Polycarboxylic Acid Patents (Class 560/171)
  • Patent number: 9956305
    Abstract: A method of reducing radiation exposure of a non-cancerous tissue of a patient diagnosed with a cancer includes administering to the patient an agent capable of competing for binding sites on a surface of the non-cancerous tissue, provided that the administration is carried out after a waiting period that follows administration of a compound including a radionuclide to the patient, the compound having affinity for both a cancerous tissue and the non-cancerous tissue, and, further provided that the binding sites have an affinity for both the agent and the compound.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: May 1, 2018
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. Babich, Shawn Hillier, John Joyal
  • Patent number: 9884132
    Abstract: The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. Because they present multiple copies of the pharmacophore, multivalent ligands can bind to receptors with high avidity and affinity, thereby serving as powerful inhibitors. The modular multivalent scaffolds of the present invention, in one or more embodiments, contains a lysine-based (?, ?-) dialkyne residue for incorporating two or more antigen binding moieties, such as PSMA binding Lys-Glu urea moieties, exploiting click chemistry and one or more additional lysine residues for subsequent modification with an imaging and/or therapeutic nuclides or a cytotoxic ligands for tumor cell killing.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: February 6, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Sangeeta Ray, Ronnie C. Mease, Hassan Shallal
  • Patent number: 9238736
    Abstract: The present invention relates to surface modified organic black pigments, surface modified carbon blacks, pigment mixtures and dispersions formed with these pigments, curable compositions, black matrices, and products incorporating them. The surface modified organic black pigment can have attached at least one organic group having the formula -X-Z, wherein X, which is directly attached to the pigment, represents an arylene group, a heteroarylene group, an alkylene group, an aralkylene group, or an alkarylene group, and Z represents at least one ionic group, at least one ionizable group, at least one nonionic group, at least one polymeric group, or any combinations thereof. Also disclosed are carbon black pigment combinations with the surface modified organic black pigments, low dielectric black dispersions, films, and black matrices containing them. Methods of preparing and making these various materials also are provided.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: January 19, 2016
    Assignee: Cabot Corporation
    Inventors: Agathagelos Kyrlidis, Alexander I. Shakhnovich, Qingling Zhang, Joseph B. Carroll
  • Patent number: 9090536
    Abstract: The present invention relates to a process for the preparation of a mixture of aspartic acid diethoxy succinate and an amino acid derivative of the general formula (I) wherein n is 1-10, m is 0 or 1, and R is hydrogen or an alkali metal or alkaline earth metal ion, comprising reacting maleate with diethanol amine under alkaline conditions in the presence of a lanthanoid catalyst to form aspartic acid diethoxy succinate followed by adding aspartic acid which reacts with unreacted maleate to form imino disuccinic acid, i.e. an amino acid derivative of formula (I) wherein m is 0, or by adding a diamine derivative of the general formula (II) NH2(CH2)nNH2 wherein n is as defined above, which reacts with unreacted maleate to form an amino acid derivative of formula (I) wherein m is 1 and n is as defined above.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: July 28, 2015
    Assignee: KEMIRA OYJ
    Inventors: Reijo Aksela, Jussi Rissanen
  • Patent number: 9061276
    Abstract: The present invention relates to a method for recovering lanthanoid catalyst from the preparation of aspartic acid diethoxy succinate comprising contacting a carbonate source with a solution containing lanthanoid ions derived from said preparation and a chelating agent different from aspartic acid diethoxy succinate to precipitate lanthanoid carbonate followed by separating the precipitated lanthanoid carbonate from the solution.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: June 23, 2015
    Assignee: KEMIRA OYJ
    Inventors: Reijo Aksela, Jussi Rissanen
  • Patent number: 9044468
    Abstract: The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+ PC3 PIP tumors.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: June 2, 2015
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ray Sangeeta, Ronnie C. Mease, Catherine Foss
  • Publication number: 20150133519
    Abstract: The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Application
    Filed: April 16, 2013
    Publication date: May 14, 2015
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Publication number: 20150118548
    Abstract: Provided is a lithium secondary cell which has high capacity, suppresses deterioration in capacity and improves cycle characteristics particularly when used in high-temperature environments and has long lifespan. Provided is a lithium secondary cell including a positive electrode active material layer containing a positive electrode active material, a negative electrode active material layer containing a negative electrode active material and an electrolytic solution for immersing the positive and negative electrode active material layers, wherein the electrolytic solution contains at least one certain ester compound.
    Type: Application
    Filed: May 28, 2013
    Publication date: April 30, 2015
    Applicant: NEC Corporation
    Inventors: Masahiro Suguro, Midori Shimura
  • Publication number: 20150073172
    Abstract: The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to <7; wherein L represents a C2-C20 alkyl group, a C6-C20 aryl group, or a C7-C20 alkylaryl group; R1 and R2 can be identical or different and represent a hydrogen atom, a C1-C4 alkyl group, a C1-C4 hydroxyalkyl group, a C1-C4 thioether group, a C6-C20 aryl group, a C7-C26) alkylaryl group, a C7-C20 alkylhydroxyaryl group, a C4-C20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C1-C4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C1-C6 alkyl group or a C7-C20 alkylaryl group; R3 represents a C1-C4 alkyl group; R4 represents a hydrogen atom, or a C1-C4 alkyl group; R5 represent
    Type: Application
    Filed: May 13, 2013
    Publication date: March 12, 2015
    Inventors: Martin Bindl, Roland Herrmann, Gunter Knaup
  • Publication number: 20150065443
    Abstract: A composition having a structure of: X-L-Y wherein X comprises at least one embelin moiety; L comprises a linker; and Y comprises a hydrophilic moiety. Also disclosed is a micelle that includes: a core that includes at least one hydrophobic active agent and at least one embelin moiety; and a hydrophilic zone surrounding the core and comprising at least one hydrophilic moiety.
    Type: Application
    Filed: April 4, 2013
    Publication date: March 5, 2015
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Educatioon
    Inventors: Song Li, Xiang Gao, Yixian Huang, Jianqin Lu
  • Publication number: 20150005363
    Abstract: The present invention relates to a cationic lipid of formula (I) having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 1, 2015
    Inventors: Steven M Ansell, Xinyao Du
  • Publication number: 20140377706
    Abstract: An aqueous solution containing 0.1-20 wt % of a substituted choline or thiocholine hydroxide is a useful developer for photosensitive resist materials. A resist pattern is formed by applying a chemically amplified positive resist composition onto a substrate to form a resist film, exposing the resist film to high-energy radiation, and developing the exposed resist film in an ammonium hydroxide-containing aqueous solution.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 25, 2014
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masaki Ohashi
  • Publication number: 20140364604
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Patent number: 8907120
    Abstract: Compounds containing at least one perfluoropolyether segment and at least two oxalylamino groups as well as methods of making these compounds are described. The compounds can be polymeric materials or can be used in the preparation of various copolymeric materials by reaction with compounds having at least two primary or secondary amino groups.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 9, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Yu Yang, Miguel A. Guerra, Richard G. Hansen, David S. Hays, Suresh S. Iyer, Ramesh C. Kumar, George G. I. Moore
  • Publication number: 20140357828
    Abstract: The present invention relates to a compound of a formula (I) in which R1, R2, R3 are respectively independent equal or various organic radicals that have no Zerewitinoff active hydrogen, R4 are independently hydrogen, equal or different organic radicals, having no Zerewitinoff active hydrogen, or together form an unsaturated or aromatic ring, which can potentially contain heteroatoms, wherein R4 have no Zerewitinoff active hydrogen, X is a linear or branched, potentially even a substituted organic radical in the chain with heteroatom, which does not have Zerewitinoff active hydrogen, n 0<n?2 and m 0?m<2, wherein n+m=2. The invention also relates to a process for producing a compound of said formula (I) as well as a polyurea system containing such a compound.
    Type: Application
    Filed: January 4, 2013
    Publication date: December 4, 2014
    Applicant: Medical Adhesive Revolution GmbH
    Inventors: Christoph Eggert, Heike Heckroth
  • Patent number: 8853283
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 7, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Publication number: 20140275048
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • Publication number: 20140245929
    Abstract: A particulate material for the production of a cement foam which material includes particles including, attached to the particle surface, a surfactant which renders the particles hydrophilic, the surfactant including a moiety which is hydrolysable under alkaline conditions, which surfactant, after loss of the moiety by alkaline hydrolysis, renders the particles partially hydrophobic.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 4, 2014
    Applicant: LAFARGE
    Inventors: Ellis Gartner, Lê-Chiên Hoang
  • Publication number: 20140243532
    Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.
    Type: Application
    Filed: April 30, 2012
    Publication date: August 28, 2014
    Applicant: PIRAMAL IMAGING SA
    Inventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
  • Publication number: 20140213726
    Abstract: A multifunctional polymerizable ionic liquid is described comprising an anion and a cationic group having at least two ethylenically unsaturated polymerizable groups, each bonded to the cationic group via a divalent non-alkyl linking group. The multifunctional linking groups independently comprise a heteroatom such as oxygen or nitrogen. The linking groups may independently comprise one or more linkages such as an amide, urea, and more typically a urethane or ester linkage. The ethylenically unsaturated polymerizable groups are typically (meth)acrylate groups. Coatings and coated articles are also described.
    Type: Application
    Filed: April 2, 2014
    Publication date: July 31, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Kevin M. Lewandowski, Larry R. Krepski, Yizhong Wang, Joel D. Oxman, Peiwang Zhu, Brian N. Holmes, Thomas P. Klun, Bryan V. Hunt
  • Publication number: 20140161830
    Abstract: Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 12, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Kathryn Ann Whitehead, Joseph R. Dorkin, Arturo Jose Vegas, Yunlong Zhang
  • Publication number: 20140155646
    Abstract: A process is proposed for the preparation of a powder comprising one or more derivatives of glycine-N,N-diacetic acid and/or one or more derivatives of glutamine-N,N-diacetic acid with a degree of crystallinity of a ?30%, starting from an aqueous solution comprising the one or more derivatives of glycine-N,N-diacetic acid and/or the one or more derivatives of glutamine-N,N-diacetic acid in a concentration range from 20 to 60% by weight, based on the total weight of the aqueous solution, where the aqueous solution is concentrated in a first process step in an evaporator with rotating internals, which are arranged at a distance relative to the inside wall of the evaporator of ?1% of the diameter of the evaporator, to give a crystal slurry with a solids concentration in the range from 60 to 85% by weight, based on the total weight of the crystal slurry, and where in a second process step the crystal slurry is left to ripen in a paste bunker and then in a thin-film contact dryer, and where the residence time i
    Type: Application
    Filed: November 26, 2013
    Publication date: June 5, 2014
    Applicant: BASF SE
    Inventors: Frank Mrzena, Hans-Juergen Kinder, Michael Schoenherr, Gerhard Cox, Thomas Schmidt, Volker Huett
  • Publication number: 20140121140
    Abstract: A method of preparing a lubricating oil additive composition comprising reacting (A) a nitrogen-containing reactant derived from reacting a first reaction product with a triglyceride, wherein the first reaction product is derived by reacting an alkanolamine and a base, wherein the nitrogen-containing reactant comprises three equivalents of a nitrogen-containing compound and one equivalent of glycerol, and wherein the nitrogen-containing reactant contains less than 10 mass percent of glycerol alkyl ester; (B) a source of boron; and (C) glycerol.
    Type: Application
    Filed: October 30, 2012
    Publication date: May 1, 2014
    Applicant: Chevron Oronite Company LLC
    Inventors: Yat Fan Suen, Jennifer Elizabeth Barbarow
  • Publication number: 20140107194
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein R is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein R1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.
    Type: Application
    Filed: July 20, 2012
    Publication date: April 17, 2014
    Applicant: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20140046087
    Abstract: A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound represented by the following general formula (2), a compound represented by the following general formula (3), and a compound represented by the following general formula (4): wherein R1 represents any of a protective group of a carboxyl group, and a hydrogen atom, R2 and R3 each independently represent any of a protective group of an amino group, and a hydrogen atom, and R4 represents any of a protective group of a carboxyl group, and a hydrogen atom.
    Type: Application
    Filed: September 4, 2013
    Publication date: February 13, 2014
    Applicant: Microbial Chemistry Research Foundation
    Inventors: Masakatsu SHIBASAKI, Kenzo YAMATSUGU
  • Publication number: 20130331304
    Abstract: The present invention relates to a chelating agent precursor that contains glutamic acid N,N-diacetic acid (GLDA) and/or methylglycine N,N-diacetic acid (MGDA) wherein at least one of the carboxylic acid groups is present as a carboxylic acid derivative selected from the group of amides, anhydrides, and esters, combinations thereof, and salts thereof, provided that it is not the triethyl ester of GLDA, the triethyl mono-t-butyl ester of GLDA, the tri-t-butyl ester of GLDA, the monobenzyl tri-t-butyl ester of GLDA, any ester or amide that contains azacycloalkane groups, any amide that contains biotin groups, any amide that contains minoethylcarbamoyl based amide groups, (S)-diethyl 2,2?-(1-benzyloxy)-1,5-dioxo-5-(prop-2-ynylamino)pentan-2-ylazanediyl-diacetate, diethyl 2,2?-(5-(3-azidopropylamino)-1-(benzyloxy)-1,5-dioxo-pentan-2-ylazanediyl-diacetate, the trimethyl ester of MGDA, the monomethyl ester dimethylamide of MGDA, the dibenzyl ester of MGDA, the dibenzyl mono t-butyl ester of MGDA, the di t-butyl est
    Type: Application
    Filed: February 20, 2012
    Publication date: December 12, 2013
    Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: James N. Lepage, Cornelia Adriana De Wolf, Johanna Hendrika Bemelaar, Adrianus Maria Reichwein, Axel Carstens, Edwin Rudolf Antony Bang
  • Publication number: 20130217893
    Abstract: The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing pharmaceuticals. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxypyrrolidine-3-carboxamide derivative, or it's enantiomer by carrying out asymmetric hydrogenation using an optically active catalyst of a 4-oxopyrrolidine-3-carboxamide derivative represented by the general formula (I). [in the formula (I), PG1 represents a protective group for an amino group, and R1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted].
    Type: Application
    Filed: October 24, 2011
    Publication date: August 22, 2013
    Applicant: KYORIN PHARMACEUTICAL CO., LTD.
    Inventors: Ichiro Araya, Koichi Kiyota, Muneki Nagao
  • Patent number: 8507174
    Abstract: A positive resist composition comprising (A) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, (B) a resin capable of increasing the solubility in an alkali developer by the action of an acid, and (C) a compound having a specific structure, which decomposes by the action of an acid to generate an acid, a pattern forming method using the positive resist composition, and a compound for use in the positive resist composition are provided as a positive resist composition exhibiting good performance in terms of pattern profile, line edge roughness, pattern collapse, sensitivity and resolution in normal exposure (dry exposure), immersion exposure and double exposure, a pattern forming method using the positive resist composition and a compound for use in the positive resist composition.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: August 13, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Hidenori Takahashi, Kenji Wada, Sou Kamimura
  • Publication number: 20130204035
    Abstract: The present invention relates to a process for the preparation of a mixture of aspartic acid diethoxy succinate and an amino acid derivative of the general formula (I) wherein n is 1-10, m is 0 or 1, and R is hydrogen or an alkali metal or alkaline earth metal ion, comprising reacting maleate with diethanol amine under alkaline conditions in the presence of a lanthanoid catalyst to form aspartic acid diethoxy succinate followed by adding aspartic acid which reacts with unreacted maleate to form imino disuccinic acid, i.e. an amino acid derivative of formula (I) wherein m is 0, or by adding a diamine derivative of the general formula (II) NH2(CH2)nNH2 wherein n is as defined above, which reacts with unreacted maleate to form an amino acid derivative of formula (I) wherein m is 1 and n is as defined above.
    Type: Application
    Filed: May 30, 2011
    Publication date: August 8, 2013
    Applicant: Kemira OYJ
    Inventors: Reijo Aksela, Jussi Rissanen
  • Publication number: 20130190526
    Abstract: The present invention relates to a method for recovering lanthanoid catalyst from the preparation of aspartic acid diethoxy succinate comprising contacting a carbonate source with a solution containing lanthanoid ions derived from said preparation and a chelating agent different from aspartic acid diethoxy succinate to precipitate lanthanoid carbonate followed by separating the precipitated lanthanoid carbonate from the solution.
    Type: Application
    Filed: May 31, 2011
    Publication date: July 25, 2013
    Inventors: Reijo Aksela, Jussi Rissanen
  • Patent number: 8466081
    Abstract: Disclosed are halogenated amide esters that are suitable as internal electron donors in procatalyst compositions. Ziegler-Natta catalyst compositions containing the present procatalyst compositions exhibit improved catalyst activity and/or improved catalyst selectivity and produce propylene-based olefins with broad molecular weight distribution.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: June 18, 2013
    Assignee: Dow Global Technologies LLC
    Inventors: Linfeng Chen, Tak W. Leung, Tao Tao, Kuanqiang Gao, James X. Shu
  • Publication number: 20130096193
    Abstract: Disclosed are creatine ?-alaninate, compositions and formulations containing same, and methods of use therefor.
    Type: Application
    Filed: November 30, 2012
    Publication date: April 18, 2013
    Inventor: Bruce W. Kneller
  • Publication number: 20130058990
    Abstract: The present invention relates to a cosmetic composition containing a combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II) below: in which at least one or two of the radicals contain: either an alkylsulfonate radical in its acid or salified form, or one or two hydroxyl radicals. The invention also relates to a process for the radiation-photostabilization of at least one screening agent of the dibenzoylmethane derivative type with an effective amount of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II).
    Type: Application
    Filed: March 7, 2011
    Publication date: March 7, 2013
    Applicant: L'OREAL
    Inventors: Herve Richard, Benoit Muller
  • Publication number: 20130036939
    Abstract: The invention relates to enamine resins which are the reaction products of a) an acetoacetylated resin, and a C1-C20 alkyl amine or a mixture of C1-C20 alkyl amines. The acetoacetylated resin is the reaction product of a polyol having 4 or more hydroxyl groups; and at least one acetoacetate. The invention also relates to an acetoacetylated resin which is the reaction product of a polyol having 4 or more hydroxyl groups and at least one acetoacetate, where a portion of the hydroxyl groups of the polyol are replaced by acetoacetate groups and the remaining hydroxyl groups are replaced by a saturated monofunctional carboxylic acid ester, unsaturated monofunctional carboxylic acid ester, or a mixture thereof; as well as to enamine resins prepared from these acetoacetylated resins. The invention also relates to curable coating compositions containing such resins or a mixture of those resins, at least one metallic drier compound; and optionally one or more solvents.
    Type: Application
    Filed: February 4, 2011
    Publication date: February 14, 2013
    Inventors: Dean C. Webster, Thomas J. Nelson, Xiao Pan
  • Publication number: 20120302783
    Abstract: What is proposed is a process for preparing aminopolycarboxylates proceeding from the corresponding polyalkanolamines by oxidative dehydrogenation in the presence of a catalyst comprising 1 to 90% by weight of copper, based on the total weight of the catalyst, using a base, which comprises first performing a partial conversion of the polyalkanolamine to a reaction mixture comprising the aminopolycarboxylate at a temperature in the range from 140 to 180° C. until at least 10 to 90 mol % of the polyalkanolamine has been depleted, and then continuing the conversion at elevated temperature.
    Type: Application
    Filed: April 2, 2012
    Publication date: November 29, 2012
    Applicant: BASF SE
    Inventors: Robert BAUMANN, Markus Christian Biel, Axel Franzke, Alfred Oftring, Friedhelm Teich, Paul Klingelhoefer, Marie Katrin Schröter
  • Publication number: 20120289736
    Abstract: Compounds containing at least one perfluoropolyether segment and at least two oxalylamino groups as well as methods of making these compounds are described. The compounds can be polymeric materials or can be used in the preparation of various copolymeric materials by reaction with compounds having at least two primary or secondary amino groups.
    Type: Application
    Filed: December 22, 2010
    Publication date: November 15, 2012
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Yu Yang, Miguel A. Guerra, Richard G. Hansen, David S. Hays, Suresh S. Iyer, Ramesh C. Kumar, George G.I. Moore
  • Publication number: 20120270943
    Abstract: D-aspartic acid is prepared as its hydrochloride salt or as the hydrochloride salt of its diethyl ester, thereby providing soluble forms of D-aspartic acid that are readily taken up by a human body via its digestive tract. The D-aspartic acid is administered as pills, capsules, powdered drink mixes, beverages, confectionaries, syrups, chewable tablets, nasal sprays, or injectable formulations.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 25, 2012
    Inventors: Kyung Suk Kim, Bryan Joseph Krause
  • Publication number: 20120226013
    Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Application
    Filed: October 11, 2010
    Publication date: September 6, 2012
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20120210634
    Abstract: The present invention relates to the novel compounds of the formula (I), as well as to their manufacture and use and compositions comprising them. The invention also relates to a change in oxidation reactions of hydrocarbons admixed to these compounds. Furthermore the invention relates to (bio)diesel fuel comprising such compounds.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 23, 2012
    Inventors: Max Hugentobler, Steffen Ruf, Bettina Wuestenberg
  • Publication number: 20120202756
    Abstract: The present invention relates to prodrugs of a wide variety of drugs and pharmaceutical compositions containing such prodrugs. Methods for minimizing locally mediated (from within the gut lumen) adverse gastrointestinal events associated with the underivatised drug and increasing the sustainment of plasma drug levels with the aforementioned prodrugs are also provided. Thus, the present invention relates to the use of prodrugs of a wide diversity of drugs (other than opioids) to transiently inactivate them and so reduce directly, locally mediated adverse gastrointestinal (GI) side-effects normally evident after administration of the parent compound. Additionally, such prodrugs may confer improved pharmacokinetics.
    Type: Application
    Filed: October 5, 2011
    Publication date: August 9, 2012
    Inventors: Richard Franklin, Martin Quibell, Robert G. Tyson, Bernard T. Golding
  • Publication number: 20120197028
    Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
    Type: Application
    Filed: January 31, 2011
    Publication date: August 2, 2012
    Applicant: Confluent Surgical, Inc
    Inventors: Rachit Ohri, Phillip Blaskovich, Joshua Kennedy, Steven L. Bennett, Arthur Driscoll
  • Publication number: 20120189492
    Abstract: In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.
    Type: Application
    Filed: June 24, 2010
    Publication date: July 26, 2012
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Pedro J.J. Alvarez, Jaesang Lee, Lon J. Wilson, Yuri Mackeyev, Jaehong Kim
  • Publication number: 20120149936
    Abstract: The present invention relates to a process for preparing a crystalline solid from glycine-N,N-diacetic acid derivatives (e.g., MGDA) of sufficiently low hygroscopicity, which is characterized in that at least one crystalline compound of the formula I is introduced as seed, and a spray granulation is carried out with at least one compound of the formula I, preferably followed by a heat treatment.
    Type: Application
    Filed: August 25, 2010
    Publication date: June 14, 2012
    Applicant: BASF SE
    Inventor: Andreas Baranyai
  • Publication number: 20120149860
    Abstract: A compound represented by the following formula (a): CH2?CR1—CONJ-CKR2—(CH2)n—COO-Q1-Rf1??(a) is provided. This compound is capable of forming a polymer having an oil repellency equivalent to polymers containing a polyfluoroalkyl group containing at least 8 carbon atoms, although the polyfluoroalkyl group contains up to 6 carbon atoms. In the formula, R1 is hydrogen atom or methyl group, R2 is hydrogen atom or a group represented by —(CH2)m—COO-Q2-Rf2 (r), n and m are independently an integer of 0 to 4, Rf1 and Rf2 are independently a polyfluoroalkyl group or a polyfluoroether group containing 1 to 6 carbon atoms, Q1 and Q2 are independently single bond or a divalent linkage group, J is hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, K is hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, and j and k are independently single bond or an alkylene group containing 1 to 3 carbon atoms with the proviso that j and k are not simultaneously single bond.
    Type: Application
    Filed: August 17, 2010
    Publication date: June 14, 2012
    Applicant: AGC SEIMI CHEMICAL CO.,LTD.
    Inventors: Fusae Ishiwata, Ryo Hirabayashi, Hirotaka Shimizu
  • Patent number: 8148414
    Abstract: Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: April 3, 2012
    Assignee: XenoPort, Inc.
    Inventors: Archana Gangakhedkar, Xuedong Dai, Noa Zerangue, Peter A. Virsik
  • Publication number: 20120046491
    Abstract: A process is proposed for the preparation of a powder comprising one or more derivatives of glycine-N,N-diacetic acid and/or one or more derivatives of glutamine-N,N-diacetic acid with a degree of crystallinity of ?30%, starting from an aqueous solution comprising the one or more derivatives of glycine-N,N-diacetic acid and/or the one or more derivatives of glutamine-N,N-diacetic acid in a concentration range from 20 to 60% by weight, based on the total weight of the aqueous solution, where the aqueous solution is concentrated in a first process step in an evaporator with rotating internals, which are arranged at a distance relative to the inside wall of the evaporator of ?1% of the diameter of the evaporator, to give a crystal slurry with a solids concentration in the range from 60 to 85% by weight, based on the total weight of the crystal slurry, and where in a second process step the crystal slurry is left to ripen in a paste bunker and then in a thin-film contact dryer, and where the residence time in t
    Type: Application
    Filed: May 19, 2010
    Publication date: February 23, 2012
    Applicant: BASF SE
    Inventors: Frank Mrzena, Hans-Juergen Kinder, Michael Schoenherr, Gerhard Cox, Thomas Schmidt, Volker Huett
  • Publication number: 20110315910
    Abstract: The present invention relates to the use of an alkoxylate based on 2-propylheptylamine which has been alkoxylated with ethylene oxide, propylene oxide, butylene oxide, pentylene oxide, styrene oxide, cyclohexylene oxide and/or decylene oxide, and/or its quaternized derivative in cleaning compositions, as emulsifier, in the manufacture of fibers, for leather treatment, in printing inks, in formulations for construction chemistry or in formulations for flotation. Furthermore, the present invention relates to a mixture comprising at least one of the specified alkoxylates and also at least one surface-active substance and use thereof.
    Type: Application
    Filed: June 27, 2011
    Publication date: December 29, 2011
    Applicant: BASF SE
    Inventors: Paul KLINGELHOEFER, Jürgen Tropsch, Rolf-Dieter Kahl, Andreas Senf
  • Publication number: 20110306600
    Abstract: The invention discloses a number of therapeutic compounds and a method of treating a disorder in mammal.
    Type: Application
    Filed: June 10, 2011
    Publication date: December 15, 2011
    Applicant: Grunenthal GmbH
    Inventor: Ramesh SESHA
  • Publication number: 20110251197
    Abstract: The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.
    Type: Application
    Filed: November 6, 2009
    Publication date: October 13, 2011
    Inventors: Alicja Bielawska, Aiping Bai, Zdzislaw M. Szulc, Yusef A. Hannun, James Norris, Liu Xiang
  • Publication number: 20110251421
    Abstract: The present disclosure provides analogs and derivatives of phorbol compounds for the treatment of viral infections, neoplastic diseases, inflammatory reactions, and use as analgesics.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Applicant: SALVIA SCIENCES, INC.
    Inventors: Rensheng Xu, Weimin Zhao, Chun Jiang