Plural Nitrogens In Acid Moiety Patents (Class 560/13)
  • Patent number: 4783213
    Abstract: Compounds of the formula ##STR1## wherein X is oxy, thio, sulfinyl or sulfonyl;R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl, trifluoromethyl or difluoromethyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are C.sub.2 -C.sub.5 alkylene;R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl with the proviso that R.sup.1 and R.sup.3 are not both phenyl or substituted phenyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or phenyl;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: November 8, 1988
    Assignee: Stauffer Chemical Company
    Inventor: David L. Lee
  • Patent number: 4782175
    Abstract: The molecule of the new urethanes contains an aliphatic fluoroalcohol, an isocyanate and an aromatic dihydroxy, diamino, aminohydroxy, aminocarboxy or hydroxycarboxy compound. They are prepared by reacting an aliphatic fluoroalcohol with a diisocyanate or triisocyanate to give the fluoroalcohol/isocyanate adduct and by reacting this adduct with said aromatic compound to give the desired urethanes composed of an aliphatic fluoroalcohol, an isocyanate and the bifunctional aromatic compound mentioned, and also be reacting a urethane of this type which also carries an active hydrogen atom on the bifunctional aromatic compound, with an isocyanate compound containing one or more isocyanate groups. The new urethanes are preferably used for imparting an oleophobic and hydrophobic finish to textiles and leather.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: November 1, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Wehowsky, Rolf Kleber, Lothar Jaeckel
  • Patent number: 4781751
    Abstract: Compounds of the formula ##STR1## wherein R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; trifluoromethyl or difluoromethyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, halogen, phenyl or substituted phenyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are C.sub.2 -C.sub.5 alkylene;R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl, with the proviso that R.sup.1 and R.sup.3 are not both phenyl or substituted phenyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.5 is hydrogen, halogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is halogen, cyano, nitro, trifluoromethyl, --C(O)--OR.sup.f wherein R.sup.f is C.sub.1 -C.sub.4 alkyl, or --C(O)NR.sub.2.sup.b wherein R.sup.b is hydrogen or C.sub.1 -C.sub.2 alkyl;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: November 1, 1988
    Assignee: Stauffer Chemical Company
    Inventor: Hsiao-Ling M. Chin
  • Patent number: 4780550
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen; halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; or R.sup.a SO.sub.m -- wherein m is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are methyl or ethyl;R.sup.5 and R.sup.6 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) --NR.sup.c R.sup.d wherein R.sup.c and R hu d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)-- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or (12) --SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are as defined; and (13) --N(R.sup.c)C(O)R.sup.d wherein R.sup.c and R.sup.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: October 25, 1988
    Assignee: Stauffer Chemical Company
    Inventor: Charles G. Carter
  • Patent number: 4780127
    Abstract: Compounds of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, cyano, nitro, S(O).sub.n R wherein R is C.sub.1 -C.sub.4 alkyl and n is the integer 0, 1 or 2; and R.sup.2 through R.sup.8 are hydrogen or certain substituents, their salts, herbicidal compositions containing the compound or salts and the herbicidal use thereof.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: October 25, 1988
    Assignee: Stauffer Chemical Company
    Inventors: William J. Michaely, Gary W. Kraatz
  • Patent number: 4766233
    Abstract: Herbicidal utility for 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs is disclosed and exemplified. Many of the disclosed compounds are novel. Methods for preparing the herbicidal compounds and intermediates therefor are also disclosed.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: August 23, 1988
    Assignee: FMC Corporation
    Inventor: John W. Lyga
  • Patent number: 4762551
    Abstract: A compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 can be oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; and R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: August 9, 1988
    Assignee: Stauffer Chemical Company
    Inventor: Christopher G. Knudsen
  • Patent number: 4752615
    Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.
    Type: Grant
    Filed: November 13, 1986
    Date of Patent: June 21, 1988
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
  • Patent number: 4744818
    Abstract: N-halo-5-(substituted-phenoxy or -pyridyloxy)-2-substituted benzoic acid sulfonamides and sulfamates, their preparation and use as herbicides are disclosed.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: May 17, 1988
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: El-Ahmadi I. Heiba
  • Patent number: 4745128
    Abstract: The present invention relates to pesticides containing carbamic acid ester derivatives of the formula (I), ##STR1## to pesticide compositions containing these compounds and to a process for their preparation.In the general formulaR.sup.1 is alkyl of from one to four carbon atoms;R.sup.2 represents alkyl of from one to four carbon atoms or (when X is alkyl of from one to twelve carbon atoms) alkyl of from one to twelve carbon atoms;R.sup.3 is H, methyl or ethyl;R.sup.4 and R.sup.5 are, independently from each other, H or halogen atoms;n=0, 1 or 2;X represents alkyl of from one to twelve carbon atoms or an 4-aryloxyphenoxyalkyl group of formula (II). ##STR2## The pesticide of the invention can be used for controlling insects and mites.
    Type: Grant
    Filed: January 9, 1987
    Date of Patent: May 17, 1988
    Assignee: Innofinance Altalanos Innovacios Penzintezet
    Inventors: Istvan Ujvari, Gyorgy Matolcsy, Ivan Belai, Laszlo Varjas, Bela Darvas
  • Patent number: 4736055
    Abstract: Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR.sup.5, --COOH, COOR.sup.6, --COCl, --CH.sub.2 Hal, --SO.sub.2 Cl or --NCO group, Z is an (x+y)-valent connecting member, R.sup.1 and R.sup.2 are monovalent organic radicals, m is 0 or 1, x is 1 or 2 and y is 1 or 2, can be converted into polymers which can be thermally or photochemically dissociated to form free sulfonic acid groups. Said polymers can therefore be used as photoresists which can be developed with aqueous alkalis.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: April 5, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Kurt Dietliker, Werner Rutsch, Godwin Berner, Max Hunziker, Christopher G. Demmer
  • Patent number: 4730008
    Abstract: The invention provides compounds of the general formula (I) ##STR1## wherein Ar, R.sup.1, R.sup.2, X, Y and Q are defined in the specification and physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at .beta..sub.2 -adrenoreceptors and may be used, inter alia, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: March 8, 1988
    Assignee: Glaxo Group Limited
    Inventors: Ian F. Skidmore, Harry Finch, Alan Naylor, Lawrence H. C. Lunts, Ian B. Campbell
  • Patent number: 4723029
    Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.
    Type: Grant
    Filed: September 23, 1983
    Date of Patent: February 2, 1988
    Assignee: Schering Corporation
    Inventors: Dhiru B. Vashi, Jeffrey N. Clark, Neil A. Lindo
  • Patent number: 4721717
    Abstract: The present invention provides aminoalcohols of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be same or different, are hydrogen atoms, hydroxyl groups, C.sub.1 -C.sub.4 -alkoxy, benzyloxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.1 -C.sub.4 -alkanesulphonylamino, C.sub.1 -C.sub.4 -alkanesulphinyl or C.sub.1 -C.sub.4 -alkanesulphonyl radicals, m is 2, 3 or 4, X and Y, which can be the same or different, are hydrogen atoms or benzyl radicals and R.sub.3 is a phenyl radical substituted twice by C.sub.1 -C.sub.6 -alkyl radicals, a nitrophenyl radical, an aminophenyl radical, a 1,3,5-tri-C.sub.1 -C.sub.6 -alkyl-2,4-dioxo-1H,3H-pyrimidin-6-yl radical, an indolyl radical, an indazolyl radical, a benzimidazolyl radical, a 1,4-di-C.sub.1 -C.sub.6 -alkylpyrazol-5-yl radical or a radical of the general formula: ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different, are C.sub.1 -C.sub.4 -alkyl radicals and R.sub.6 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: January 26, 1988
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Wolfgang Kampe, Erwin Bohm, Klaus Strein
  • Patent number: 4717736
    Abstract: Compounds having the formula: ##STR1##are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents and cytoprotective agents.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: January 5, 1988
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Joshua Rokach, Robert N. Young
  • Patent number: 4701447
    Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.
    Type: Grant
    Filed: September 23, 1983
    Date of Patent: October 20, 1987
    Assignee: Schering Corporation
    Inventors: Dhiru B. Vashi, Jeffrey N. Clark, Neil A. Lindo
  • Patent number: 4673582
    Abstract: Sweetening agents of general formula: ##STR1## wherein: X is a CN, COOC.sub.1 -C.sub.3 alkyl, COC.sub.1 -C.sub.3 alkyl, CONHC.sub.1 -C.sub.3 alkyl, SO.sub.2 C.sub.1 -C.sub.3 alkyl, SOC.sub.1 -C.sub.3 alkyl, SO.sub.2 NHC.sub.1 -C.sub.3 alkyl, NO.sub.2, F, Cl substituent;n is a number equal to 0 or 1;M is a hydrogen atom, or an organic or inorganic physiologically acceptable cation;Y is a COOC.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl, CH.sub.2 OH, CHOHCH.sub.3, CF.sub.3 substituent;Z is a C.sub.1 -C.sub.5 n-alkyl, isobutyl, isopentyl, phenyl, cyclohexyl, benzyl, cyclohexylmethyl, CH.sub.2 C.sub.6 H.sub.4 OH(p), CH.sub.2 OC.sub.1 -C.sub.4 alkyl, CH.sub.2 COOC.sub.1 -C.sub.4 alkyl, CH.sub.2 SC.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.sub.2 SCH.sub.3, CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3, COOC.sub.1 -C.sub.4 alkyl, COOC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.2 -C.sub.4 alkyl, CONHC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.3 -C.sub.7 thiacycloalkyl, or CONHCH.sub.2 COOCH.sub.3 group;characterized in that A is an N--CN group.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: June 16, 1987
    Assignee: Universite Claude Bernard/Lyon 1
    Inventors: Claude Nofre, Jean M. Tinti
  • Patent number: 4668703
    Abstract: This invention is for .gamma.-allenyl-.gamma.-aminobutyric acid derivatives which are .gamma.-aminobutyric acid transaminase inhibitors.
    Type: Grant
    Filed: July 1, 1985
    Date of Patent: May 26, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Alexander Krantz, Arlindo L. Castelhano, Diana H. Pliura
  • Patent number: 4666510
    Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: X is selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkynyl, alkenyloxy, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, amino, substituted amino, and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;m is an integer chosen from 3 to 5.
    Type: Grant
    Filed: January 25, 1983
    Date of Patent: May 19, 1987
    Assignee: ICI Australia Limited
    Inventors: Keith G. Watson, Lynette A. Garson, Graham J. Bird, Lindsay E. Cross, Graeme J. Farquharson
  • Patent number: 4665193
    Abstract: Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: May 12, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
  • Patent number: 4661515
    Abstract: Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, and cycloalkyl, and may be the same or different; n is an integer from 0 to 4 inclusive; M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cyloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl, or M and R.sub.6 taken together with the nitrogen to which M is bonded and the carbon to which R.sub.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: April 28, 1987
    Assignee: USV Pharmaceutical Corporation
    Inventors: Edward S. Neiss, John T. Suh, John J. Piwinski
  • Patent number: 4659855
    Abstract: Certain novel aryl sulfonyl fluorides, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity.
    Type: Grant
    Filed: May 9, 1983
    Date of Patent: April 21, 1987
    Assignee: Georgia Tech Research Corporation
    Inventor: James C. Powers
  • Patent number: 4659366
    Abstract: Herbicidally and fungicidally active novel 2-(alkoximiminoalkoxycarbonyl)-phenylsulphonylureas of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy or nitro,R.sup.2 represents hydrogen, alkyl or optionally substituted aryl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen, alkyl, alkoxy, alkylthio, alkoxyalkyl, alkylthioalkyl, cyano, alkoxycarbonyl or optionally substituted aryl,R.sup.5 represents hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, alkoxyalkyl, alkylthioalkyl or optionally substituted aralkyl,Y represents oxygen or sulphur andHet represents a heterocyclic radical of the formula ##STR2## wherein E represents nitrogen or the CH group andR.sup.6 and R.sup.7 independently of one another each represent alkyl, alkoxy or alkoxyalkyl.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: April 21, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jorg Stetter, Robert R. Schmidt, Hans-Joachim Santel, Gerd Hanssler, Ludwig Eue
  • Patent number: 4654369
    Abstract: Amides and esters of 2-(substituted sulfamyl)-6-nitro-benzoic acid, in which the substituents on the sulfamyl nitrogen are non-basic, such as: hydrogen, alkyl, hydroxyalkyl and non-basic heterocycles, which are useful as adjuncts to radiation therapy.
    Type: Grant
    Filed: November 6, 1985
    Date of Patent: March 31, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Walfred S. Saari
  • Patent number: 4652303
    Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: W are selected from the group consisting of:the groups R.sup.5 --CO-- and R.sup.5 --CS-- wherein: R.sup.5 is selected from alkenyl, alkynyl, benzyl, phenyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted benzyl, substituted phenyl and the acetal, hemiacetal, oxime, imine and Schiff base derivatives of the group R.sup.5 --CO--;the groups Y--CO-- and Y--CS-- wherein Y is selected from hydroxy, mercapto, alkylthio and the groups MO-- and MS-- wherein M is an organic or an inorganic cation;the groups R.sup.6 R.sup.7 NCO-- and R.sup.6 R.sup.7 NCS-- wherein R.sup.6 and R.sup.7 are independently selected from hydrogen, alkyl, substituted alkyl, alkanoyl, carboxy, alkoxycarbonyl, alkylsulfonyl, benzoyl, benzenesulfonyl, substituted benzoyl, substituted benzenesulfonyl, or R.sup.6 and R.sup.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: March 24, 1987
    Assignee: ICI Australia Limited
    Inventors: Keith G. Watson, Graham J. Bird, Graeme J. Farquharson
  • Patent number: 4647588
    Abstract: 2-(Substituted sulfamyl) derivatives of 6-nitrobenzoic acid wherein at least one of the sulfamyl substituents is a basic substituent selected from amino-(lower alkyl), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl) are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
    Type: Grant
    Filed: November 6, 1985
    Date of Patent: March 3, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Edward L. Engelhardt, Walfred S. Saari
  • Patent number: 4645678
    Abstract: Compounds of the formula: ##STR1## in which: X represents at least one lone-electron pair donor group;A represents an oxygen or a sulfur atom, or an optionally substituted imino or methylene group;R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms;n represents a number equal to zero or to one;B represents a COOH or COOM group (M designating a cation);Y represents either a lone-electron pair donor group, or an alkyl group R' of 1 to 4 carbon atoms;Z representseither an optionally substituted hydrophobic group R", R" designating an alkyl, cycloalkyl or aryl group of 1 to 12 carbon atoms;or a lone-electron pair donor group on which a hydrophobic group R" is fixed;are useful as sweetening agents.
    Type: Grant
    Filed: September 15, 1983
    Date of Patent: February 24, 1987
    Assignee: Universite Claude Bernard - Lyon 1
    Inventors: Claude Nofre, Jean-Marie Tinti
  • Patent number: 4629491
    Abstract: The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of urease through use of such compounds.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: December 16, 1986
    Assignee: Allied Corporation
    Inventors: Michael D. Swerdloff, Milorad M. Rogic, Larry L. Hendrickson
  • Patent number: 4628109
    Abstract: The invention relates to new 2-ketosulfonamides of the formula ##STR1## and to a process for their preparation, wherein the 3-amino-2-sulfamoylalk-2-enoic acid esters of the formula ##STR2## obtained by reacting 3-aminoalk-2-enoic acid esters of the formula ##STR3## with amidosulfonyl chlorides of the formula X-SO.sub.2 -NH-R.sup.2, are subjected to hydrolysis and decarboxylation. The invention also relates to the 3-amino-2-sulfamoylalk-2-enoic acid esters which can be isolated as intermediates.
    Type: Grant
    Filed: June 27, 1984
    Date of Patent: December 9, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Erwin Schmidt, Dieter Gunther, Klaus-Dieter Kampe
  • Patent number: 4623658
    Abstract: Pesticidal benzoylurea compounds of the formula: ##STR1## wherein R represents a moiety --C(O)OR.sup.1 or --NR.sup.2 R.sup.3, and the meanings of each of the other symbols is described in the specification.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: November 18, 1986
    Assignee: Shell Oil Company
    Inventor: Martin Anderson
  • Patent number: 4623652
    Abstract: Novel compounds of the general formula ##STR1## wherein R.sub.1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkenylene; x is 1 or 2, provided that when x is greater than 1, different occurrences of the ##STR2## group may be the same or different; Ar is heterocyclic, unsubstituted aromatic or aromatic substituted with lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halogen, acetamido, amino, nitro, lower alkylamino, hydroxy, lower hydroxyalkyl or cyano; W is alkylene containing from 1 to about 10 carbon atoms; and B is --NR.sub.2 COR.sub.3, --NR.sub.2 CONR.sub.3 R.sub.4, --NR.sub.2 SO.sub.2 R.sub.3, --NR.sub.2 SO.sub.2 NR.sub.3 R.sub.4, or --NR.sub.2 COOR.sub.5, wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R.sub.3 and R.
    Type: Grant
    Filed: January 16, 1985
    Date of Patent: November 18, 1986
    Assignee: American Hospital Supply Corporation
    Inventors: Paul W. Erhardt, William L. Matier
  • Patent number: 4621098
    Abstract: The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, Q is an oxygen or sulphur atom or an NH group, A is a straight-chained or branched C.sub.2 -C.sub.8 alkylene radical which is optionally substituted by a hydroxyl group or can be interrupted by an ethenylene or ethynylene group, n is 0, 1 or 2, and R is a hydrogen atom or a straight-chained or branched alkyl radical which is optionally substituted one or more times by the same or different radicals selected from alkoxycarbonyl, alkoxy, hydroxyl, carboxyl or optionally substituted carbamoyl or amino; as well as the pharmacologically acceptable salts thereof, with the proviso that A cannot be ethylene when Ar is a phenyl radical, Q is an oxygen atom and R is the group --CH.sub.2 COOH.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: November 4, 1986
    Assignee: Boehringer Mannheim GmbH
    Inventors: Robert Umminger, Walter-Gunar Friebe, Wolfgang Kampe, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4621149
    Abstract: A process for producing a urethane compound which comprises reacting at least one compound selected from the group consisting of a primary amine, a secondary amine and a urea compound with carbon monoxide and an organic hydroxyl compound in the presence of a catalyst system comprising:(a) at least one member selected from the group consisting of platinum group metals and compounds containing at least one platinum group element; and(b) at least one halogen-containing compound selected from the group consisting of alkali or alkaline earth metal halides, onium halides, compounds capable of forming onium halides in the reaction, oxo acids of halogen atoms and their salts, complex compounds containing halogen ions, organic halides and halogen molecules,in the presence of molecular oxygen and/or an organic nitro compound as an oxidizing agent at a temperature of from about 80.degree. C. to about 300.degree. C. under a pressure of from about 1 Kg/cm.sup.2 to about 500 Kg/cm.sup.2.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: November 4, 1986
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Shinsuke Fukuoka, Masazumi Chono
  • Patent number: 4618708
    Abstract: Derivatives having the general formula: ##STR1## in which the various radicals A,B,X,R.sub.1, R.sub.2, R.sub.3 and n have indicated definitions. These compounds have in particular enkephalinase-inhibiting, antalgic, antidepressive, antidiarrhea and hypotensive activities.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: October 21, 1986
    Inventors: Bernard Roques, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Patent number: 4609673
    Abstract: The present invention provides carboxylic acid derivatives of the general formula: ##STR1## wherein R is a hydrogen atom, alkyl, a metal cation or an ammonium or alkylammonium ion, R.sub.1 is a hydrogen atom, a hydroxyl group or an alkyl, O-alkyl,O-benzyl or O-acyl radical, R.sub.2 is a hydrogen atom or an alkyl, aryl or aralkyl radical, n is 0, 1 or 2 and R.sub.
    Type: Grant
    Filed: December 18, 1984
    Date of Patent: September 2, 1986
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hermann Eggerer, Bernd Hagenbruch, Tran G. Nguyen, Karlheinz Stegmeier, Johannes Pill
  • Patent number: 4609753
    Abstract: The invention relates to new diphenyl ethers of the general formula ##STR1## wherein X is a trifluoromethyl group or an alkylsulphonyl group having 1-4 carbon atoms;R is an alkylene or alkylidene group having 1-12 carbon atoms; andA is a bis(alkoxyethoxy)phosphinyl group having 6-12 carbon atoms, a bis(alkoxyethoxyethoxy)phosphinyl group having 10-16 carbon atoms, a carboxy group, an alkenyloxycarbonyl group having 3-6 carbon atoms, an unsubstituted aminocarbonyl group, an N-alkylaminocarbonyl group having 2-5 carbon atoms, the alkyl group of which is substituted with a dialkylamino group having 2-4 carbon atoms, a cyano group, or an alkyloxycarbonyl group having 2-5 carbon atoms, the alkyl group of which may be substituted with an alkoxy, alkylthio or alkylsulphonyl group having 1-4 carbon atoms, with an alkoxyethoxy group having 3-6 carbon atoms, with a dialkylamino group having 2-4 carbon atoms, or with a hydroxyalkyldithio group having 2-4 carbon atoms;with the provisos, that(a) when X is a trifluoromethy
    Type: Grant
    Filed: May 2, 1984
    Date of Patent: September 2, 1986
    Assignee: Duphar International Research B.V.
    Inventors: Gerard B. Paerels, Cornelis W. Raven
  • Patent number: 4606737
    Abstract: Fluorochemical allophanates containing one or more monovalent fluoroaliphatic radicals having at least three fully fluorinated terminal carbon atoms and one or more allophanate moieties, the radicals and moieties bonded together by hetero atom-containing or organic linking groups are provided. These fluorochemical allophanates are useful in the form of aqueous dispersions or emulsions or organic solutions in the treatment of fibrous substrates, such as textile fibers, to impart oil and water repellency.
    Type: Grant
    Filed: June 26, 1984
    Date of Patent: August 19, 1986
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Richard M. Stern
  • Patent number: 4596823
    Abstract: Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo[2,2,1]hept-2Z-ene, bicyclo[2,2,1]heptane, 7-oxabicyclo[2,2,1]hept-2Z-ene, 7-oxabicyclo[2,2,1]heptane, bicyclo[2,2,2]oct-2Z-ene or bicyclo[2,2,2]octane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group C(R.sup.2).dbd.NR, a 6,6-dimethyl-bicyclo[3,1,1]heptane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group C(R.sup.2).dbd.NR or at the 5-position by the group C(R.sup.2).dbd.NR and at the 6-position by the group R.sup.1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R.sup.1 and at the 5-position by the group C(R.sup.2).dbd.NR, or a 1-hydroxycyclopentane substituted at the 2-position by the group R.sup.1 and at the 2-position by the group C(R.sup.2).dbd.NR, R.sup.1 is a 6-caboxyhex-2-enyl group or a modification thereof as defined herein, R.sup.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: June 24, 1986
    Assignee: National Research Development Corporation
    Inventors: Robert L. Jones, Norman H. Wilson
  • Patent number: 4593116
    Abstract: Urethanes are made by reacting an organic nitro compound with an organic compound containing at least one hydroxyl group in the presence of carbon monoxide, hydrogen and a catalyst system. The carbon monoxide and hydrogen are used in quantities such that the molar ratio of CO to H.sub.2 is from 0.3:1 to 3:1. The catalyst system is made up of at least one noble metal or compound of a noble metal from Group VIIIB of the Periodic System of Elements, at least one organic nitrogen base and a co-catalyst combination of iron or copper oxidic or hydroxidic compound and a chloride compound. The product urethanes are useful in the production of isocyanates and pesticides.
    Type: Grant
    Filed: June 13, 1984
    Date of Patent: June 3, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Stammann, Johann Grolig, Robert Becker, Helmut Waldmann
  • Patent number: 4589914
    Abstract: Herbicidally effective diphenyl ether compounds of the formula: ##STR1## where, for example, X is a halogen atom or a nitro group, R.sup.1 is a hydrogen atom or a chlorine, bromine or iodine atom, and R.sup.2 is a group --OR.sup.3 wherein R.sup.3 is an alkyl group containing from 1 to 12 carbon atoms.
    Type: Grant
    Filed: March 27, 1984
    Date of Patent: May 20, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventor: David Cartwright
  • Patent number: 4582923
    Abstract: Urethanes are made by reacting a primary amine with carbon monoxide and a compound containing at least one hydroxyl group in the presence of an oxidizing agent and a catalyst system. The catalyst system is made up of (i) a noble metal and/or a noble metal compound of a metal of the Eighth Secondary Group of the Periodic System of Elements and (ii) an oxidizing quinoid and/or a compound capable of being converted to an oxidizing quinoid compound under the reaction conditions. The catalyst system may optionally include (iii) metal compounds of elements of the Third to Fifth Main Groups and/or First to Eighth Secondary Groups of the Periodic System of Elements and/or (iv) a tertiary amine. This reaction is generally carried out at a temperature of from 100.degree. to 300.degree. C. and at a pressure of from 5 to 500 bars. The product urethanes are useful in the production of isocyanates and pesticides.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: April 15, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Stammann, Robert Becker, Johann Grolig, Helmut Waldmann
  • Patent number: 4564695
    Abstract: An N.sup..alpha. -protected-N.sup.G -protected-arginyl-p-nitro-anilide with high purity can be produced in high yield by reacting an N.sup..alpha. -protected-N.sup.G -protected-arginine with p-nitroaniline in pyridine in the presence of a condensing agent.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: January 14, 1986
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Katsumasa Kuroiwa, Shuichi Nakatsuyama, Takeshi Nagasawa
  • Patent number: 4550189
    Abstract: Soil repellents derived from fluorinated acrylates and aromatic amines are disclosed which have excellent durability and resistance to laundering. The compounds are represented by the formula(R).sub.m --Ar--(NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.f).sub.nwherein n is 1 to 3 and m is 0 to 4, Ar is an aromatic radical containing from 1 to 3 benzene rings which may be fused together or linked through a single carbon-carbon bond or a linking group, R.sub.f is a fluorinated radical, R.sub.1 is H or CH.sub.3, and R is independently selected from lower alkyl, lower alkoxy, halogen, hydroxy, nitro, cyano, amino, lower alkylamino, lower acylamino, --CO.sub.2 R.sub.3 and --NHCH.sub.2 CH(R.sub.1)CO.sub.2 R.sub.3 wherein R.sub.3 is lower alkyl, --CH.sub.2 CH.sub.2 OH, or --CH.sub.2 CH(OH)CH.sub.2 Cl. Also disclosed are polyester and nylon fibers having these compounds incorporated therein.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: October 29, 1985
    Assignee: American Hoechst Corporation
    Inventors: Michael G. Kelly, James H. Covill
  • Patent number: 4545995
    Abstract: The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.
    Type: Grant
    Filed: July 12, 1983
    Date of Patent: October 8, 1985
    Assignee: Schering A.G.
    Inventors: William C. Lumma, Jr., Ronald A. Wohl
  • Patent number: 4537621
    Abstract: Diphenyl ethers of the formula ##STR1## where Z.sup.1, Z.sup.2, and Z.sup.3 and R have the meanings given in the description, are used for controlling undesirable plant growth.
    Type: Grant
    Filed: March 31, 1983
    Date of Patent: August 27, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Adolf Parg, Hans Ziegler, Bruno Wuerzer
  • Patent number: 4517354
    Abstract: The compositions disclosed herein comprise compounds of the formula:DOOCArO-ArSO.sub.2 Ar'QAr'SO.sub.2 Ar-OArCOOD (I)and also derivatives and polymers therefrom or from the compound:X-ArSO.sub.2 Ar'QAr'SO.sub.2 Ar-Xin which compounds D is hydrogen, halogen or a monovalent hydrocarbon radical, preferably of 1-20 carbon atoms; Q is either --O-- or --SO.sub.2 --; Ar and Ar' are divalent aromatic groups including a multiplicity of aromatic groups linked by O, SO.sub.2, hydrocarbon groups, etc.; and X is preferably Cl but may be other halogen atoms. In these compounds, the central core or residue --ArSO.sub.2 Ar'QAr'SO.sub.2 Ar-- may be represented by A. Various derivatives and polymers having the core A are prepared, such as diamides of the formula R.sub.2 NOCArO-A-OArCONR.sub.2 ; polyester polymers of the formula [--OROOCArO-A-OArCO--]; polyarylate polymers of the formula [--ArCOOArO-A-OArOOCArCOO--]; polycarbonate polymers of the formula [--OCOOArO-A-OArOOCO--]; phenolic resins, and many other derivatives.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: May 14, 1985
    Assignee: Plastics Engineering Company
    Inventor: Gaetano F. D'Alelio, deceased
  • Patent number: 4517193
    Abstract: A benzoylurea compound of formula: ##STR1## in which each of P and Q independently represents a halogen atom or an alkyl group; m represents 0, 1 or 2; R represents an optionally-substituted alkyl, alkenyl, alkynyl, cycloalkyl or phenyl group, a hydrogen atom, one equivalent of an alkali metal or alkaline earth metal, or an ammonium or substituted ammonium group; each X independently represents a halogen atom, a cyano, nitro or carboxy group, or an optionally-substituted alkyl, alkoxy, alkylthio, cycloalkyl, cycloalkyloxy, cycloalkylthio, alkenyl, alkenylthio, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, alkynyl, phenyl, phenoxy, phenylthio or amino group; q=0, 1, 2, 3 or 4; T represents a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyloxy or haloalkenyloxy group, or a phenoxy or pyridyloxy group optionally substituted by one or more substituents selected from halogen atoms and nitro, alkyl, haloalkyl and cyano groups; each Y independently represents a halogen atom or a nitro, cyano, alkyl or
    Type: Grant
    Filed: September 7, 1983
    Date of Patent: May 14, 1985
    Assignee: Shell Oil Company
    Inventor: Martin Anderson
  • Patent number: RE32215
    Abstract: 2-nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: July 22, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen
  • Patent number: RE32216
    Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: July 29, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen
  • Patent number: RE32243
    Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: September 9, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen