Nitrogen In Acid Moiety Other Than As Nitroso Or Isocyanate (e.g., Amino Acid Esters, Etc.) Patents (Class 560/155)
  • Patent number: 9981907
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 29, 2018
    Assignee: SIRNA THERAPEUTICS, INC.
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Patent number: 9908838
    Abstract: The subject matter of the present invention is an improvement in the continuous production of methyl (meth)acrylate or of ethyl (meth)acrylate by direct esterification of (meth)acrylic acid with methanol or ethanol, under reaction conditions for which the acid is in excess relative to the alcohol, in particular with an acid/alcohol molar ratio of between 1.0 and 4, and under a pressure ranging from atmospheric pressure to 5 bar. The process of the invention makes it possible to minimize the formation of ethyl ethoxypropionate during the esterification reaction, and results in an improvement in the material balance, simplification of the purification train for the desired ester, and optimization of the energy balance.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 6, 2018
    Assignee: ARKEMA FRANCE
    Inventors: Serge Tretjak, Stephane Denis, Lionel Delais, Anne Moreliere
  • Patent number: 9643914
    Abstract: A process for preparation of diethyl 2-aetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (Ia) having associated impurities below the regulatory limits.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: May 9, 2017
    Assignee: EMCURE PHARMACEUTICALS LIMITED
    Inventors: Mukund K. Gurjar, Narendra K. Tripathy, Kaliaperumal Neelakandan, Prasad P. Panchabhai, Nandala Srinivas, Prabhakaran Balasubramanian, Sandip B. Buchude, Balaji R. Mugale, Pravin P. Ahirrao, Samit S. Mehta
  • Patent number: 9464032
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: October 11, 2016
    Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE CORSE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Félix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 9458090
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: October 4, 2016
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Patent number: 9326964
    Abstract: This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: May 3, 2016
    Assignee: PHOTOCURE ASA
    Inventor: Gry Stensrud
  • Patent number: 9296683
    Abstract: The present invention concerns a process for preparing esteramide compounds. More particularly, the invention relates to a process for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the basic compound and the amine in gaseous form are co-added to the diester, the reaction being conducted at a temperature of 30° C. or higher.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: March 29, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Thierry Vidal, Rabih Rached, Massimo Guglieri
  • Patent number: 9249086
    Abstract: The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: February 2, 2016
    Assignee: Photocure ASA
    Inventors: Jon Erik Brænden, Colin Barry Charnock, Aslak Godal, Jo Klaveness, Nils Olav Nilsen
  • Patent number: 9029590
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: May 12, 2015
    Assignee: SIRNA Therapeutics, Inc.
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Publication number: 20150079163
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 19, 2015
    Inventors: Bassam B. DAMAJ, Richard Martin
  • Publication number: 20150018515
    Abstract: A method of producing an epoxy compound, which comprises reacting hydrogen peroxide with a compound having a carbon-carbon double bond, in the presence of at least one of a tungsten compound and a molybdenum compound; and an onium salt comprising 20 or more carbon atoms and one or more of substituents convertible to a functional group containing an active hydrogen or a salt thereof.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Akemi HOSOKAWA, Haruhiko KUSAKA
  • Publication number: 20140357713
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: May 7, 2014
    Publication date: December 4, 2014
    Applicant: NexMed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard Martin
  • Patent number: 8900625
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 2, 2014
    Assignee: Nexmed Holdings, Inc.
    Inventors: Bassam B. Damaj, Richard M. Martin
  • Patent number: 8877958
    Abstract: The invention pertains to a new route to prepare ?-functionalized carboxylic acid esters in a one-pot reaction, by reacting an olefinic acid ester in the presence of a catalyst system, comprising a Rh(I)-complex, together with an aryl boron or a diamine as nucleophilic compounds, and under oxygen-free conditions and elevated temperatures.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 4, 2014
    Assignee: Cognis IP Management GmbH
    Inventors: Lukas J. Gooβen, Dominik Ohlmann, Markus Dierker
  • Patent number: 8871960
    Abstract: Methods to convert unsaturated fatty acids derived from biobased oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: October 28, 2014
    Assignee: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark
  • Patent number: 8853270
    Abstract: The present invention relates to stilbene and quinine compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis- or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BBOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior stilbenes.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: October 7, 2014
    Assignee: University of Salford
    Inventors: John Anthony Hadfield, Alan Thomson McGown, Stephen Patrick Mayalarp, Edward John Land, Ian Hamblett, Keira Gaukroger, Nicholas James Lawrence, Lucy Annette Hepworth, John Butler
  • Patent number: 8853283
    Abstract: The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (2S)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: October 7, 2014
    Assignee: Merck Patent GmbH
    Inventors: Michael Platscher, Alfred Hedinger
  • Publication number: 20140288146
    Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: April 25, 2013
    Publication date: September 25, 2014
    Applicant: Protiva Biotherapeutics, Inc.
    Inventors: James Heyes, Mark Wood, Alan Martin
  • Publication number: 20140288142
    Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Inventors: Nicoletta ALMIRANTE, Stefano BIONDI, Ennio ONGINI, Laura STORONI, Alessia NICOTRA
  • Publication number: 20140221211
    Abstract: One subject of the present invention is the use, as solvents, of compounds of esteramide type. Another subject of the invention are particularly practical processes for preparing esteramides. Another subject of the invention are novel esteramides, which may in particular be used as solvents, for example in phytosanitary formulations.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: RHODIA OPERATIONS
    Inventors: Olivier JENTZER, Massimo GUGLIERI
  • Patent number: 8778838
    Abstract: The present invention relates to aqueous concentrate formulations for plant protection comprising: 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide in the form of its anhydrate; N-(phosphonomethyl)glycine in the form of its free acid, in the form of the ammonium salt or a substituted ammonium salt or a mixture thereof; at least two different non-ionic surfactants with at least one of them comprising an ethylene oxide polymer moiety or an ethylene oxide/C3-C4-alkylene oxide block copolymer moiety, and water; wherein the pH-value of the formulation is below 6.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: July 15, 2014
    Assignee: BASF SE
    Inventors: Michael Krapp, Wolfgang Gregori, Sven Adam, Klaus Kolb, Juergen Jakob, Bernd Sievernich, Joerg Steuerwald, Steven Bowe, Joseph Zawierucha, Rex Liebl
  • Publication number: 20140170207
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 19, 2014
    Inventors: Bassam B. Damaj, Richard M. Martin
  • Patent number: 8748651
    Abstract: The invention relates to a method for the synthesis of ?-amino alkanoic acids or esters thereof starting from unsaturated natural fatty acids passing through an ?-unsaturated nitrile intermediate compound.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: June 10, 2014
    Assignee: Arkema France
    Inventor: Jean-Luc Dubois
  • Publication number: 20140121393
    Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
    Type: Application
    Filed: January 7, 2014
    Publication date: May 1, 2014
    Applicant: Tekmira Pharmaceuticals Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Narayanannair K. Jayaprakash, Muthusamy Jayaraman, Martin Maier
  • Patent number: 8703108
    Abstract: Cleansing compositions include a mixture of alkyl ether carboxylic acids and/or salts thereof, each having a structure according to formula (1): R1—O—(CH2CH2O)n—CH2—COOM??(1) where R1 is an alkyl group having 4 to 22 carbon atoms, n is a number of from 0 to 20, and M is a hydrogen atom, alkali metal, alkaline earth metal, ammonium, or organic ammonium. The mixture includes alkyl ether carboxylic acids and/or salts having at least two different alkyl groups R1, an average carbon number of alkyl groups R1 of alkyl ether carboxylic acids and/or salts in the mixture is from 10.8 to 12.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: April 22, 2014
    Assignee: Kao Corporation
    Inventors: Hiroki Takeuchi, Masahiro Miyaki, Naoko Yamamoto, Natsuko Toshida, Jurgen Benade
  • Patent number: 8697379
    Abstract: The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 15, 2014
    Assignee: MUSC Foundation for Research Development
    Inventors: Alicja Bielawska, Aiping Bai, Zdzislaw M. Szulc, Yusuf A. Hannun, James S. Norris, Liu Xiang
  • Patent number: 8692014
    Abstract: The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: April 8, 2014
    Assignee: Photocure ASA
    Inventors: Jon Erik Braenden, Aslak Godal, Nils Olav Nilsen, Jo Klaveness
  • Patent number: 8673818
    Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula in which W is methyl, X is alkyl, alkenyl or alkinyl, Y is hydrogen, methyl, ethyl, i-propyl, alkenyl or alkinyl, and Z is hydrogen, alkyl, alkenyl or alkinyl, with the proviso that at least one of X, Y, or Z represents a chain having at least two carbon atoms and with the further proviso that X is not ethyl when Z is hydrogen and Y is methyl, and CKE represents the group in which B is hydrogen, alkyl or alkoxyalkyl, A and Q1 together are optionally substituted alkanediyl or alkenediyl, Q2 is represents hydrogen or C1-C4-alkyl, and G represents hydrogen or an acyl or acyl-like group, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 18, 2014
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
  • Patent number: 8642792
    Abstract: The invention relates to a method for the synthesis of amino acids/esters of general formula NH2—(CH2)n—COOR in which n is an integer between 5 and 14, and R is either H or an alkyl radical including from 1 to 4 carbon atoms, from natural long-chain mono-unsaturated fatty acids or esters including at least 10 adjacent carbon atoms per molecule, said method comprising: first converting, if necessary, said natural long-chain fatty acid or ester into a monounsaturated fatty acid/ester of general formula R1—(CH2)m—CH?CH—(CH2)p—COOR in which R1 is H, CH3 or a COOR radical, m is an integer between 0 and 14 and p is an integer between 2 and 11, then submitting the latter to a crossed catalytic metathesis reaction with a compound of formula R2—CH?CH—R3 in which R2 is either H or CN and R3 is CN or CH2NH2, provided that if R2 is CN, R3 can be only CN, and finally converting the resulting product of the general formula R3—CH?CH—(CH2)p—COOR into an amino-acid, either by hydrogenation, or by hydrogenation of the triple t
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: February 4, 2014
    Assignee: Arkema France
    Inventor: Jean-Luc Dubois
  • Publication number: 20130338210
    Abstract: A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids.
    Type: Application
    Filed: December 7, 2010
    Publication date: December 19, 2013
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Khallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Mamta Kapoor, Rajesh Kumar Kainthan
  • Publication number: 20130338227
    Abstract: Multifunctional green (eco-friendly) and antimicrobial compositions are described containing cationic glycine betaine esters and/or cationic glycine betaine amides. Particular glycine betaine esters and amides are alkyl(ene) betainate methane sulfonates and betainyl amino alkyl(ene) methane sulfonates. The glycine betaine components are cationic, have a hydrophobic group attached to a carboxylate group through an ester or amide linkage, and are derived from a natural source, such as sugar beets. The glycine betaine esters and amides serve as cationic surfactants which have effective antimicrobial activity. The surfactant compositions are effective as crude mixtures or semi-purified mixtures or purified surfactant compounds of glycine betaine components. The addition of sodium chloride or potassium chloride or magnesium chloride or natural gum or polysaccharide to compositions containing the cationic glycine betaine ester and/or glycine betaine amide derivatives serves to thicken or gel the composition.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 19, 2013
    Inventors: Marie-Esther SAINT VICTOR, Thierry Benvegnu, Hakima-Fatima Azira
  • Publication number: 20130310245
    Abstract: The present invention is directed to a process for the production of high density polyethylene by polymerisation of ethylene in the presence of a supported chromium oxide based catalyst which is modified with an organic compound comprising oxygen and a nitrogen atom which is selected from the group consisting of saturated heterocyclic organic compounds with a five or six membered ring, amino esters and amino alcohols. Such organic compounds allow manufacturing of HDPE with increases molecular weight distribution and increased molecular weight.
    Type: Application
    Filed: October 4, 2011
    Publication date: November 21, 2013
    Applicant: SAUDI BASIC INDUSTRIES CORPORATION
    Inventors: Vugar O. Aliyev, Ali Saad Headan, Jaiprakash Brijal Sainani
  • Publication number: 20130291764
    Abstract: An anti-foam additive for a cement composition, including a fatty alcohol ester that is soluble in an aqueous medium at acidic pH, and hydrolysable in a basic medium, i.e. when the ester is incorporated into the cement composition, while releasing an active anti-foam molecule. This ester is preferably a fatty alcohol ester of a quaternary ammonium carboxylate, that is soluble in an aqueous solution of a superplasticizer, such as a polycarboxylate with poly(ethylene oxide) side chains. The additive can used for reducing the amount of air entrained during mixing or blending of mortars or concretes.
    Type: Application
    Filed: December 20, 2011
    Publication date: November 7, 2013
    Applicant: CIMENTS FRANCAIS
    Inventors: Soraya Mehalebi, Anne-Elisabeth Desmotz
  • Publication number: 20130274504
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Application
    Filed: October 17, 2011
    Publication date: October 17, 2013
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Patent number: 8552212
    Abstract: The invention relates to a series of novel chiral phosphorus ligands of formulae (Ia) and (Ib): wherein R, 1-rR>4 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral phosphorus ligands. The chiral metal complexes are useful as catalysts for carrying out asymmetric hydro genation.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 8, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bo Qu, Chris Hugh Senanayake, Wenjun Tang, Xudong Wei, Nathan K. Yee
  • Patent number: 8546447
    Abstract: The invention provides use of a photosensitiser, which is a derivative (e.g., an ester) of 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the prevention or treatment of acne.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: October 1, 2013
    Assignee: Photocure ASA
    Inventors: Aslak Godal, Jo Klaveness, Hilde Morris
  • Publication number: 20130237722
    Abstract: The present invention relates to a method for preparing esteramide compounds. More particularly, the invention relates to a method for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the amine is solubilized in an organic solvent or in the diester, when the amine is solubilized in an organic solvent, the diester is added onto the reaction mixture comprising the amine and the basic compound, when the amine is solubilized in the diester, the basic compound is added onto the reaction mixture comprising the amine and the diester (II), the reaction is conducted at a temperature greater than or equal to 30° C., the amine is present in molar excess ranging from 0.01 to 50% relatively to the diester.
    Type: Application
    Filed: June 9, 2011
    Publication date: September 12, 2013
    Applicant: RHODIA OPERATIONS
    Inventors: Thierry Vidal, Rabih Rached, Massimo Guglieri
  • Publication number: 20130225857
    Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
    Type: Application
    Filed: April 15, 2013
    Publication date: August 29, 2013
    Applicants: Covidien LP, Confluent Surgical, Inc.
    Inventors: Confluent Surgical, Inc., Covidien LP
  • Publication number: 20130225852
    Abstract: The invention pertains to a new route to prepare ?-functionalized carboxylic acid esters in a one-pot reaction, by reacting an olefinic acid ester in the presence of a catalyst system, comprising a Rh(I)-complex, together with an aryl boron or a diamine as nucleophilic compounds, and under oxygen-free conditions and elevated temperatures.
    Type: Application
    Filed: August 31, 2011
    Publication date: August 29, 2013
    Applicant: Cognis IP Management GmbH
    Inventors: Lukas J. Goossen, Dominik Ohlmann, Markus Dierker
  • Publication number: 20130211129
    Abstract: The present invention concerns a process for preparing esteramide compounds. More particularly, the invention relates to a process for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the basic compound and the amine in gaseous form are co-added to the diester, the reaction being conducted at a temperature of 30° C. or higher.
    Type: Application
    Filed: May 31, 2011
    Publication date: August 15, 2013
    Applicant: RHODIA OPERATIONS
    Inventors: Thierry Vidal, Rabih Rached, Massimo Guglieri
  • Publication number: 20130210933
    Abstract: The use of an esteramide compound, alone or as a mixture of the following formula (I): R1OOC-A-CONR2R3??(I) is described, wherein: A is a covalent bond or a methylene group —CH2—, R1 is an optionally substituted hydrocarbon group having from 1 to 36 carbon atoms, R2 and R3, either identical or different, are groups selected from a hydrogen atom and optionally substituted hydrocarbon groups comprising from 1 to 36 carbon atoms, R2 and R3 may form together a ring having the nitrogen atom to which they are bound, said ring being, if need be, substituted and/or having an additional heteroatom and R2 and R3 not being simultaneously hydrogens. Also described, are applications for using the esteramide compound as a solvent, a co-solvent, a coalescence agent, a crystallization inhibitor, a plasticizer or an agent for increasing biological activity.
    Type: Application
    Filed: March 16, 2011
    Publication date: August 15, 2013
    Applicant: RHODIA OPERATIONS
    Inventors: Massimo Guglieri, Thierry Vidal
  • Publication number: 20130210634
    Abstract: An esteramide compound of the following formula (I): R1OOC-A-CONR2R3??(I) is described, wherein: A is a covalent bond or a methylene group —CH2—; R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms, R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, and R2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.
    Type: Application
    Filed: March 17, 2011
    Publication date: August 15, 2013
    Applicant: RHODIA OPERATIONS
    Inventors: Massimo Guglieri, Thierry Vidal
  • Patent number: 8507174
    Abstract: A positive resist composition comprising (A) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, (B) a resin capable of increasing the solubility in an alkali developer by the action of an acid, and (C) a compound having a specific structure, which decomposes by the action of an acid to generate an acid, a pattern forming method using the positive resist composition, and a compound for use in the positive resist composition are provided as a positive resist composition exhibiting good performance in terms of pattern profile, line edge roughness, pattern collapse, sensitivity and resolution in normal exposure (dry exposure), immersion exposure and double exposure, a pattern forming method using the positive resist composition and a compound for use in the positive resist composition.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: August 13, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Hidenori Takahashi, Kenji Wada, Sou Kamimura
  • Patent number: 8492578
    Abstract: The present invention relates to photosensitizer compounds for use in cosmetic and therapeutic applications of photodynamic therapy. The compounds of the present invention are designed for topical application and are characterized by a low permeability to the stratum corneum (the outer skin layer of an individual) and/or a low allergenic potential. Surprisingly, such compounds have beneficial properties in the treatment of certain diseases and lack the undesired damages to healthy skin entailed by prior art compounds. ALA (5-aminolevulinic acid)-esters of body-owned, natural compound such as aminoacids, steroids, carbohydrates, alcohols are preferred examples of photosensitizers of the present invention. The compounds of the present invention are used in the treatment of skin diseases such as psoriasis, sebaceous glands related conditions including acne, seborrhoic dermatitis, rosacea, skin cancer and precancer, as well as in cosmetic hair removal.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: July 23, 2013
    Assignee: Photoderma SA
    Inventors: Thomas Glanzmann, Jérôme Barge, Georges Wagnieres
  • Publication number: 20130184423
    Abstract: Described herein are the synthesis and polymerization of a series of N-Boc-protected amino acid vinyl ester (BAAVE) monomers. Homopolymers and heteropolymers containing the monomers are described, particularly heteropolymers with vinyl ester monomers such as vinyl acetate. Deprotection can be used to produce hydrophilic and hydrophobic polymers that are particular useful in biological applications such as cellular delivery of biological materials.
    Type: Application
    Filed: January 10, 2013
    Publication date: July 18, 2013
    Applicant: Wisconsin Alumini Research Foundation
    Inventor: Wisconsin Alumini Research Foundation
  • Publication number: 20130165685
    Abstract: The invention relates to a process for preparing omega-amino acids or their esters, which is characterized by the following steps: c) ozonolysis of unsaturated fatty acids or fatty acid derivatives, d) reductive amination of the reaction mixture obtained from the reaction with ozone, to give the omega-amino acid or ester thereof, the reaction being carried out with a C1-C5 alcohol in a mixture with at least 0.5% by weight of water as solvent, based on the total amount of solvent.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 27, 2013
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Peter Hannen, Harald Haeger, Martin Roos
  • Patent number: 8450509
    Abstract: The invention relates to a method for synthesizing 9-aminononanoic acid or the esters thereof from natural unsaturated fatty acids, comprising at least one step of metathesis of the natural fatty acid and an oxidation step by oxidative cleaving. Said synthetic method uses widely available renewable starting materials and hence economical.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: May 28, 2013
    Assignee: Arkema France
    Inventor: Jean-Luc Dubois
  • Publication number: 20130129785
    Abstract: A lipid particle can include a cationic lipid. Synthesis of the cationic lipid can include a ylide-based reaction, such as a Wittig reaction or sulfur ylide reaction. In some cases, the synthesis can also include a Michael addition or a related addition reaction.
    Type: Application
    Filed: May 10, 2011
    Publication date: May 23, 2013
    Applicant: ALNYLAM PHARMACEUTICALS, INC
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev
  • Publication number: 20130123338
    Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: May 12, 2011
    Publication date: May 16, 2013
    Applicant: Protiva Biotherapeutics, Inc.
    Inventors: James Heyes, Mark Wood, Alan Martin
  • Patent number: 8410172
    Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: April 2, 2013
    Assignee: Photocure ASA
    Inventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjørseth