Plural Nitrogens In Alcohol Moiety Patents (Class 560/251)
  • N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4069329
    Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, aralkyloxy, and alkoxy substituted with an alkoxy group; ##STR2## wherein R.sub.1 and R.sub.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: January 17, 1978
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Shosuke Okamoto, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Shinji Tonomura
  • N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4066758
    Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, respectively containing not more than 10 carbon atoms, aralkyloxy of not more than 15 carbon atoms, and alkoxy of not more than 10 carbon atoms substitured with an alkoxy group of not more than 10 carbon atoms; ##STR2## wherein R.sub.1 and R.sub.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: January 3, 1978
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Shosuke Okamoto, Ryoji Kikumoto, Kazuo Ohkubo, Shinji Tonomura, Yoshikuni Tamao, Tohru Tezuka, Akiko Hijikata
  • N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4066759
    Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, respectively containing not more than 10 carbon atoms, aralkyloxy of not more than 15 carbon atoms, and alkoxy of not more than 10 carbon atoms substituted with an alkoxy group of not more than 10 carbon atoms; ##STR2## wherein R.sub.1 and R.sub.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: January 3, 1978
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Shosuke Okamoto, Akiko Hijikata, Ryoji Kikumoto, Yoshikuno Tamao, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura
  • Process for the preparation of substituted trichloroacetamidine derivatives
    Patent number: 4065465
    Abstract: Substituted trichloroacetamidine derivatives are prepared by reacting an appropriately substituted amine with trichloroacetamidine or a trichloroacetimidate. The substituted amines are 3-aminomethyl indole and 2-acetoxy-3-phenoxy propylamine.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventor: George H. Denny
  • Process for the preparation of substituted trichloroacetamidine derivatives
    Patent number: 4065464
    Abstract: Substituted trichloroacetamidine derivatives are prepared by reacting trichloroacetamidine with an appropriately substituted compound also substituted with a suitable leaving group. The leaving groups are halogen, quaternary or tertiary amines, methanesulfonate, toluenesulfonate, and the like.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: George H. Denny, Walfred S. Saari
  • X-ray contrast media
    Patent number: 4065554
    Abstract: The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: December 27, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • X-Ray contrast media
    Patent number: 4065553
    Abstract: The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: December 27, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • Substituted N-(carboxymethyl)-3-aminopropan-2-ol derivatives
    Patent number: 4064252
    Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
    Type: Grant
    Filed: June 4, 1976
    Date of Patent: December 20, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
  • N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
    Patent number: 4062963
    Abstract: N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, respectively containing not more than 10 carbon atoms, aralkyloxy of not more than 15 carbon atoms, and alkoxy of not more than 10 carbon atoms substituted with an alkoxy group of not more than 10 carbon atoms; ##STR2## wherein R.sub.1 and R.sub.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: December 13, 1977
    Assignees: Mitsubishi Chemical Industries Limited, Shosuke Okamoto
    Inventors: Shosuke Okamoto, Ryoji Kikumoto, Kazuo Ohkubo, Shinji Tonomura, Yoshikuni Tamao
  • Tetrasubstituted urea compounds and herbicidal compositions
    Patent number: 4058392
    Abstract: New N,N'-tetrasubstituted ureas of the formula ##STR1## in which X is oxygen, sulfur or an NR.sup.5 -- or SO.sub.2 --group,R is alkyl or an optionally substituted aryl group, or an optionally substituted aralkyl group,R.sup.1 and R.sup.4 are individually optionally substituted hydrocarbyl which may contain oxygen or sulfur,R.sup.2 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxy or cycloalkyl,R.sup.3 is alkyl, which may optionally be substituted by halogen, or is alkenyl, orR.sup.2 and R.sup.3 conjointly form an alkylene bridge, which can be interrupted by a hetero-atom, such as O, or N-alkyl group and which forms a heterocyclic ring with the adjoining nitrogen atom,R.sup.1 and R.sup.
    Type: Grant
    Filed: September 10, 1973
    Date of Patent: November 15, 1977
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Thomas, Wolfgang Kramer, Ludwig Eue, Carl Metzger, Gerhard Jager
  • 10-Aza-11,12-secoprostaglandins
    Patent number: 4055597
    Abstract: This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: October 25, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking