Polyoxy Alcohol Moiety Patents (Class 560/189)
  • Patent number: 9643912
    Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: May 9, 2017
    Assignee: CHEMSMART, LLC
    Inventors: Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
  • Patent number: 9315446
    Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 19, 2016
    Assignee: CHEMSMART, LLC
    Inventors: Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, Jr.
  • Patent number: 9255059
    Abstract: A method for making an alkyl 3-hydroxybutyrate is provided. The method can include reacting an alkyl alcohol with diketene to form an alkyl acetoacetate and then hydrogenating the alkyl acetoacetate to form the alkyl 3-hydroxybutyrate. The method of the present invention may also include separating one or more impurities an alkyl acetoacetate stream and subjecting the purified acetoacetate mixture to hydrogenation to form the alkyl 3-hydroxybutyrate. Methods of the present invention can be carried out on a lab, pilot, or commercial scale.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: February 9, 2016
    Assignee: Eastman Chemical Company
    Inventors: Garry Kenneth Weakley, Charles Everette Kelly
  • Publication number: 20150065571
    Abstract: Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-?-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 5, 2015
    Applicant: TDELTAS LIMITED
    Inventors: Kieran Clarke, Peter Cox
  • Publication number: 20140308719
    Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 16, 2014
    Inventors: Kieran Clarke, Richard Lewis Veech, M. Todd King
  • Publication number: 20130178646
    Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders.
    Type: Application
    Filed: September 16, 2011
    Publication date: July 11, 2013
    Applicant: CHEMSMART, LLC
    Inventors: Joseph P. St. Laurent, Scott A. Goodrich, Gerald S. Jones, JR.
  • Patent number: 8426639
    Abstract: The present invention relates to the isomerization of cis,cis and/or cis,trans muconic acid or esters thereof to trans,trans muconic acid or esters thereof and to the esterification of such muconic acids.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: April 23, 2013
    Assignee: Amyris, Inc.
    Inventors: John W. Frost, Adeline Miermont, Dirk Schweitzer, Vu Bui
  • Patent number: 8357736
    Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: January 22, 2013
    Assignee: Kusumoto Chemicals, Ltd.
    Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
  • Patent number: 8247500
    Abstract: A polymeric resin comprising guanidine groups having at least one C4-C22 tertiary alkyl substituent.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: August 21, 2012
    Assignee: Rohm and Haas Company
    Inventors: Rajiv Manohar Banavali, Alfred Karl Schultz
  • Publication number: 20120064147
    Abstract: The invention concerns a pharmaceutical preparation which improves penetration of active substances through the tissue membrane or barrier of the target organ.
    Type: Application
    Filed: April 19, 2011
    Publication date: March 15, 2012
    Applicants: Genzyme Corporation, Max-Planck Gesellschaft Zur Foerderung Der Wissenshaften E.V.
    Inventors: Hans-Jorg EIBL, Peter Hoffmann
  • Patent number: 8133945
    Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: March 13, 2012
    Assignee: Kusumoto Chemicals, Ltd.
    Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
  • Patent number: 8044235
    Abstract: A monomer is provided which is excellent in reactivity, can give high heat resistance and high refractive index, and has two or more polymerizable functional groups with different polymerization properties and an aromatic ring in the molecule. An industrial advantageous process for producing the monomer is also provided. The monomer is an aromatic isocyanate compound containing a (meth)acryloyl group, and is represented by Formula (I): wherein R1 is a single bond or a linear or branched alkylene group of 1 to 5 carbon atoms, R2 is a hydrogen atom or a methyl group, R3 is a single bond or a linear or branched alkylene group of 1 to 3 carbon atoms, X is independently a halogen atom or an electron-withdrawing group, m is an integer ranging from 0 to 4, n is an integer ranging from 1 to 3, and 1?m+n?5.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: October 25, 2011
    Assignee: Showa Denko K.K.
    Inventors: Kaneo Nozawa, Katsutoshi Ohno, Yotaro Hattori
  • Patent number: 7981964
    Abstract: Disclosed herein is a heat-hardenable paint composition comprising a base resin, wherein the base resin comprises (A) a lactone modified resin comprising hydroxyl groups, wherein 20 to 70 weight percent of the structural units are based on the lactone compound, and the hydroxyl group value is from 50 to 400 mgKOH/g, and (B) an acrylic resin comprising hydroxyl groups and cyclic structures, wherein 10 to 80 weight percent of structural units are based on a radically polymerizable monomer comprising a cyclic structure, the hydroxyl group value is from 50 to 150 mgKOH/g, and the crosslinking resin is an isocyanate compound, wherein the weight ratio of the solid fractions of (A):(B) in the base resin is from 95:5 to 20:80.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: July 19, 2011
    Assignee: BASF Coatings Japan Ltd.
    Inventors: Tetsu Konishi, Shinji Mitsumune, Masayuki Takemoto, Takehito Ito, Hiroyuki Tagkagi, Rui Nimi
  • Publication number: 20090143495
    Abstract: The polyurethane foam composition of the present invention comprises a polyol, a catalyst, a surfactant, a foaming agent and a polyisocyanate, wherein the polyol contains, at least, (A) a polyol that is produced by using a raw material obtained from plant-derived oil, contains more than three side chains per molecule, each side chain comprising a hydrocarbon chain having 4 or more carbon atoms, and has an average number of functional groups of 1.5 to 4.5 and a hydroxyl value of 80 to 140 mgKOH/g. The polyurethane foam of the present invention is produced by foaming the above polyurethane foam composition. The polyurethane foam contributes to reducing environmental burdens, and has excellent low rebound property, particularly a characteristic that the increase in hardness at low temperatures is suppressed.
    Type: Application
    Filed: August 11, 2006
    Publication date: June 4, 2009
    Inventors: Katsuhisa Nozawa, Masahiro Sasaki, Kazuhiko Ohkubo
  • Publication number: 20090124807
    Abstract: The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.
    Type: Application
    Filed: January 22, 2008
    Publication date: May 14, 2009
    Inventors: Juan Antonio Perez Andres, Pere Dalmases Barjoan, Joan Huguet Clotet
  • Patent number: 7420079
    Abstract: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: September 2, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Truc Chi Vu, David B. Brzozowski, Rita Fox, Jollie Duaine Godfrey, Jr., Ronald L. Hanson, Sergei V. Kolotuchin, John A. Mazzullo, Ramesh N. Patel, Jianji Wang, Kwok Wong, Jurong Yu, Jason J. Zhu, David R. Magnin, David J. Augeri, Lawrence G. Hamann
  • Patent number: 7101909
    Abstract: Novel multibinding compounds are disclosed. The compounds of this invention comprise 2–10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: September 5, 2006
    Assignee: Theravance, Inc.
    Inventors: Yu-Hua Ji, Maya Natarajan, John H. Griffin, Thomas E. Jenkins
  • Patent number: 6919388
    Abstract: The admixtures for a cementitious composition of the invention, which have the above-mentioned constitutions, can suitably be used in cement pastes, mortar, concrete and like cement compositions and can stabilize the amount of air entrained with the lapse of time and thus facilitate the quality control of cement compositions and, further, can improve the workability of cement compositions owing to their excellent dispersing capacities. The cement compositions of the invention which comprise such admixture for a cementitious composition are excellent in water-reducing ability and workability and can give hardened products excellent in strength and durability and, further, can stably maintain the amount of air entrained without allowing increases in the amount of air even when the time of kneading is prolonged in the production.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: July 19, 2005
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tomotaka Nishikawa, Hirokatsu Kawakami, Daisuke Imai, Hiromichi Tanaka, Tsuyoshi Hirata, Tsutomu Yuasa
  • Patent number: 6811722
    Abstract: The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH2(OOR1)CH(OOR2)CH2(OOR3) wherein at least two of R1, R2, and R3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifying glycerin with a mixture of acids in the presence of a catalyst. Preferably, the mixture of acids includes at least two selected from the group consisting of alkyl acids and aryl acids, with each acid in the mixture containing up to about 11 carbon atoms, and more preferably from about 4 to about 9 carbon atoms each. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 2, 2004
    Assignee: Ferro Corporation
    Inventors: Lei Zhou, George Schaefer, William W. Knickmeyer, David Paul
  • Patent number: 6740254
    Abstract: The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH2(OOR1)CH(OOR2)CH2(OOR3) wherein at least two of R1, R2, and R3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifying glycerin with a mixture of acids in the presence of a catalyst. In the presently most preferred embodiment of the invention, the mixture of acids includes benzoic acid and butanoic acid. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: May 25, 2004
    Assignee: Ferro Corporation
    Inventors: Lei Zhou, George Schaefer
  • Publication number: 20040082808
    Abstract: The invention relates to reaction products of glycols, diglycols, higher glycols or glycerol with &agr;-hydroxycarboxylic acids in a molar ratio of 1:2 or higher, especially conforming to the general formula (V) where R is hydrogen or a C1-3 alkyl group, preferably methyl, nx is from 1 to 5, preferably from 1 to 3, n is 1 or 2 and when n=1 the radical R″ is C1-4 alkylene, preferably ethylene, x is defined as x′ and y is not less than 1, preferably from 1 to 5, especially 1 or 2, and when n=2 the radical R″ is a glycerol radical, x is defined as x″ and y is 1.
    Type: Application
    Filed: September 4, 2003
    Publication date: April 29, 2004
    Inventor: Juerg Heller
  • Patent number: 6652774
    Abstract: The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH2(OOR1)CH(OOR2)CH2(OOR3) wherein at least two of R1, R2, and R3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifying glycerin with a mixture of acids in the presence of a catalyst. Preferably, the mixture of acids includes at least two selected from the group consisting of alkyl acids and aryl acids, with each acid in the mixture containing up to about 11 carbon atoms, and more preferably from about 4 to about 9 carbon atoms each. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 25, 2003
    Assignee: Ferro Corporation
    Inventors: Lei Zhou, George Schaefer, William W. Knickmeyer, David Paul
  • Patent number: 6639098
    Abstract: The preferred embodiments provide for a family of novel compositions to serve as substrates that release hydroxy acid slowly over time. Preferably the hydroxy acid is an &agr;-hydroxy acid, more preferably it is lactic acid. The compositions are preferably made by reaction of poly(lactic acid) with multifunctional alcohols. Also disclosed are formulations based on the compounds and methods of use for both the compositions and the formulations. The preferred use of the compositions and formulations is for bioremediation purposes wherein they provide a time-release source of lactic acid to support the growth and reductive activity of microbes present in a system or medium, such as an aquifer, bioreactor, soil, industrial process, wastestream, body of water, river or well. The microbes destroy or inactivate compounds which are capable of being reduced, such as nitrogen-containing organic compounds, oxygen-containing organic compounds, polyaromatic hydrocarbons, and halogen-containing organic compounds.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: October 28, 2003
    Assignee: Regenesis Bioremediation Products
    Inventors: William A. Farone, Stephen S. Koenigsberg, Tracy Palmer
  • Patent number: 6392061
    Abstract: This invention relates to novel processes for making (2S, 3S, 5S) oxetanone derivative lipase inhibitor compounds and intermediates therefor, which processes for producing such derivatives that are useful as lipase inhibitors are capable of being scaled to commercial quantities. Further the invention relates to processes for producing salts and for producing pharmaceutical compositions compounds comprising at least one such oxetanone derivative or salt, as well as methods for using such compounds and compositions for inhibiting lipases.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: May 21, 2002
    Assignee: Zpro Chemical, Inc.
    Inventor: John Jason Gentry Mullins
  • Patent number: 6388041
    Abstract: Disclosed are polyoxyethylene derivatives having different functional groups at both ends of the molecule represented by the following formula (I) and a process for producing the derivatives by anionic living polymerization. The present invention provides polymers which are especially suitable for use as medical materials. wherein A′ and B′ are organosilyl type amino-protecting groups, R is a hydrogen atom or a C1-6 alkyl group, and Y is a hydrogen atom, an alkali metal or a certain functional group.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: May 14, 2002
    Assignee: Nano Carrier Co Ltd
    Inventors: Kazunori Kataoka, Masao Kato, Yukio Nagasaki, Takahisa Hayashida, Michihiro Iijima, Teruo Okano
  • Patent number: 6365637
    Abstract: The use of esters or amides of hydroxylated carboxylic acids as solubilizers, particularly for pharmaceutical, cosmetic and food preparations, is described.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: April 2, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Zirnstein, Folker Ruchatz, Karl Kolter, Knut Oppenländer
  • Patent number: 6342626
    Abstract: The present invention relates to a catalyst-free process for the conversion of commercial lactic acid to alkyl ester of carbon C1 to C8 which comprises simultaneous hydrolysis of dimers or highpolymers of lactic acid present in commercial lactic acid to free lactic acid and esterification of free lactic acid with an alcohol in the presence of water at a temperature in the range of 130-250° C. for 4-11 hrs at a pressure of 5-25 kg/cm2, to obtain desired esters.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: January 29, 2002
    Assignee: Council of Scientific & Industrial Research
    Inventors: Thengumpillil Narayana Balagopala Kaimal, Penumarthy Vijayalakshmi, Bandi Ramalinga, Ayyagari Ananta Laxmi
  • Patent number: 6265495
    Abstract: A method for the production of an esterified product is provided which affords an esterified product with high quality by repressing, during the esterification reaction of an alcohol with (meth)acrylic acid, the occurrence of impurities, particularly gel, to be formed owing to the polymerization of the alcohol and the (meth)acrylic acid as raw materials, the esterified product consequently formed, or the mixture thereof.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: July 24, 2001
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tsuyoshi Hirata, Tsutomu Yuasa
  • Patent number: 6248839
    Abstract: The invention relates to polymethacrylate acid-polyalkylene oxide block copolymers, to a process for their preparation and to their use as dispersants or suspension stabilizers for pigments and fillers, e.g. for metal oxides in ceramic materials, for pigments in inks used in ink jet printing and for fillers in thermosplastic and thermoset polymers.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: June 19, 2001
    Assignee: Th. Goldschmidt AG
    Inventors: Eberhard Esselborn, Jürgen Fock, Arno Knebelkamp
  • Patent number: 6242639
    Abstract: A method for preparing neopentyl glycol hydroxypivalate granules by application of a neopentyl glycol hydroxypivalate melt (1) onto a cooling belt (6) on which the melt solidifies, wherein the melt contains at least so 3 wt % of neopentyl glycol hydroxypivalate crystals, based on the total amount of neopenlyl glycol hydroxypivalate.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: June 5, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Jürgen Weyer, Bernd Eck, Dieter Baumann, Bernhard Maltry
  • Patent number: 6140453
    Abstract: The thermoplastic polyurethane material has the general formula I ##STR1## (1<f<500; 1<f'<15; R and R'=alkyl or aryl) and X has formula II ##STR2## (2<n<140; 1<(n'+n")<51). The process for the preparation thereof comprises reacting a polyether-polycaprolactone block copolymer having a molecular weight ranging from 1000 to 6000 of formula IIa ##STR3## with a chain extender of formula HO--R'--OH and a diisocyanate of formula OCN--R--NCO.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: October 31, 2000
    Assignee: Merquinsa Mercados Quimicos, S.L.
    Inventors: Joaquim Julia Barges, Jose Luis Ayuso Piqueras
  • Patent number: 5936115
    Abstract: In a process for the production of neopentyl glycol hydroxypivalate granules by depositing a neopentyl glycol hydroxypivalate melt on a chill surface, on which the melt solidifies, as a flat film, which, after solidification, is comminuted to give granules. The melt contains less than 3% by weight, based on the total amount of neopentyl glycol hydroxypivalate, of neopentyl glycol hydroxypivalate crystals.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: August 10, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Johann-Peter Melder, Dieter Baumann, Bernhard Maltry
  • Patent number: 5866606
    Abstract: A nutritional formulation containing an amount of diacetyltartaric acid esters of mono- and diglycerides effective to inhibit the infectious activity of pathogenic microorganisms is provided. A process of inhibiting the infectious activity of pathogenic microorganisms including the step of feeding the nutritional composition to a subject is also provided.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: February 2, 1999
    Assignee: Abbott Laboratories
    Inventors: Joseph Schaller, Steven N. Anderson, Terry Bruce Mazer, Milo Duane Hilty, Melinda Guzman-Harty, Theresa Siu-Ling Wai Lee, Tammy Marie Bowman, Jill M. Lamm, Jin-Zhou Liu
  • Patent number: 5739332
    Abstract: A process for the product of a 2,3-cis-dihydroxycycloalkane-1-carboxamide, comprises dihydroxylation of the corresponding cycloalkene-1-carboxamide. Some products are new. The stereoselective dihydroxylation is surprising.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: April 14, 1998
    Assignee: Chiroscience Limited
    Inventors: Raymond McCague, Graham Ruecroft, Christopher Palmer
  • Patent number: 5728182
    Abstract: A polyalkyl ester of a substituted polyphenylether having the formula: ##STR1## wherein A is amino, aminomethyl, cyano, nitro, N-alkylamino or N-alkylaminomethyl wherein the alkyl group contains about 1 to about 6 carbon atoms, or N,N-dialkylamino or N,N-dialkylaminomethyl wherein each alkyl group independently contains about 1 to about 6 carbon atoms; R.sub.1 a polyalkyl group having an average molecular weight in the range of about 450 to about 5000; and x is an integer from about 1 to about 10 and y is an integer from 0 to about 10. The polyalkyl esters of the substituted polyphenyl ethers of the present invention are useful as fuel additives for the prevention and control of engine deposits.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: March 17, 1998
    Assignee: Chevron Chemical Company
    Inventor: Richard E. Cherpeck
  • Patent number: 5693850
    Abstract: A process for the production of water soluble glycerol esters useful as parenteral nutrients is disclosed. The process comprises the reaction of glycerol or a protected glycerol and an acetoacetate ester or acetoacetate precursor, yielding an acetoacetyl glycerol which is thereafter reduced, providing a glycerol ester of 3-hydroxybutyric acid.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 2, 1997
    Assignee: Eastman Chemical Company
    Inventors: Ronald H. Birkhahn, Robert J. Clemens, Charles A. McCombs
  • Patent number: 5245003
    Abstract: Provided are certain novel fluid ternary glycol mixtures. Also provided is an improved process for preparing polyesters comprised of residues of the glycols which comprise the fluid ternary glycol/water mixtures.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: September 14, 1993
    Assignee: Eastman Kodak Company
    Inventor: Larry K. Johnson
  • Patent number: 5209827
    Abstract: Disclosed is a process for the recovery of purified hydroxypivalyl hydroxypivalate (HPHP) from a crude, HPHP containing material containing inorganic catalyst residues and low-boiling and high-boiling (with respect to the boiling point of HPHP) impurities. The purification process employs two distillation zones, a first distillation zone wherein inorganic and high-boiling impurities are removed and a second distillation zone wherein low- and high-boiling impurities are removed.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: May 11, 1993
    Assignee: Eastman Kodak Company
    Inventors: Gerald E. Butler, Garrett C. Luce, Don L. Morris
  • Patent number: 5200553
    Abstract: Biologically active carboxylic acid esters which promote antitumor or immune response are selected from the group consisting of compounds having formulas (I), (II) and (III):XCH.sub.2 --CHX--CHX--C(.dbd.O)--O--Z (I)CH.sub.3 --CO--CH.sub.2 --C(.dbd.O)--O--Z (II)CH.sub.3 --CH.sub.2 --CO--C(.dbd.O)--O--Z (III)wherein X is H, or one X only may be OH; Z is --CHR--O--(O.dbd.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: April 6, 1993
    Assignee: Kupat Holim Health Insurance Institution of the General Federation of Labor
    Inventors: Abraham Nudelman, Matitiahu Shaklai, Ada Rephaeli
  • Patent number: 5171462
    Abstract: Mixtures of block alkoxy co- or terpolymer hydrocarboxylates and aminopolyazole increase the oxidation and corrosion resistance of lubricants, particularly diesel engine oil.
    Type: Grant
    Filed: December 23, 1991
    Date of Patent: December 15, 1992
    Assignee: Texaco Inc.
    Inventors: Thomas F. DeRosa, Rodney L. Sung, Benjamin J. Kaufman, Ronald L. O'Rourke
  • Patent number: 5155253
    Abstract: A process for the transvinylation of a vinyl derivative of a Bronsted acid with a different Bronsted acid which comprises providing a liquid phase mixture containing said vinyl derivative and said Bronsted acid in the presence of a ruthenium compound at a temperature at which transvinylation occurs and recovering as a product of transvinylation the vinyl derivative of the different Bronsted acid. The process is most favorably employed using carboxylic acids to make vinyl esters of carboxylic acids.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: October 13, 1992
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventor: Rex E. Murray
  • Patent number: 5140044
    Abstract: A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.
    Type: Grant
    Filed: March 27, 1990
    Date of Patent: August 18, 1992
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Teruo Kishi, Hiromitsu Saito, Hiroshi Sano, Isami Takahashi, Tatsuya Tamaoki
  • Patent number: 5135683
    Abstract: An improved process for the hydrolysis and purification of an alkoxylated polyol containing a ketal protective functionality is described. The process may be employed to prepare reduced calorie esterified alkoxylated polyol fat mimetics useful in cooking and in food compositions.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: August 4, 1992
    Assignees: Arco Chemical Technology, L.P., CPC International Inc.
    Inventor: Charles F. Cooper
  • Patent number: 5103042
    Abstract: Polyethers having terminal allyl unsaturation are subject to hydrogenolysis by reaction with a hydrogen donor in the presence of a n-allyl complex forming catalyst. The product polyethers have extremely low levels of unsaturation, and thus are useful in preparing polyurethanes having improved properties and processing.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: April 7, 1992
    Assignee: The Dow Chemical Company
    Inventors: Visweswara R. Durvasula, Franz J. Luxem
  • Patent number: 5053528
    Abstract: Ester group-containing dihydroxy compounds of reduced reactivity for use in polyurethane chemistry have the formula I ##STR1## where R is linear or branched alkylene of from 2 to 20 carbon atoms, substituted or unsubstituted cycloalkylene of from 5 to 10 carbon atoms or polyoxyalkylene of from 2 to 50 oxyalkylene groups in a random or blockwise arrangement and having from 2 to 4 carbon atoms in the alkylene radical, and are prepared by transesterification of alkyl hydroxypivalates with alkanediols, cycloalkanediols or polyoxyalkylene glycols.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: October 1, 1991
    Assignee: BASF Aktiengesellschaft
    Inventor: Kaspar Bott
  • Patent number: 5041621
    Abstract: Process is disclosed for the preparation of dihydroxy esters such as hydroxypivalyl hydroxypivalate from hydroxy aldehydes such as hydroxypivaldehyde by contacting said hydroxy aldehydes with low levels of at least one elemental metal selected from a defined group of metals. Reaction product is readily recovered without the need for extensive catalysts neutralization and/or removal procedures.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: August 20, 1991
    Assignee: Eastman Kodak Company
    Inventors: Don L. Morris, Gary C. Luce
  • Patent number: 5024772
    Abstract: A process for producing 2,2-dimethyl-3-hydroxypropyl-2,2-dimethyl-3-hydroxypropionate (HPN) and neopentyl glycol (NP) blends from a neopentyl glycol production by-product stream containing neopentyl glycol, hydroxypivalic acid, and HPN using an acid catalyst.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: June 18, 1991
    Assignee: BASF Corporation
    Inventors: Laurance R. Thurman, Joseph P. Dowd, Kathy J. Fischer
  • Patent number: 4997976
    Abstract: Compositions for parenteral nutrition comprising a nutritionally effective amount of a compound of the following formula: ##STR1## R.sup.2 is methyl or ethyl, and R.sup.3 and R.sup.4 are ##STR2## or H, and X is --C.dbd.O or --HC--OH,or a compound of the following formula: ##STR3## wherein R.sup.2 is methyl or ethyl, andX is --C.dbd.O or --C--OH,or mixtures thereof in association with a carrier.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: March 5, 1991
    Inventors: Henri Brunengraber, Sylvain Desrochers, Bernard R. Landau
  • Patent number: 4922001
    Abstract: Differentiation of the two enantiotopic groups in prochiral glycerol derivatives gives chiral molecules directly, which in turn are easily converted either into the S-series or into the R-series by selective manipulation of the functional groups.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: May 1, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Schneider, Kurt Laumen, Detlef Breitgoff, Dieter Wullbrandt, Merten Schilingmann, Reinhold Keller
  • Patent number: 4916254
    Abstract: .epsilon.-caprolactone-modified hydroxyalkyl acrylate or methyacrylate can be effectively produced from .epsilon.-caprolactone and a hydroxyalkyl acrylate or methacrylate in the presence of a stannous halide as a catalyst. The obtained monomer is used together with another copolymerizable monomer to produce a copolymer which is suitable for coating and photocurable composition.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: April 10, 1990
    Assignee: Daicel Chemical Industries, Inc.
    Inventors: Shoji Watanabe, Kiyoshi Okitsu