Abstract: New optically active bis phosphine compounds which are usful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.

Abstract: Cationic dyestuffs of the formula[(D--N.dbd.N--K) (--R).sub.n ].sup.m.sym. m An.crclbar.whereinD denotes the radical of a diazo component,K denotes the radical of a coupling component,m and n independently of one another denote 1 or 2,An.crclbar. denotes an anion andR denotes a radical of the general formulae--A--O --(B--O).sub.p --E--A--O--CO--F--O--(B--O).sub.p --E or--A--(O--F).sub.p.sbsb.1 --CO--O--(B--O).sub.p --EwhereinA represents optionally substituted alkylene with 2 to 4 C-atoms or a direct bond,B represents optionally substituted alkylene with 2 to 4 C atoms,E represents hydrogen or optionally substituted alkyl, alkenyl, cycloalkyl, formyl, alkylcarbonyl or alkenylcarbonyl or optionally substituted phenylcarbonyl, phenylalkylcarbonyl, phenoxyalkylcarbonyl, phenylalkyl or phenyl,F represents alkylene,p represents 1-3 andp.sub.1 represents 0 or 1,at least one of the radicals A or B represents substituted alkylenepossess good coloristic properties.

Abstract: This disclosure describes 4-monoalkylaminophenyl carbinols (primary, secondary, and tertiary alcohols) and with derivatives and salts thereof useful as hypolipidemic and anti-atherosclerotic agents.

Abstract: Prostaglandin derivatives wherein the atom at the position 13 of the lower side-chain is replaced by nitrogen.The new compounds have abortifacient activity.

Abstract: Phenolic age resistors such as 4-(3,5-ditertiary butyl-4-hydroxyphenyl)-2-butyl 2-methyl-4-thia-6-octanoyloxyhexanoate are used as antioxidants in diene rubbers, such as butadiene-styrene types and in polyolefins, such as polypropylene.

Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkanoyl; R.sub.2 is alkyl; R.sub.3 is alkylamino, dialkylamino, a 1-piperazinyl group, 4-aryl-1,2,3,6-tetrahydro-1-pyridinyl, or N-alkyl-N-(pyridinylalkyl)amino; and n is 1, 2 or 3; have useful hypotensive activity.

Abstract: The invention provides novel phenoxyalkylcarboxylic acids which are useful in therapy as metabolic regulators and in agriculture as selective herbicides.

Abstract: There are disclosed N-acyl substituted benzamides of the general formula: ##STR1## wherein: X is carbon or nitrogen;R.sub.1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy;Y is the radical --O--, --NH-- or --S--;Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group;R.sub.2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; andThe value of n, m, and p may each be 0 or 1, and in the case of p=1, pharmaceutically acceptable salts thereof.Also disclosed is a method for making such compounds and pharmaceutical compositions containing such compounds.

Abstract: Novel 4-amino-cyclohexan-1-ols are formulated into pharmaceutical compositions for the relief of pain in mammals in need of said treatment.

Abstract: Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxylakylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Abstract: The preparation of (.+-.)-9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and (.+-.)-3-[.alpha.-(2.alpha., 3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclopentyl)]-7-substituted-v-tr iazolo[4,5d]pyrimidines: ##STR2## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR3## wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity.

Abstract: Mono-, di- and tri-esters of 3-(hydroxy or hydroxymethyl)-4-hydroxy-.alpha.-(aminomethyl)benzyl alcohols, obtained by methods involving reduction of the corresponding mono- and di-ester ketones, are useful for producing sympathomimetic effects, such as bronchodilation, of long duration with low cardiovascular stimulating effect, in warm-blooded mammals.

Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, ##STR2## R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and cycloalkyl or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a ring of the formula ##STR3## N IS 0 OR AN INTEGER FROM 1 TO 3; M IS AN INTEGER FROM 1 TO 3; R.sub.3 and R.sub.4 are independently selected from hydrogen and lower alkyl; X is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; and their salts; are disclosed. These compounds possess useful antiinflammatory properties.

Abstract: Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

Abstract: Anilide derivative compounds of the formula ##STR1## e.g., trans-N-(2-hydroxycyclopentyl)-3',4'-dichloropropionanilide, have been found to possess potent Central Nervous System (CNS) antidepressant properties.These compounds are promising antidepressant drugs which are characterized by less toxicity than imipramine, and long-acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are also disclosed.

Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R.sub.1 is alkanoyl; and R.sub.2 is a tertiary amino group; have hypotensive activity.

Abstract: 1,1-Diphenyl-2-hydroxy-3-aminopropane derivatives are useful for their psychotropic activity and, in particular are useful as antidepressants.

Abstract: Compounds having the structure ##STR1## wherein R.sub.1 is alkyl or arylalkyl; R.sub.2 is --C.tbd.N, --C.tbd.CH or ##STR2## wherein R.sub.4 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.

Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Abstract: 8-Chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine is transformed by various microorganisms into compounds having useful pharmacological properties or useful as intermediates in the synthesis of various pharmaceutical compounds. Among the microorganisms useful for this purpose are Trichoderma lignorum NRRL 8138, Hormodendrum sp. NRRL 8133, Cladosporium lignicolum NRRL 8131, Hormodendrum cladosporioides NRRL 8132, Pullularia pullulans NRRL 8137, Penicillium sp. NRRL 8136, Mucor sp. NRRL 8135, Chaetomium sp. NRRL 8130, and Hormodendrum sp. NRRL 8134.

Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.

Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.

Abstract: Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

Abstract: Substituted trichloroacetamidine derivatives are prepared by treating an appropriately substituted imidate with ammonia. The imidate intermediates are prepared by treating an appropriately substituted amine with an imidating reagent.

Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.

Abstract: This invention relates to 10-aza-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators.