Oxy In Acid Moiety Patents (Class 560/179)
  • Patent number: 11332429
    Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, heating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: May 17, 2022
    Assignee: CARGILL, INCORPORATED
    Inventors: Timothy Walter Abraham, Anthony Louis Duran, Stephen C. Edgar, Ravi R. Gokarn
  • Patent number: 11186535
    Abstract: Provided is a method of efficiently preparing alkyl lactate from by-products which are generated during a process of converting lactic acid into lactide, or from poly(lactic acid) (PLA).
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: November 30, 2021
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Jieun Kim, Changyub Oh, Chang Suk Lee, Young Lyeol Yang
  • Patent number: 10343986
    Abstract: A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid or ?-hydroxy methionine analogs from a sugar in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water. The invention facilitates Lewis acid catalyst stability in a continuous reaction process where the water is present in an amount of up to or equal to 10 vol. % of the organic solvent.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: July 9, 2019
    Assignee: Haldor Topsoe A/S
    Inventors: Irantzu Sadaba Zubiri, Esben Taarning
  • Patent number: 10252251
    Abstract: The present disclosure provides a method for producing organic compounds, such as esters, from an organic feedstock that includes at least one of a biopolymer or a lipid. The method includes heating the feedstock in the presence of a solid catalyst, such as a solid, inorganic Lewis acid catalyst, and reaction medium that includes an alcohol. At least certain ester products have an ester group corresponding to a substituent of the alcohol.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 9, 2019
    Assignee: Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno
    Inventors: Hongfei Lin, Lisha Yang
  • Patent number: 10240238
    Abstract: Provided in one embodiment includes a multi-fully alloyed powder that provides a wear-resistant and corrosion-resistant coating on a substrate when applied by a thermal spraying process. The coating exhibits desirable hardness, toughness, and bonding characteristics in a highly dense coating that is suitable for a wide range of temperatures. The embodiment provides a method of forming a coating, the method comprising: providing a substrate; and disposing onto the substrate a coating, comprising: a powder-containing composition comprising an alloy, the alloy comprising a solid solution comprising nickel, and a first component comprising at least one transition metal element and at least one nonmetal element.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: March 26, 2019
    Assignee: Crucible Intellectual Property, LLC
    Inventor: Gerald A. Croopnick
  • Patent number: 10047035
    Abstract: The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: August 14, 2018
    Assignee: BASF SE
    Inventors: Stefanie Demming, Suman Thotla, Jens Wittenberg, Gabriele Iffland, Till Christian Brueggemann, Yvonne Hoelzl, Wolfgang Siegel, Stephan Freyer
  • Patent number: 9975113
    Abstract: A process for the preparation of lactic acid and 2-hydroxy-3-butenoic acid or esters thereof from a sugar in the presence of a metallo-silicate material, a metal ion and a solvent, wherein the metal ion is selected from one or more of the group consisting of potassium ions, sodium ions, lithium ions, rubidium ions and caesium ions.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 22, 2018
    Assignee: Haldor Topsoe A/S
    Inventors: Martin Spangsberg Holm, Irantzu Sadaba Zubiri, Søren Tolborg, Christian Mårup Osmundsen, Esben Taarning
  • Patent number: 9963414
    Abstract: The disclosed methods for preparing and isolating carboxylic esters ensure a high product purity and minimize technical complexity. These methods are based on the reaction of a carboxylic acid with an alcohol in an aqueous medium. In some examples, the alcohol is used both for the esterification and for the precipitation of the salts, preferably ammonium salts, formed in the synthesis.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 8, 2018
    Assignees: THYSSENKRUPP INDUSTRIAL SOLUTIONS AG, THYSSENKRUPP AG
    Inventors: Markus Fritsch, Armin Börner, Ivan Shuklov, Zeljko Knez
  • Patent number: 9944586
    Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, heating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: April 17, 2018
    Assignee: CARGILL, INCORPORATED
    Inventors: Timothy Walter Abraham, Anthony Louis Duran, Stephen C. Edgar, Ravi R. Gokarn
  • Patent number: 9926257
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: March 27, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvia Ceragioli, Pietro Delogu, Armando Mortillaro, Alfonso Nardelli, Stefano Sguassero, Rosario Velardi, Carlo Felice Viscardi
  • Patent number: 9573123
    Abstract: A process for the preparation of lactic acid and 2-hydroxy-3-butenoic acid or esters thereof from a sugar in the presence of a metallo-silicate material, a metal ion and a solvent, wherein the metal ion is selected from one or more of the group consisting of potassium ions, sodium ions, lithium ions, rubidium ions and caesium ions.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: February 21, 2017
    Assignee: Haldor Topsie A/S
    Inventors: Martin Spangsberg Holm, Irantzu Sadaba Zubiri, Søren Tolborg, Christian Mårup Osmundsen, Esben Taarning
  • Patent number: 9193808
    Abstract: The present invention relates to a process for obtaining a catalyst of high activity based on a mixture of supports, more specifically, the mixture of supports being Al2O3 plus MgCl2, intended for the production of polyolefins. The catalyst of the present invention involves the use of a spherical support based on special alumina that serves as a porous matrix, which is impregnated, by precipitation, with magnesium chloride by dissolving the latter in ethers and/or alcohols.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: November 24, 2015
    Assignee: PETROLEO BRASILEIRO S.A.-PETROBRAS
    Inventors: Noemi Tatizawa, Jaime Correia Da Silva, Danielle De Carvalho Pinto Freitas, Katia Simone Zanco Palma, Richard Faraco Amorim, Leandro Dos Santos Silveira
  • Publication number: 20150148513
    Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
    Type: Application
    Filed: June 3, 2013
    Publication date: May 28, 2015
    Applicant: Genomatica, Inc.
    Inventors: Priti Pharkya, Anthony P. Burgard, Stephen J. Van Dien, Robin E. Osterhout, Mark J. Burk, John D. Trawick, Michael P. Kuchinskas, Brian Steer
  • Publication number: 20150148560
    Abstract: Provided herein are methods that utilize polyhydroxyalkanoates (PHAs) as a substrate for further conversion to C4 and C5 compounds. Polyhydroxyalkanoates can undergo esterification to yield alkyl hydroxyalkanoates and alkyl alkenoates, which may serve as useful precursors in the production of alkadienes and alkenedioic acids, including for example butadiene and butenedioic acid.
    Type: Application
    Filed: May 31, 2013
    Publication date: May 28, 2015
    Applicant: MICROMIDAS, INC.
    Inventors: Ryan L. Smith, John Bissell, Makoto N. Masuno, Douglas Cannon, Alex B. Wood, Marc Foster
  • Patent number: 9040739
    Abstract: A catalyst for synthesis of lactic acid and it derivatives is provided. The catalyst includes SnY2.mH2O and at least one of NH4X or quaternary ammonium salts, wherein X and Y are selected from F—, Cl—, Br—, I—, CH3SO3—, C6H5SO3—, CH3C6H4SO3— or CN—, m represents an integer of 1 to 15. A method for synthesis of lactic acid and it derivatives with the above catalyst is also provided. By using the above catalyst and method, it is capable of converting carbohydrate-containing raw material to lactic acid and its derivatives directly in a more efficient and economical way.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: May 26, 2015
    Assignee: MICROVAST POWER SYSTEMS CO., LTD.
    Inventors: Xiaoping Zhou, Rui Bi
  • Patent number: 9040740
    Abstract: This disclosure relates to a method for preparing alkyl lactate with high yield and high selectivity, comprising the step of reacting glycerol with water or alcohol in the presence of a catalyst. In addition, the present invention provides a method for efficiently preparing lactamide using the alkyl lactate.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: May 26, 2015
    Assignee: LG Chem, Ltd.
    Inventors: Sung-Cheol Yoon, Seung-Young Park, In-Su Lee
  • Patent number: 8987505
    Abstract: An alternative method for efficiently producing lactic acids from a carbohydrate-containing raw material such as cellulose is provided. The method for producing lactic acid and/or lactic acid ester comprises performing heat treatment on a carbohydrate-containing raw material in a solvent containing a catalyst, wherein the catalyst is at least one type of compound selected from the group consisting of a tin compound, an indium compound, and a rhenium compound, and the solvent contains water and/or alcohol.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: March 24, 2015
    Assignees: Nippon Shokubai Co., Ltd, National Institute of Advanced Industrial Science and Technology
    Inventors: Kenichi Tominaga, Atsushi Mori, Kazuhiko Satoh, Shigeru Shimada, Hideaki Tsuneki, Yoshiaki Hirano
  • Publication number: 20150038734
    Abstract: A method for making an alkyl 3-hydroxybutyrate is provided. The method can include reacting an alkyl alcohol with diketene to form an alkyl acetoacetate and then hydrogenating the alkyl acetoacetate to form the alkyl 3-hydroxybutyrate. The method of the present invention may also include separating one or more impurities an alkyl acetoacetate stream and subjecting the purified acetoacetate mixture to hydrogenation to form the alkyl 3-hydroxybutyrate. Methods of the present invention can be carried out on a lab, pilot, or commercial scale.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 5, 2015
    Applicant: Eastman Chemical Company
    Inventors: Garry Kenneth Weakley, Charles Everette Kelly
  • Publication number: 20150025142
    Abstract: The invention relates to the use of one or more oligomers of lactic acid or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefits from an acidic environment, especially a gynaecological infection including a bacterial infection such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human Immunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).
    Type: Application
    Filed: June 20, 2014
    Publication date: January 22, 2015
    Inventors: Greg Batcheller, Thomas Hedner, Joergen Johnsson, Werner Schubert, Christer Sjoegren, Olov Sterner, Malgorzat Sznitowska
  • Publication number: 20150005378
    Abstract: [Problem] To provide a novel antimicrobial agent that has excellent antimicrobial activity and which is prepared from an ester composed of propanediol and a ?-hydroxycarboxylic acid. [Solution] An antimicrobial agent which is prepared from a propanediol mono-?-hydroxycarboxylic acid ester expressed by the following formula (1) or formula (2) (wherein R1 and R2 are both branched or unbranched, and saturated or unsaturated alkyl groups having 5 to 9 carbon atoms).
    Type: Application
    Filed: February 13, 2012
    Publication date: January 1, 2015
    Inventors: Shuji Kanatani, Soota Iwamoto
  • Publication number: 20140371417
    Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
    Type: Application
    Filed: April 25, 2014
    Publication date: December 18, 2014
    Applicant: Genomatica, Inc.
    Inventors: Priti PHARKYA, Anthony P. BURGARD, Stephen J. VAN DIEN, Robin E. OSTERHOUT, Mark J. BURK, John D. TRAWICK, Michael P. KUCKINSKAS, Brian STEER
  • Publication number: 20140343119
    Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
    Type: Application
    Filed: April 17, 2014
    Publication date: November 20, 2014
    Applicant: Concert Pharmaceuticals, Inc.
    Inventors: Roger D. Tung, Adam J. Morgan, I. Robert Silverman
  • Publication number: 20140309451
    Abstract: A process for producing high purity 3-hydroxypropionic acid from a fermentation cell broth is described. The 3-hydroxypropionic acid can be converted to a variety of products, such as acrylamide, 3-hydroxypropionic esters, acrylic esters, and 3-HP amide. This process features a high degree of product flexibility, limited or no solvent recycle, discrete waste streams, an efficient water removal process, and efficient recovery of products and solvents with proven and scalable equipment.
    Type: Application
    Filed: March 12, 2014
    Publication date: October 16, 2014
    Applicant: OPX Biotechnologies, Inc.
    Inventors: Robert TENGLER, David DeCOSTER
  • Publication number: 20140296337
    Abstract: A method is provided for treating a subject in need of therapy for depression, anxiety, impaired cognition and/or pain comprising administering to said subject an amount of a ketogenic material sufficient to produce a ketosis in the subject sufficient to provide anti-depressant effect, cognition enhancing and/or analgesic effect. Preferred materials produce a ketosis is such that the total concentration of acetoacetate and (R)-3-hydroxybutyrate in the blood of the subject is raised to between 0.1 and 30 mM.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: David Greenwood, Wilfried Dimpfel
  • Patent number: 8846353
    Abstract: Preparation of derivatives of ?-hydroxycarboxylic acid, including ?-hydroxycarboxylic acid esters, ?,?-unsaturated carboxylic acid, esters of ?,?-unsaturated carboxylic acid, and alkoxy derivatives, such as preparation of acrylic acid from 3-hydroxypropionic acid.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: September 30, 2014
    Assignee: Cargill, Incorporated
    Inventors: Paraskevas Tsobanakis, Xiangsheng Meng, Timothy Walter Abraham
  • Patent number: 8835670
    Abstract: A method for synthesis of lactic acid and its derivatives is provided. First, a mixture is prepared, which includes: at least one carbohydrate-containing raw material, at least one alcohol, at least one composite catalyst containing metal chloride(s) (MCln) and tin-containing compound(s), and at least one solvent, wherein M is selected from a group consisting of Li+, Na+ K+, Mg2+, Ca2+, Sr2+, Ga3+, In3+, Sb3+, Bi3+, Cr3+, Mn2+, Fe2+, Co2+, Ni2+, Zn2+, and n represents 1, 2 or 3. Then, the mixture is heated to obtain lactic acid and its derivatives. By using the above catalyst and method, it is capable of converting carbohydrate-containing raw material to lactic acid and its derivatives directly in a more efficient and economical way.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: September 16, 2014
    Assignee: Microvast Power Systems Co., Ltd.
    Inventors: Xiaoping Zhou, Rui Bi
  • Publication number: 20140227161
    Abstract: An organosolv process for producing bio-products by decomposing lignocellulosic materials comprises providing an initial lignin solvent with water, an acid, and a lignin dissolving chemical comprising at least one of an organic ester, butyl acetate, an organic furan, and furfural. The process also includes placing the lignin solvent in contact with a biomass to form a circulation solvent, and recycling at least a portion of the circulation solvent by circulating the circulation solvent back into contact with the biomass. The circulating of the circulation solvent occurs for a period of time, after which, the process then includes separating material such as chemicals and lignin from the circulation solvent. The chemicals can be recycled as new solvent or sold while lignin can be used as natural and renewable colorant for polymers such as poly lactic acid.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 14, 2014
    Applicant: AMERICAN SCIENCE AND TECHNOLOGY CORPORATION
    Inventors: Ali Manesh, Reza Hemyeri, Susanta Mohapatra, John Guenther, Edwin Zoborowski, Mohammad Ali Manesh
  • Publication number: 20140194509
    Abstract: A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
    Type: Application
    Filed: December 10, 2013
    Publication date: July 10, 2014
    Applicants: Government of the USA, as Represented by the Secretary, Department of Health and Human Services, Isis Innovation Limited
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Publication number: 20140187810
    Abstract: Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.
    Type: Application
    Filed: June 28, 2013
    Publication date: July 3, 2014
    Applicant: Actelion Pharmaceuticals, Ltd.
    Inventors: Robert ALONSO, Martin STOGNIEW, Peter A. CROOKS, Mark A. PIMLEY, David R. WORTHEN
  • Patent number: 8759566
    Abstract: Provided is a process for producing ?-hydroxycarboxylic esters from ?-hydroxycarboxylic amides and aliphatic alcohols, wherein it is a production process which is inhibited in a production cost and enhanced in a conversion rate and a selectivity and which is industrially advantageous. To be specific, it is a production process for ?-hydroxycarboxylic ester characterized by subjecting ?-hydroxycarboxylic amide and aliphatic alcohol to a gas phase reaction in the presence of a zirconium dioxide catalyst. A catalyst lifetime is improved to a large extent by using a zirconium dioxide catalyst containing a specific element.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: June 24, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Hideho Matsuda, Yuuichi Sugano, Yoshikazu Shima, Masaki Takemoto, Genki Nogami
  • Patent number: 8759559
    Abstract: Provided are processes for preparing polytrimethylene ether glycol monoester or diesters composition wherein polytrimethylene ether glycol containing less than about 1 weight % of unreacted diol monomer is reacted with an equivalent excess of a monocarboxylic acid.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: June 24, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Hari Babu Sunkara, Sam Cotterill
  • Publication number: 20140135521
    Abstract: The present invention relates to a continuous process for preparing alpha-hydroxycarboxylic esters by reacting at least one alpha-hydroxycarboxamide present in the liquid phase with an alcohol in the presence of a catalyst, which is characterized in that the resulting alpha-hydroxycarboxylic ester is at least partly separated from the reaction mixture via the gas phase.
    Type: Application
    Filed: July 3, 2012
    Publication date: May 15, 2014
    Applicant: Evonik Roehm GmbH
    Inventors: Martin Koestner, Willi Ploesser, Alexander May
  • Publication number: 20140100376
    Abstract: ?-Hydroxycarboxylic esters and ?-lactones which are suitable as flavors can be prepared by electrochemical reductive cross-coupling of ?,?-unsaturated esters with carbonyl compounds in an undivided electrolysis cell having a cathode composed of lead, lead alloys, cadmium, cadmium alloys, mercury, steel, glassy carbon or boron-doped diamonds and a basic aqueous electrolyte comprising an electrolyte salt which suppresses the cathodic formation of hydrogen.
    Type: Application
    Filed: October 25, 2013
    Publication date: April 10, 2014
    Applicant: BASF SE
    Inventors: Itamar Michael Malkowsky, Florian Stecker, Simone Lutter, Olivier Abillard, Ralf Pelzer
  • Patent number: 8674131
    Abstract: The dehydrated alkali metal salts of carboxylic acid are dissolved in the alcohol such as methanol or ethanol or butanol to make their solution in corresponding alcohol. The solution alcohol is further treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature such as 150 to 200° C. The carboxylic acid gets converted into corresponding alkyl ester and calcium carbonate or sodium carbonate or potassium carbonate as the byproduct. Calcium lactate or sodium lactate or sodium acetate or sodium benzoate or sodium salicylate as alkali metal salt solution prepared in methanol or ethanol or butanol when treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature gets converted to methyl lactate or ethyl lactate or methyl acetate or methyl benzoate or methyl salicylate as product.
    Type: Grant
    Filed: September 6, 2010
    Date of Patent: March 18, 2014
    Assignee: Council of Scientific and Industrial Research
    Inventors: Prashant Purushottam Barve, Bhaskar Dattatraya Kulkarni, Milind Yashwant Gupte, Sanjay Narayan Nene, Ravindra William Shinde
  • Patent number: 8642654
    Abstract: A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: February 4, 2014
    Assignees: ISIS Innovation Limited, Government of the USA, as Represented by the Sec-Retary, Department of Health and Human Services
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Publication number: 20140024853
    Abstract: A method for synthesizing lactic acid and lactate is invented from carbohydrates, such as monosaccharides and/or polysaccharides in the presence of the catalyst that is the combinations of nitrogen-heterocycle aromatic ring cation salts and metal compounds. In the reaction, at least one alcohol and at least one solvent are used. Specifically, in the presence of [SnCl4-1-ethyl-3-methylimidazolium chloride ([EMIM]Cl)], SnCl4-1,3-dimethylimidazolium methyl sulfate ([DMIM]CH3SO4)], [SnCl2-1-ethyl-3-methylimidazolium chloride ([EMIM]Cl)], or SnCl2-1,3-dimethylimidazolium methyl sulfate ([DMIM]CH3SO4)] in methanol.
    Type: Application
    Filed: November 10, 2011
    Publication date: January 23, 2014
    Applicant: MICROVAST, INC.
    Inventors: Xiaoping Zhou, Jiaruo Huang
  • Publication number: 20130345470
    Abstract: A process for producing high purity 3-hydroxypropionic acid from a fermentation cell broth is described. The 3-hydroxypropionic acid can be converted to a variety of products, such as acrylamide, 3-hydroxypropionic esters, acrylic esters, and 3-HP amide. This process features a high degree of product flexibility, limited or no solvent recycle, discrete waste streams, an efficient water removal process, and efficient recovery of products and solvents with proven and scalable equipment.
    Type: Application
    Filed: June 20, 2012
    Publication date: December 26, 2013
    Applicant: OPX Biotechnologies, Inc.
    Inventors: Robert Tengler, David DeCoster
  • Patent number: 8609172
    Abstract: A method of using organic compounds and providing slow release flavoring in or for food products wherein flavor precursors are added to flavor compositions and/or food products and release flavor compounds upon consumption of the food products, and novel flavor precursor compounds. The flavor precursors can be prepared from mono- and/or diglycerides and lactone flavor compounds.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 17, 2013
    Assignee: Givaudan SA
    Inventor: Willi Grab
  • Patent number: 8569539
    Abstract: Alpha-hydroxycarboxylic esters are prepared by a continuous process in which alpha-hydroxycarboxamide is reacted with an alcohol in the presence of a catalyst to obtain a product mixture which contains alpha-hydroxycarboxylic ester, ammonia, unconverted alpha-hydroxycarboxamide and alcohol, and catalyst; wherein reactant streams containing an alpha-hydroxycarboxamide, an alcohol and a catalyst are fed into a pressure reactor. The reactant streams are reacted with one another in the pressure reactor at a pressure in the range of 1 bar to 100 bar; and the product mixture is depleted in alcohol and ammonia by distilling off ammonia at a pressure which is constantly kept greater than 1 bar without the aid of additional stripping media. The continuous process can be employed particularly advantageously on the industrial scale.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: October 29, 2013
    Assignee: Evonik Roehm GmbH
    Inventors: Alexander May, Bernd Vogel, Hermann Siegert, Jochen Ackermann, Soenke Broecker
  • Publication number: 20130281723
    Abstract: Provided are processes for preparing polytrimethylene ether glycol monoester or diesters composition wherein polytrimethylene ether glycol containing less than about 1 weight % of unreacted diol monomer is reacted with an equivalent excess of a monocarboxylic acid.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 24, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Hari Babu Sunkara, Sam Cotterill
  • Publication number: 20130274505
    Abstract: The present invention relates to an industrial process for producing a lactic ester containing in total at least seven carbon atoms, from a fermentation liquor containing ammonium lactate in order to avoid the inherent production of gypsum, with a high yield and according to which the loss of lactic ester in the form of lactamide is limited as much as possible.
    Type: Application
    Filed: October 17, 2011
    Publication date: October 17, 2013
    Applicant: GALACTIC S.A.
    Inventors: Aurelie Bernard, Pierre-Antoine Mariage, Jean-Christophe Bogaert
  • Publication number: 20130231497
    Abstract: A method for synthesizing lactic acid and lactate is invented from carbohydrates, such as monosaccharides and/or polysaccharides in the presence of the catalyst that is the combinations of nitrogen-heterocycle aromatic ring cation salts and metal compounds. In the reaction, at least one alcohol and at least one solvent are used. Specifically, in the presence of [SnCl4-1-ethyl-3-methylimidazolium chloride ([EMIM]Cl)], SnCl4-1, 3-dimethylimidazolium methyl sulfate ([DMIM] CH3SO4)], [SnCl2-1-ethyl-3-methylimidazolium chloride ([EMIM]Cl)], or SnCl2-1, 3-dimethylimidazolium methyl sulfate ([DMIM] CH3SO4)] in methanol.
    Type: Application
    Filed: November 10, 2011
    Publication date: September 5, 2013
    Applicant: MICROVAST, INC.
    Inventors: Xiaoping Zhou, Jiaruo Huang, Whensheng Li
  • Publication number: 20130225822
    Abstract: The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.
    Type: Application
    Filed: November 18, 2011
    Publication date: August 29, 2013
    Inventors: Qilin Zhou, Jianhua Xie, Xiaoyan Liu, Jianbo Xie, Lixin Wang
  • Publication number: 20130204036
    Abstract: An alternative method for efficiently producing lactic acids from a carbohydrate-containing raw material such as cellulose is provided. The method for producing lactic acid and/or lactic acid ester comprises performing heat treatment on a carbohydrate-containing raw material in a solvent containing a catalyst, wherein the catalyst is at least one type of compound selected from the group consisting of a tin compound, an indium compound, and a rhenium compound, and the solvent contains water and/or alcohol.
    Type: Application
    Filed: March 31, 2011
    Publication date: August 8, 2013
    Applicants: National Institute of Advanced Industrial Science and Technology, Nippon Shokubai Co. Ltd.
    Inventors: Kenichi Tominaga, Atsushi Mori, Kazuhiko Satoh, Shigeru Shimada, Hideaki Tsuneki, Yoshiaki Hirano
  • Publication number: 20130150616
    Abstract: Preparation of derivatives of ?-hydroxycarboxylic acid, including ?-hydroxycarboxylic acid esters, ?,?-unsaturated carboxylic acid, esters of ?,?-unsaturated carboxylic acid, and alkoxy derivatives.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 13, 2013
    Applicant: CARGILL, INCORPORATED
    Inventor: CARGILL, INCORPORATED
  • Publication number: 20130096192
    Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders.
    Type: Application
    Filed: March 11, 2011
    Publication date: April 18, 2013
    Inventors: Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, JR.
  • Patent number: 8410305
    Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of epothilones and use new alane reagents which are broadly applicable and can provide selected components having a variety of substituents groups.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: April 2, 2013
    Assignee: Kosan Biosciences Incorporated
    Inventors: Yue Chen, Yong Li
  • Patent number: 8410304
    Abstract: Disclosed herein are processes for preparing aqueous ?-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reactants is controlled to provide the product at the desired pH.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: April 2, 2013
    Assignee: Norac Pharma
    Inventors: James Luchi, Daniel Levin
  • Publication number: 20130079547
    Abstract: This disclosure relates to a method for preparing alkyl lactate with high yield and high selectivity, comprising the step of reacting glycerol with water or alcohol in the presence of a catalyst. In addition, the present invention provides a method for efficiently preparing lactamide using the alkyl lactate.
    Type: Application
    Filed: May 17, 2011
    Publication date: March 28, 2013
    Applicant: LG Chem, Ltd.
    Inventors: Sung-Cheol Yoon, Seung-Young Park, In-Su Lee
  • Publication number: 20130052237
    Abstract: A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a pharmaceutically active agent.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Applicant: INTARCIA THERAPEUTICS, INC.
    Inventors: Rom Ezer Eliaz, Yuanpeng Zhang, Catherine Manya Rohloff, Eric William Weeks, Gunjan Junnarkar