Plural Nitrogens In Acid Moiety Patents (Class 560/13)
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Patent number: 4126634Abstract: Aminosulfonylcarboxylic acids and their manufacture from diamines and chlorosulfonylcarboxylic acids.Type: GrantFiled: August 1, 1977Date of Patent: November 21, 1978Assignee: BASF AktiengesellschaftInventors: Lucien Thil, Martin Fischer, Wolfgang Kindscher
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Patent number: 4125625Abstract: Tropone derivatives characterized by having a derivative of oxamic acid at positions 2 and or 5 are disclosed. In addition, the tropone nucleus can be optionally further substituted. The foregoing compounds are useful for preventing or treating allergic conditions in a mammal. Methods for the preparation and use of said compounds are disclosed.Type: GrantFiled: May 31, 1977Date of Patent: November 14, 1978Assignee: Ayerst, McKenna & Harrison LimitedInventors: Jehan F. Bagli, Tibor Bogri
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Patent number: 4120896Abstract: s-Phenenyltris(sulfonylimino)tri-anionic substituted benzene dicarboxylic acids and substituted alkyl amino acids and their salts, useful as complement inhibitors.Type: GrantFiled: June 13, 1977Date of Patent: October 17, 1978Assignee: America Cyanamid CompanyInventors: Ransom Brown Conrow, Seymour Bernstein
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Patent number: 4119658Abstract: The present invention relates to isocyanato-polysulphonic acids comprising from 1 to 3 aromatically bound isocyanate groups which may be present at least partly in the dimerized form as uretdione groups and from 2 to 6 sulphonic acid groups for each non-dimerized isocyanato-polysulphonic acid or for each monomeric isocyanato-polysulphonic acid on which the dimer is based. These acids are produced by reacting mono- or poly-isocyanates having exclusively aromatically bound isocyanate groups with sulphur trioxide at -10.degree. C to 140.degree. C, wherein the isocyanate used as starting material which is to be sulphonated is reacted with at least 50% by weight of sulphur trioxide, based on the quantity of isocyanate used as starting material. Alternatively they may be produced using isocyanate-monosulphonic acids which have exclusively aromatically bound isocyanate-groups.Type: GrantFiled: March 30, 1977Date of Patent: October 10, 1978Assignee: Bayer AktiengesellschaftInventor: Dieter Dieterich
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Patent number: 4118587Abstract: Novel 3-(butylamino) or (1-pyrrolidinyl)-4-phenoxy-5-sulfamylbenzoic acid derivatives where the butyl group contains either a double bond or a hydroxy, ketone, acid or ester functional group or groups, said compounds being useful as diuretics.Type: GrantFiled: November 1, 1976Date of Patent: October 3, 1978Assignee: Hoffmann-La Roche Inc.Inventor: David Llewellyn Coffen
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Patent number: 4118575Abstract: The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine.The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.Type: GrantFiled: September 5, 1975Date of Patent: October 3, 1978Assignee: Choay S.A.Inventors: Meir Rigbi, Yakir Klausner, Pierre Lefrancier, Edgar Sache
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Patent number: 4115105Abstract: L-2-amino-4-(2-aminoethoxy)-butanoic acid, methods for its preparation and novel intermediates employed in these processes are disclosed. L-2-amino-4-(2-aminoethoxy)-butanoic acid enhances ethylene production in fruit and therefore has utility as a ripening agent and as an abscission agent.Type: GrantFiled: August 29, 1977Date of Patent: September 19, 1978Assignee: Hoffmann-La Roche Inc.Inventors: James Parnell Scannell, Arthur Stempel
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Patent number: 4113876Abstract: Sulfonic acid-N'-methylamido-N'-sulfenyl-N-methyl-carbamic acid esters of the formula ##STR1## in which R.sup.1 is dialkylamino with 1-4 carbon atoms in each alkyl group, phenyl substituted in the o- or m-position by halogen or by alkyl with 1-4 carbon atoms, or phenyl substituted in the o-, m- or p-position by NO.sub.2, CF.sub.3 or CN, andR.sup.2 is phenyl, naphthyl, benzodioxolanyl or indanyl; phenyl, naphthyl, benzodioxolanyl or indanyl substituted by trihalogenomethyl, halogen, nitro, cyano, formamidino, dioxanyl or dioxolanyl, or by alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, alkynoxy, alkylmercapto, alkenylmercapto or dialkylamino wherein each hydrocarbon portion has 1-4 carbon atoms; cycloalkyl of 5-7 carbon atoms, or ##STR2## in which R.sup.3 and R.sup.4 each independently is cyano or alkyl, alkoxy, alkylthio or alkoxycarbonyl with 1-4 carbon atoms in each alkyl group, or R.sup.3 and R.sup.4 together form a ring, or, provided that R.sup.1 is a NO.sub.2 -substituted phenyl, R.sup.Type: GrantFiled: July 2, 1975Date of Patent: September 12, 1978Assignee: Bayer AktiengesellschaftInventors: Peter Siegle, Engelbert Kuhle, Ingeborg Hammann, Bernhard Homeyer, Wolfgang Behrenz
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Patent number: 4113463Abstract: A method for regulating the elongation of plants so as to increase their resistance to lodging by applying a plant regulating effective amount of a plant growth regulator containing as active ingredient a benzenesulfonamide compound of the formula ##STR1## wherein X, R.sub.1, R.sub.2 and n are as defined hereinbelow.Type: GrantFiled: March 11, 1977Date of Patent: September 12, 1978Assignee: Sumitomo Chemical Company, LimitedInventors: Hiromichi Oshio, Hiroyuki Konishi, Shiunzi Matsumura, Kikuichi Ishikawa, Eiichi Yoneyama
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Patent number: 4108887Abstract: Disclosed are compounds of formula I ##STR1## in which R.sub.1 and R.sub.4, independently, are hydrogen, a non-chromophoric second order substituent, or alkyl or alkenyl unsubstituted or substituted by a non-chromophoric group,R.sub.2 and R.sub.5, independently, are hydrogen or alkyl or alkenyl, unsubstituted or substituted by a non-chromophoric group,R.sub.3 and R.sub.6, independently, are hydrogen, alkyl, carboxyl or a non-chromophoric esterified carboxyl group, orR.sub.2, together with R.sub.3, and/or R.sub.5 together with R.sub.6, signify an alkylene bridge,R.sub.7 and R.sub.8, independently, signify hydrogen or a non-chromophoric substituent, or, whenR.sub.7 is in the 3-position and/or R.sub.8 in the 3' position, R.sub.7 together with R.sub.2, and/or R.sub.8 together with R.sub.5 signify an alkylene bridge,With the proviso that no more than one of R.sub.1 and R.sub.2 and no more than one of R.sub.4 and R.sub.5 signify hydrogen, their production and use as optical brightening agents.Type: GrantFiled: January 29, 1976Date of Patent: August 22, 1978Assignee: Sandoz Ltd.Inventors: Fritz Fleck, Juerg Heller
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Patent number: 4106925Abstract: The invention is concerned with new herbicidally active 4-phenoxy-.alpha.-phenoxy-alkanecarboxylic acid derivatives, especially propionic acid esters of the type ##STR1## bearing in the first phenoxy radical a nitro group besides another substituent R.sub.1 which is preferably a halogen atom, the CF.sub.3 group is lower alkyl, alkoxy or alkoxycarbonyl group. The invention is further concerned with herbicidal compositions containing such new derivatives and with methods for the selective control of grass-like weeds in crops of dicotyledonous and monocotyledonous cultivated plants such as cereals.Type: GrantFiled: November 16, 1976Date of Patent: August 15, 1978Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Otto Rohr, Georg Pissiotas, Beat Bohner
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Patent number: 4101653Abstract: N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.Type: GrantFiled: January 19, 1977Date of Patent: July 18, 1978Assignees: Mitsubishi Chemical Industries Limited, Shosuke OkamotoInventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuni Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura
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Patent number: 4097472Abstract: N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.Type: GrantFiled: January 19, 1977Date of Patent: June 27, 1978Assignees: Mitsubishi Chemical Industries Limited, Shosuke OkamotoInventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura
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Patent number: 4097526Abstract: An in-situ process for preparing organic sulfone compounds by oxidizing the corresponding sulfide compound with a mixture of hydrogen peroxide, a carboxylic acid in the presence of a catalytic amount of a mineral acid or an organic sulfonic acid.Type: GrantFiled: February 10, 1977Date of Patent: June 27, 1978Assignee: Union Carbide CorporationInventor: John Kai-Fai Chan
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Patent number: 4096269Abstract: Novel N-haloalkanesulfenylcarbamoyloxime compounds have been found to have exceptional miticidal and insecticidal activity.Type: GrantFiled: May 20, 1976Date of Patent: June 20, 1978Assignee: Union Carbide CorporationInventor: Themistocles Damasceno Joaquim D'Silva
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Patent number: 4094863Abstract: A process for the cross-linking or chain-extension of hydrocarbon polymers which contain ethylenically unsaturated groups which comprises forming an intimate mixture of the polymer with a mono-sulphonyloxycarbamate of the formula:A -- O -- CO -- NH -- O -- SO.sub.2 R (1)wherein A is an alkyl group, a cycloalkyl group, an alkenyl group, a substituted alkyl group, a substituted aryl group or a heterocyclic group, and R is an optionally substituted alkyl or aryl group.The process is useful for natural and synthetic rubbers. The rate and extent of cross linking may be modified by the additives such as tertiary amines or conventional rubber additives e.g. tetramethyl and zinc diethyl dithiocarbamates, which contain tertiary amino groups.Type: GrantFiled: February 22, 1977Date of Patent: June 13, 1978Assignee: Imperial Chemical Industries LimitedInventors: John Langshaw Brooks, Richard Budziarek
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Patent number: 4093712Abstract: N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.Type: GrantFiled: January 19, 1977Date of Patent: June 6, 1978Assignees: Mitsubishi Chemical Industries Limited, Shosuke OkamotoInventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura
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Patent number: 4088780Abstract: N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.Type: GrantFiled: May 26, 1976Date of Patent: May 9, 1978Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Herbert Thomas, Arno Widdig, Hartmund Wollweber
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Patent number: 4086255Abstract: Phenyl-substituted perfluoroalkanesulfonanilides in which the phenyl rings are linked by sulfur, sulfinyl or sulfonyl and salts thereof in which the rings and the perfluoroalkylsulfonamido nitrogen are optionally substituted. The compounds are active herbicides and some are anti-inflammatory agents and analgesic agents.Type: GrantFiled: January 10, 1977Date of Patent: April 25, 1978Assignee: Minnesota Mining and Manufacturing CompanyInventors: George G. I. Moore, Joseph Kenneth Harrington
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Patent number: 4083848Abstract: Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.Type: GrantFiled: January 3, 1977Date of Patent: April 11, 1978Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masumi Itoh, Takashi Kamiya, Daijiro Hagiwara
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Patent number: 4072696Abstract: Carbalkoxythioureidobenzene derivatives represented by the following formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SR.sup.2, --SOR.sup.2, --SO.sub.2 R.sup.2, --OR.sup.2, --SCN, --SC(O)NR.sup.3 R.sup.4, or --M'(CH.sub.2).sub.n MR.sup.7 where n is 1-4; R.sup.2 is lower alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, aralkyl or aryl, provided that when R.sup.1 is --SO.sub.2 R.sup.2, R.sup.2 is not aralkyl or phenyl; R.sup.3 and R.sup.4 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, --NHC(O) (CH.sub.2).sub.m COOH where m is 1-6, or --NHC(S)NHCOOR; M and M' are independently O, S or ##STR2## and R.sup.7 is lower alkyl having 1 to 4 carbon atoms or aryl. The R.sup.1 substitution is either at the 4- or 5-position.Type: GrantFiled: January 18, 1974Date of Patent: February 7, 1978Assignee: Syntex (U.S.A.) Inc.Inventors: Colin C. Beard, John A. Edwards, John H. Fried
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Patent number: 4071686Abstract: Certain nuclear substituted benzylidene amino oxyalkyl carboxylic acids esters, amides and salts thereof have been found to have a strong anti-inflammatory activity and a potent analgetic activity. In addition, some of the compounds have an activity against Rhino virus. An example is [(4-chlorobenzylideneamino)oxy] acetic acid.Type: GrantFiled: December 17, 1976Date of Patent: January 31, 1978Assignee: U.S. Philips CorporationInventors: Jan van Dijk, Volkert Claassen, Johannes Maria Antonius Zwagemakers
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Patent number: 4071528Abstract: Benzene derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl, R.sup.2 is a group --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3 or --OR.sup.3, in which R.sup.3 is alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl or cycloalkylalkyl, whose position on the benzene ring is either para to --NHCOAZ or para to the heterocyclo group, A is a C.sub.1-4 aliphatic hydrocarbon radical, B is a bivalent methylene or ethylene group, and Z is a primary, secondary or tertiary amino group, and acid addition salts and quaternary ammonium derivatives thereof, are new compounds useful as anthelmintics and antifungal agents.Type: GrantFiled: October 27, 1976Date of Patent: January 31, 1978Assignee: May & Baker LimitedInventors: Sally Elizabeth Dalton, William George Gingell, David Conwil Jenkins, Leslie George King, Glyn Evan Lee, Garth Molesdale Thompson
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Patent number: 4070178Abstract: Diphenyl ethers of the formula ##STR1## whereinR.sup.1 is hydrogen or halogen,R.sup.2 is hydrogen, halogen, or cyano,R is ##STR2## wherein R.sup.3 is hydrogen, halogen, nitro, alkyl, or alkoxy,R.sup.4 is a divalent alkylene radical, andR.sup.5 is cyano or -COR.sup.6, wherein R.sup.6 is alkoxy, hydroxy or salt thereof, allyloxy, alkoxyalkoxy, amino, alkyl or dialkyl amino, aminoalkoxy, or alkyl or dialkylaminoalkoxy,And diphenyl sulfides, sulfoxides, and sulfones of the formula ##STR3## wherein R.sup.8 is hydrogen, halogen, cyano, nitro, alkyl, alkoxy, or trifluoromethyl,R.sup.2 is hydrogen, halogen or cyano,X is sulfur, sulfinyl, or sulfonyl, andR is as defined above,And compositions containing these compounds exhibit herbicidal activity.Type: GrantFiled: July 30, 1976Date of Patent: January 24, 1978Assignee: Rohm and Haas CompanyInventors: Wayne O. Johnson, Roy Y. Yih
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Patent number: 4069325Abstract: 3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives are disclosed as well as a process for their manufacture. The compounds are suitable for combatting helminths and especially gastrointestinal Strongylides and liver flukes.Type: GrantFiled: September 17, 1976Date of Patent: January 17, 1978Assignee: Hoechst AktiengesellschaftInventors: Heinz Loewe, Josef Urbanietz, Dieter Duwel, Reinhard Kirsch
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Patent number: 4069343Abstract: Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals;And pharmaceutically acceptable salts thereof.Type: GrantFiled: March 23, 1976Date of Patent: January 17, 1978Assignee: American Home Products CorporationInventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
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Patent number: 4054740Abstract: This invention relates to a synthesis of biotin by the reduction of dehydrobiotin. The dehydrobiotin is prepared from 6-hydroxy-7-nitro-heptanoic acid methyl ester. Novel intermediates are also obtained by this synthesis.Type: GrantFiled: September 5, 1975Date of Patent: October 18, 1977Assignee: Hoffmann-La Roche Inc.Inventor: George Francis Field
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Patent number: 4052420Abstract: In the process for preparing a diurethane, particularly an aromatic diurethane, by the reaction of an organic dinitro compound, particularly an aromatic dinitro compound, carbon monoxide, and an organic hydroxyl compound in the presence of a catalyst, the improvement which comprises employing as said catalyst rhodium oxide, particularly substantially amorphous rhodium oxide, and carrying out the reaction in two stages, the first stage being carried out at a first temperature and pressure and the second stage being carried out at a higher temperature and pressure, and optionally conducting the reaction in a nitrilic solvent.Type: GrantFiled: September 22, 1975Date of Patent: October 4, 1977Assignee: Ethyl CorporationInventor: George C. Licke
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Patent number: 4052437Abstract: In the process for preparing a urethane, particularly an aromatic urethane, by the reaction of an organic nitro compound, particularly an aromatic nitro compound, carbon monoxide, and an organic hydroxy compound in the presence of a catalyst, the improvement which comprises employing as said catalyst rhodium oxide, particularly substantially amorphous rhodium oxide, and optionally conducting the reaction in a nitrilic solvent.Type: GrantFiled: September 22, 1975Date of Patent: October 4, 1977Assignee: Ethyl CorporationInventor: George C. Licke
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Patent number: 4052444Abstract: N-(aminobenzoyl)-aminoarylsulfonic acids and their alkali metal salts of the formula ##STR1## WHEREIN X is hydrogen, chlorine, bromine, lower alkyl, lower alkoxy, alkylamino, trifluoromethyl, phenyl, phenoxy, nitro or cyano, Y represents hydrogen, chlorine, bromine, lower alkyl or lower alkoxy, A is phenylene or naphthylene and n is 1 or 2, the sulfo group standing in 4-position to the benzoylamino group (which is in 1-position), are diazo components for the preparation of azo dyestuffs and the color toners and color lakes which may be obtained therefrom and which possess very good properties of fastness.Type: GrantFiled: June 12, 1975Date of Patent: October 4, 1977Assignee: Hoechst AktiengesellschaftInventors: Gunter Laubert, Joachim Ribka
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N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
Patent number: 4041156Abstract: N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.Type: GrantFiled: February 6, 1976Date of Patent: August 9, 1977Assignee: Mitsubishi Chemical Industries LimitedInventors: Shosuke Okamoto, Ryoji Kikumoto, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura, Yoshikuni Tamao, Akiko Hijikata -
Patent number: RE29669Abstract: A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50.degree.-150.degree. C., said products being antiinflammatory agents.Type: GrantFiled: November 30, 1976Date of Patent: June 13, 1978Assignee: Pfizer, Inc.Inventor: Joseph G. Lombardino