Sulfur, Halogen Or Additional Nitrogen Or Oxygen In Carbamic Acid Moiety Patents (Class 560/137)
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Patent number: 8633001Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.Type: GrantFiled: February 5, 2010Date of Patent: January 21, 2014Assignees: Dainippon Sumitomo Pharma Co., Ltd., Kyowa Hakko Bio Co., Ltd.Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai
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Publication number: 20120059007Abstract: This application relates to pharmacologically-active vanilloid compounds which are useful for the treatment of various anti-inflammatory states characterized by inhibition of FAAH, such as, Alzheimer's dementia, Parkinson's disease, depression, pain, rheumatoid arthritis, pathophysiology of mood disorders, multiple sclerosis, and inflammation, or antagonism of TRPV1, such as, for example, Huntington's disease, hypertension, arthritis, allergic airway inflammation, Crohn's disease, ulcerative colitis, and neuropathic pain.Type: ApplicationFiled: September 15, 2010Publication date: March 8, 2012Inventors: Jeffrey D. Laskin, Diane E. Heck, Carl Jeffrey Lacey, Erik Aponte, Mou-Tuan Huang, Ned D. Heindel
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Publication number: 20120034660Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.Type: ApplicationFiled: February 5, 2010Publication date: February 9, 2012Applicants: KYOWA HAKKO BIO CO., LTD., DAINIPPON SUMITOMO PHARMA CO., LTD.Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai
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Publication number: 20110160476Abstract: The present invention provides a method for producing N-substituted carbamic acid-O-aryl ester derived from a compound having an ureido group, the method comprising the step of carrying out esterification or esterification and transesterification from the compound having the ureido group and a hydroxy composition containing one type or a plurality of types of hydroxy compounds.Type: ApplicationFiled: September 29, 2009Publication date: June 30, 2011Inventors: Nobuhisa Miyake, Masaaki Shinohata, Atsushi Okubo
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Patent number: 6495719Abstract: Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of histone deacetylase can lead to the histone deacetylase-mediated transcriptional repression of tumor suppressor genes. For example, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, such as hematopoiesis, and genetic related metabolic disorders, such as, cystic fibrosis and adrenoleukodystrophy.Type: GrantFiled: March 27, 2001Date of Patent: December 17, 2002Assignee: CircaGen PharmaceuticalInventors: Hsuan-Yin Lan-Hargest, Robert J. Kaufman, Norbert L. Wiech
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Patent number: 6184412Abstract: The present invention provides a process for making N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives by reacting a chloroformate with a thiocyanate, in the presence of an aqueous solvent and a catalytic amount of a N,N-dialkylarylamine, to produce a N-alkoxy(or aryloxy)carbonyl isothiocyanate intermediate product, wherein the intermediate product is converted to a N-alkoxy(or aryloxy)carbonyl isothiocyanate derivative in high yield and purity.Type: GrantFiled: June 10, 1999Date of Patent: February 6, 2001Assignee: Bayer CorporationInventors: Shekhar V. Kulkarni, Vijay C. Desai
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Patent number: 6156895Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.Type: GrantFiled: August 4, 1999Date of Patent: December 5, 2000Assignee: Merck & Co., Inc.Inventors: Kai Rossen, Philip J. Pye, Ralph P. Volante, Paul J. Reider
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Patent number: 6143917Abstract: A process for producing an aryl carbamate of a high purity at a high yield by reacting a diaryl carbonate with an amine compound having one or more hydrogen atoms bonded to the N position in the presence of carboxylic acid(s) of the following general formulae (I): R.sup.1 --COOH and/or (II): R.sup.2 --COOH (wherein R.sup.1 represents an alkyl or cycloalkyl group having an .alpha.-positioned carbon atom bonded to only one hydrogen atom, an alkyl group having an .alpha.-positioned carbon atom bonded to no hydrogen atom, or an aryl or heterocyclic group, and R.sup.2 represents an alkyl group having an .alpha.-positioned carbon atom bonded to two or more hydrogen atoms).Type: GrantFiled: October 13, 1998Date of Patent: November 7, 2000Assignee: Ube Industries, Ltd.Inventors: Katsumasa Harada, Ryoji Sugise, Kohichi Kashiwagi, Tsunao Matsuura
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Patent number: 6066754Abstract: The present invention provides a process for making N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives by reacting a chloroformate with a thiocyanate, in the presence of an organic solvent and a catalytic amount of a N,N-dialkylarylamine, to produce a N-alkoxy(or aryloxy)carbonyl isothiocyanate intermediate product, wherein the intermediate product is converted to a N-alkoxy(or aryloxy)carbonyl isothiocyanate derivative in high yield and purity.Type: GrantFiled: June 10, 1999Date of Patent: May 23, 2000Assignee: Bayer CorporationInventor: Shekhar V. Kulkarni
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Patent number: 5977364Abstract: An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxaimide, an intermediate for an HIV protease inhibitor.Type: GrantFiled: February 2, 1999Date of Patent: November 2, 1999Assignee: Merck & Co., Inc.Inventors: Kai Rossen, Philip J. Pye, Ralph P. Volante, Paul J. Reider
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Patent number: 5958971Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.Type: GrantFiled: October 22, 1997Date of Patent: September 28, 1999Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
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Patent number: 5817863Abstract: The present invention relates to a novel process for preparing triazolinones of the general formula (I) ##STR1## in which R.sup.1 represents halogenoalkyl, andR.sup.2 represents hydrogen, hydroxyl or amino, or represents alkyl, alkenyl, alkinyl, alkoxy, alkylamino, dialkylamino, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl which are in each case optionally substituted,and also to novel intermediates for preparing these triazolinones and to processes for preparing the intermediates themselves.Type: GrantFiled: July 23, 1997Date of Patent: October 6, 1998Assignee: Bayer AktiengesellschaftInventor: Heinz-Jurgen Wroblowsky
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Patent number: 5714148Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.Type: GrantFiled: September 30, 1996Date of Patent: February 3, 1998Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
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Patent number: 5660829Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.Type: GrantFiled: May 16, 1995Date of Patent: August 26, 1997Assignees: Zeneca Limited, Cancer Research Campaign TechnologyInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger
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Patent number: 5587161Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT).Type: GrantFiled: December 21, 1994Date of Patent: December 24, 1996Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer
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Patent number: 5523463Abstract: A process for the manufacture of N-protected .alpha.-aminoketones and N-protected .alpha.-aminoalcohols of the formula ##STR1## wherein X is halogen, one of Q.sup.1 and Q.sup.2 is hydrogen and the other is hydroxy or Q.sup.1 and Q.sup.2 together are oxo, R.sup.1 is an amino protecting group and R.sup.2 is hydrogen or the characterizing group of an .alpha.-aminocarboxylic acid,starting from the corresponding lower alkyl N-protected .alpha.-aminocarboxylates via corresponding lower alkyl N-silyl protected .alpha.-aminocarboxylates.Type: GrantFiled: August 21, 1995Date of Patent: June 4, 1996Assignee: Hoffmann-La Roche Inc.Inventor: Hans Hilpert
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Patent number: 5405990Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.Type: GrantFiled: July 22, 1993Date of Patent: April 11, 1995Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer
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Patent number: 5315032Abstract: An N-hydroxycarbamate compound of the formula ROCONHOH in which R is C.sub.1-8 alkyl, C.sub.3-12 cycloalkyl, aryl or aralkyl group, is produced by reacting a carbonic acid diester of the formula ROCOOR in which R is as defined above, with hydroxylamine in the presence of a basic substance, for example, an alkali metal hydroxide or alkoxide.Type: GrantFiled: May 26, 1993Date of Patent: May 24, 1994Assignee: Ube Industries, Ltd.Inventors: Keigo Nishihira, Shuji Tanaka, Katsuhiko Mizutare, Masahiro Kondo
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Patent number: 5254715Abstract: A compound of the following general formula which is useful in treating hypocholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a heterocyclic group, or a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds and each of R.sub.2 and R.sub.3 is selected from hydrogen, provided both are not hydrogen, an aralkyl group, a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds, an w-substituted alkylC.sub.1-6, a heterocyclic group, phenyl, substituted phenyl or NR.sub.2 R.sub.3 taken together form a monocyclic heterocyclic group.Type: GrantFiled: August 19, 1991Date of Patent: October 19, 1993Assignee: Warner-Lambert CompanyInventors: Joseph A. Picard, Drago R. Sliskovic
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Patent number: 5209930Abstract: Antimicrobial compounds of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of H, lower (C.sub.1 -C.sub.4)alkyl, alkyl aryl, CH.sub.2 OR, CH.sub.2 SR, and CH(CH.sub.3)OR; andR, R.sup.2, and R.sup.3 are independently selected from H, (C.sub.1 -C.sub.4)alkyl, aryl, arylalkyl, alkaryl, and halopropargyl.Type: GrantFiled: December 10, 1990Date of Patent: May 11, 1993Assignee: Rohm and Haas CompanyInventors: Margaret M. Bowers-Daines, Barry C. Lange
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Patent number: 5206417Abstract: The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R.sup.1, and R.sup.1 is a radical ##STR2## where R.sup.2 to R.sup.6 are each H, alkyl, OH, Oalkyl, SH, Salkyl, halogen, N(alkyl).sub.2 or N(alkyl)(aryl), and not less than one but not more than three of the radicals R.sup.2 to R.sup.6 are each a radical ##STR3## where X is alkylene or oxaalkylene, each of 2 to 10 carbon atoms, and Y is H or CH.sub.3. These compounds have particularly high photochemical reactivity in the medium-wavelength to relatively long-wavelength UV range.Type: GrantFiled: December 18, 1991Date of Patent: April 27, 1993Inventors: Andreas Boettcher, Gerd Rehmer
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Patent number: 5194673Abstract: Alkoxy and aryloxy isothiocyanates are produced by the reaction of a haloformate and an alkali or alkaline earth metal thiocyanate in the presence of water and (i) a catalyst comprising a six membered mononuclear or ten membered fused polynuclear aromatic, heterocyclic compound having 1 or 2 nitrogen atoms as the only hetero atoms in the ring and (ii) a co-catalyst comprising an alkali metal or alkaline earth metal salt of an acid having a pKa of about 10.sup.-3 or below. The co-catalyst accelerates the reaction rate, increases product purity and reduces the adverse effects of impurities in certain grades of the thiocyanate reactants.Type: GrantFiled: July 27, 1992Date of Patent: March 16, 1993Assignee: American Cyanamid CompanyInventors: Samuel S. Wang, Lino G. Magliocco
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Patent number: 5189058Abstract: The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R.sub.1 and R.sub.2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, aralkyl, a hydrocarbon chain, a hetero group, or a heteroalkyl group, and the compounds are useful in treating atherosclerosis.Type: GrantFiled: April 9, 1991Date of Patent: February 23, 1993Assignee: Warner-Lambert CompanyInventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
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Patent number: 5072020Abstract: Disclosed is a novel route to diamines and triamines comprising reacting nitroalcohols with isocyanates to prepare di- and trinitro compounds which are subsequently reduced over a metal hydrogenation catalyst to the corresponding polyamino compound.Type: GrantFiled: March 21, 1990Date of Patent: December 10, 1991Assignee: Texaco Chemical CompanyInventors: George P. Speranza, Michael Cuscurida, Wei-Yang Su
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Patent number: 5043474Abstract: The invention relates to rhodium complexes of the formula[A--O--(CH.sub.2 CH.sub.2 O).sub.n --A].sup.2+ 2X.sup.- (Ia)and[A--O--(CH.sub.2 CH.sub.2 O).sub.m --CH.sub.3 ].sup.+ X.sup.-(Ib)in whichn=5-1,000,m=5-250,X.sup.- denotes a tetrafluoroborate, hexafluorophosphate or per-chlorate anion,A denotes a radical of the formula ##STR1## (en).sub.2 denotes two molecules of a monoolefin or one molecule of a diolefinAr denotes phenyl or phenyl which is substituted by one or two alkyl groups having 1 or 2 carbon atoms andR.sup.1 denotes an arylene or alkylene bridge,and their use for the preparation of L-phosphinothricin and its derivatives by enantioselective catalytic hydrogenation of 2,3-dehydrophosphinothricin (derivatives).Type: GrantFiled: January 17, 1990Date of Patent: August 27, 1991Assignee: Hoechst AktiengesellschaftInventors: Wolf-Dieter Muller, Hans-Jerg Kleiner
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Patent number: 5015753Abstract: Poly(alkylene carbonate) monoahls and polyahls useful as nonionic surfactants and having a poly(alkylene carbonate) backbone are prepared by reacting an oligomeric poly(alkylene carbonate) polyahl with a compound having mono- or difunctional active hydrogen moieties, such as alcohols, carboxylic acids, mercaptans, amides, primary or secondary amines, or substituted phenols, optionally in the presence of a catalyst, under transesterification conditions.Type: GrantFiled: November 13, 1989Date of Patent: May 14, 1991Assignee: The Dow Chemical CompanyInventor: Robert F. Harris
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Patent number: 4985587Abstract: Polyunsaturated compounds useful in radiation curable compositions are made by reacting p-vinylphenol and a polyisocyanate in the ratio of one mole of p-vinylphenol for each isocyanate group of the polyisocyanate.Type: GrantFiled: October 29, 1987Date of Patent: January 15, 1991Inventors: James W. Watkins, Darrell D. Hicks
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Patent number: 4935413Abstract: A physical property-improving reagent which comprises an alkenoylcarbamate compound of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is an oxygen atom (--O--), a sulfur atom (--S--) or a substituted or unsubstituted imino group (--NR'--), R' being a hydrogen atom or a lower alkyl group, and Y is the residue of an active hydrogen atom-containing compound excluding --X-H therefrom dissolved in an organic solvent having a solubility parameter of not less than 8, which can impact excellent physical properties to a polymer produced with the same.Type: GrantFiled: June 5, 1987Date of Patent: June 19, 1990Assignee: Nippon Paint Co., Ltd.Inventors: Satoshi Urano, Ryuzo Mizuguchi, Noriyuki Tsuboniwa, Kei Aoki, Yuji Suzuki, Takeyasu Itoh
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Patent number: 4927965Abstract: Compounds having the formula: ##STR1## wherein R.sup.1 is --NH(C.dbd.O)OR.sup.5, --NH(C.dbd.NH)NH.sub.2 or --NH(C.dbd.N--NO.sub.2)HN.sub.2 ; R.sup.2 is hydrogen, C.sub.1-8 alkyl or C.sub.6-8 aryl; n is 2 to 6; and R.sup.5 is hydrogen,C.sub.1-8 alkyl, C.sub.6-8 aryl, or C.sub.7-8 alkaryl; are disclosed in addition to methods to employ such compounds to induce migration of endothelial cells into denuded areas of vessel lining and to treat malignant hypercalcemia.Type: GrantFiled: November 3, 1988Date of Patent: May 22, 1990Assignee: Merck & Co., Inc.Inventors: Gabriel F. Eilon, Wayne J. Thompson
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Patent number: 4925971Abstract: A method for producing aliphatic O-arylurethanes by the reaction of an aliphatic primary amine with an aromatic hydroxyl compound and urea. Ammonia produced as a by-product in the reaction is removed during the reaction so that the ammonia concentration of the reaction solution is maintained at 2 wt % or less.Type: GrantFiled: December 2, 1988Date of Patent: May 15, 1990Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Toshiya Aoki, Hiroshi Ishida, Shinsuke Fukuoka
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Patent number: 4921996Abstract: The present invention relates to isocyanto-acylurethanes corresponding to Formula I ##STR1## wherein R has a valency of m+n and is a hydrocarbon group,R' is a hydrocarbon group andm and n may be identical or different, and each have a value of 1 or 2.The present invention also relates to a process for preparation of these isocyanato-acylurethanes which comprises reacting isocyanato-carboxylic acid chlorides with carbamic acid esters. Finally, the present invention is directed to the use of these isocyanato-acylurethanes as intermediate products for the production of thermally cross-linkable synthetic resins or synthetic resin precursors and also as intermediate products for the preparation of cross-linking agents for synthetic resins.Type: GrantFiled: August 2, 1988Date of Patent: May 1, 1990Assignee: Bayer AktiengesellschaftInventors: Walter Schafer, Hanns P. Muller, Tillmann Hassel
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Patent number: 4914124Abstract: A method of combating endoparasites which comprises applying thereto or to an endoparasite habitat an endoparasiticidally effective amount of an N-organooxycarbamic acid ester of the formula ##STR1## in which R.sup.1 represents alkyl, cycloalkyl, alkenyl, alkinyl or aryl, which can optionally be substituted,R.sup.2 represents alkyl, alkenyl or alkinyl, which can optionally be substituted, andR.sup.3 represents alkyl, alkenyl or alkinyl, which can optionally be substituted.Those compounds wherein one of R.sup.2 and R.sup.3 is alkinyl are new.Type: GrantFiled: January 25, 1988Date of Patent: April 3, 1990Assignee: Bayer AktiengesellschaftInventors: Nikolaus Muller, Peter Andrews
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Patent number: 4883903Abstract: The subject of the invention is a novel procedure for the preparation of the compounds of formula I: ##STR1## in which n varies in particular from 2 to 5 and R represents Cl, Br or FZ represents in particular hydrogen, characterized in that the halogenoformate of formula II: ##STR2## R and n having the meanings indicated above, Y representing a halogen, is made to react with NH.sub.2 CH.sub.2 CH.sub.2 Cl to form the compound of formula Ia: ##STR3## in which R has the meanings indicated above, and in that the compound Ia is treated directly with nitrosylsulfuric acid.Type: GrantFiled: April 22, 1988Date of Patent: November 28, 1989Assignee: SanofiInventors: Pierre Roger, Jean-Paul Fournier, Rolande Leroy
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Patent number: 4870203Abstract: Prepare .alpha., .beta.-saturated geminal biscarbamates by contacting an .alpha.,.beta.-unsaturated ether with a carbamate under reaction conditions, optionally in the presence of a catalyst.Type: GrantFiled: August 21, 1986Date of Patent: September 26, 1989Assignee: The Dow Chemical CompanyInventor: Michael J. Mullins
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Patent number: 4782175Abstract: The molecule of the new urethanes contains an aliphatic fluoroalcohol, an isocyanate and an aromatic dihydroxy, diamino, aminohydroxy, aminocarboxy or hydroxycarboxy compound. They are prepared by reacting an aliphatic fluoroalcohol with a diisocyanate or triisocyanate to give the fluoroalcohol/isocyanate adduct and by reacting this adduct with said aromatic compound to give the desired urethanes composed of an aliphatic fluoroalcohol, an isocyanate and the bifunctional aromatic compound mentioned, and also be reacting a urethane of this type which also carries an active hydrogen atom on the bifunctional aromatic compound, with an isocyanate compound containing one or more isocyanate groups. The new urethanes are preferably used for imparting an oleophobic and hydrophobic finish to textiles and leather.Type: GrantFiled: July 1, 1987Date of Patent: November 1, 1988Assignee: Hoechst AktiengesellschaftInventors: Frank Wehowsky, Rolf Kleber, Lothar Jaeckel
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Patent number: 4778921Abstract: Alkoxy and aryloxy isothiocyanates are produced by the reaction of a haloformate and an alkali or alkaline earth metal thiocyanate in the presence of water and a catalyst comprising a six membered mononuclear or ten membered fused polynuclear aromatic, heterocyclic compound having 1 or 2 nitrogen atoms as the only hetero atoms in the ring.Type: GrantFiled: January 22, 1986Date of Patent: October 18, 1988Assignee: American Cyanamid CompanyInventors: Morris E. Lewellyn, Samuel S. Wang, Peter J. Strydom
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Patent number: 4776875Abstract: Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 denote alkyl, OH, CF.sub.3 or cyanoethyl, A preferably denotes --COOH, R.sub.3 denotes inter alia alkoxycarbonylalkoxy, fairly high-molecular (>C.sub.12) alkoxy, alkylcarbonylalkoxy or nitrobenzyloxy, are valuable herbicides and growth regulators.Type: GrantFiled: March 26, 1986Date of Patent: October 11, 1988Assignee: Hoechst AktiengesellschaftInventors: Heinz J. Loher, Klaus Bauer, Hermann Bieringer
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Patent number: 4704470Abstract: An addition polymerizable antioxidant is prepared by reacting an isocyanatoalkyl ester of an addition polymerizable carboxylic acid (2-isocyanatoethyl methacrylate) with an antioxidant functionality bearing an active hydrogen moiety which is reactive with the isocyanate.Type: GrantFiled: May 9, 1984Date of Patent: November 3, 1987Assignee: The Dow Chemical CompanyInventor: Mark R. Johnson
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Patent number: 4665228Abstract: Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, halogen, C.sub.1-6 alkyl, or haloalkyl; R.sub.4 is hydrogen; C.sub.1-4 alkyl, alkenyl, alkoxy, haloalkyl; C.sub.1-2 alkylamino, C.sub.1-2 alkylthio, C.sub.2-4 cycloalkyl, C.sub.2-6 alkoxyalkyl, C.sub.2-6 alkylthiomethyl, amino, phenoxy, phenamino, or furan; and R.sub.5 is hydrogen or C.sub.1-4 alkyl, are useful to retard the growth of turf grass.Type: GrantFiled: April 4, 1986Date of Patent: May 12, 1987Assignee: Monsanto CompanyInventors: Gerhard H. Alt, John P. Chupp, Lane A. Clizbe
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Patent number: 4663475Abstract: A stable copolymer dispersion is prepared by addition copolymerization of (1) a monomeric adduct of an active hydrogen compound, e.g., a polyether polyol or polyether monool, and an ethylenically unsaturated N-chlorosulfonyl carbamyl compound such as acryloxyethylchlorosulfonylcarbamate or an unsaturated N-chlorocarbonyl carbamyl compound with (2) ethylenically unsaturated monomer(s), e.g., styrene or a mixture thereof with acrylonitrile, while (1) and (2) are dispersed or dissolved in an excess of an active hydrogen polyfunctional compound such as a polyether polyol. The molar ratio of carbamyl moiety to active hydrogen compound is preferably less than about 0.1:1. The resulting dispersion has a controlled particle size and a viscosity such that it is suitably employed in the production of polyurethane foams.Type: GrantFiled: November 23, 1984Date of Patent: May 5, 1987Assignee: The Dow Chemical CompanyInventor: Thomas E. Fisk
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Patent number: 4606862Abstract: A process for preparing insecticidal N-acyl-tetrahydro-2-nitromethylene-2H-1,3-thiazines, intermediates involved therein and certain of the products.Type: GrantFiled: March 21, 1985Date of Patent: August 19, 1986Assignee: Shell Oil CompanyInventor: Martin Harris
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Patent number: 4599407Abstract: The invention concerns new 1-tert.-alkyl-thiohydrazine-1,2-dicarboxylic a derivatives, their production, and their use as reagents for the transfer of a 1-tert.-alkylthio residue, particularly of a 1-tert.-butylthio residue as a protective group for thiols.Type: GrantFiled: August 5, 1985Date of Patent: July 8, 1986Assignee: Max Planck Gesellschaft zur Forderung der Wissenschaften e.V.Inventor: Erich Wunsch
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Patent number: 4595769Abstract: Carbamate-sulfenyl-carbamoyl fluoride compounds are valuable insecticidal compositions and are also useful intermediates in the production of bis-carbamate compounds.Type: GrantFiled: April 20, 1984Date of Patent: June 17, 1986Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4594098Abstract: Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 denote alkyl, CF.sub.3, benzyl cyclohexyl, cyanoethyl, phenyl or OH and A denotes, inter alia, the groups --CO--, CHOH or CH--NH.sub.2 and --COR.sub.3 denotes a carboxyl, carboxylic ester or carboxamido group, are active herbicides.Type: GrantFiled: July 16, 1985Date of Patent: June 10, 1986Assignee: Hoechst AktiengesellschaftInventors: Klaus Bauer, Hermann Bieringer, Helmut Burstell, Jean Kocur
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Patent number: 4551472Abstract: Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.Type: GrantFiled: January 9, 1984Date of Patent: November 5, 1985Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4491671Abstract: The present invention relates to a process for the preparation of N-substituted imido-dicarboxylic acid diaryl ester compound of the formulaR.sup.1 --N(CO--OR.sup.2).sub.2 (I)whereinR.sup.1 is an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical; andR.sup.2 is an optionally substituted aryl radical, which are useful as intermediates for the production of known herbicides, which process comprises reacting a primary amine of the formulaR.sup.1 --NH.sub.2 (II)with a carbonic acid aryl ester halide of the formulaX--CO--OR.sup.2 (III)wherein X is a halogen atom, at a temperature between 100.degree. and 300.degree. C.Type: GrantFiled: June 10, 1982Date of Patent: January 1, 1985Assignee: Bayer AktiengesellschaftInventors: Karlfried Dickore, Engelbert Kuhle
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Patent number: 4486447Abstract: Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests.Type: GrantFiled: June 24, 1983Date of Patent: December 4, 1984Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4482737Abstract: N-substituted N-isocyanatocarbonyl-carbamates, some of which are new, of the general formula ##STR1## are prepared by reacting an N-substituted carbamic acid ester of the general formulaR--NH--COOR.sup.1 (II)with chlorocarbonyl isocyanate of the formulaCl--CO--NCO (III)in a diluent, at a temperature between 50.degree. and 200.degree. C. The compounds (I) can be used as intermediate products for the preparation of new pest-combating agents.Type: GrantFiled: November 3, 1982Date of Patent: November 13, 1984Assignee: Bayer AktiengesellschaftInventors: Engelbert Kuhle, Hermann Hagemann
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Patent number: 4474808Abstract: N-Sulphenylated biuret-N"-carboxylic acid esters of the general formula ##STR1## in which R.sup.1 and R.sup.2 can be identical or different and represent an optionally substituted aliphatic, cycloaliphatic, aromatic or araliphatic radical,R.sup.3 represents a hydrogen atom or an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical andR.sup.4 represents a trihalogenomethyl radical,are obtained by the reaction of an acyl isocyanate of the general formula ##STR2## with a sulphenamide of the general formula ##STR3## if appropriate in the presence of a diluent. The compounds of the formula (I) are new. They can be used as pest-combating agents which are microbicides, especially fungicides or bactericides.Type: GrantFiled: November 3, 1982Date of Patent: October 2, 1984Assignee: Bayer AktiengesellschaftInventors: Engelbert Kuhle, Paul Reinecke, Karl-Heinz Kuck
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Patent number: 4451406Abstract: Novel N-substituted imido-dicarboxylic acid diaryl ester compounds of the general formula ##STR1## in which R.sup.1 represents an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic, heterocyclic radical andR.sup.2 and R.sup.3 can be identical or different and represent an optionally substituted aryl radical,and a process for their preparation characterized in that a carbamic acid aryl ester of the general formula:R.sup.1 --NH--CO--OR.sup.2 (II)in which R.sup.1 and R.sup.2 have the abovementioned meanings, is reacted with a carbonic acid aryl ester halide of the general formulaX--CO--OR.sup.3 (III)in whichR.sup.3 has the abovementioned meaning andX represents a halogen atom, optionally in the presence of a diluent, optionally at a temperature between 100.degree. and 300.degree. C.The new compounds (I) can be used as intermediate products for the preparation of known herbicidal active compounds from the 1,3,5-triazine,2,4-(1H,3H)-dione series.Type: GrantFiled: August 5, 1983Date of Patent: May 29, 1984Assignee: Bayer AktiengesellschaftInventors: Karlfried Dickore, Engelbert Kuhle