Cyclic Alcohol Moiety Patents (Class 560/188)
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Patent number: 9662286Abstract: The present invention relates to a method of preparing liquid compositions essentially consisting of menthol and menthyl lactate and the use of such compositions as a cooling agent, flavoring agent and/or fragrance agent, products containing such compositions and methods of providing a physiological cooling effect by applying such compositions.Type: GrantFiled: November 26, 2013Date of Patent: May 30, 2017Assignee: BASF SEInventors: Nitin Gupte, Avinash Salaskar, Parag Kulkarni
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Publication number: 20150087856Abstract: The present invention provides a melanin production inhibitor containing a compound having a (2-isopropyl-5-methyl)cyclohexyl group or a (2-isopropenyl-5-methyl)cyclohexyl group.Type: ApplicationFiled: April 2, 2013Publication date: March 26, 2015Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Toshiaki Narukami, Eiko Tamai
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Publication number: 20140296444Abstract: Monomers, polymers and copolymers are provided that incorporate at least one naturally occurring phenolic compound, such as a plant phenol.Type: ApplicationFiled: March 11, 2014Publication date: October 2, 2014Applicant: NDSU RESEARCH FOUNDATIONInventors: BRET JA CHISHOLM, SAMIM ALAM, MUKUND SIBI, SELVAKUMAR SERMADURAI
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Publication number: 20140186272Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.Type: ApplicationFiled: March 5, 2014Publication date: July 3, 2014Applicant: The Procter & Gamble CompanyInventors: Kenneth Edward YELM, Gregory Mark BUNKE, John Christian HAUGHT
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Patent number: 8476472Abstract: The present invention provides a cooling component or sensate component which has further strong cooling intensity and is excellent in the persistency or refresh-feeling and cool-feeling, a sensate composition comprising the same, and various products comprising the sensate composition.Type: GrantFiled: April 23, 2010Date of Patent: July 2, 2013Assignee: Takasago International CorporationInventors: Kazuma Hojo, Takashi Aida, Kenya Ishida
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Publication number: 20130079405Abstract: Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y?C14 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.Type: ApplicationFiled: October 13, 2010Publication date: March 28, 2013Applicant: West China Hospital Sichuan UniversityInventors: Wensheng Zhang, Jun Yang, Jin Liu
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Patent number: 8389671Abstract: The present invention can provide a composition for optical members, which contains (a) a compound having one or more of any group selected from the group consisting of an acryloyl group, a methacryloyl group, an allyl group and a vinyl group and one or more ?-epithiopropyl groups in a molecule. In a preferable embodiment of the present invention, the composition for optical members further contains at least one compound selected from (b) a compound having one or more ?-epithiopropyl groups in a molecule while having no polymerizable unsaturated bond group, (c) an inorganic compound having a sulfur atom and/or a selenium atom, (d) a compound having one or more thiol groups in a molecule, (e) a compound having one or more amino groups in a molecule while having no heterocyclic ring, and (f) a compound having one or more of at least one group selected from the group consisting of a vinyl group, an acryloyl group, a methacryloyl group and an allyl group in a molecule.Type: GrantFiled: March 11, 2008Date of Patent: March 5, 2013Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Motoharu Takeuchi, Hiroshi Horikoshi, Hiroaki Tanaka, Hirohito Ishizuka
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Publication number: 20130005807Abstract: The objective of the present invention is to provide an antimicrobial composition that can be safely used with a broad range of foods and beverages, cosmetics, drugs, and other similar products while showing growth inhibition activity against a wide variety of microorganisms. The present invention relates to the antimicrobial composition comprising at least one cooling agent selected from the group consisting of menthyl 3-hydroxybutanoate, 2-methyl-3-(menthoxy)propane-1,2-diol, 2-(menthoxy)ethanol, 3-menthoxypropan-1-ol, 2-(2-menthoxyethoxy)ethanol, and menthyl glyoxylate.Type: ApplicationFiled: June 29, 2012Publication date: January 3, 2013Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kenya ISHIDA, Tomoko YAMAMOTO, Miho SUZUKI
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Patent number: 8329938Abstract: Retinyl hydroxyesters and retinyl oligo-hydroxyesters were prepared using a chemoenzymatic process from retinol and short chain esters of hydroxycarboxylic acids or short chain esters of hydroxycarboxylic acids. The presence of the hydroxyl group on the acid can result in a mixture of esters from various oligomers of the hydroxycarboxylic acid. The retinyl ester products are readily enzymatically hydrolyzed in vitro, which indicates that application to the skin should result in release of the anti-aging ingredient retinol (without the inherent instability and irritation) along with the acid, which, if chosen appropriately, should also have desirable biological effects. This combination should be effective as an anti-aging skin care ingredient.Type: GrantFiled: February 21, 2011Date of Patent: December 11, 2012Assignee: Eastman Chemical CompanyInventor: Neil Warren Boaz
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Publication number: 20120252997Abstract: Fluorinated arylene-containing compounds and fluorinated polymers formed from fluorinated arylene-containing compounds, and methods are described. Fluorinated polymers formed from fluorinated arylene-containing compound can be used to provide a low energy surface.Type: ApplicationFiled: December 17, 2010Publication date: October 4, 2012Inventors: Yu Yang, George G.I. Moore, John C. Clark
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Publication number: 20110281945Abstract: To provide a drug, quasi-drug, food or drink that can act as a gastric acid secretion suppressant or a potassium channel inhibitor by including a composition that can be safely used and can be inexpensively produced. Each of these products contains one or more cooling sensation compositions that are compounds providing cooling sensation in an amount sufficient for exhibiting the efficacy thereof in a living body to which the product is administered.Type: ApplicationFiled: January 26, 2010Publication date: November 17, 2011Inventors: Yuichi Suzuki, Kenya Ishida, Mitsuhiko Fujiwhara
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Patent number: 8044235Abstract: A monomer is provided which is excellent in reactivity, can give high heat resistance and high refractive index, and has two or more polymerizable functional groups with different polymerization properties and an aromatic ring in the molecule. An industrial advantageous process for producing the monomer is also provided. The monomer is an aromatic isocyanate compound containing a (meth)acryloyl group, and is represented by Formula (I): wherein R1 is a single bond or a linear or branched alkylene group of 1 to 5 carbon atoms, R2 is a hydrogen atom or a methyl group, R3 is a single bond or a linear or branched alkylene group of 1 to 3 carbon atoms, X is independently a halogen atom or an electron-withdrawing group, m is an integer ranging from 0 to 4, n is an integer ranging from 1 to 3, and 1?m+n?5.Type: GrantFiled: March 15, 2006Date of Patent: October 25, 2011Assignee: Showa Denko K.K.Inventors: Kaneo Nozawa, Katsutoshi Ohno, Yotaro Hattori
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Patent number: 7968744Abstract: A method of imparting a physiological cooling effect to a consumer product is disclosed. The method comprises formulating into the consumer product a composition comprising at least one lactoyl ester of menthyl lactate. Also disclosed is a method of providing physiological cooling by contacting skin or mucous membranes with the lactoyl ester compositions. Coolants comprising the lactoyl esters and additional coolants are also disclosed. The lactoyl esters are conveniently prepared from menthol and lactic acid.Type: GrantFiled: August 10, 2010Date of Patent: June 28, 2011Assignee: Renessenz, LLCInventors: Mark B. Erman, Patrick J. Whelan, Joe W. Snow
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Publication number: 20110118500Abstract: Provided that a method for inexpensively producing optically active ?-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active ?-ionone obtained by the aforementioned method. A method for producing optically active ?-ionone, comprising allowing ?-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained ?-ionone enol ester; a method for producing optically active ?-ionone comprising subjecting ?-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active ?-ionol to react with an esterification agent to give an optically active ?-ionol ester, hydrolyzing the obtained optically active ?-ionol ester after purification as necessary, and then oxidizing the obtained optically active ?-ionol; and a perfume composition comprising thus obtained optically active ?-ionone.Type: ApplicationFiled: January 24, 2011Publication date: May 19, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Tetsuya Yamamoto, Kenji Yagi, Kenya Ishida
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Patent number: 7919651Abstract: A compound represented by general formula (I) shown below; and a polymeric compound having a structural unit (a0) represented by general formula (a0-1) shown below: wherein R1 represents a hydrogen atom, a lower alkyl group or a halogenated lower alkyl group; A represents a divalent hydrocarbon group of 2 or more carbon atoms which may have a substituent; B represents a divalent hydrocarbon group of 1 or more carbon atoms which may have a substituent; and R2 represents an acid dissociable, dissolution inhibiting group.Type: GrantFiled: August 6, 2009Date of Patent: April 5, 2011Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Daiju Shiono, Takahiro Dazai, Hiroaki Shimizu
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Publication number: 20100303740Abstract: The present invention provides a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling, a sensate composition which comprises the same, and various products that comprise said sensate composition.Type: ApplicationFiled: April 23, 2010Publication date: December 2, 2010Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kazuma HOJO, Takashi AIDA, Kenya ISHIDA
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Publication number: 20100280110Abstract: The present invention provides a cooling component or sensate component which has further strong cooling intensity and is excellent in the persistency or refresh-feeling and cool-feeling, a sensate composition comprising the same, and various products comprising the sensate composition.Type: ApplicationFiled: April 23, 2010Publication date: November 4, 2010Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kazuma HOJO, Takashi AIDA, Kenya ISHIDA
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Patent number: 7803963Abstract: A method of imparting a physiological cooling effect to a consumer product is disclosed. The method comprises formulating into the consumer product a composition comprising at least one lactoyl ester of menthyl lactate. Also disclosed is a method of providing physiological cooling by contacting skin or mucous membranes with the lactoyl ester compositions. Coolants comprising the lactoyl esters and additional coolants are also disclosed. The lactoyl esters are conveniently prepared from menthol and lactic acid.Type: GrantFiled: October 15, 2007Date of Patent: September 28, 2010Assignee: Millennium Specialty Chemicals, Inc.Inventors: Mark B. Erman, Patrick J. Whelan, Joe W. Snow
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Publication number: 20100076068Abstract: A compound of formula (1) Including pharmaceutically acceptable salts thereof, wherein: R1 is aryl or heteroaryl optionally substituted with R8; R2 is H or alkyl or CH2 (when forming part of a ring with R3, R4 or R5); R3 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2; R4 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2; R5 is H, alkyl, CH2OH or CH2OR6 and can be part of a ring with R2; R6 is H, alkyl, COH, COOR9, CON(R9)2, COR9, COR10, COR11, P(O)nR9, P(O)nR10S(O)nR10 or S(O)nR9 and can be part of a ring with R2, R3, R4 or R5; R7 is H, alkyl, COOR9, COOR11, COR9 or CON(R9)2, and can be part of a ring with R2, R3, R4, R5 or R6; R8 is alkyl, CF3, OR9, OCOR9, CONH2, CN, F, Cl, Br, I, N(R9)2, NO2, NHCHO, NHCONH2, NHSO2R9, CON(R9)2, S(O)nR9, CH2OH Or OCON(R9)2; R9 is H, alkyl or cycloalkyl; R10 is aryl or heteroaryl (optionally substituted with R8) or a four to seven membered ring (which is optionally substituted with R8 and can contain one or more additional heteroatoms selected fromType: ApplicationFiled: December 12, 2007Publication date: March 25, 2010Inventors: Andrea Walmsley, Elena Lasterra
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Patent number: 7655816Abstract: A method for stabilizing menthyl lactate is disclosed. The method comprises combining water with a solution comprising menthyl lactate and a water-miscible organic solvent in amounts effective to precipitate menthyl lactate from the resulting aqueous mixture. The aqueous precipitation method is simple to practice, and it provides menthyl lactate having remarkably improved storage stability.Type: GrantFiled: March 28, 2008Date of Patent: February 2, 2010Assignee: Millennium Specialty ChemicalsInventors: Mark B. Erman, Joe W. Snow
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Publication number: 20090325972Abstract: Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it induces cell cycle arrest and cell death. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1.Type: ApplicationFiled: August 28, 2008Publication date: December 31, 2009Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Byoung Mog KWON, Dong Cho HAN, Hye Nan KIM, Young Min HAN, Dae Seop SHIN, Yeong Rim Kang
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Publication number: 20090312573Abstract: A compound represented by general formula (I) shown below; and a polymeric compound having a structural unit (a0) represented by general formula (a0-1) shown below: wherein R1 represents a hydrogen atom, a lower alkyl group or a halogenated lower alkyl group; A represents a divalent hydrocarbon group of 2 or more carbon atoms which may have a substituent; B represents a divalent hydrocarbon group of 1 or more carbon atoms which may have a substituent; and R2 represents an acid dissociable, dissolution inhibiting group.Type: ApplicationFiled: August 6, 2009Publication date: December 17, 2009Applicant: TOKYO OHKA KOGYO CO., LTD.Inventors: Daiju Shiono, Takahiro Dazai, Hiroaki Shimizu
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Patent number: 7582791Abstract: A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate, to thereby produce Compound (3), and subjecting Compound (3) to desulfurization reaction: (wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; R1 represents a C1 to C12 alkyl group or a phenyl group; and * represents S- or R-absolute configuration). The present invention provides a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity.Type: GrantFiled: August 24, 2006Date of Patent: September 1, 2009Assignee: Kowa Co., Ltd.Inventors: Takaaki Araki, Yukiyoshi Yamazaki, Kimiyuki Shibuya
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Patent number: 7425644Abstract: The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.Type: GrantFiled: November 23, 2004Date of Patent: September 16, 2008Assignee: TEVA Gyógyszergyár Zártkörűen Működő RészvénytársaságInventors: Vilmos Keri, Istvan Melczer
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Patent number: 7381834Abstract: A method for stabilizing menthyl lactate is disclosed. The method comprises combining water with a solution comprising menthyl lactate and a water-miscible organic solvent in amounts effective to precipitate menthyl lactate from the resulting aqueous mixture. The aqueous precipitation method is simple to practice, and it provides menthyl lactate having remarkably improved storage stability.Type: GrantFiled: April 18, 2007Date of Patent: June 3, 2008Assignee: Millennium Specialty Chemicals, Inc.Inventors: Mark B. Erman, Joe W. Snow
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Patent number: 7247743Abstract: A process for making monomenthyl esters of dicarboxylic acids is disclosed. Menthol reacts with a saturated, cyclic anhydride in the presence of a base catalyst under conditions effective to produce a mixture of mono- and bis-menthyl esters in which the molar ratio of mono- to bis-menthyl esters is enhanced compared with the ratio of esters produced in a similar uncatalyzed process.Type: GrantFiled: February 27, 2006Date of Patent: July 24, 2007Assignee: Millennium Specialty Chemicals, Inc.Inventors: Mark B. Erman, Joe W. Snow, Mikhail Y. Lebedev
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Patent number: 7196128Abstract: A carboxylic ester of the formula in which A is —(CH2)x— where x=1–10, a process for its preparation which esters are useful lubricated and plasticizers for high molecular polymeric thermoplastics.Type: GrantFiled: July 8, 2004Date of Patent: March 27, 2007Assignee: Celanese Chemicals Europe GmbHInventors: Peter Lappe, Christoph Balzarek
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Patent number: 7173146Abstract: A simple, high-yield process for making menthyl lactate (ML) is disclosed. Menthol and lactic acid react to produce a mixture comprising menthyl lactate and one or more higher lactoyl esters of ML. Hydrolysis of the esterification mixture follows in the presence of aqueous base under conditions effective to convert the higher lactoyl esters to menthyl lactate. Coincidentally, the conditions minimize hydrolysis of menthyl lactate to menthol, thereby maximizing the overall yield of ML.Type: GrantFiled: October 13, 2005Date of Patent: February 6, 2007Assignee: Millennium Specialty Chemicals, Inc.Inventors: Mark B. Erman, Joe W. Snow
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Patent number: 7109371Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.Type: GrantFiled: January 5, 2004Date of Patent: September 19, 2006Assignee: Johnson Matthey Public Limited CompanyInventors: Derek Wyndham Clissold, Stuart Wilbert Craig, Rajendrakumar Reddy Gadikota, Min He, Jurjus Fayez Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Kumar Sharma
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Patent number: 7064102Abstract: The invention relates to novel alicyclic esters, methods for the their preparation, their use as fragrances and also perfumed products and fragrance mixtures containing the compounds according to the invention.Type: GrantFiled: March 29, 2003Date of Patent: June 20, 2006Assignee: Symrise GmbH & Co, KGInventor: Marcus Eh
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Patent number: 6936731Abstract: The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.Type: GrantFiled: October 5, 2001Date of Patent: August 30, 2005Assignee: TEVA Gyógyszergyár RészvénytársaságInventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Arvai Edit Nagyne
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Patent number: 6884906Abstract: Described is a genus of menthyl half acid ester derivatives having the structure: and processes for producing same, wherein n is an integer of from 1 to 5; wherein X is either —OR? or —NRR?; wherein R? is hydrogen, C1-C5 lower alkyl or C3-C6 lower alkenyl; wherein R is hydrogen, C1-C5 lower alkyl, 2-hydroxyethyl or cyclopropyl and wherein R? is hydrogen, methyl or ethyl; with the proviso that when X is —OR?, n is an integer of from 3 to 5, having utility for augmenting, enhancing or imparting a taste or cooling effect or refreshing effect in or to an ingestible or topical composition.Type: GrantFiled: July 1, 2003Date of Patent: April 26, 2005Assignee: International Flavors & Fragrances Inc.Inventors: Mark L. Dewis, Michelle E. Huber, Michael V. Cossette
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Patent number: 6858749Abstract: The present invention relates to a novel process for producing a ?-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-?-lactone.Type: GrantFiled: February 10, 2003Date of Patent: February 22, 2005Assignee: Roche Colorado CorporationInventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
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Publication number: 20040167352Abstract: A process for purifying pravastatin sodium comprising the steps of:Type: ApplicationFiled: May 14, 2003Publication date: August 26, 2004Inventors: Jing-Chen Mai, Chiou-Jour Laih, Yu-Chin Chiang
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Patent number: 6689590Abstract: A composition comprising pravastatin sodium substantially free of pravastatin lactone is described.Type: GrantFiled: July 23, 2002Date of Patent: February 10, 2004Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs, Csaba Szabo, Edit Arvai Nagyne
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Patent number: 6586619Abstract: The present invention relates to novel monomers which can be used to form polymers which are useful in a photolithography employing a light source in the far ultraviolet region of the light spectrum, copolymers thereof, and photoresist compositions prepared therefrom. Photoresist monomers of the present invention are represented by the following Chemical Formula 1: wherein, R is substituted or non-substituted linear or branched (C1-C10) alkyl, substituted or non-substituted (C1-C10) ether, substituted or non-substituted (C1-C10) ester, or substituted or non-substituted (C1-C10) ketone; X and Y are independently CH2, CH2CH2, oxygen or sulfur; and i is 0 or an integer of 1 to 2.Type: GrantFiled: February 19, 2002Date of Patent: July 1, 2003Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Geun Su Lee, Cha Won Koh, Jae Chang Jung, Min Ho Jung, Ki Ho Baik
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Patent number: 6548459Abstract: A process for the preparation of CNSL phenoxy carboxylic acid derivatives for use as an additive in a lubricant composition so as to impart improved rust inhibiting properties, including the steps of (a) partially hydrogenating distilled technical cashew nut shell liquid with palladium or nickel or platinum catalyst; to hydrogenate the olefinic chain; (b) reacting cashew nut shell liquid or partially hydrogenated technical cashew nut shell liquid with halogeno carboxylic acid derivatives to obtain unpolymerized cashew nut shell liquid phenoxy carboxylic acid derivatives, the reaction being carried out at a temperature ranging from 20 to 140° C. A lubricant containing a major proportion of a material selected from the group consisting of an oil of lubricating viscosity and a grease; and remainder an additive including CNSL phenoxy carboxylic acid derivative prepared by the foregoing process.Type: GrantFiled: April 2, 2002Date of Patent: April 15, 2003Assignee: Indian Oil Corporation LimitedInventors: Pankaj Kumar Mondal, Khem Chand Dohhen, Rakesh Sarin, Deepak Kumar Tuli, Niranjan Raghunath Raje, Akhilesh Kumar Bhatnagar
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Publication number: 20030050198Abstract: A process for the preparation of CNSL phenoxy carboxylic acid derivatives for use as an additive in a lubricant composition so as to impart improved rust inhibiting properties, including the steps of (a) partially hydrogenating distilled technical cashew nut shell liquid with palladium or nickel or platinum catalyst; to hydrogenate the olefinic chain; (b) reacting cashew nut shell liquid or partially hydrogenated technical cashew nut shell liquid with halogeno carboxylic acid derivatives to obtain unpolymerized cashew nut shell liquid phenoxy carboxylic acid derivatives, the reaction being carried out at a temperature ranging from 20 to 140° C. A lubricant containing a major proportion of a material selected from the group consisting of an oil of lubricating viscosity and a grease; and remainder an additive including CNSL phenoxy carboxylic acid derivative prepared by the foregoing process.Type: ApplicationFiled: April 2, 2002Publication date: March 13, 2003Applicant: Indian Oil Corporation LimitedInventors: Pankaj Kumar Mondal, Khem Chand Dohhen, Rakesh Sarin, Deepak Kumar Tuli, Niranjan Raghunath Raje, Akhilesh Kumar Bhatnagar
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Patent number: 6495713Abstract: This invention encompasses a process for making a compound of Formula A These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.Type: GrantFiled: January 17, 2002Date of Patent: December 17, 2002Assignee: Merck & Co., Inc.Inventors: Cheng Yi Chen, Weirong Chen, Paul O'Shea, Lushi Tan, Richard Tillyer, Feng Xu, Philippe Dagneau
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Publication number: 20020143205Abstract: This invention encompasses a process for making a compound of Formula A 1Type: ApplicationFiled: January 17, 2002Publication date: October 3, 2002Inventors: Cheng Yi Chen, Weirong Chen, Paul O'Shea, Lushi Tan, Richard Tillyer, Feng Xu, Philippe Dagneau
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Patent number: 6444452Abstract: A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.Type: GrantFiled: November 28, 2000Date of Patent: September 3, 2002Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Edit Arvai Nagyne
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Patent number: 6391916Abstract: Novel C3-substituted cyclodeca-1,5-diynes can be prepared through novel synthetic procedures using starting (E)-C3-substituted-4-(aryl- or heteroarylmethylidene)cyclodeca-1,5-diynes reagents. Both the C3-substituted cyclodeca-1,5-diyn-3-enes and the starting reagents have improved thermal stability compared to unsubstituted counterparts.Type: GrantFiled: July 21, 2000Date of Patent: May 21, 2002Assignee: The Hong Kong University of Science and TechnologyInventors: Wei-Min Dai, Anxin Wu, Yuk Ha Lee, Wataru Hamaguchi, Sei-ichi Nishimoto, Ling Zhou, Atsushi Ishii
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Patent number: 6365382Abstract: The very effective conversion of ML-236B substances and derivatives thereof into 6′-hydroxylated products with the microorganisms of species Amycolatopsis orientalis, or with an extract or a hydroxylation-effective enzyme derived from said microorganism, is described. The products obtained are suitable as HMG-CoA reductase inhibitors or intermediates thereof. Thus, the products can be used, for example, as an antihypercholesterolemic in pharmacy.Type: GrantFiled: December 27, 2000Date of Patent: April 2, 2002Assignee: LEK Pharmaceuticals and Chemical Company D.D.Inventors: Sa{haeck over (s)}o Kranjc, Irena Ivanc, Manica Schauer
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Patent number: 6348494Abstract: This invention provides O-&agr;-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): wherein: the configuration at the steriogenic center (*) may be R, S, or RS (the racemate); wherein radicals R1, R2, R3, R4, and R5 are as defined in the specification; as well as pharmaceutical compositions and methods treating central nervous system disorders.Type: GrantFiled: November 21, 2000Date of Patent: February 19, 2002Assignee: American Home Products CorporationInventors: John P. Yardley, Magid A. Abou-Gharbia, John W. Ullrich
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Patent number: 6306629Abstract: The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to pravastatin.Type: GrantFiled: December 29, 1999Date of Patent: October 23, 2001Assignee: Yungjin Pharmaceutical Ind. Co., Ltd.Inventors: Joo-Kyung Lee, Joo-Woong Park, Dong-Jin Seo, Sang-Choon Lee, Ji-Yoon Kim
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Patent number: 6118019Abstract: A 3-alkoxypropionic ester derivative, an olefin polymerization solid catalyst component using the same, an olefin polymerization catalyst using the same, and a process for the preparation of a polyolefin using the same. The 3-alkoxypropionic ester derivative is represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrocarbon group having from 1 to 10 carbon atoms; R.sup.2 represents a hydrocarbon group having from 1 to 20 carbon atoms; R.sup.3 represents a hydrocarbon group having from 1 to 20 carbon atoms; and R.sup.4 represents a branched hydrocarbon group having 3 or more carbon atoms.Type: GrantFiled: December 29, 1998Date of Patent: September 12, 2000Assignee: Showa Denko K.K.Inventors: Masaki Fushimi, Shintaro Inazawa
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Patent number: 6107286Abstract: Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula, and m has variable or identical values within the groupings (a) or --(CH.sub.2).sub.m ; R is a hydrogen atom or a radical of general formula (II), wherein X or X.sup.1, which are the same or different, are an oxygen atom, a methylene grouping --(CH.sub.2).sub.q -- where q is 0, 1, 2 or 3, or an amino grouping --NH-- or NR.sup.1 --, where R is a C.sub.1-4 alkyl grouping; Y and Y.sup.1, which are the same or different, are a hydrogen atom or an optionally substituted C.sub.1-4 alkyl radical, and p is 0-5; and R.sub.6 is a cholesterol derivative or an alkylamino grouping --NR.sub.1 R.sub.2, where R.sub.1 and R.sub.2 are, independently of each other, a straight or branched, saturated or unsaturated C.sub.12-22 aliphatic radical.Type: GrantFiled: June 4, 1997Date of Patent: August 22, 2000Assignee: Rhone-Poulenc Rorer S.A.Inventors: Gerardo Byk, Daniel Scherman, Catherine Dubertret
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Patent number: 6057460Abstract: Polymerizable hybrid monomers with norbornenyl or norbornadienyl groups are described which can be radically cured at room temperature and are suitable in particular for use in the dental field.Type: GrantFiled: February 21, 1997Date of Patent: May 2, 2000Assignee: Ivoclar AGInventors: Norbert Moszner, Volker Rheinberger, Frank Zeuner
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Patent number: 6028214Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.Type: GrantFiled: April 21, 1998Date of Patent: February 22, 2000Assignees: Northwestern University, Warner-Lambert CompanyInventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
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Patent number: 5972313Abstract: Stable, topically applicable cosmetic/dermatological compositions well suited for artificially tanning or browning human skin and appropriately packaged, comprise at least one dihydroxyacetone (DHA) derivative convertible into DHA and, advantageously, at least one active species for effecting such conversion.Type: GrantFiled: March 18, 1997Date of Patent: October 26, 1999Assignee: Societe L'Oreal S.A.Inventors: Remy Tuloup, Christian Blaise, Michel Philippe, Daniel Sera, Armelle De Salvert