Substituted Patents (Class 560/266)
-
Patent number: 10246400Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: GrantFiled: April 5, 2018Date of Patent: April 2, 2019Assignee: Bracco Imaging S.P.A.Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
-
Patent number: 9963416Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.Type: GrantFiled: June 10, 2015Date of Patent: May 8, 2018Assignee: Bracco Imaging S.P.A.Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
-
Patent number: 9090556Abstract: The disclosure relates to a process for forming an acyloxy carboxylic acid or a derivative of the acid. A hydroxy acid compound is reacted with a carboxylic acid in a reaction vessel and in the presence of a catalyst, such as in a reactive distillation column containing the catalyst. The reaction product formed in the reaction vessel includes an acyloxy carboxylic acid compound, which can be removed continuously from the vessel in a product stream. Another product stream containing unreacted (excess) carboxylic acid and/or reaction byproducts such as water can be separately removed continuously from the reaction vessel.Type: GrantFiled: December 7, 2012Date of Patent: July 28, 2015Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventors: Dennis Miller, Carl T. Lira, Lars Peereboom, Aspi K. Kolah
-
Publication number: 20150132702Abstract: A method for fabricating a semiconductor product includes applying a photo-resist layer to a substrate, the photo-resist layer including a higher acid concentration at an upper portion of the photo-resist layer than at a lower portion of the photo-resist layer. The method also includes exposing the photo-resist layer to a light source through a mask including a feature, the photo-resist layer including a floating, diffusing acid that will diffuse into a region of the photo-resist layer affected by the feature while not diffusing into a feature formed by the mask.Type: ApplicationFiled: January 16, 2015Publication date: May 14, 2015Inventors: Ching-Yu Chang, Ming-Feng Shieh, Wen-Hung Tseng
-
Publication number: 20140275603Abstract: A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.Type: ApplicationFiled: March 26, 2012Publication date: September 18, 2014Applicant: ANGUS Chemical CompanyInventors: Raymond J. Swedo, George David Green, Charles E. Coburn
-
Publication number: 20140256928Abstract: A protecting group for 1-nitrogen atom of an indole group including a sulfonylethyl carbamate group, wherein the protecting group is represented by the following General Formula (I) and capable of being removed from the 1-nitrogen atom of the indole group in an aprotic solvent: where R represents an alkyl group, a derivative of the alkyl group, a phenyl group or a derivative of the phenyl group.Type: ApplicationFiled: May 9, 2014Publication date: September 11, 2014Applicant: APTA BIOSCIENCES LTD.Inventor: Tsuyoshi FUJIHARA
-
Patent number: 8829231Abstract: The present invention relates to a new way for the production of 4-acetoxy-2-methyl-butanal, wherein a non-acidic catalytic system is used.Type: GrantFiled: January 16, 2012Date of Patent: September 9, 2014Assignee: DSM IP Assets B.V.Inventors: Werner Bonrath, Jan Schütz
-
Patent number: 8741966Abstract: The present disclosure relates to lipid compounds of formula (I): wherein: R1 is chosen from a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, and a C10-C21 alkynyl having 1-6 triple bonds; R2 and R3 are the same or different and are chosen from hydrogen and a C1-C6 alkyl; X is chosen from O, S, SO, SO2, Si, and Se; n=1 or 3; and P1 is chosen from hydrogen; a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, a C10-C21 alkynyl having 1-6 triple bonds, optionally substituted; a group of formula (II) or formula (III), wherein P2, P3, and P4 are chosen from hydrogen, an alkyl, an alkenyl, and an alkynyl, optionally substituted; and a group of formula (IV) or formula (V), wherein P5 is chosen from hydrogen and a C1-C6 alkyl; or a pharmaceutically acceptable salt, complex, or solvate thereof.Type: GrantFiled: November 6, 2008Date of Patent: June 3, 2014Assignee: Pronova Biopharma Norge ASInventor: Anne Kristin Holmeide
-
Publication number: 20140081042Abstract: The present invention relates to a new way for the production of 4-acetoxy-2-methyl-butanal, wherein a non-acidic catalytic system is used.Type: ApplicationFiled: January 16, 2012Publication date: March 20, 2014Applicant: DSM IP ASSETS B.V.Inventors: Werner Bonrath, Jan Schütz
-
Publication number: 20130295229Abstract: The present invention relates to the use of 3-mercaptoheptyl carboxylate in the form of any one of its stereoisomers or in the form of a mixture thereof. The compounds of the invention are valuable flavoring ingredients capable of imparting fruity, citrus and/or teas aftertaste with a well-balanced long-lastingness. The present invention also concerns the compositions or articles containing the compound.Type: ApplicationFiled: July 11, 2013Publication date: November 7, 2013Inventors: Sina Dorothea Escher, Yvan Niclass, Lionel Saudan
-
Publication number: 20130150619Abstract: The disclosure relates to a process for forming an acyloxy carboxylic acid or a derivative of the acid. A hydroxy acid compound is reacted with a carboxylic acid in a reaction vessel and in the presence of a catalyst, such as in a reactive distillation column containing the catalyst. The reaction product formed in the reaction vessel includes an acyloxy carboxylic acid compound, which can be removed continuously from the vessel in a product stream. Another product stream containing unreacted (excess) carboxylic acid and/or reaction byproducts such as water can be separately removed continuously from the reaction vessel.Type: ApplicationFiled: December 7, 2012Publication date: June 13, 2013Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventor: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
-
Publication number: 20120197036Abstract: A method for manufacturing a ketone, includes oxidizing an internal olefin or a cyclic olefin having a functional group containing a hetero atom and one carbon-carbon double bond or more at a position other than terminals of a molecule thereof in an amide-based solvent in the presence of water, a palladium catalyst, and molecular oxygen, without oxidizing the functional group, thereby bonding an oxo group to at least one of the carbon atoms constituting the carbon-carbon double bond. The amide-based solvent is represented by formula (1): wherein R1 represents an alkyl group having 1 to 4 carbon atoms; R2 and R3 each independently represent an alkyl group having 1 to 4 carbon atoms or an aryl group; and when R1 and R2 are alkyl groups, R1 and R2 may be bonded to each other to form a ring structure.Type: ApplicationFiled: October 8, 2010Publication date: August 2, 2012Applicants: Osaka University, JX NIPPON OIL & ENERGY CORPORATIONInventors: Kiyotomi Kaneda, Hisashi Sone
-
Publication number: 20120083619Abstract: Described herein is a process for the manufacture of hydrofluoroalkanols of the structure RfCFClCHROH. Also described herein are methods of manufacturing hydrofluoroalkenes of the structure RfCF?CHR from halofluorocarbons of the structure RfCFX2. In particular, 2,3,3,3,-tetrafluoro-1-propene may be manufactured with this process. Also described are compounds of the formula RfCFClCHROC(?O)R?.Type: ApplicationFiled: October 11, 2011Publication date: April 5, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Mario Joseph Nappa, Xuehui Sun, Lev Moiseevich Yagupolskii, Andrey Anatolievich Filatov, Vladimir Nikolaevich Boiko, Yurii Lvovich Yagupolskii
-
Patent number: 8143440Abstract: There is provided a method for separating and collecting at least alcohol with a high purity from an azeotropic mixture of olefin and alcohol.Type: GrantFiled: January 9, 2009Date of Patent: March 27, 2012Assignee: Daikin Industries, Ltd.Inventors: Yuuki Matsuda, Kazuyoshi Ichihara, Takeomi Hirasaka, Takuya Ichida
-
Patent number: 8124805Abstract: A process for the production of 4-acetoxybutyraldehyde is described. The process comprises reacting allyl acetate with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a substituted or unsubstituted 2,2?-bis(dihydrocarbylphosphino)diphenyl ether. The process gives a high ratio of 4-acetoxybutyraldehyde:3-acetoxy-2-methylpropionaldehyde.Type: GrantFiled: November 25, 2009Date of Patent: February 28, 2012Assignee: Lyondell Chemical Technology, L.P.Inventor: Daniel F. White
-
Publication number: 20110178323Abstract: Provided is a method for producing a tetrafluoro nitrogen-containing heterocyclic compound such as tetrafluoropyrrolidine in good yield and at low cost. The method comprises the steps of: (A) reacting a compound represented by the formula (I) with fluorine gas to produce a tetrafluoro compound represented by the formula (II), (B) converting the tetrafluoro derivative represented by the formula (II) to a compound represented by the formula (III), and (C) reacting the compound represented by the formula (III) with an amine compound represented by the formula NH2R9 to produce a tetrafluoro nitrogen-containing heterocyclic compound represented by the formula (IV) or salt thereof.Type: ApplicationFiled: October 2, 2009Publication date: July 21, 2011Applicant: NIPPON SODA CO., LTD.Inventor: Yasuhiro Miyashita
-
Publication number: 20110118455Abstract: A protecting group for 1-nitrogen atom of an indole group including a sulfonylethyl carbamate group, wherein the protecting group is represented by the following General Formula (I) and capable of being removed from the 1-nitrogen atom of the indole group in an aprotic solvent: where R represents an alkyl group, a derivative of the alkyl group, a phenyl group or a derivative of the phenyl group.Type: ApplicationFiled: November 19, 2010Publication date: May 19, 2011Applicant: FUJITSU LIMITEDInventor: Tsuyoshi FUJIHARA
-
Publication number: 20100280109Abstract: The present disclosure relates to lipid compounds of formula (I): wherein: R1 is chosen from a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, and a C10-C21 alkynyl having 1-6 triple bonds; R2 and R3 are the same or different and are chosen from hydrogen and a C1-C6 alkyl; X is chosen from O, S, SO, SO2, Si, and Se; n=1 or 3; and P1 is chosen from hydrogen; a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, a C10-C21 alkynyl having 1-6 triple bonds, optionally substituted; a group of formula (II) or formula (III), wherein P2, P3, and P4 are chosen from hydrogen, an alkyl, an alkenyl, and an alkynyl, optionally substituted; and a group of formula (IV) or formula (V), wherein P5 is chosen from hydrogen and a C1-C6 alkyl; or a pharmaceutically acceptable salt, complex, or solvate thereof.Type: ApplicationFiled: November 6, 2008Publication date: November 4, 2010Inventor: Anne Kristin Holmeide
-
Publication number: 20100209827Abstract: There is disclosed a sulfonate shown by the following general formula (2). R1—COOC(CF3)2—CH2SO3?M+??(2) (In the formula, R1 represents a linear, a branched, or a cyclic monovalent hydrocarbon group having 1 to 50 carbon atoms optionally containing a hetero atom. M+ represents a cation.) There can be provided: a novel sulfonate which is effective for a chemically amplified resist composition having a sufficiently high solubility (compatibility) in a resist solvent and a resin, a good storage stability, a PED stability, a further wider depth of focus, a good sensitivity, in particular a high resolution and a good pattern profile form; a photosensitive acid generator; a resist composition using this; a photomask blank, and a patterning process.Type: ApplicationFiled: February 16, 2010Publication date: August 19, 2010Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Masaki OHASHI, Takeshi KINSHO, Youichi OHSAWA
-
Patent number: 7544831Abstract: The present invention provides a green catalytic process for the synthesis of acetyl salicylic acid using solid acid catalysts at atmospheric pressure. The invention involve the solid acid catalyst such as sulfated transition metal oxides namely nano-crystalline sulfated zirconia, sulfated titania; modified zeolites namely zeolite H-beta, H-Y, H-ZSM-5 and K-10 montmorillonite clay in a solvent free environment using salicylic acid and acetic anhydride with yield about 95% and high selectivity (100%). The solid acid catalysts can be recovered, regenerated and reused.Type: GrantFiled: September 21, 2007Date of Patent: June 9, 2009Assignee: Council of Scientific and Industrial ResearchInventors: Raksh Vir Jasra, Beena Tyagi, Manish Kumar Mishra
-
Patent number: 6444842Abstract: The present invention provides an improved method for the preparation of carboxylic acid esters of alkylene glycol monoalkyl ethers by the acid catalyzed esterification of the monoalkyl ether with a carboxylic acid. In a preferred embodiment of the invention, the carboxylic acid and alcohol are reacted in a reactor/column and the resulting ester product is distilled into an overhead decanter/extractor as a single phase. A small amount of solvent, preferably a hydrocarbon is added to the mixture causing the resulting distillate to separate into two phases, one phase containing the desired product, the other containing primarily water. The process described is applicable to both batch and continuous operation and is not constrained by the difficulty of separating closely boiling azeotropes and results in substantially higher production rates than achieved by current processes.Type: GrantFiled: April 19, 2000Date of Patent: September 3, 2002Assignee: Celanese International CorporationInventors: H. Robert Gerberich, R. Jay Warner
-
Patent number: 6348622Abstract: There is provided a compound of the formula[I]: wherein R represents a hydrogen atom or a protective group for a hydroxyl group; and A represents a hydrogen atom, a halogen atom or a group of the formula A1: Q represents Q3: when A represents a halogen atom or a protective group for a hydroyl group, A represents Q4: wherein R1 and R2 represent a hydrogen atom or a protective group for a hydroxyl group; and when A represents a hydrogen atom, Q is Q2:Type: GrantFiled: February 9, 2000Date of Patent: February 19, 2002Assignee: Sumitomo Chemical Company, LimitedInventors: Toshiya Takahashi, Shinzo Seko, Takashi Miki
-
Patent number: 6323174Abstract: The invention provides a chain diene compound with desirable regioselectivity, in the presence of a specific ruthenium compound. This chain diene compound is a promising raw material for terpene. It has a structure represented by the general formula (I): wherein R1 represents H, a C1-C6 alkyl group which may be substituted or a C2-C6 alkenyl group which may be substituted, R2 represents a phenyl group which may have a C1-C4 alkyl group or a C1-C12 acyloxy group which may have a phenyl group or a naphthyl group, or a benzyl group or R2 is a hydroxy group which reversibly forms an aldehyde group through shifting of the position of the double bond adjacent to said hydroxy group. The chain diene compound is produced by reacting 2-substituted-1,3-butadienes with terminal olefins in the presence of a ruthenium compound in a hydrophilic solvent.Type: GrantFiled: May 16, 2000Date of Patent: November 27, 2001Assignee: Takasago International CorporationInventors: Mitsuhiko Fujiwhara, Takenobu Nishikawa, Yoji Hori, Toshimitsu Hagiwara, Hisao Iwai, Takashi Miura
-
Patent number: 6288285Abstract: A process for producing dichloroacetoxypropane comprising reacting allyl acetate with chlorine in a gaseous phase in the presence of a catalyst comprising an element of Group 16 of the long-form Periodic Table or in the absence of a catalyst. The dichloroacetoxypropane obtained may be converted to dichloropropanol and epichlorohydrin.Type: GrantFiled: March 29, 2000Date of Patent: September 11, 2001Assignee: Showa Denko K.K.Inventors: Takanori Aoki, Takami Ohe, Haruki Ishikami
-
Patent number: 6124270Abstract: A cationic amphipathic compound of formula (I), ##STR1## wherein A is a single bond, an NH--R' grouping or (a), wherein --R'-- is a straight or branched, optionally substituted, saturated or unsaturated C.sub.1-22 aliphatic chain optionally interrupted by one or more O, S or N heteroatoms and one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals; each of R.sub.1, R.sub.2 and R.sub.3, which are the same or different, is a higher acyl or alkyl grouping; each of R.sub.7, R.sub.8 and R.sub.9, which are the same or different, is a (CH.sub.2).sub.n alkylene radical where 1.ltoreq.N.ltoreq.6; each of R.sub.4, R.sub.5 and R.sub.6, which are the same or different, is a hydrogen atom or an optionally substituted C.sub.1-22 alkyl, alkenyl, alkynyl or acyl radical optionally interrupted by one or more heteroatoms selected from), S and N, or one or more saturated, unsaturated or aromatic carbocyclic or heterocyclic radicals, or else at least two of the groupings R.sub.4, R.sub.5 and R.sub.Type: GrantFiled: March 3, 1997Date of Patent: September 26, 2000Assignee: Pasteur Merieux Serums et VaccinsInventor: Jean Haensler
-
Patent number: 6118030Abstract: A process for producing dichloroacetoxypropane comprising reacting allyl acetate with chlorine in a gaseous phase in the presence of a catalyst. The dichloroacetoxypropane obtained may be converted to dichloropropanol and epichlorohydrin.Type: GrantFiled: February 16, 1999Date of Patent: September 12, 2000Assignee: Showa Denko K.K.Inventors: Takanori Aoki, Takami Ohe, Haruki Ishikami, Taketoshi Naitoh, Tatsuharu Arai
-
Patent number: 5777140Abstract: Process for the preparation of acyloxyalkanesulfonates having improved properties The acyloxyalkanesulfonates are obtained in accordance with the invention by direct esterification in which at least one fatty acid is esterified with at least one ammonium hydroxyalkanesulfonate of the formula HO-A-SO.sub.3.sup.- + NR.sup.1 R.sup.2 R.sup.3 R.sup.4 in which A is a C.sub.2 -C.sub.4 -alkylene and R.sup.1.sub.1 R.sup.2.sub.1 R.sup.3 and R.sup.4 are hydrogen or a C.sub.1 -C.sub.4 -alkylene group in the presence of an esterification catalyst at a temperature of not more than 200.degree. C., with removal of the water present. This process gives a product of high acyloxyalkane-ammonium sulfonate content without the need for a consistency regulator to be added.Type: GrantFiled: March 27, 1996Date of Patent: July 7, 1998Assignee: Hoechst AktiengesellschaftInventor: Dirk Buhring
-
Patent number: 5665877Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.Type: GrantFiled: May 17, 1996Date of Patent: September 9, 1997Assignee: Eli Lilly and CompanyInventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski, II
-
Patent number: 5648513Abstract: The invention relates to a method of suppressing human body malodor by utilizing a deodorant composition containing a competitive substrate for the enzymatic creation of axillary body malodor. The compound is present in a dermatologically acceptable vehicle, and in an amount effective to reduce the conversion of malodor producing precursor. The present invention also relates to novel O-acylated serine compounds and method for the production thereof.Type: GrantFiled: November 22, 1995Date of Patent: July 15, 1997Inventor: Judith Wolfe Laney
-
Patent number: 5635571Abstract: Polyoxazolines having the structural formula: ##STR1## wherein R is phenylene or alkylene containing 2 to 18 carbon atoms, R.sup.2 is C.sub.1-4 alkyl and R.sub.1 is selected from the group consisting of C.sub.1-12 alkyl, vinyl, isopropylidene, pentafluoroethyl, phenyl, hydroxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups, C.sub.1-2 -alkoxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups and .paren open-st.CH.sub.2 CH.sub.2 --O.paren close-st..sub.r CH.sub.3 in which r ranges from 1-20, X is NH.sub.2 or OH, n ranges from 2 to 50 and m ranges from 0 to 50, wherein R.sub.1 is hydroxyphenyl optionally interrupted by up to 20 ethylene oxide groups only when X is NH.sub.2, are polymerizable to form hyperbranched polymers which have a number average molecular weight ranging from 5,000 to 150,000, a weight average molecular weight ranging from 5,500 to 5,000,000 and a polydispersity ranging from 1.Type: GrantFiled: June 5, 1996Date of Patent: June 3, 1997Assignee: Cornell Research Foundation, Inc.Inventors: Jean M. J. Frechet, Koji Yui
-
Patent number: 5629423Abstract: A process for synthesizing enantiomerically pure chiral secondary alcohol compounds linked to a heterocyclic core moiety, using a natural chiral molecule starting material. The inventive process is particularly useful for bulk manufacturing of chiral secondary alcohol compounds.Type: GrantFiled: May 23, 1995Date of Patent: May 13, 1997Assignee: Cell Therapeutics, Inc.Inventors: J. Peter Klein, Alistair J. Leigh, John Michnick, Anil M. Kumar, Gail E. Underiner
-
Patent number: 5614647Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.Type: GrantFiled: May 25, 1995Date of Patent: March 25, 1997Assignee: Eli Lilly and CompanyInventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski, II
-
Patent number: 5541347Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.Type: GrantFiled: October 3, 1994Date of Patent: July 30, 1996Assignee: Eli Lilly and CompanyInventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski II
-
Patent number: 5491145Abstract: Novel compound of the general formula: ##STR1## wherein R.sup.1 stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R.sup.2 and R.sup.3 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, provided that either R.sup.2 or R.sup.3 is a hydrogen atom, the other being an optionally substituted lower alkyl group, or R.sup.2 and R.sup.3 may, taken together with the adjacent --C=C-- group, form a 5- to 7-membered ring; X stands for an oxygen atom or S(O).sub.p (p stands for an integer from 0 to 2; Y stands for a group of the formula: ##STR2## (R.sup.4 and R.sup.5 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R.sup.6 and R.sup.7 each stands for a hydrogen atom, an optionally substituted lower lakyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R.sup.Type: GrantFiled: November 21, 1994Date of Patent: February 13, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Akio Miyake, Yasuhiko Kawano, Yasuko Ashida
-
Patent number: 5488135Abstract: The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances, in free form and, where such forms exist, in salt form. The compounds have potent antihyperproliferative/antiinflammatory and anticancer activity.Type: GrantFiled: October 16, 1992Date of Patent: January 30, 1996Assignee: Sandoz Ltd.Inventors: Peter Nussbaumer, Anton Stutz
-
Patent number: 5455371Abstract: A process for producing difluoromethyl ethers and esters by reacting an ether or an acid with a cadmium, zinc or bismuth compound containing the CF.sub.3 group and selected from the group consisting of Cd(CF.sub.3).sub.2, Zn(CF.sub.3).sub.2,Bi(CF.sub.3).sub.3, CdHal(CF.sub.3), ZnHal(CF.sub.3), BiHal(CF.sub.3).sub.2 and BiHal.sub.2 (CF.sub.3) in the presence of a Lewis acid.Type: GrantFiled: June 15, 1993Date of Patent: October 3, 1995Assignee: Solvay Fluor und Derivative GmbHInventors: Dieter Naumann, Wieland Tyrra, Regina Moeckel
-
Patent number: 5360938Abstract: This invention relates to asymmetric syntheses in which a prochiral or chiral compound is contacted in the presence of an optically active metal-ligand complex catalyst to produce an optically active product.Type: GrantFiled: July 16, 1992Date of Patent: November 1, 1994Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: James E. Babin, Gregory T. Whiteker
-
Patent number: 5359128Abstract: The invention comprises compositions and methods for the treatment of psoriasis.Type: GrantFiled: February 11, 1993Date of Patent: October 25, 1994Inventor: Izhak Blank
-
Patent number: 5344952Abstract: A method for enzyme immunoassay for a ligand suspected to be present in a liquid sample includes signal amplification by use of at least two enzymes and a blocked modulator for one of the enzymes. Ligand present in the liquid binds to an antiligand and an enzyme-labeled tracer. The resulting bound fraction is separated and the enzyme in the tracer removes the blocking group from the blocked modulator. The modulator activates or inhibits a second enzyme which catalyzes the conversion of a substrate to a product. The presence or absence of the ligand in the liquid is indicated by a signal, such as a color change or a rate of color change, associated with the product. The invention includes a new class of enzyme inhibitors and blocked inhibitors and a kit of materials useful for performing the method of the invention.Type: GrantFiled: March 22, 1993Date of Patent: September 6, 1994Assignee: Becton, Dickinson and CompanyInventors: Patrick D. Mize, James P. O'Connell
-
Patent number: 5231221Abstract: Compounds of the formula ##STR1## can advantageously be prepared by reacting compounds the formula II ##STR2## in which the substituents R.sup.1 -R.sup.4 have the meanings given, with the anhydride of the formula III ##STR3## in the presence of dimethyl sulfoxide and the acid corresponding to the anhydride of the formula III.Type: GrantFiled: March 18, 1991Date of Patent: July 27, 1993Assignee: Hoechst AktiengesellschaftInventors: Winfried Hertzsch, Gerhard Jahne
-
Patent number: 5210315Abstract: A process for producing an .alpha.-hydroxyketone represented by formula (I): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or an alkoxycarbonyl group; and R.sup.2 and R.sup.3 each represent a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aralkyl group, provided that they do not simultaneously represent a hydrogen atom; or a pair of R.sup.1 and R.sup.2, a pair of R.sup.1 and R.sup.3, or a pair of R.sup.2 and R.sup.3 is taken together to form a ring; and the pair of R.sup.1 and R.sup.2 and the pair of R.sup.2 and R.sup.3 may form a ring simultaneously, is disclosed, comprising reacting a compound represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined above, with an oxidizing agent in the presence of a ruthenium compound and water. .alpha.-Hydroxyketones useful as physiologically active substances are produced with good selectivity and in high yield.Type: GrantFiled: October 18, 1991Date of Patent: May 11, 1993Assignee: Takasago International CorporationInventors: Takao Saito, Hidenori Kumobayashi, Shunichi Murahashi
-
Patent number: 5175348Abstract: The invention relates to a novel process for the preparation of halogenated carboxylic acid esters of formula I ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or aryl, R.sub.2 hydrogen is alkyl or cycloalkyl, and R.sub.3 is halogen having an atomic number of from 9 up to and including 53, which process comprises reacting an acylal of formula II ##STR2## with a hydrogen halide of the formula H--R.sub.3 (III).Type: GrantFiled: March 10, 1992Date of Patent: December 29, 1992Assignee: Saurefabrik SchweizerhallInventors: Pasquale Gallegra, Gerhard Degischer
-
Patent number: 5171879Abstract: The invention relates to a novel process for the preparation of chlorinated carboxylic acid esters of formula I ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or aryl and R.sub.2 hydrogen is alkyl or cycloalkyl, which process comprises reacting an acylal of formula II ##STR2## with thionyl chloride.Type: GrantFiled: March 10, 1992Date of Patent: December 15, 1992Assignee: Saurefabrik SchweizerhallInventors: Pasquale Gallegra, Gerhard Degischer
-
Patent number: 5155256Abstract: An improved process for preparing 2-bromoethyl acetate involves reacting ethylene glycol with an aqueous solution of hydrogen bromide and acetic acid in the presence of a solvent such as toluene which forms an azeotrope with water but not with 2-bromoethyl acetate. The resulting reaction mixture is heated under reflux conditions to separate toluene and water therefrom and acetic anhydride or acetic acid is added to convert bromoethanol in the reaction mixture to additional 2-bromoethyl acetate.Type: GrantFiled: June 21, 1991Date of Patent: October 13, 1992Assignee: Mallinckrodt Medical, Inc.Inventor: Robert C. Chapman
-
Patent number: 5130462Abstract: Cyclobutane derivatives of the formulas ##STR1## wherein P is a hydroxy protecting group and X is a leaving group are useful intermediates in the preparation of antiviral compounds.Type: GrantFiled: February 19, 1991Date of Patent: July 14, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: William A. Slusarchyk, Robert Zahler
-
Patent number: 5117045Abstract: The invention relates to a method for producing solvent-soluble chlorinated ethylene-vinyl acetate copolymer by conducting homogeneous chlorination of ethylene-vinyl acetate copolymer in aqueous suspension by irradiation or by organic or inorganic radical generation, which method comprises conducting the chlorination upon a powder of ethylene-vinyl acetate copolymer containing 5 to 35 wt % of vinyl acetate and having a specific surface area of not less than 300 cm.sup.2 /g at a reaction temperature dependent upon the content of vinyl acetate as expressed in the relationship:20.ltoreq.[reaction temperature (.degree. C.)].ltoreq.60-[vinyl acetate content (wt. %)].Type: GrantFiled: November 5, 1990Date of Patent: May 26, 1992Assignee: Sanyo-Kokusaku Pulp Co., Ltd.Inventors: Yoshitatsu Nishijima, Terumasa Fujitaka, Kazuo Shimizu
-
Patent number: 5091598Abstract: Process of preparation of alcohols by the reaction of an organic halide with a carbonyl compound in an organic solvent, in the presence of metallic manganese, followed by hydrolysis of the reaction product; the reaction is initiated and activated by an ester present in the reaction medium.Type: GrantFiled: December 28, 1988Date of Patent: February 25, 1992Assignee: Societe Nationale Elf AquitaineInventors: Gerard Cahiez, Pierre-Yves Chavant, Pierre Tozzolino
-
Patent number: 5091560Abstract: A method for synthesizing an acyloxycarboxylic acid by providing a reaction chamber, establishing sources of an .alpha.-hydroxycarboxylic acid and an acid chloride, and repeatedly contacting substantially equal molar amounts of the .alpha.-hydroxycarboxylic acid and the acid chloride within the reaction chamber. The acyloxycarboxylic acid so synthesized is useful as a starting material for conversion to various esters which, when placed in aqueous solution with a source of hydrogen peroxide, result in a peracid and are useful for bleaching applications.Type: GrantFiled: December 21, 1990Date of Patent: February 25, 1992Assignee: The Clorox CompanyInventor: Richard R. Rowland
-
Patent number: 5004569Abstract: The invention relates to a process for the production of carboxylic acid esters from carboxylic acids and alcohols which is characterized in that neutral phosphites containing oxetane groups are used as esterification catalysts.Type: GrantFiled: December 6, 1988Date of Patent: April 2, 1991Assignee: Bayer AktiengesellschaftInventors: Helmut-Martin Meier, Klaus Kircher, Klaus Berg
-
Patent number: 4959187Abstract: The invention provides novel bleaching compositions comprising peracid precursors with the general structure ##STR1## with R, R', R" and L as defined in the specification. Novel peracids and precursors are also herein disclosed. These peracid precursors provide new, proficient and cost-effective compounds for fabric bleaching.Type: GrantFiled: October 14, 1988Date of Patent: September 25, 1990Assignee: The Clorox CompanyInventors: Ronald A. Fong, Sheldon N. Lewis, Richard J. Wiersema, Alfred G. Zielske