsten Mattke, Matthias Kloetzer, Eckhard Stroefer, Bernhard Geissler, Peter Zehner
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Patent number: 8779194Abstract: The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.Type: GrantFiled: October 25, 2007Date of Patent: July 15, 2014Assignee: Metkinen Chemistry OyInventors: Andrey Yagodkin, Alex Azhayev
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Patent number: 8609881Abstract: The present invention provides compound(s) selected from the group of compounds represented by structural Formula (I): wherein X, Y and R1 are as described herein, use of such compounds as anaerobic cure accelerators, and compostions including such compounds.Type: GrantFiled: May 7, 2008Date of Patent: December 17, 2013Assignee: Henkel IP US LCCInventors: Andrew Messana, Anthony F. Jacobine, Steven Thomas Nakos, David M. Glaser
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Publication number: 20120059007Abstract: This application relates to pharmacologically-active vanilloid compounds which are useful for the treatment of various anti-inflammatory states characterized by inhibition of FAAH, such as, Alzheimer's dementia, Parkinson's disease, depression, pain, rheumatoid arthritis, pathophysiology of mood disorders, multiple sclerosis, and inflammation, or antagonism of TRPV1, such as, for example, Huntington's disease, hypertension, arthritis, allergic airway inflammation, Crohn's disease, ulcerative colitis, and neuropathic pain.Type: ApplicationFiled: September 15, 2010Publication date: March 8, 2012Inventors: Jeffrey D. Laskin, Diane E. Heck, Carl Jeffrey Lacey, Erik Aponte, Mou-Tuan Huang, Ned D. Heindel
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Patent number: 8110704Abstract: Stable NCO prepolymers are produced from polyisocyanates having a melting point greater than 70° C., preferably, naphthalene diisocyanate, having advantageous physical properties. An important feature of the process of the present invention is the rapid cooling of the prepolymer. The process of the present invention may be carried out on a continuous or batch basis. The prepolymers of the present invention are particularly suitable for the production of cast polyurethane elastomers.Type: GrantFiled: November 2, 2006Date of Patent: February 7, 2012Assignees: Bayer MaterialScience LLC, Bayer MaterialScince AGInventors: James Michael Barnes, Hartmut Nefzger, Erika Bauer, Stefan Penninger, Thomas Schultz, Heinrich Lutz, Horst Di Mews, Charles S. Gracik
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Publication number: 20110318807Abstract: Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.Type: ApplicationFiled: September 6, 2011Publication date: December 29, 2011Inventors: Patrick G. Harran, Michael S. Brown, Joseph L. Goldstein, Jin Yang, Tong-Jin Zhao
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Patent number: 8058469Abstract: The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate which can be further derivitized to form non-activated carbamate or a urea. The urea or carbamate can be subjected to a pyrolysis reaction to form isocyanate.Type: GrantFiled: December 31, 2008Date of Patent: November 15, 2011Assignee: Sabic Innovative Plastics IP B.V.Inventors: Hatem Abdallah Belfadhel, Hans-Peter Brack, Ricardo Godoy-Lopez, Dennis James Patrick Maria Willemse
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Patent number: 7767843Abstract: A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein R1 and R2 independently are hydrogen or a C1-6 alkyl; R3 and R4 are the same or different and each is a C1-6 alkyl; or R3 and R4 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; R5 and R6 independently are hydrogen, linear, branched or cyclic C1-6 alkyl; or R5 and R6 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; the carbon centre designated “*” can be racemic or enantiomerically enriched in the (R)- or (S)- configuration; and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: March 2, 2006Date of Patent: August 3, 2010Assignee: Apotex Pharmachem Inc.Inventors: Zhi-Xian Wang, Stephen E. Horne, K. S. Keshava Murthy
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Patent number: 7737295Abstract: Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.Type: GrantFiled: April 8, 2005Date of Patent: June 15, 2010Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Joann Bohn, Qiaolin Deng, Zhijian Lu, Peter J. Sinclair, Gayle E. Taylor, Christopher F. Thompson, Nazia Quraishi
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Patent number: 7683205Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).Type: GrantFiled: October 31, 2006Date of Patent: March 23, 2010Assignee: Alembic LimitedInventors: Pandurang Balwant Deshpande, Kishore Khemani, Bharat Becharbhai Boda, Tushar Rajnikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Patent number: 7495028Abstract: R-enantiomer of Bambuterol, its preparation and therapeutic uses are disclosed. A composition includes R-Bambuterol or its therapeutically acceptable salt. A composition of R-Bambuterol includes at least 80% by weight of the R-enantiomer and not more than 20% by weight of the S-enantiomer based on a total weight of the Bmbuterol. A process includes: (a) asymmetrically reducing a suitably substituted and suitably protected bromoacetophenone compound to a chiral phenyl-bromoethanol comprising a primary bromo group and a secondary hydroxyl group; (b) displacing the bromo group by a suitably substituted and optionally protected primary amine to produce a protected chiral phenylethanolamine, and (c) removing the protecting groups to convert the protected chiral phenylethanolamine to a chiral phenylethanolamine.Type: GrantFiled: February 8, 2005Date of Patent: February 24, 2009Inventors: Wen Tan, Jiang Long Cheng
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Publication number: 20080045743Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).Type: ApplicationFiled: October 31, 2006Publication date: February 21, 2008Applicant: ALEMBIC LIMITEDInventors: Pandurang Balwant Deshpande, Kishore Khemani, Bharat Becharbhai Boda, Tushar Rajnikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
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Patent number: 7329689Abstract: A compound having formula (I) and a process for the preparation thereof are described.Type: GrantFiled: June 10, 2005Date of Patent: February 12, 2008Assignee: Italfarmaco SpAInventors: Massimo Pinori, Paolo Mascagni
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Patent number: 7253282Abstract: The invention is concerned with novel hexafluoroisopropanol substituted cyclohexane derivatives of formula (I) wherein R1 to R4, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.Type: GrantFiled: December 16, 2005Date of Patent: August 7, 2007Assignee: Hoffman-La Roche Inc.Inventors: Henrietta Dehmlow, Bernd Kuhn, Raffaello Masciadri, Narendra Panday, Hasane Ratni, Matthew Blake Wright
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Publication number: 20070155707Abstract: Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. Esters of alkylcarbamic acids are disclosed that are inhibitors of FAAH activity. Compounds disclosed herein inhibit FAAH activity. Described herein are processes for the preparation of esters of alkylcarbamic acid compounds, compositions that include them, and methods of use thereof.Type: ApplicationFiled: November 20, 2006Publication date: July 5, 2007Applicant: Kadmus Pharmaceuticals, Inc.Inventors: Olivier Dasse, David Putman, Timothy R. Compton
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Patent number: 7164037Abstract: Enzymatic preparation of (meth)acrylic esters containing urethane groups, and their use in radiation-curable compositions.Type: GrantFiled: December 4, 2003Date of Patent: January 16, 2007Assignee: BASF AktiengesellschaftInventors: Frank Dietsche, Dietmar Haering, Eva Wagner, Reinhold Schwalm, Heinz-Peter Rink, Erich Beck
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Patent number: 7122696Abstract: Herein are disclosed a process for increasing in purity, or purifying, an N-protected-?-aminoalcohol which process comprises (i) adding water to a polar organic solvent in which an N-protected-?-aminoalcohol such as a (2R,3S)- or (2S,3R)-3-tert-butoxycarbonylamino-1-halo-2-hydroxy-4-phenylbutane or the like, or (ii) crystallizing such an N-protected-?-aminoalcohol from a diol or a diol-based mixed solvent, and a process for producing the corresponding N-protected-?-aminoepoxide which process comprises treating, with a base, the thus purity-enhanced N-protected-?-aminoalcohol. Such N-protected-?-aminoalcohols and N-protected-?-aminoepoxides are both useful as synthetic intermediates for medicine compounds, such as, e.g., HIV protease inhibitor and the like.Type: GrantFiled: November 30, 2001Date of Patent: October 17, 2006Assignee: Ajinomoto Co., Inc.Inventors: Naoko Hirose, Tomoyuki Onishi, Daigaku Hideura, Yasuyuki Otake, Kunisuke Izawa
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Publication number: 20040087813Abstract: This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-[4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl]-L-glutamic acid: wherein: X2 is a halo group, and is —F, —Cl, —Br, or —I; n is an integer from 0 to 4; and, each RA is an aryl substituent. The methods comprise, at least, the steps of: glutamate conjugation (GC); silyloxy deprotection (SD); and, sulfonic esterification (SU). Certain preferred methods comprise the steps of: amine substitution (AS); silyloxy protection (SP); phenolic deprotection (PD); activation (AC); glutamate conjugation (GC); silyloxy deprotection (SD); sulfonic esterification (SU); halogenation (HL); glutamate deprotection (GD); and glutamic acid protection (GP).Type: ApplicationFiled: July 29, 2003Publication date: May 6, 2004Inventors: Caroline Joy Springer, Dan Niculescu-Duvaz
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Patent number: 6686494Abstract: A method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting a precursor thiol reagent with trichloroacetyl chloride to produce an S-alkyl and S-aryl trichloroacetyl thioester intermediate, which is reacted with an amine to yield the corresponding thiocarbamate product. Also disclosed is the method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting an amine with trichloroacetyl chloride to produce a trichloroacetamide intermediate, which is then reacted with the precursor thiol to yield the corresponding thiocarbamate product.Type: GrantFiled: March 6, 2003Date of Patent: February 3, 2004Assignee: The United States of America as represented by the Secretary of the NavyInventors: James W. Wynne, Arthur W. Snow
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Publication number: 20030229201Abstract: A novel method for synthesizing functional PNA having superior cost performance and which enables functional molecules to be-introduced extremely rapidly, and compounds used therein. Disclosed is a method for producing a functional PNA oligomer; wherein a PNA monomer unit having adenine, guanine, cytosine or thymine protected by a protecting group is reacted with. Fmoc-&ohgr;-amino acid-BocPNA-OH, and after synthesizing PNA oligomer, a functional molecule having free carboxylic acid is introduced into that PNA oligomer followed by deprotecting the protecting group; compounds synthesized by the method; and, Fmoc-&ohgr;-amino acid-BocPNA-OH that functions as a precursor PNA monomer unit.Type: ApplicationFiled: April 24, 2003Publication date: December 11, 2003Inventors: Hisafumi Ikeda, Madoka Tonosaki
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Patent number: 6642408Abstract: Novel addition products of isocyanates with oxyalkylene-substituted aminophenol compounds as intermediates for the production of urethane-substituted xanthene colorants, particularly triphenylmethane derivatives such as rhodamines, are provided. The xanthene colorants exhibit improved wax and/or oil solubility and high purity. The urethane-substituted xanthene colorant features very good wax and/or oil solubility, and is believed to be relatively nontoxic. A method for producing this novel colorant is also provided.Type: GrantFiled: September 25, 2002Date of Patent: November 4, 2003Assignee: Milliken & CompanyInventors: Rajnish Batlaw, Patrick D. Moore
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Publication number: 20030166961Abstract: Phenylurethane compounds of the following general formula (1); asymmetric urea compounds of the following general formula (10) obtained from the phenylurethane compounds; barbituric acid derivatives of general formula (18) produced from the asymmetric urea compounds, which have specific substituents and are useful in diazo thermal recording materials; and diazo thermal recording materials containing the barbituric acid derivative.Type: ApplicationFiled: January 27, 2003Publication date: September 4, 2003Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Akinori Fujita, Naoto Yanagihara, Yohsuke Takeuchi, Daisuke Arioka, Kimi Ikeda, Sachiko Arai
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Publication number: 20030125577Abstract: A compound of the formula (I) 1Type: ApplicationFiled: November 4, 2002Publication date: July 3, 2003Inventors: Paul F. Corey, Steven W. Felman, Gary E. Rehm, Michael J. Pugia
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Patent number: 6566481Abstract: A polyisocyanate of formula (I) OCN—R1—[—NX—CO—O—R2—O—CO—NH—R1—]n—NCO in which the units R1, X and R2 have the meanings: R1 is a unit of the formula (II): —CH2—CH2—CH2—CH2—CH2—CH2— (II) X is hydrogen or a unit of the formula (III): —CO—NH—R1—NCO (III), with the proviso that at least one of the units X in the polyisocyanates is a unit of formula (III); and R2 • is a 4-, 5- or 6-membered cycloalkylene group containing radical.Type: GrantFiled: January 26, 2001Date of Patent: May 20, 2003Assignees: BASF Aktiengesellschaft, BASF Coatings AGInventors: Bernd Bruchmann, Hans Renz, Günter Mohrhardt, Hubert Baumgart, Simone Bitter
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Patent number: 6548696Abstract: A low monomer 1:1-monoadduct from a diisocyanate and a hydroxy(meth)acrylate with a free diisocyanate content of less than 0.7% by weight and a free NCO content of 10.4-16.4% by weight can be used as a starting material for an acrylic or NCO functionalized crosslinker; a bonding agent for coatings and adhesives; and a linker for solid-phase synthesis of oligo-nucleotides, polynucleotides or peptides. The monoadduct is obtained by converting 5-20 mol diisocyanate with 1 mol hydroxy(meth)acrylate at a temperature of 40-120° C. in the presence of at least one inhibitor; subsequently separating a non-converted diisocyanate from a reaction product by short-path distillation at 80-220° C./0.1-10 mbar; feeding air, nitrogen monoxide or oxygen or a mixture containing (a) air, oxygen or nitrogen monoxide and (b) a proportion of 1-90% by volume of carbon dioxide, nitrogen, an inert gas or a mixture thereof through a reaction apparatus.Type: GrantFiled: August 8, 2001Date of Patent: April 15, 2003Assignee: Degussa AGInventors: Stephan Kohlstruk, Lothar Hayen, Emmanouil Spyrou
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Patent number: 6545160Abstract: Disclosed are compounds which bind &agr;4&bgr;7 integrin. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by &agr;4&bgr;7 integrin. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.Type: GrantFiled: May 20, 2002Date of Patent: April 8, 2003Assignee: Elan Pharmaceuticals, Inc.Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett
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Publication number: 20030023017Abstract: The invention relates to positional isomer diethyloctandioldicarbamates and diethyloctandioldiallophanates, to a method for the production thereof and to the use thereof as synthetic building blocks and constituents of adhesives, luting compounds and coating materials.Type: ApplicationFiled: July 22, 2002Publication date: January 30, 2003Inventors: Heinz-Peter Rink, Jochem Henkelmann, Werner-Alfons Jung, Paul J Harris, Swaminathan Ramesh
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Publication number: 20020161041Abstract: The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.Type: ApplicationFiled: December 21, 2001Publication date: October 31, 2002Inventors: Andrew Francis Browning, Eric William Collington, Martin James Procter, Joanna Victoria Geden
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Patent number: 6437078Abstract: An aliphatic polyurea prepolymer prepared by the catalyst-free, exothermic reaction of a caprolactone monomer, an aliphatic primary polyamine, and an aliphatic monomer-free polyisocyanate, such as a hexamethylene diisocyanate dimer or trimer or mixtures thereof.Type: GrantFiled: February 2, 2001Date of Patent: August 20, 2002Assignee: Hehr International Inc.Inventor: Stuart B. Smith
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Patent number: 6410781Abstract: Disclosed are compounds which bind &agr;4&bgr;7 integrin. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by &agr;4&bgr;7 integrin. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.Type: GrantFiled: February 28, 2000Date of Patent: June 25, 2002Assignee: Elan Pharmaceuticals, Inc.Inventors: Andrei W. Konradi, Michael A. Pleiss, Eugene D. Thorsett
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Patent number: 6392001Abstract: The present invention relates to a process for the production of polyisocyanates containing allophanate groups and having aliphatically and/or cycloaliphatically bound isocyanate groups by reacting organic compounds containing urethane groups with organic polyisocyanates containing aliphatically and/or cycloaliphatically bound isocyanate groups in the presence of tin compounds and to the use of these polyisocyanates, optionally blocked with blocking agents for isocyanate groups, as an isocyanate component in the production of polyurethanes, in particular polyurethane coatings.Type: GrantFiled: May 1, 1995Date of Patent: May 21, 2002Assignee: Bayer AktiengesellschaftInventors: Harald Mertes, Josef Pedain, Reinhard Halpaap
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Patent number: 6320012Abstract: The reactivity of isocyanate formulations is controlled by including a chain extender corresponding to the formula HO—R1—NR2—X—NR3—R4—OH (I) in which R1, R2, X, R3 and R4 represent specified groups is included in the isocyanate formulation.Type: GrantFiled: November 30, 1999Date of Patent: November 20, 2001Assignee: Bayer CorporationInventors: Rick L. Adkins, William E. Slack, Edward P. Squiller
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Patent number: 6284918Abstract: The present invention provides a compound of the formula wherein when X is S; R is selected from the group consisting of CH3, CH2CH3, CH2Ph, (CH2)2Ph, (CH2)2CH3, (CH2)3CH3, (CH2)4CH3, CH2)5CH3, (CH2)6CH3, (CH2)2O(CH2)3CH3, CH2HC═CH(CH2)3CH3, CH2C≡C(CH2)3CH3, CH2C≡C(CH2)2CH3, CH2C≡CCH2CH3, CH2C≡CCH3, CH2C≡CH, CH2C≡C(CH2)4CH3, CH2C≡C(CH2)5CH3, CH2C≡C(CH2)6CH3, (CH2)2C≡C(CH2)2CH3, CH(Ch3)C≡C(CH2)3CH3, (CH2)6I, (CH2)6Br, (CH2)5Br, (CH2)5COOH and (CH2)5OCOCH3, and R′ is selected from the group consisting of CH3, CF3, CH2Cl, CH2Br, CH2CH3, NH2, and OSO2CH3; wherein when R is CH3, R′ can not be CH3 or CH2Cl; wherein when R is CH2CH3, R′ can not be CH3; wherein when X is Se, R is (CH2)6CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof; and wherein when X is O, R is CH2C≡C(CH2)3CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof.Type: GrantFiled: April 6, 1999Date of Patent: September 4, 2001Assignee: Vanderbilt UniversityInventors: Lawrence J. Marnett, Amit S. Kalgutkar
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Patent number: 6239247Abstract: The present invention provides a method for preparing a fluorochemical composition comprising a urethane by reacting: (A) fluorochemical oligomer of the formula (I): MfmMn—Q1—T1 wherein MfmMn represents a fluorochemical oligomer comprising m units derived from fluorinated monomer and n units derived from fluorine-free monomer and wherein the fluorinated monomers and fluorine-free monomers may be the same or different; m is a value of about 2 to 40; n is a value of about 0 to 20; T1 is an —OH or —NH2 moiety; Q1 and T1 together represent an organic residue obtained by removing a hydrogen atom from a chain transfer agent that is functionalized with T1; (B) monofunctional compound capable of reacting with an isocyanate and comprising a poly(oxyalkylene) group; (C) isocyanate blocking agent or a fluorine-free oligomer; and (D) isocyanate-reactive compound other than said fluorochemical oligomer, said isocyanate blocking agent, said fluorine-free oligomer and said monofunctional compound; wiType: GrantFiled: September 24, 1999Date of Patent: May 29, 2001Assignee: 3M Innovative Properties CompanyInventors: Kathy E. M. L. A. Allewaert, Rudolf J. Dams, Pierre J. Vander Elst
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Patent number: 6228979Abstract: Six-membered cyclic carbonates (2-oxo-1,3-ioxanes) in which keto or carbohydrocarbyloxy groups are bound to the 5 position of the ring are disclosed. They react surprising quickly with primary or secondary cyclic amines, and the novel product hydroxyurethanes are usefull as reactive diluents.Type: GrantFiled: December 13, 1999Date of Patent: May 8, 2001Assignee: E. I. du Pont de Nemours and CompanyInventors: Neville E. Drysdale, Mike Fryd, Sapé Quashie
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Patent number: 6143917Abstract: A process for producing an aryl carbamate of a high purity at a high yield by reacting a diaryl carbonate with an amine compound having one or more hydrogen atoms bonded to the N position in the presence of carboxylic acid(s) of the following general formulae (I): R.sup.1 --COOH and/or (II): R.sup.2 --COOH (wherein R.sup.1 represents an alkyl or cycloalkyl group having an .alpha.-positioned carbon atom bonded to only one hydrogen atom, an alkyl group having an .alpha.-positioned carbon atom bonded to no hydrogen atom, or an aryl or heterocyclic group, and R.sup.2 represents an alkyl group having an .alpha.-positioned carbon atom bonded to two or more hydrogen atoms).Type: GrantFiled: October 13, 1998Date of Patent: November 7, 2000Assignee: Ube Industries, Ltd.Inventors: Katsumasa Harada, Ryoji Sugise, Kohichi Kashiwagi, Tsunao Matsuura
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Patent number: 6072069Abstract: Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being triiodo-3,5-diaminobenzoic acid derivatives, where the functional groups are derivatized with hydroxyalkyl groups and the amino functionalities are further derivatized with acyl substituents of one carbon acids. Also, triiodophloroglucinol oxyalkyl substituted derivatives are provided.Type: GrantFiled: November 4, 1998Date of Patent: June 6, 2000Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglass, III
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Patent number: 6034096Abstract: The present invention provides medicinal compounds that are characterized by a cyclic moiety (A) linked through a carboxamido group (more specifically, a carbamate group or a urea group) to another cyclic moiety (B) which is in turn linked to another, N-substituted carboxamido group. These compounds can be used an anti-inflammatory and immunosuppressive agents, as demonstrated by their inhibition of the production of IL-1.beta. in vitro and TNF.alpha. in vivo.Type: GrantFiled: November 12, 1998Date of Patent: March 7, 2000Assignee: Italfarmaco S.p.A.Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Jacques Mizrahi, Gianfranco Pavich, Paolo Mascagni
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Patent number: 6022989Abstract: A process is disclosed for the preparation of an N-acylated activated derivative of an amino acid or a salt thereof.Type: GrantFiled: June 28, 1996Date of Patent: February 8, 2000Assignee: Abbott LaboratoriesInventors: Patricia A. Oliver, Arthur J. Cooper, Joseph B. Paterson, Jr., Denton C. Langridge, Jieh-Heh J. Tien
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Patent number: 5859163Abstract: The present invention relates to coating compositions containinga) aldimines andb) polyisocyanates whichi) contain 2 to 35% by weight of allophanate groups, based on the weight of the polyisocyanates,ii) have a viscosity of less than 3000 mpa.s at 25.degree. C. when measured at a solids content of 100%,iii) are based on the reaction products of aliphatic polyisocyanates with1) 10 to 90 mole percent of monohydroxy compounds and2) 10 to 90 mole percent of polyhydric alcohols, wherein the mole percentages of 1) and 2) add up to 100, and the percentages are based on the total moles of monohydroxy compounds 1) and polyhydric alcohols 2) andiv) contain less than 10 mole percent of urethane groups, based on the total moles of urethane groups obtained from monohydroxy compounds 1) and polyhydric alcohols 2).Type: GrantFiled: August 22, 1997Date of Patent: January 12, 1999Assignee: Bayer CorporationInventors: William E. Slack, Edward P. Squiller, Hans Georg Schmelzer
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Patent number: 5849750Abstract: Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.Type: GrantFiled: March 5, 1997Date of Patent: December 15, 1998Assignee: California Institute of TechnologyInventor: Andrew Gordon Myers
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Patent number: 5807957Abstract: A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I)R--(CO).sub.m Y.sup.1 --(CH.sub.2 CHR.sup.1 O).sub.n --?CONH--Z--NHCO(OCH.sub.2 CHR.sup.2).sub.n' --Y.sup.2 --(CH.sub.2 CHR.sup.2 O).sub.n" !.sub.p --CONH--Z--NHCO--(OCH.sub.2 CHR.sup.1).sub.n --Y.sup.1 (CO).sub.m R (I)where R represents (i) an alkyl, alkenyl or alkaryl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group or polybutylene oxide group; R.sup.1 and R.sup.2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; when m=0, Y.sup.1 represents O, NR.sup.3 or N.sup.+ R.sup.3 R.sup.4 X.sup.- and when m=1 Y.sup.1 represents O; Y.sup.2 represents O, NR.sup.3, N.sup.+ R.sup.3 R.sup.4 X.sup.-, (R.sup.3 NCH.sub.2 CH.sub.2).sub.t, or ?(R.sup.3 R.sup.4 N.sup.+ CH.sub.2 CH.sub.2)X.sup.- !.sub.t ; R.sup.3 and R.sup.4, independently, represent C.sub.1 -C.sub.Type: GrantFiled: December 23, 1996Date of Patent: September 15, 1998Assignee: MacroChem CorporationInventors: Carlos M. Samour, Scott F. Krauser
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Patent number: 5767220Abstract: The present invention relates to ethylenically unsaturated polyurethanes which are substantially free from isocyanate groups and havea) a total content of (meth)acryloyl groups (calculated as C=C, MW 24) of 1 to 20% by weight.b) an allophanate group content (calculated as N.sub.2 C.sub.2 HO.sub.3, MW 101) of 1 to 20% by weight andc) an isocyanurate group content (calculated as N.sub.3,C.sub.3,O.sub.3, MW 126) of up to 18% by weight,in which the allophanate and isocyanurate groups are prepared from aliphatic polyisocyanates.The present invention also relates to a one-component coating composition containing these ethylenically unsaturated polyurethanes.Type: GrantFiled: August 25, 1997Date of Patent: June 16, 1998Assignee: Bayer CorporationInventors: Lanny D. Venham, Arthur W. Mason, Michael K. Jeffries, Michael J. Dvorchak
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Patent number: 5734082Abstract: This invention relates to a class of aminimides structurally characterized as an acyl nitrogen-nitrogen ylide such that the acyl moiety possess the structural diversity element G, the quaternary nitrogen possess structural diversity elements E and F, and the quaternary nitrogen is bonded to a hydroxyethyl substituent, which in turn is bonded to an aminomethylene moiety that possess structural diversity elements A and B from the amino group and diversity element C from the methylene substituent, as shown below, ##STR1## wherein structural diversity element A, B, C, D, E, F and G are chosen from the set of elements consisting of substituted and unsubstituted as well as branched and straight chain alkyl, aryl, alkaryl, aralkyl, carbocyclic, heterocyclic, hydrogen, amino acid, peptide, polypeptide, protein, depsipeptide, carbohydrate derivatives, nucleotide derivatives, oligonucleotide derivatives, naturally occurring or synthetic organic structural motifs, reporter elements, organic moieties containing at leastType: GrantFiled: October 20, 1994Date of Patent: March 31, 1998Assignee: Arqule Inc.Inventors: Joseph C. Hogan, Jr., David Casebier, Paul S. Purth, Steve Gallion, Alan Kaplan
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Patent number: 5491256Abstract: A composition of matter comprising ureas, biurets or allophanates structurally represented, respectively, by ##STR1## where R is hydrogen or a (C.sub.1 -C.sub.50) linear or branched aliphatic, alkenyl, alkynyl or aryl hydrocarbon; ##STR2## where R is hydrogen or a (C.sub.1 -C.sub.50) linear or branched aliphatic, alkenyl, alkynyl or aryl hydrocarbon; or ##STR3## where R is hydrogen or a (C.sub.1 -C.sub.50) linear or branched aliphatic, alkenyl, alkynyl or aryl hydrocarbon.Type: GrantFiled: April 4, 1994Date of Patent: February 13, 1996Assignee: Texaco Inc.Inventors: Thomas F. Derosa, Rodney L. Sung, Benjamin J. Kaufman
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Patent number: 5414120Abstract: The present invention relates to novel polyether-substituted compounds of imides and their use as surface-active agents.Type: GrantFiled: November 12, 1993Date of Patent: May 9, 1995Assignee: Bayer AGInventors: Klaus Pohmer, Rainer Weber, Cornelia Dorzbach-Lange, Reinhard Haida, Hans-Heinrich Moretto
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Patent number: 5413615Abstract: Polyalkyl hydroxy and amino aromatic carbamates having the formula: ##STR1## or a fuel-soluble salt thereof; wherein X is hydroxy or amino;R.sub.1 and R.sub.2 are independently hydrogen, hydroxy, lower alkyl having 1 to 6 carbon atoms, lower alkoxy having 1 to 6 carbon atoms, nitro, amino, N-alkylamino wherein the alkyl group contains 1 to 6 carbon atoms, or N,N-dialkylamino wherein each alkyl group independently contains 1 to 6 carbon atoms;R.sub.3 is hydrogen or lower alkyl having 1 to 6 carbon atoms; andR.sub.4 is a polyalkyl group having an average molecular weight in the range of about 400 to 5,000.The polyalkyl hydroxy and amino aromatic carbamates of formula I are useful as fuel additives for the prevention and control of engine deposits.Type: GrantFiled: May 2, 1994Date of Patent: May 9, 1995Assignee: Chevron Chemical CompanyInventor: Richard E. Cherpeck
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Patent number: 5318993Abstract: The present invention relates to novel benzoquinones which are useful as antihyperlipidemic agents. The present invention also provides a process for their preparation, pharmaceutical compositions, and a method for treating birds and mammals in need thereof which comprises administering to said host an effective amount of a benzoquinone of the present invention.Type: GrantFiled: April 16, 1993Date of Patent: June 7, 1994Assignee: Bristol-Myers Squibb CompanyInventor: Bradley C. Pearce