Sulfur In Acid Moiety Patents (Class 560/147)
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Patent number: 11377522Abstract: A silicon-containing polymer which results in a composition that forms a coated film having good adhesive properties to a substrate and does not easily peel off the substrate, a film-forming composition including the polymer, a method for forming a silicon-containing polymer coating using the composition, a method for forming a silica-based coating using the composition, and a production method for the polymer. In a silicon-containing polymer including at least one of poly- or oligo-siloxane chain and poly- or oligo-silane chain in a molecular chain, a group having a silyl group and a sulfide group, which can be subjected to a condensation reaction, is introduced into the molecular chain, for example, by an ene-thiol reaction.Type: GrantFiled: May 11, 2020Date of Patent: July 5, 2022Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Kunihiro Noda, Takehiro Seshimo, Keisuke Kubo, Yohei Kinoshita
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Patent number: 11015007Abstract: There is provided an active energy ray-curable composition having excellent storage stability. The active energy ray-curable composition includes: active energy ray-curable compound (A) having an unsaturated ethylenic double bond; thiol compound (B) having two or more mercapto groups in one molecule; reaction inhibitor (C) configured to inhibit a reaction between the unsaturated ethylenic double bond and the mercapto groups; radical polymerization inhibitor (D); and water (E), wherein the content of water (E) is 0.05 ppm by mass or more and less than 1% by mass. When the total content of active energy ray-curable compound (A) and thiol compound (B) is 100 parts by mass, the content of reaction inhibitor (C) is 0.005 parts by mass or more and 10 parts by mass or less, and the content of radical polymerization inhibitor (D) is 0.005 parts by mass or more and 5 parts by mass or less.Type: GrantFiled: February 2, 2017Date of Patent: May 25, 2021Assignee: SHOWA DENKO K.K.Inventors: Mina Onishi, Tomokazu Sugawara
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Patent number: 10975332Abstract: Described herein are home care compositions comprising: a surfactant system comprising a non-ionic surfactant; and a carrier.Type: GrantFiled: December 27, 2018Date of Patent: April 13, 2021Assignee: Colgate-Palmolive CompanyInventor: Juan Leon Navarro
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Patent number: 10745652Abstract: Described herein, are dishwashing paste compositions comprising: an abrasive; a pH modifying agent in an amount effective to provide a pH greater than 7; a structuring agent; and a source of polyvalent cations. Methods of making and using these compositions are also described.Type: GrantFiled: June 21, 2019Date of Patent: August 18, 2020Assignee: Colgate-Palmolive CompanyInventors: Joshua Gerardo Henderson Villalpando, Ammanuel Mehreteab, Lidia Venegas, Margarita Zapata Menchaca, Arianis Riofrio, Mario Alejandro Herrera Lazo De La Vega, Santiago Salas
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Patent number: 10696627Abstract: A process for producing a pentaerythritol mercaptocarboxylic acid ester of the present invention includes: a step of reacting pentaerythritol with a mercaptocarboxylic acid, in which an absorbance of a 5 wt % aqueous solution of the pentaerythritol at a wavelength of 270 nm, which is measured using a quartz cell having an optical path length of 50 mm, is 0.07 or less.Type: GrantFiled: June 24, 2016Date of Patent: June 30, 2020Assignee: MITSUI CHEMICALS, INC.Inventors: Shigetoshi Kuma, Masayuki Furuya, Takeshi Nishimura
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Publication number: 20150133533Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing cough may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of acute respiratory tract infections, asthma, gout, fibromyalgia, facilitating conception, promotes secondary mucosal secretions in the respiratory system, muscle relaxant, allergy, asthma, chronic obstructive pulmonary disorders, spasms, respiratory and neurological diseases.Type: ApplicationFiled: January 30, 2013Publication date: May 14, 2015Inventor: Mahesh Kandula
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Patent number: 9023957Abstract: The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-terminal tertiary N,N-bis(2-mercaptoethyl)-amide (BMEA) undergo N-to-S acyl transfer at weakly acidic pH to form a transient thioester which can be captured for direct ligation with a cysteinyl peptide. These C-terminal BMEA peptides are easily prepared with standard Fmoc solid-phase synthesis protocols, thus giving a very convenient access to the thioester components for native chemical ligation.Type: GrantFiled: July 6, 2011Date of Patent: May 5, 2015Assignee: Nanyang Technological UniversityInventor: Chuan Fa Liu
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Publication number: 20150073109Abstract: An intermediate compound for forming a RAFT agent is provided that can have the formula: where n is an integer from 1 to 20; m is an integer from 0 to 20; R1 is H, an alkyl group, or a cyano group; R2 is H, an alkyl group, or a cyano group; Y is OH, COOH, or NH2; and X is OH, COOH, NH2, a nitrobenzyl, benzyl, or para-methyl benzyl group. A RAFT agent is also provided that comprises a thiocarbonylthio-containing organic compound having a phosphonic end group. A method is also provided for forming a polymer chain on a surface of a nanoparticle utilizing the RAFT agent, along with nanoparticles and nanocomposites formed therefrom.Type: ApplicationFiled: September 12, 2014Publication date: March 12, 2015Inventors: Brian Benicewicz, Anand Viswanath, Alexandra Nicole Green
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Patent number: 8907119Abstract: In the acid-catalyzed esterification of mercaptoalkyl alcohols by means of carboxylic acids to form mercaptoalkly carboxylates, formation of undesirable, usually sparingly soluble by-products usually occurs. The process of the invention in the absence of acid catalysts avoids the formation of such by-products. Particularly when the esterification of the invention is carried out as reactive distillation using reactive column and residence vessel, good degrees of conversion can also be obtained without acid catalyst and at the same time the formation of the by-products can be largely avoided.Type: GrantFiled: August 22, 2012Date of Patent: December 9, 2014Assignee: BASF SEInventors: Florian Garlichs, Jens Baldamus, Gerd Kaibel
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Publication number: 20140350290Abstract: A composition having a compound having the structure: wherein n is an integer greater than or equal to 1; wherein X is an alkyl moiety or aryl moiety; wherein X1 is an alkyl moiety or aryl moiety; wherein Y is an alkyl moiety or aryl moiety, having a carbon number that is greater than or equal to 0, and wherein if Y has a carbon number of 0, the compound has the structure:Type: ApplicationFiled: May 21, 2014Publication date: November 27, 2014Inventors: Donald STEVENSON, John NUSSBAUMER, Louis E. BONA
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Patent number: 8748070Abstract: Provided is a thiol group-containing charge transporting material represented by the following general formula (1): F-[(G)a1-(X)a2—Y—SH]b??(1) wherein F represents an organic group derived from a charge transporting compound, G represents a divalent organic group having 1 to 5 carbon atoms, X represents a group selected from a —CO—O— group, an —O—CO— group, and an —O— group, Y represents a divalent organic group having 1 to 5 carbon atoms, a1 and a2 each independently represent 0 or 1, and b represents an integer of 1 or more and 6 or less.Type: GrantFiled: August 25, 2011Date of Patent: June 10, 2014Assignee: Fuji Xerox Co., Ltd.Inventors: Katsumi Nukada, Kenya Sonobe, Wataru Yamada, Takatsugu Doi, Tsuyoshi Miyamoto, Yuko Iwadate
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Publication number: 20140155518Abstract: The present invention relates to silica-containing rubber mixture produced from at least one rubber, from a sulphur-containing alkoxysilane, from a crosslinking agent, from a filler, and optionally from further rubber auxiliaries, where the said mixture comprises from 0.Type: ApplicationFiled: April 27, 2012Publication date: June 5, 2014Applicant: LANXESS Deutschland GmbHInventors: Melanie Wiedemeier, Hermann-Josef Weidenhaupt, Ulrich Feldhues, Irene Moll
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Publication number: 20140154525Abstract: The present invention generally relates to an aqueous solution for the formation of a passivation layer on a zinc layer or zinc-alloy layer. More particularly, the invention relates to the formation of a black passivation layer on a zinc layer or zinc-alloy layer, which passivation layer is substantially free of hexavalent chromium. Furthermore, the present invention relates to method for the formation of a passivation layer on a zinc layer or zinc-alloy layer, as well as a passivation layer on a zinc layer or zinc-alloy layer itself. The solution used contains trivalent chromium ions, nitrate ions, an organic acid and a dithioglycolate.Type: ApplicationFiled: February 23, 2012Publication date: June 5, 2014Applicant: ENTHONE INC.Inventors: Rene Van Schaik, Keith Richard Zone
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Patent number: 8741966Abstract: The present disclosure relates to lipid compounds of formula (I): wherein: R1 is chosen from a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, and a C10-C21 alkynyl having 1-6 triple bonds; R2 and R3 are the same or different and are chosen from hydrogen and a C1-C6 alkyl; X is chosen from O, S, SO, SO2, Si, and Se; n=1 or 3; and P1 is chosen from hydrogen; a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, a C10-C21 alkynyl having 1-6 triple bonds, optionally substituted; a group of formula (II) or formula (III), wherein P2, P3, and P4 are chosen from hydrogen, an alkyl, an alkenyl, and an alkynyl, optionally substituted; and a group of formula (IV) or formula (V), wherein P5 is chosen from hydrogen and a C1-C6 alkyl; or a pharmaceutically acceptable salt, complex, or solvate thereof.Type: GrantFiled: November 6, 2008Date of Patent: June 3, 2014Assignee: Pronova Biopharma Norge ASInventor: Anne Kristin Holmeide
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Publication number: 20140142227Abstract: The present invention relates to silica-containing rubber mixture produced from at least one rubber, from a sulphur-containing alkoxysilane, from a crosslinking agent, from a filler, and optionally from further rubber auxiliaries, where the said mixture comprises from 0.Type: ApplicationFiled: April 27, 2012Publication date: May 22, 2014Applicant: LANXESS Deutschland GmbHInventors: Melanie Wiedemeier, Hermann-Josef Weidenhaupt, Ulrich Feldhues, Irene Moll
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Publication number: 20140100267Abstract: Novel compounds, and in particular to diacylglycerol (1, 3-DAG) and alpha-lipoic acid (LA) and/or dihydro-alpha-lipoic acid (DHLA) derivatives. In particular these novel compounds are used as functional food additives. These may for example be used as nutraceuticals and/or pharmaceuticals in the prevention and treatment of obesity, diabetes, atherosclerosis, oxidative stress and other lifestyle-related diseases.Type: ApplicationFiled: December 6, 2013Publication date: April 10, 2014Inventor: Paresh DUTTA
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Publication number: 20140066589Abstract: High molecular weight disulfide polymers are synthesized in aqueous media by exposing dithiol compounds to a mild oxidizing environment in the presence of a tertiary amine catalyst. The unique oxidizing system polymerizes monomers through the formation of sulfur-sulfur bonds between dithiol compounds. The same oxidizing system may be used to make disulfide-crosslinked gels from compounds containing multiple thiol groups. The oxidizing system is comprised of oxygen at atmospheric concentration and dilute hydrogen peroxide. A filler such as carbon black may be incorporated into the polymer or cross-linked gel during polymerization. A polydisulfide polymer is provided having a weight average molecular weight of greater than about 100,000 g/mol and a polydispersity index of about 2 or less. A tetrathiol composition results from a reaction of a diacrylate with a trithiol.Type: ApplicationFiled: September 3, 2013Publication date: March 6, 2014Applicant: The University of AkronInventors: Judit E. Puskas, Emily Q. Rosenthall
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Publication number: 20140020932Abstract: The purpose of the present invention is to provide a printed circuit board wherein a resin layer exhibits excellent adhesion and a method for manufacturing said printed circuit board. This printed circuit board is provided with an insulating substrate, metal wiring laid out on said insulating substrate, and an insulating layer disposed on top of said metal wiring. A layer consisting of a thiol compound having at least four functional groups represented by formula (1) is interposed between the metal wiring and the insulating layer at the interface therebetween.Type: ApplicationFiled: September 27, 2013Publication date: January 23, 2014Applicant: FUJIFILM CorporationInventor: Koichi MINAMI
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Patent number: 8624052Abstract: S-t-butyl protected cysteine di-peptide analogs and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).Type: GrantFiled: November 11, 2011Date of Patent: January 7, 2014Assignee: Promentis Pharmaceuticals, Inc.Inventors: Edward M. Johnson, Daniel G. Lawton
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Patent number: 8604234Abstract: The invention relates to a method for preparing acrolein from glycerol or glycerin, according to which dehydration of glycerol or glycerin is carried out in the presence of a catalyst which consists in at least one silica modified with zirconium dioxide, titanium dioxide or tungsten trioxide or any combination of these oxides, and a heteropolyacid. This method may be used for making 3-(methylthio)propionic aldehyde (MMP), 2-hydroxy-4-methylthiobutyronitrile (HMBTN), methionine or its analogs, from acrolein.Type: GrantFiled: December 21, 2010Date of Patent: December 10, 2013Assignees: Adisseo France S.A.S., Centre National de la Recherche Scientifique, Universite Lille 1-Sciences et TechnologiesInventors: Sebastien Paul, Benjamin Katryniok, Franck Dumeignil, Mickael Capron
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Patent number: 8536364Abstract: The present invention provides a method for producing sulfur-containing carboxylic acid esters that are useful for aromatizing and flavoring purpose and can cater to the needs for diversified aromatized and/or flavored products, and to further provide a fragrance and/or flavor composition comprising the ester producible by the method and an aromatized and/or flavored product comprising the same. The sulfur-containing carboxylic acid ester is represented by the following formula (3): wherein R1 represents an alkyl group having 1 to 10 carbon atoms or an optionally substituted phenyl group (wherein the substituent thereof is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms), R2 and R3 independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkenyl group having 2 to 10 carbon atoms, or R2 and R3 together form an alkylene group, and R4 represents an alkyl group having 1 to 4 carbon atoms.Type: GrantFiled: April 25, 2011Date of Patent: September 17, 2013Assignee: Takasago International CorporationInventors: Teruhiko Inaba, Kazuma Hojo, Kenya Ishida
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Publication number: 20130217912Abstract: In the acid-catalyzed esterification of mercaptoalkyl alcohols by means of carboxylic acids to form mercaptoalkly carboxylates, formation of undesirable, usually sparingly soluble by-products usually occurs. The process of the invention in the absence of acid catalysts avoids the formation of such by-products. Particularly when the esterification of the invention is carried out as reactive distillation using reactive column and residence vessel, good degrees of conversion can also be obtained without acid catalyst and at the same time the formation of the by-products can be largely avoided.Type: ApplicationFiled: August 22, 2012Publication date: August 22, 2013Applicant: BASF SEInventors: Florian Garlichs, Jens Baldamus, Gerd Kaibel
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Patent number: 8466309Abstract: The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier.Type: GrantFiled: May 13, 2009Date of Patent: June 18, 2013Inventors: Marie-Claude Fournie-Zaluski, Hervé Poras, Bernard Roques
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Publication number: 20130131286Abstract: The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-terminal tertiary N,N-bis(2-mercaptoethyl)-amide (BMEA) undergo N-to-S acyl transfer at weakly acidic pH to form a transient thioester which can be captured for direct ligation with a cysteinyl peptide. These C-terminal BMEA peptides are easily prepared with standard Fmoc solid-phase synthesis protocols, thus giving a very convenient access to the thioester components for native chemical ligation.Type: ApplicationFiled: July 6, 2011Publication date: May 23, 2013Applicant: NANYANG TECHNOLOGICAL UNIVERSITYInventor: Chuan Fa Liu
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Publication number: 20120277294Abstract: Novel compounds, and in particular to diacylglycerol (1,3-DAG) and alpha-lipoic acid (LA) and/or dihydro-alpha-lipoic acid (DHLA) derivatives. In particular these novel compounds are used as functional food additives. These may for example be used as nutraceuticals and/or pharmaceuticals in the prevention and treatment of obesity, diabetes, atherosclerosis, oxidative stress and other lifestyle-related diseases.Type: ApplicationFiled: December 23, 2010Publication date: November 1, 2012Inventor: Paresh Dutta
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Patent number: 8287846Abstract: The present invention relates to odour improved dermatological or cosmetic preparations comprising N-acetylcysteine and a polyol system containing one or more polyols as masking odour agents. The emulsions of the present invention are useful in the treatment of dermatological disorders or cosmetic skin conditions.Type: GrantFiled: July 13, 2007Date of Patent: October 16, 2012Assignee: ZAMBON S.p.A.Inventors: Luca Rampoldi, Alberto Moretto, Alessandro Grassano
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Publication number: 20120220596Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.Type: ApplicationFiled: May 7, 2012Publication date: August 30, 2012Applicants: UWM RESEARCH FOUNDATION, INC., MARQUETTE UNIVERSITYInventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
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Publication number: 20120208949Abstract: To provide a polyalkylene glycol chain-containing thiol polymer which is excellent in various performances, particularly significantly excellent in cement dispersibility, and useful in various applications such as an admixture for cement; a thiol-modified monomer or mixture thereof, which can produce such polymer; production methods of the polymer and the monomer; and a dispersant and an admixture for cement, each including the polymer. The polyalkylene glycol chain-containing thiol polymer is a polyalkylene glycol chain-containing thiol polymer, wherein the polymer comprises a polyalkylene glycol chain and a polymer segment bonded to at least one end of the polyalkylene glycol chain with a sulfur atom-containing group therebetween, the polymer segment includes a constitutional unit derived from an unsaturated monomer component, and the unsaturated monomer component includes an unsaturated carboxylic acid monomer and an unsaturated polyalkylene glycol monomer.Type: ApplicationFiled: April 20, 2012Publication date: August 16, 2012Applicant: NIPPON SHOKUBAI CO, LTDInventors: Noboru Sakamoto, Tsutomu Yuasa
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Publication number: 20120197028Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.Type: ApplicationFiled: January 31, 2011Publication date: August 2, 2012Applicant: Confluent Surgical, IncInventors: Rachit Ohri, Phillip Blaskovich, Joshua Kennedy, Steven L. Bennett, Arthur Driscoll
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Publication number: 20120196215Abstract: Provided is a thiol group-containing charge transporting material represented by the following general formula (1): F-[(G)a1-(X)a2—Y—SH]b??(1) wherein F represents an organic group derived from a charge transporting compound, G represents a divalent organic group having 1 to 5 carbon atoms, X represents a group selected from a —CO—O— group, an —O—CO— group, and an —O— group, Y represents a divalent organic group having 1 to 5 carbon atoms, a1 and a2 each independently represent 0 or 1, and b represents an integer of 1 or more and 6 or less.Type: ApplicationFiled: August 25, 2011Publication date: August 2, 2012Applicant: FUJI XEROX CO., LTD.Inventors: Katsumi NUKADA, Kenya SONOBE, Wataru YAMADA, Takatsugu DOI, Tsuyoshi MIYAMOTO, Yuko IWADATE
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Publication number: 20120128583Abstract: The present invention relates to DTPA derivatives capable of forming complexes by combining with metals and the like, metal complexes formed by combining with the DTPA derivatives, MR and CT contrast agents including gold (Au) nano-particles of which surfaces are coated with the metal complexes, and a method for manufacturing the same. The MR and CT contrast agents according to the present invention have a high magnetic relaxation rate, thereby providing an excellent contrast enforcement effect and a long image acquisition time. Furthermore, the MR and CT contrast agents are not toxic to the human body, and are image contrast agents of dual molecules capable of being applied to both MR and CT.Type: ApplicationFiled: December 13, 2009Publication date: May 24, 2012Applicant: Kyungpook National University Industry Academic Cooperation FoundationInventors: Tae Jung Kim, Yong Min Jang, Ji Ae Park
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Publication number: 20120128782Abstract: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.Type: ApplicationFiled: May 17, 2010Publication date: May 24, 2012Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Jordan J. Green, Joel C. Sunshine, Nupura S. Bhise, Ron B. Shmueli, Stephany Y. Tzeng
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Publication number: 20110301288Abstract: The present invention relates to thioic acids according to formula (II) suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (—CH2—)2, —CH2—O—CH2— or (—CH2—)3, R2 is preferably chosen from a biodegradable oligomer or polymer chosen from poly(lactide) (PLLA), polyglycolide (PGA), co-oligomers or copolymers of PLA and PGA (PLGA), poly(anhydrides), poly(trimethylenecarbonates), poly(orthoesters), poly(dioxanones), poly(?-caprolactones) (PCL) or polyesteramides and n>1.Type: ApplicationFiled: December 18, 2009Publication date: December 8, 2011Applicant: DSM IP ASSETS B.V.Inventors: Mark Johannes Boerakker, Aylvin Jorge Angelo Dias, Ronny Mathieu Versteegen
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Publication number: 20110282089Abstract: The present invention provides a method for producing sulfur-containing carboxylic acid esters that are useful for aromatizing and flavoring purpose and can cater to the needs for diversified aromatized and/or flavored products, and to further provide a fragrance and/or flavor composition comprising the ester producible by the method and an aromatized and/or flavored product comprising the same. The sulfur-containing carboxylic acid ester is represented by the following formula (3): wherein R1 represents an alkyl group having 1 to 10 carbon atoms or an optionally substituted phenyl group (wherein the substituent thereof is an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms), R2 and R3 independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms or an alkenyl group having 2 to 10 carbon atoms, or R2 and R3 together form an alkylene group, and R4 represents an alkyl group having 1 to 4 carbon atoms.Type: ApplicationFiled: April 25, 2011Publication date: November 17, 2011Inventors: Teruhiko Inaba, Kazuma Hojo, Kenya Ishida
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Publication number: 20110269903Abstract: The present invention provides bis(hydroxyalkyl)mercaptosuccinates of the formula: and derivatives thereof, where X1, X2, Z1, Z2, Y1, Y2, Ra, Rb, R1, and R2 are those defined herein. The present invention also provides methods for producing and using the same.Type: ApplicationFiled: April 29, 2011Publication date: November 3, 2011Applicant: WYSIS TECHNOLOGY FOUNDATION, INC.Inventors: John P. Droske, Mark J. Juetten
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Publication number: 20110257107Abstract: Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.Type: ApplicationFiled: June 27, 2011Publication date: October 20, 2011Applicant: University of RochesterInventors: Shey-Shing Sheu, Marion W. Anders, Lin Xu, Virendra K. Sharma, Dhanajaya Nauduri
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Publication number: 20110245530Abstract: A process for producing pentaerythritol mercaptocarboxylic ester by reacting pentaerythritol with a mercaptocarboxylic acid having a content of thioester formed by condensation of two molecules of the acid of 5% or below (in terms of area percentage) as determined by the high-performance liquid chromatography in the case of the total area of the mercaptocarboxylic acid and thioester formed by intermolecular condensation of the acid is taken as 100%.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Applicant: Mitsui Chemicals, Inc.Inventors: Michiharu SAKATA, Shigetoshi Kuma, Seiichi Kobayashi
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Publication number: 20110245531Abstract: Pentaerythritol which contains none of the alkali metals and the alkaline earth metals or which contains at least one of these in a total amount of 1.0 weight % or smaller is reacted with a mercaptocarboxylic acid to produce a pentaerythritol mercaptocarboxylic acid ester.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Applicant: Mitsui Chemicals, Inc.Inventors: Shigetoshi KUMA, Koichi Tokunaga, Norihiko Fukatsu, Seiichi Kobayashi
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Publication number: 20110237765Abstract: A perfluoropolyether thiol compound comprises a perfluoropolyether segment, at least one mercapto group (—SH), and at least one intervening divalent carbonylimino moiety (—C(?O)—NR—, wherein R is hydrogen or alkyl). The compound can be produced, for example, by a ring-opening reaction of thiolactones with perfluoropolyether-substituted, primary or secondary amines. The compound can be used, for example, as a polymerization chain transfer agent, as an intermediate for the preparation of functional group-containing fluorochemical derivatives such as disulfides, and as a fluorinated surface treatment.Type: ApplicationFiled: December 2, 2009Publication date: September 29, 2011Inventors: Suresh S. Iyer, Mark J. Pellerite, Chetan P. Jariwala
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Patent number: 7989655Abstract: Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cross-linked thiol esters. The thiol ester composition can be used to produce cross-linked thiol esters, sulfonic acid-containing esters, sulfonate containing esters and thioacrylate containing esters. The thiol ester compositions can be used to produce polythiourethanes. The polythiourethanes can be used in fertilizers and fertilizer coatings.Type: GrantFiled: February 17, 2005Date of Patent: August 2, 2011Assignee: Chevron Phillips Chemical Company LPInventors: Mitchell D. Refvik, Daniel M. Hasenberg, Michael S. Hankinson, Michael S. Matson, Dale M. Solaas, Steven J. Herron, Jim D. Byers
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Publication number: 20110150880Abstract: The invention relates to the compositions of synthetic oligo-?-(1?6)-2-amino-2-deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same.Type: ApplicationFiled: July 21, 2009Publication date: June 23, 2011Applicant: The Brigham and Women's Hospital, Inc.Inventors: Gerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
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Publication number: 20110124891Abstract: Compounds of formula (I): are disclosed. In these compounds Y is —CH(OH)—, —CH(NHR6)—, —C(=0)-, —CH?CHCO— or—formula (II)—and R1 and R2 are hydrogen, OH, alkyl, alkoxy, benzyloxy and aryl, and, when Y is —CH(OH)—, additionally alkenyl or alkynyl. Processes for the production of these compounds are also disclosed.Type: ApplicationFiled: August 16, 2008Publication date: May 26, 2011Inventors: John Welch, Silvana Ngo, Dong Sung Lim
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Patent number: 7919650Abstract: Organofunctional silanes, inclusive of dimers and oligomers, are provided in which individual silanes possess both free and blocked mercaptan functionality or particular mixtures of the organofunctional silanes possess both free and blocked mercaptan functionality. The organofunctional silanes and silane mixtures are useful, inter alia, as coupling agents for elastomeric compositions, e.g., rubber formulations employed in the manufacture of tires, where they exhibit a desirable balance of low scorch and good performance properties.Type: GrantFiled: February 21, 2006Date of Patent: April 5, 2011Assignee: Momentive Performance Materials Inc.Inventors: Antonio Chaves, Eric R. Pohl, Linda Vecere, Lesley Hwang
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Publication number: 20110071218Abstract: The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier.Type: ApplicationFiled: May 13, 2009Publication date: March 24, 2011Applicant: PHARMALEADSInventors: Marie-Claude Fournie-Zaluski, Hervé Poras, Bernard Roques
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Publication number: 20110065887Abstract: A process for producing pentaerythritol mercaptocarboxylic ester by reacting pentaerythritol with a mercaptocarboxylic acid having a content of thioester formed by condensation of two molecules of the acid of 5% or below (in terms of area percentage) as determined by the high-performance liquid chromatography in the case of the total area of the mercaptocarboxylic acid and thioester formed by intermolecular condensation of the acid is taken as 100%.Type: ApplicationFiled: July 28, 2010Publication date: March 17, 2011Applicant: Mitsui Chemicals, Inc.Inventors: Shigetoshi KUMA, Koichi Tokunaga, Norihiko Fukatsu, Seiichi Kobayashi
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Publication number: 20100323990Abstract: The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.Type: ApplicationFiled: June 21, 2007Publication date: December 23, 2010Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond Andersen, Matthew Nodwell, Alice Mui
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Publication number: 20100292431Abstract: A process for producing pentaerythritol mercaptocarboxylic ester by reacting pentaerythritol with a mercaptocarboxylic acid having a content of thioester formed by condensation of two molecules of the acid of 5% or below (in terms of area percentage) as determined by the high-performance liquid chromatography in the case of the total area of the mercaptocarboxylic acid and thioester formed by intermolecular condensation of the acid is taken as 100%.Type: ApplicationFiled: July 26, 2010Publication date: November 18, 2010Applicant: Mitsui Chemicals, Inc.Inventors: Michiharu Sakata, Shigetoshi Kuma, Seiichi Kobayashi
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Publication number: 20100273940Abstract: It is an object of the present invention to provide an epoxy resin curing agent which has a favorable pot life and good storage stability as a curing agent for epoxy resins and from which an epoxy resin cured product having good water resistance and hardness is obtained through curing. The present invention is an epoxy resin curing agent containing a secondary or tertiary branched thiol compound having a substituent on a carbon atom at the ?-position to a thiol group, and is also an epoxy resin composition comprising a polyvalent epoxy compound and the epoxy resin curing agent.Type: ApplicationFiled: December 8, 2008Publication date: October 28, 2010Applicant: SHOWA DENKO K.K.Inventors: Yoshifumi Urakawa, Hideo Miyata, Isao Yamagami, Katsumi Murofushi
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Patent number: 7816389Abstract: 14-O—[(((C1-6)Alkoxy-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O—[(((C1-6)Mono- or dialkylamino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Hydroxy-(C1-6)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Formyl-(C0-5)-alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Guanidino-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Ureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Thioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins, 14-O-[((Isothioureido-imino-(C1-6)alkyl)-phenylsulfanyl)-acetyl]-mutilins and their use as pharmaceuticals.Type: GrantFiled: January 11, 2007Date of Patent: October 19, 2010Assignee: Nabriva Therapeutics Forschungs GmbHInventors: Klaus Thirring, Gerd Ascher, Susanne Paukner, Werner Heilmayer, Rodger Novak
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Publication number: 20100234613Abstract: The present application provides a process for continuously producing 3-isothiazolinone derivatives and intermediate products thereof, comprising continuously carrying out four steps, i.e., sulfuration, purification, amination and chlorination. Compared with the batch process of the prior art, the process of the present application may reduce the amount of manufacturing devices, lower energy consumption, simplify operations, and is therefore particularly suitable for mass production.Type: ApplicationFiled: October 24, 2008Publication date: September 16, 2010Applicant: Beijing Tianqing Chemicals Co., LtdInventors: Yuechun Jin, Kezhong Li, Xueting Lu, Xiaolin Zhang, Yu Wang, Shuailin Zhou, Chao Li