Polycarboxylic Acid Patents (Class 560/176)
  • Patent number: 11389419
    Abstract: A method for treatment of disorders arising due to mutation of one or more genes in humans. The method includes the step of orally administering a composition comprising L-carnitine tartrate, pyridoxal-5?-phosphate, and fumaric acid.
    Type: Grant
    Filed: July 5, 2021
    Date of Patent: July 19, 2022
    Inventor: Deborah Warner
  • Patent number: 10035753
    Abstract: The purpose of the present invention is to provide a method for continuously producing a ketomalonic acid compound such as a ketomalonic acid diester or a hydrate thereof, which is an industrially useful compound, on an industrial scale and in a safe and steady manner. The present invention relates to: a method in which a malonic acid diester, a carboxylic acid compound and a chlorous acid compound are used as raw material compounds, and these raw material compounds are mixed together to prepare a mixture and the mixture is supplied to a flow reactor continuously, thereby continuously producing a corresponding ketomalonic acid diester or a hydrate thereof; and a continuous production apparatus for performing the method.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: July 31, 2018
    Assignee: Kumiai Chemical Industry Co., Ltd.
    Inventor: Shinki Tani
  • Patent number: 9446060
    Abstract: The present invention relates to a therapeutic agent, wherein the therapeutic agent is D-Boramine. The therapeutic agent is prepared by mixing L-carnitine tartrate, pyridoxal 5? phosphate and fumaric acid. D-Boramine, when administered orally or parenterally in therapeutic quantities, is effective for use in the prevention of cancer that arises from mutations to the BRCA1 and BRCA2 genes, i.e., breast and ovarian and the treatment of several types of human diseases including, but not limited to, Antiphospholipid Syndrome, Disseminate Intravascular Coagulation (DIC), infections arising from viruses (including strains of Human Papillomavirus, Herpes Simplex Virus and Simian Virus), tuberculosis (including XDR Tuberculosis) and mycoplasma, Hepatitis A, B and C, MTHFR genetic mutations.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 20, 2016
    Inventor: Deborah Warner
  • Publication number: 20150057450
    Abstract: The present invention provides novel Ruthenium-based transition metal complex catalysts comprising specific ligands, their preparation and their use in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, and olefin selective.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 26, 2015
    Applicants: LANXESS DEUTSCHLAND GMBH, THE GOVERNING COUNCIL OF UNIVERSITY OF TORONTO
    Inventors: Julia Maria Jeschko, Douglas Stephan, Clinton Lund, Michael Sgro, Christopher Ong, Renan Cariou
  • Publication number: 20140377707
    Abstract: A composition for forming a liquid immersion upper layer film includes a polymer component including a polymer having a structural unit represented by a formula (1); and a solvent. R1 represents a carboxy group or a group represented by a formula (2); X represents a single bond, a divalent hydrocarbon group having 1 to 20 carbon atoms or a divalent fluorinated hydrocarbon group having 1 to 20 carbon atoms; R2 represents a hydrocarbon group having 1 to 20 carbon atoms and a valency of (n+1), a fluorinated hydrocarbon group having 1 to 20 carbon atoms and a valency of (n+1), or one of these groups each including between adjacent two carbon atoms thereof —CO—, —COO—, —O—, —NR?—, —CS—, —S—, —SO—, —SO2— or a combination thereof; and R3 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms.
    Type: Application
    Filed: September 20, 2013
    Publication date: December 25, 2014
    Applicant: JSR CORPORATION
    Inventors: Shinya MINEGISHI, Kiyoshi TANAKA, Kazunori KUSABIRAKI
  • Publication number: 20140316156
    Abstract: A method for producing a therapeutic agent and the agent thus produced. This therapeutic agent, referred to as D-boramine, has the following chemical formula:[(CH3)3NCH2CHOHCH2CO2H]2[O2CCHOHCHOHCO2] and has the following empirical formula: C18H36N2O12. The D-boramine is produced by allowing a reaction between approximately 500 mg of L-carnitine and approximately 2.5 mg of pyridoxal 5 phosphate in the presence of approximately 10 mg of fumaric acid. The reaction creates the D-boramine molecule as the reaction product. The D-boramine molecule has an orthorhombic crystalline structure and has been shown to be useful as a therapeutic agent in treating a variety of human cancers, ailments and diseases.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 23, 2014
    Inventor: DEBORAH WARNER
  • Patent number: 8859803
    Abstract: Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: October 14, 2014
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventor: Shinki Tani
  • Publication number: 20140288230
    Abstract: The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
    Type: Application
    Filed: October 18, 2012
    Publication date: September 25, 2014
    Inventors: Bernard M. Malofsky, Adam G. Malofsky, Tanmoy Dey
  • Publication number: 20140178607
    Abstract: The present invention provides a liquid crystal additive, a liquid crystal composition and a liquid crystal panel thereof. The liquid crystal additive of the present invention has a higher clear point, so that adding the liquid crystal additive into a liquid crystal composition of a liquid crystal panel can omit the process of forming alignment films to reduce manufacturing costs and time of liquid crystal panels; meanwhile, the MURA phenomenon due to the different effects of liquid crystal molecules and liquid crystal reactive monomers on alignment films is avoided, so as to improve the uniformity of liquid crystal panel.
    Type: Application
    Filed: November 23, 2012
    Publication date: June 26, 2014
    Applicant: SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventor: Houng-Chieh Lu
  • Patent number: 8735598
    Abstract: The present invention provides a method for producing a 1-biphenylmethylimidazole compound having superior angiotensin II receptor antagonistic activity, or an intermediate thereof. The present invention provides a method for producing a compound having the formula (5) (R1, Ra: H, an alkyl group) by oxidizing a compound having the formula (1) (Ra: H, an alkyl group) using an oxidizing agent in the presence of a radical initiation reagent, and then reacting with an ammonia-generating reagent and a compound having the formula R1CHO(R1: H, an alkyl group) or a compound having the formula R1C(ORb)3 (R1: H, an alkyl group; Rb: an alkyl group).
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: May 27, 2014
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Koji Sato, Tsutomu Yagi, Kenji Sakuratani, Yuichiro Tani
  • Publication number: 20140093826
    Abstract: A composition for forming a liquid immersion upper layer film includes a polymer component including a polymer having a structural unit represented by a formula (1); and a solvent. R1 represents a carboxy group or a group represented by a formula (2); X represents a single bond, a divalent hydrocarbon group having 1 to 20 carbon atoms or a divalent fluorinated hydrocarbon group having 1 to 20 carbon atoms; R2 represents a hydrocarbon group having 1 to 20 carbon atoms and a valency of (n+1), a fluorinated hydrocarbon group having 1 to 20 carbon atoms and a valency of (n+1), or one of these groups each including between adjacent two carbon atoms thereof —CO—, —COO—, —O—, —NR?—, —CS—, —S—, —SO—, —SO2— or a combination thereof; and R3 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms.
    Type: Application
    Filed: September 20, 2013
    Publication date: April 3, 2014
    Applicant: JSR CORPORATION
    Inventors: Shinya MINEGISHI, Kiyoshi TANAKA, Kazunori KUSABIRAKI
  • Publication number: 20140037961
    Abstract: The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 6, 2014
    Applicant: ADC BIOTECHNOLOGY LIMITED
    Inventor: David Evans
  • Publication number: 20130338390
    Abstract: A compound having the structure: wherein bond ? is present or absent, wherein when bond ? is absent, then R1 is ?O or S(CH2)1-3-phenyl and when bond ? is present, then R1 is H, wherein the phenyl is substituted or unsubstituted; R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently H or OR11 wherein each occurrence of R11 is independently H, methyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, phosphate, sulfate, sulfonic ester, or ester; when ? is absent and R1 is ?O, then R10 is other than OH; and when ? is absent and R1 is S(CH2)1-3-phenyl, then R10 is other than OCH3, or a salt thereof.
    Type: Application
    Filed: July 21, 2011
    Publication date: December 19, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Scott Alan Snyder
  • Patent number: 8609321
    Abstract: A radiation-sensitive resin composition includes a polymer having a structural unit represented by a formula (I). In the formula (I), R1 represents a hydrogen atom or a methyl group. X represents a bivalent alicyclic hydrocarbon group not having or having a substituent. Y represents a bivalent hydrocarbon group having 1 to 20 carbon atoms. R2 represents a methyl group or a trifluoromethyl group.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 17, 2013
    Assignee: JSP Corporation
    Inventors: Hiromitsu Nakashima, Reiko Kimura, Kazuo Nakahara, Mitsuo Sato
  • Publication number: 20130296601
    Abstract: Ketocarboxylic acids such as levulinic acid can be efficiently purified in high yield by esterification with a hydrocarbon polyol to the corresponding polyketocarboxylic ester, which can be readily purified, for example recrystallized. After purification, the ketocarboxylic ester can be hydrolyzed to provide pure ketocarboxylic acid, or a salt thereof, after removal of the esterifying hydrocarbon polyol, or used for other synthetic transformations. Advantageously, the polyketocarboxylic esters, ketocarboxylic acids, and salts thereof produced by this method are obtained in high purity.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 7, 2013
    Inventors: Brian D. Mullen, Leo E. Manzer, Cora M. Leibig
  • Patent number: 8507174
    Abstract: A positive resist composition comprising (A) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, (B) a resin capable of increasing the solubility in an alkali developer by the action of an acid, and (C) a compound having a specific structure, which decomposes by the action of an acid to generate an acid, a pattern forming method using the positive resist composition, and a compound for use in the positive resist composition are provided as a positive resist composition exhibiting good performance in terms of pattern profile, line edge roughness, pattern collapse, sensitivity and resolution in normal exposure (dry exposure), immersion exposure and double exposure, a pattern forming method using the positive resist composition and a compound for use in the positive resist composition.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: August 13, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Hidenori Takahashi, Kenji Wada, Sou Kamimura
  • Publication number: 20130189621
    Abstract: A radiation-sensitive resin composition includes a polymer having a structural unit represented by a formula (I). In the formula (I), R1 represents a hydrogen atom or a methyl group. X represents a bivalent alicyclic hydrocarbon group not having or having a substituent. Y represents a bivalent hydrocarbon group having 1 to 20 carbon atoms. R2 represents a methyl group or a trifluoromethyl group.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 25, 2013
    Applicant: JSR CORPORATION
    Inventor: JSR CORPORATION
  • Publication number: 20120171581
    Abstract: Disclosed are a nonaqueous electrolytic solution of an electrolyte dissolved in a nonaqueous solvent, which contains a carboxylate represented by the following general formula (I) in an amount of from 0.01 to 10% by mass of the nonaqueous electrolytic solution; and an electrochemical element using it.
    Type: Application
    Filed: September 14, 2010
    Publication date: July 5, 2012
    Applicant: UBE INDUSTRIES, LTD.
    Inventors: Koji Abe, Shoji Shikita, Kazuyuki Kawabe, Masahide Kondo, Tatsuo Fujino
  • Publication number: 20120157609
    Abstract: Substituted 3-oxopentanoates are disclosed that correspond to the following formula 1: in which R is hydrogen, or a methyl group; X is a straight-chain, branched, or cyclic alkyl or alkyl ether group having from 1 to 15 carbon atoms or aromatic group having from 6 to 15 carbon atoms; and Y1 and Y2 are independently hydrogen or an alkyl having 1 to 2 carbon atoms. Also disclosed are emulsion polymers, suspension polymers, and solution polymers that comprise residues from the substituted 3-oxopentanoate monomers, and that may also include one or more additional ethylenically unsaturated monomers. Also disclosed are coating compositions that include a latex emulsion polymer and the substituted 3-oxopentanoate monomer of formula 1 provided as a coalescent.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 21, 2012
    Applicant: Eastman Chemical Company
    Inventors: John Thorton Maddox, Robert Lee Eagan
  • Publication number: 20120157610
    Abstract: Acetoacetate-functional monomers are disclosed that correspond to the following formula 1: in which R is hydrogen, or a methylgroup; X is a branched alkyl or a branched cyclic alkyl having from 5 to 8 carbon atoms; and Y1 and Y2 are independently hydrogen or methyl. Also disclosed are emulsion, suspension, and solution polymers comprising residues from the acetoacetate-functional monomer of formula 1 and one or more additional ethylenically unsaturated monomers. Self-curing coating compositions are likewise disclosed that comprise the acetoacetate-functional monomer of formula 1, and optionally one or more additional ethylenically unsaturated monomers. Latex formulations are also disclosed that comprise a polymer having residues from the acetoacetate-functional monomer of formula 1 dispersed in an evaporable aqueous carrier.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 21, 2012
    Applicant: Eastman Chemical Company
    Inventors: John Thorton Maddox, Stacey James Marsh
  • Publication number: 20120142590
    Abstract: The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
    Type: Application
    Filed: October 14, 2011
    Publication date: June 7, 2012
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Adam N. Goldfarb, Loretta L. Delehanty
  • Publication number: 20120123147
    Abstract: Ketocarboxylic acids such as levulinic acid can be efficiently purified in high yield by esterification with a hydrocarbon polyol to the corresponding polyketocarboxylic ester, which can be readily purified, for example recrystallized. After purification, the ketocarboxylic ester can be hydrolyzed to provide pure ketocarboxylic acid, or a salt thereof, after removal of the esterifying hydrocarbon polyol, or used for other synthetic transformations. Advantageously, the polyketocarboxylic esters, ketocarboxylic acids, and salts thereof produced by this method are obtained in high purity.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: SEGETIS, INC.
    Inventors: Brian D. MULLEN, Cora M. LEIBIG, Leo E. MANZER
  • Patent number: 8097740
    Abstract: The present invention is generally directed to the synthesis and/or manufacture of ester-based lubricant compositions. The present invention is also directed to methods of making these and other similar lubricant compositions, and to systems for implementing such methods (processes). In some embodiments, the methods for making such ester-based lubricants utilize a biomass precursor (e.g., triglyceride-bearing vegetable oils) such that the lubricant compositions generated by the methods and systems of the present invention can be properly deemed biolubricants. In these or other embodiments, lubricant precursor species can also be sourced or derived from Fischer-Tropsch (FT) and/or long-chain paraffin pyrolysis reaction products. The ester component of the lubricant compositions, produced in accordance with the methods and systems of the present invention, comprises largely diester species.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: January 17, 2012
    Assignee: Chevron U.S.A. Inc.
    Inventor: Stephen Joseph Miller
  • Publication number: 20120004443
    Abstract: Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 5, 2012
    Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.
    Inventor: Shinki Tani
  • Publication number: 20110313191
    Abstract: This invention relates to a novel process for making 3-O-(3?,3?-dimethylsuccinyl)betulinic acid (“DSB”). This invention also relates to methods of treating HIV and related diseases using pharmaceutical compositions comprising salt forms of DSB prepared according to the process of the present invention. The invention further relates to dosage forms of pharmaceutical compositions comprising salts of DSB made using the process of this invention.
    Type: Application
    Filed: July 5, 2011
    Publication date: December 22, 2011
    Applicant: Myrexis, Inc.
    Inventors: Christian Hemp, Arndt Hausherr, Theodore John Nitz, Roy Swaringen
  • Patent number: 8067468
    Abstract: Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.
    Type: Grant
    Filed: September 12, 2009
    Date of Patent: November 29, 2011
    Inventor: Jian Chen
  • Publication number: 20110275838
    Abstract: The present invention relates to a process for obtaining cinatrins C1 and C3 and derivatives thereof which comprises the hydroxylation of a compound of formula (III).
    Type: Application
    Filed: May 5, 2009
    Publication date: November 10, 2011
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Pedro Noheda Marin, Luis Miguel Lozano Gordillo, Sergio Maroto Quintana
  • Patent number: 8043789
    Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: October 25, 2011
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
  • Publication number: 20110251338
    Abstract: Provided is a Michael addition product prepared from a multifunctional acryl monomer having multiple hydroxyl groups allowing introduction of acryl functional groups, as a Michael acceptor, and a Michael donor. The Michael addition product is a novel multifunctional compound having an oligomer and a photoinitiator moiety in the molecule. Since it can be cured under a standard UV curing condition without having to add a photoinitiator, it is reduced to air pollution or health problem. Therefore the superior physical properties were obtained by cured coatings without surface tackiness. In addition, its hydroxyl groups allow, through isocyanate bonding or introduction of acryl groups, 3-dimensional crosslinking and molecular and compositional design for improving expandability, friction, and reactivity and hydrophilicity for self-adhesion, hardness of cured film, or the like. Consequently, a very useful, multifunctional or water-dispersible coating composition may be prepared.
    Type: Application
    Filed: September 7, 2010
    Publication date: October 13, 2011
    Applicant: Korea Research Institute of Chemical Technology
    Inventors: Young Chul Kim, Byung Hoon Lee
  • Patent number: 8017797
    Abstract: A method for efficiently producing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, useful as a production intermediate of herbicide L-AMPB. The method comprises using a compound represented by the below formula (4): (4) where R1 represents a C1-4 alkyl group, arylmethyl group, or substituted arylmethyl group.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: September 13, 2011
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
  • Publication number: 20110183258
    Abstract: A positive resist composition comprising (A) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, (B) a resin capable of increasing the solubility in an alkali developer by the action of an acid, and (C) a compound having a specific structure, which decomposes by the action of an acid to generate an acid, a pattern forming method using the positive resist composition, and a compound for use in the positive resist composition are provided as a positive resist composition exhibiting good performance in terms of pattern profile, line edge roughness, pattern collapse, sensitivity and resolution in normal exposure (dry exposure), immersion exposure and double exposure, a pattern forming method using the positive resist composition and a compound for use in the positive resist composition.
    Type: Application
    Filed: August 11, 2008
    Publication date: July 28, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Hidenori Takahashi, Kenji Wada, Sou Kamimura
  • Publication number: 20110092713
    Abstract: The present invention provides a method for producing a 1-biphenylmethylimidazole compound having superior angiotensin II receptor antagonistic activity, or an intermediate thereof. The present invention provides a method for producing a compound having the formula (5) (R1, Ra: H, an alkyl group) by oxidizing a compound having the formula (1) (Ra: H, an alkyl group) using an oxidizing agent in the presence of a radical initiation reagent, and then reacting with an ammonia-generating reagent and a compound having the formula R1CHO(R1: H, an alkyl group) or a compound having the formula R1C(ORb)3 (R1: H, an alkyl group; Rb: an alkyl group).
    Type: Application
    Filed: June 8, 2009
    Publication date: April 21, 2011
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Koji Sato, Tsutomu Yagi, Kenji Sakuratani, Yuichiro Tani
  • Patent number: 7855261
    Abstract: Disclosed are filter elements constructed of a filter support material coated with an acetoacetate-functional polymeric composition that reacts with and removes aldehydes, especially formaldehyde, present in gases such as air. Also disclosed are methods for the removal of aldehydes utilizing the coated filter support materials.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: December 21, 2010
    Assignee: Eastman Chemical Company
    Inventors: Thauming Kuo, Mark Kevin Vineyard, Weimin Chen Liang
  • Publication number: 20100216915
    Abstract: The present invention is directed to ester derivatives of levulinic acid that are useful as plasticizers and/or coalescent solvents in polymer compositions, compositions comprising the ester derivatives, methods of making the derivatives and the compositions, and the use of the derivatives as additives in polymer compositions.
    Type: Application
    Filed: January 22, 2007
    Publication date: August 26, 2010
    Applicant: Archer-Daniels-Midland Company
    Inventor: Paul D. Bloom
  • Patent number: 7766978
    Abstract: Provided are acidic hair dye compositions in which the dye has a high permeability into hair, the dye can be applied uniformly, and the composition has excellent staining property, safety and sense of use at the time of hair dyeing. The acidic hair dye compositions of the present invention comprise at least one dibasic acid ester compound represented by general formula I below: wherein, in general formula I, R1 is an alkylene group which may have a substituent with 2 to 4 carbon atoms, R2 and R3 are, independently from each other, an alkyl group which may have a substituent with 1 to 4 carbon atoms, R4 and R5 are, independently from each other, hydrogen, methyl group or ethyl group, m and n is, independently from each other, an integer of 0 to 4, wherein m+n?1 (with the proviso that the case is excluded in which R2 and R3 are both ethyl group, and m and n are both 1).
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: August 3, 2010
    Assignee: Kokyu Alcohol Kogyo Co., Ltd.
    Inventors: Yuki Kokeguchi, Kyoichi Takeda, Kiyotaka Kawai
  • Patent number: 7750108
    Abstract: Copolyesters containing secondary hydroxyl groups are useful polyols for manufacturing polyurethanes. These can be prepared by reacting a secondary hydroxyl-containing fatty acid or ester thereof with an initiator containing hydroxyl and/or primary or secondary amino groups. A copolyester of particular interest includes a poly(ethylene oxide) segment derived from a poly(ethylene oxide) initiator.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: July 6, 2010
    Assignee: Dow Global Technologies Inc.
    Inventors: Zenon Lysenko, David A. Babb, Kenneth J. Stutts, Robbyn Prange, Min Zhang, Alan K. Schrock
  • Publication number: 20090285728
    Abstract: The present invention is generally directed to the synthesis and/or manufacture of ester-based lubricant compositions. The present invention is also directed to methods of making these and other similar lubricant compositions, and to systems for implementing such methods (processes). In some embodiments, the methods for making such ester-based lubricants utilize a biomass precursor (e.g., triglyceride-bearing vegetable oils) such that the lubricant compositions generated by the methods and systems of the present invention can be properly deemed biolubricants. In these or other embodiments, lubricant precursor species can also be sourced or derived from Fischer-Tropsch (FT) and/or long-chain paraffin pyrolysis reaction products. The ester component of the lubricant compositions, produced in accordance with the methods and systems of the present invention, comprises largely diester species.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 19, 2009
    Applicant: Chevron U.S.A. Inc.
    Inventor: Stephen Joseph Miller
  • Publication number: 20090100609
    Abstract: Provided are acidic hair dye compositions in which the dye has a high permeability into hair, the dye can be applied uniformly, and the composition has excellent staining property, safety and sense of use at the time of hair dyeing. The acidic hair dye compositions of the present invention comprise at least one dibasic acid ester compound represented by general formula I below: wherein, in general formula I, R1 is an alkylene group which may have a substituent with 2 to 4 carbon atoms, R2 and R3 are, independently from each other, an alkyl group which may have a substituent with 1 to 4 carbon atoms, R4 and R5 are, independently from each other, hydrogen, methyl group or ethyl group, m and n is, independently from each other, an integer of 0 to 4, wherein m+n?1 (with the proviso that the case is excluded in which R2 and R3 are both ethyl group, and m and n are both 1).
    Type: Application
    Filed: October 15, 2008
    Publication date: April 23, 2009
    Applicant: Kokyu Alcohol Kogyo Co., Ltd.
    Inventors: Yuki Kokeguchi, Kyoichi Takeda, Kiyotaka Kawai
  • Publication number: 20090076292
    Abstract: Provided are intermediates and process for the preparation of statins, preferably rosuvastatin.
    Type: Application
    Filed: April 18, 2008
    Publication date: March 19, 2009
    Inventors: Vinod Kumar Kansal, Harish Ranjan, Jalinder N. Jaware, Appu Ekambaram Ponnuswamy
  • Publication number: 20090035699
    Abstract: Fluorinated monomers of formula (1) are useful in producing polymers for the formulation of radiation-sensitive resist compositions. R1 is H or monovalent C1-C20 hydrocarbon group, R2 is H, F, methyl or trifluoromethyl, R3 and R4 are H or a monovalent C1-C8 hydrocarbon group, or R3 and R4 may form an aliphatic hydrocarbon ring, and A is a divalent C1-C6 hydrocarbon group.
    Type: Application
    Filed: June 25, 2008
    Publication date: February 5, 2009
    Inventors: Koji HASEGAWA, Takeshi KINSHO, Katsuhiro KOBAYASHI, Tsunehiro NISHI, Takeru WATANABE
  • Publication number: 20080305066
    Abstract: Use of a compound of formula 1 as malodour neutraliser wherein A, B, Y and Y have the same meaning as given in the specification, and personal care products comprising the same.
    Type: Application
    Filed: January 6, 2006
    Publication date: December 11, 2008
    Applicant: GIVAUDAN SA
    Inventors: Felix Flachsmann, Jean-Pierre Bachmann
  • Patent number: 6692728
    Abstract: The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: February 17, 2004
    Assignee: Ethox Chemicals LLC
    Inventors: Paul David Weipert, Bharat B. Desai
  • Patent number: 6548693
    Abstract: Carnitine derivatives of formula (I) are described in racemic and/or optically active form, as well as the process for their preparation and their use as pharmaceutical anti-angina active ingredients for the treatment of ischaemic heart disease. Also described is a process for producing the (R)-carnitine enantiomer from (S)-carnitine (or vice versa), using the derivatives of formula (I).
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 15, 2003
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Oreste Piccolo, Roberto Castagnani, Paolo De Witt
  • Patent number: 6540987
    Abstract: The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: April 1, 2003
    Assignee: Ethox Chemicals LLC
    Inventors: Paul David Weipert, Bharat B. Desai
  • Patent number: 6528668
    Abstract: Methods for making 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and derivatives thereof, esters of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid and derivatives thereof, which are useful as a variety of synthetic raw materials and intermediates, and are prepared as intermediates in the production step of &ohgr;-hydroxyaliphatic acid being important intermediates of large cyclic lactone-based perfumes in the perfume industry.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: March 4, 2003
    Assignee: Toray Industries, Inc.
    Inventors: Hideaki Takaoka, Sigeru Wada, Nobuhiko Ito, Akio Hasebe, Shinzo Imamura, Hideo Muraoka
  • Patent number: 6469198
    Abstract: There is disclosed chiral copper complex catalyst composition, which is obtained by contacting an optically active N-salicylideneaminoalcohol compound of formula (1): with a mono-valent or di-valent copper compound in an inert solvent, wherein R1 and R2 represent an alkyl group and the like, X1 and X2 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group, an alkoxy group, a cyano group or the like, and the amount of the mono-valent or di-valent copper compound is less than 1 mole per 1 mole of the optically active N-salicylideneaminoalcohol compound of formula (1), and a process for producing an optically active cylopropane-carboxylic acid ester using the same.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: October 22, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Gohfu Suzukamo, Makoto Itagaki, Michio Yamamoto
  • Patent number: 6403825
    Abstract: Described are processes for producing citrate esters in, an economic fashion. Esters are prepared by esterification of a citric acid-containing fermentation broth having been treated to remove cations and optionally other impurities, but containing sugar(s). Esters are also prepared by reacting an impure aqueous citric acid source with an alcohol to provide a heterogeneous aqueous/organic reacted mixture, wherein the organic phase contains the ester and the aqueous phase retains water-soluble impurities. A liquid phase separation is then used to separate the organic and aqueous phases, conveniently separating the impurities from the product and avoiding the energy-intensive distillation of water from the reaction medium.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: June 11, 2002
    Assignee: Reilly Industries, Inc.
    Inventors: Edward P. Frappier, James E. Davis, Martin Grendze, Eric F. V. Scriven, John T. Wyeth, Kuen-Wai Chiu
  • Patent number: 6258977
    Abstract: An alkyl 3-oxoalkanoate, a process for preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: July 10, 2001
    Assignee: L'Oreal
    Inventors: Michel Philippe, Bernadette Luppi, Didier Semeria, Claude Mahieu
  • Patent number: 6090974
    Abstract: This invention includes an alkyl 3-oxoalkanoate, and processes for its preparation and use for the synthesis of fatty hydroxylated amino acids, fatty amino alcohols and ceramides.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: July 18, 2000
    Assignee: L'Oreal SA
    Inventors: Michel Philippe, Bernadette Luppi, Didier Semeria, Claude Mahieu
  • Patent number: 6034052
    Abstract: Mixtures of ethylene dodecanedioate and ethylene undecanedioate which, because of their particular musk odor note, are products which can replace macrocyclic aromatic musk fragrances in inter alia perfume compositions.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: March 7, 2000
    Inventors: Alfred Korber, Peter Worner, Horst Surburg