Polyphenolic Hydroxy Or Metallate Patents (Class 560/70)
  • Patent number: 9012230
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: April 21, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Sehoon Kim, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Publication number: 20150025247
    Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
    Type: Application
    Filed: July 30, 2014
    Publication date: January 22, 2015
    Inventors: Liu DENG, Neil Warren BOAZ, Sabine DELAIRE
  • Publication number: 20150011629
    Abstract: Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jeanine D'Armiento, Kurt Reynertson, Edward Kennelly, Alison Wallace
  • Publication number: 20140378541
    Abstract: Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 25, 2014
    Applicants: WAYNE STATE UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, HONG KONG POLYTECHNIC UNIVERSITY
    Inventors: Tak-Hang Chan, Sreedhar Pamu, Qing Ping Dou, Di Chen
  • Patent number: 8846292
    Abstract: A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: September 30, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Dai Oguro
  • Patent number: 8841477
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: September 23, 2014
    Assignee: Brigham Young University
    Inventors: Merritt B. Andrus, Jing Liu
  • Publication number: 20140274974
    Abstract: Disclosed is a preservative or antimicrobial system, and methods for its use, that includes at least one ester of salicylic acid and glycerin or a salt thereof.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Mary Kay Inc.
    Inventors: James Swanzy, Leslie Lockhart
  • Patent number: 8802892
    Abstract: The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R?]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: August 12, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20140093960
    Abstract: The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a differentiation of an undifferentiated cell into a nervous system cell with high selectivity. In addition, the objective of the present invention is to provide use of a specific catechol derivative for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity, and a method for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity using a specific catechol derivative. The cell differentiation inducer of the present invention is characterized in comprising the catechol derivative having the specific chemical structure.
    Type: Application
    Filed: May 14, 2012
    Publication date: April 3, 2014
    Applicant: The University of Tokushima
    Inventors: Daisuke Tsuji, Kohji Itoh, Shigeki Sano, Michiyasu Nakao
  • Publication number: 20130231377
    Abstract: Disclosed are pactamycin analogs, pharmaceutical compositions including the analogs, and methods of using the analogs, such as to inhibit tumor growth or a pathogenic infection such as a bacterial or parasitic infection. The pactamycin analogs have a general formula where R1 is H, lower aliphatic, amide, acyl, or aminoacyl; R2 is —C(O)NR8R9 where R8 and R9 independently are hydrogen or lower aliphatic, or R1 and R2 together form a cyclic structure; R3 and R4 independently are hydrogen, hydroxyl, or lower aliphatic, or R2 and R3 together form a cyclic structure; R5 is hydrogen or acyl; R6 and R7 independently are hydrogen, hydroxyl, halogen, lower aliphatic, or amino.
    Type: Application
    Filed: August 2, 2011
    Publication date: September 5, 2013
    Applicants: Oregon State University
    Inventor: Taifo Mahmud
  • Publication number: 20130164228
    Abstract: Described herein are compositions for topical use comprising an antibacterially effective concentration of a gallate or gallamide compound which is a polysubstituted cycloalkyl or heterocycloalkyl wherein the substituents are selected from hydroxy, hydroxymethyl, fluoro, chloro, amino, nitro, or a moiety of formula -X-(CO)-(3,4,5-trihydroxyphenyl), wherein X is selected from O and NH, provided that the substituents comprise at least two moieties of formula -X-(CO)-(3,4,5-trihydroxyphenyl) attached to adjacent carbons in free or in orally or topically acceptable salt form, as well as methods of making and using the same.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 27, 2013
    Applicant: Colgate-Palmolive Company
    Inventors: Stanislav Jaracz, Guofeng Xu, Steven Miller, Leonora Leigh, Guillaume Picquet, Laurence Du-Thumm
  • Publication number: 20120294866
    Abstract: The present invention provides a liquid pharmaceutical formulation comprising a therapeutic protein, a surfactant and at least an antioxidant selected from the group of radical scavengers, chelating agents or chain terminators.
    Type: Application
    Filed: January 14, 2010
    Publication date: November 22, 2012
    Applicant: F. HOFFMANN-LA ROCHE AG
    Inventors: Hanns-Christian Mahler, Satya Krishna Kishore Ravuri
  • Publication number: 20120276651
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Application
    Filed: January 31, 2012
    Publication date: November 1, 2012
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sehoon KIM, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Publication number: 20120156614
    Abstract: Disclosed are a novel phenol compound comprising a compound represented by Chemical Formula 1, a compound represented by Chemical Formula 2, or a combination thereof, and a positive photosensitive resin composition including the same.
    Type: Application
    Filed: September 23, 2011
    Publication date: June 21, 2012
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CHEIL INDUSTRIES INC.
    Inventors: Ji-Young JEONG, Min-Kook CHUNG, Hyun-Yong CHO, Yong-Sik YOO, Jeong-Woo LEE, Jong-Hwa LEE, Hwan-Sung CHEON, Soo-Young KIM, Young-Ho KIM, Jae-Hyun KIM, Su-Min PARK
  • Publication number: 20120157370
    Abstract: The invention relates to the use of radical traps in detergents and cleaners in order to improve cleaning performance, in particular for dirt containing polymerizable dyes.
    Type: Application
    Filed: February 23, 2012
    Publication date: June 21, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Andreas Buhl, André Hätzelt
  • Publication number: 20120029195
    Abstract: A method for producing an alcohol compound, wherein a carboxylic acid ester compound is reduced with hydrogen in the presence of a ruthenium complex which is obtained by reacting a pyridine compound having at least one optionally substituted amino group with a ruthenium compound.
    Type: Application
    Filed: March 30, 2010
    Publication date: February 2, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yasutaka Aoyagi, Hiroshi Souda, Koji Hagiya
  • Publication number: 20120029198
    Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
    Type: Application
    Filed: December 22, 2010
    Publication date: February 2, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Liu Deng, Neil Warren Boaz
  • Publication number: 20110301236
    Abstract: A novel compound isolated from the plant Garcinia paucinervis. The compound's structure is as follows: The compound possesses a potent ability to activate caspase-3 in HeLa-C3 cells within 72 h at a low concentration of 25 ?M. The IC50 on HeLa cells for this compound was measured to be below 10 ?M, indicating a strong HeLa cell growth inhibitory effect.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 8, 2011
    Inventors: XUE-MEI GAO, Ting Yu, Kathy Qian Luo, Hong Xi Xu
  • Publication number: 20110152210
    Abstract: Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for inhibiting proteasomal activity and for treating cancer is also provided.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/McGILL UNIVERSITY, THE HONG KONG POLYTECHNIC UNIVERSITY, WAYNE STATE UNIVERSITY
    Inventors: Tak-Hang CHAN, Q. Ping DOU
  • Publication number: 20110124685
    Abstract: The invention provides novel phenolic ester local anesthetic compounds. The invention also provides pharmaceutical compositions that include such compounds as well as methods for making such compounds and compositions and methods for using such compounds and compositions to induce and/or maintain anesthesia and/or analgesia.
    Type: Application
    Filed: January 13, 2009
    Publication date: May 26, 2011
    Inventor: Thomas E. Jenkins
  • Publication number: 20110110885
    Abstract: Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds.
    Type: Application
    Filed: July 31, 2007
    Publication date: May 12, 2011
    Inventors: Jeanine D'Armiento, Kurt Reynertson, Edward Kennelly, Alison Wallace
  • Publication number: 20100330001
    Abstract: The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.
    Type: Application
    Filed: April 16, 2010
    Publication date: December 30, 2010
    Inventors: Toshihisa Kawai, Phllip P. Stashonko, Yoshiaka Hosokawa, Kazuhisa Ohara
  • Publication number: 20100179218
    Abstract: Compounds of the following formula are disclosed: Methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of treating patients by administration of the pharmaceutical compositions are disclosed.
    Type: Application
    Filed: February 5, 2010
    Publication date: July 15, 2010
    Applicant: QLT Inc.
    Inventors: WILLIAM L. MATIER, Ghanshyam Patil
  • Patent number: 7714161
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 11, 2010
    Assignee: Brigham Young University
    Inventors: Merritt B. Andrus, Jing Liu
  • Patent number: 7557177
    Abstract: Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: July 7, 2009
    Assignee: 3M Innovative Properties Company
    Inventors: Duane D. Fansler, Kevin M. Lewandowski, Babu N. Gaddam, Steven M. Heilmann, Larry R. Krepski, Stephen B. Roscoe, Michael S. Wendland
  • Publication number: 20080312458
    Abstract: The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.
    Type: Application
    Filed: June 13, 2008
    Publication date: December 18, 2008
    Applicant: ABBOTT LABORATORIES
    Inventor: Russell F. Lang
  • Patent number: 7456136
    Abstract: A linear compound and a metal salt or boron-containing metal salt thereof contains one or more carboxyl-containing phenol units or derivatives thereof and one or more on average at least C18 hydrocarbyl-substituted hydroxyaromatic units or derivatives thereof connected by one or more divalent bridging groups. A concentrate contains the linear compound or metal salt thereof and an organic diluent. A lubricating oil composition contains a minor amount of the linear compound or metal salt thereof and a major amount of a lubricating oil. Additional embodiments of the invention are processes to make the linear compound and the metal salt thereof.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: November 25, 2008
    Assignee: The Lubrizol Corporation
    Inventors: David J. Moreton, Stephen J. Cook, David Cressey
  • Publication number: 20080255382
    Abstract: The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from (2) to (6) carbon atoms and cycloalkyl of from (3) to (8) carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbon-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.
    Type: Application
    Filed: January 19, 2005
    Publication date: October 16, 2008
    Inventors: Merritt B. Andrus, Jing Liu
  • Patent number: 7294742
    Abstract: Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: November 13, 2007
    Assignee: 3M Innovative Properties Company
    Inventors: Duane D. Fansler, Kevin M. Lewandowski, Babu N. Gaddam, Steven M. Heilmann, Larry R. Krepski, Stephen B. Roscoe, Michael S. Wendland
  • Patent number: 6992217
    Abstract: Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: January 31, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Duane D. Fansler, Kevin M. Lewandowski, Babu N. Gaddam, Steven M. Heilmann, Larry R. Krepski, Stephen B. Roscoe, Michael S. Wendland
  • Patent number: 6802874
    Abstract: The invention disclosed herein relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicylic acid units. These compounds are useful as additives for lubricants and fuels. Metal salts of these compounds are useful as lubricant additives. A process for making these compounds is disclosed.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: October 12, 2004
    Assignee: The Lubrizol Corporation
    Inventors: David John Moreton, Rodney John McAtee
  • Publication number: 20040102517
    Abstract: The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.
    Type: Application
    Filed: December 30, 2003
    Publication date: May 27, 2004
    Inventors: Genhui Chen, John M Webster, Jianxiong Li, Wei Liu
  • Patent number: 6696585
    Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: February 24, 2004
    Assignees: Southwest Research Institute, Board of Regents, The University of Texas System
    Inventors: Stephen T. Wellinghoff, Hong Dixon, Henry R. Rawls, Barry K. Norling
  • Patent number: 6596038
    Abstract: The invention disclosed herein relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicylic acid units. These compounds are useful as additives for lubricants and fuels. Metal salts of these compounds are useful as lubricant additives. The process for making these compounds involves reacting phenol units and salicylic acid units in an organic solvent.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 22, 2003
    Assignee: The Lubrizol Corporation
    Inventors: David John Moreton, Rodney John McAtee
  • Patent number: 6410765
    Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: June 25, 2002
    Assignee: Southwest Research Institute
    Inventors: Stephen T. Wellinghoff, Hong Dixon, Henry R. Rawls, Barry K. Norling
  • Patent number: 6337411
    Abstract: Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of conditions whose course involves an increased activity of matrix-degrading enzymes, in particular stromelysin.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: January 8, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Cordula Hopmann, Martin Albert Knauf, Klaus-Ulrich Weithmann, Joachim Wink
  • Patent number: 6258974
    Abstract: There are disclosed amphoteric nano-sized metal oxide particles functionalized with silyl esters of a phosphonate and composites thereof with an acrylate-based monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Also disclosed are the method making such functionalized particular by reacting a metal oxide with a silyl ester of a phosphonate in the presence of a non-aqueous solvent and in an inert atmosphere and the method of making the composites wherein the functionalized particles are admixed with an acrylate-based matrix monomer, including liquid crystal monomers photopolymerizable at ambient temperature. Further disclosed is the method of dental repair wherein the composites are applied to a tooth and photopolymerized.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: July 10, 2001
    Assignee: Southwest Research Institute
    Inventors: Stephen T. Wellinghoff, Hong Dixon, Henry R. Rawls, Barry K. Norling
  • Patent number: 6124327
    Abstract: Natural products such as certain dimerized hydroxyphenylundecanes are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: September 26, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Keith C. Silverman, Russell B. Lingham, Sheo Bux Singh, Deborah L. Zink, Ana Teran
  • Patent number: 6110955
    Abstract: This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, modulating gene expression and particularly augmenting expression of a tumor suppressor gene, inducing tolerance to an antigen and treating, ameliorating or preventing protozoan infection. The methods of the invention use metabolically stabilized oxyalkylene esters.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: August 29, 2000
    Assignee: Beacon Laboratories, Inc.
    Inventors: Abraham Nudelman, Ada Rephaeli, Edward Neiss, Bernard Loev
  • Patent number: 5804567
    Abstract: A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: September 8, 1998
    Assignees: Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Mitsui Norin Co., Ltd.
    Inventors: Shu Jun Cheng, De Chang Wang, Yong Su Zhen, Hoyoku Nishino, Yukihiko Hara
  • Patent number: 5713966
    Abstract: Polyalkyl hydroxyaromatic esters having the formula: ##STR1## or a fuel-soluble salt thereof; where R.sub.1 and R.sub.2 are independently hydrogen, hydroxy, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms; R.sub.3 is a polyalkyl group having a weight average molecular weight in the range of about 450 to 5,000; and x is an integer from 0 to 10.The polyalkyl hydroxyaromatic esters of formula I are useful as fuel additives for the prevention and control of engine deposits.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: February 3, 1998
    Assignee: Chevron Chemical Company
    Inventor: Richard E. Cherpeck
  • Patent number: 5693374
    Abstract: .alpha.-resorcylic acid ester derivatives useful as electron-accepting compounds for recording materials, and highly durable recording materials containing these derivatives. The .alpha.-resorcylic acid derivative is represented by the following general formula (I), ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom or an alkyl group, and X represents a divalent group.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: December 2, 1997
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Hisao Yamada, Shunsaku Higashi, Ken Iwakura
  • Patent number: 5605929
    Abstract: Disclosed are a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: February 25, 1997
    Assignee: Arch Development Corp.
    Inventors: Shutsung Liao, Tehming Liang
  • Patent number: 5578118
    Abstract: The addition of from about 0.1 to about 1 parts by weight of a natural polyphenolic-containing vegetable extract (NPVE) per 100 parts of bitumens (particularly asphalt), coal tar, or other high boiling tars containing mixtures of aliphatic and aromatic hydrocarbons modifies the characteristics of the treated product to enhance its performance as hot-melt adhesives, coatings, sealants, roof-coatings, and road-coatings as compared to the base bitumen. The NPVEs are naturally occurring, are extracted from plants and include quebracho, chestnut, wattle and sumac. By forming the ammonia salt of NPVE (ammonium/NPVE) and adding it to a base or NPVE-modified bitumen, the characteristics of increased adhesion and resistance to stripping is observed. Surprisingly, the addition of commercially available anti-stripping agents to an ammonium/NPVE-modified bitumen results in a modified-bitumen having a stripping resistance greater than either of the additives alone.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: November 26, 1996
    Assignee: Saramco, Inc.
    Inventors: Mark W. Shuey, Robert S. Custer
  • Patent number: 5223637
    Abstract: KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: June 29, 1993
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kazutoshi Kuroda, Hiroshi Kase, Katsuhiko Ando, Isao Kawamoto, Toru Yasuzawa, Hiroshi Sano, Joji Goto, Koji Yamada
  • Patent number: 5202463
    Abstract: An improved process for preparing and purifying glycol ether esters is disclosed. An azeotroping agent is included at a sufficiently low level to allow removal of the water of reaction, but also permit removal of by-products from esterification in the low-boiling component.
    Type: Grant
    Filed: September 10, 1991
    Date of Patent: April 13, 1993
    Assignee: ARCO Chemical Technology, L.P.
    Inventor: Jude T. Ruszkay
  • Patent number: 5198571
    Abstract: A region-specific monofunctionalization of a phenolic hydroxy onto a polyphenol for the preparation of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, --CN, formyl, carboxy, alkoxy carbonyl of up to 9 carbon atoms, aralkoxy carbonyl or up to 12 carbon atoms and halogen and R' is a hydroxy protective group comprising reacting a polyphenol of the formula ##STR2## wherein R has the above definition with a base to form the corresponding dianion, reacting the latter with a trialkyl borate of the formulaB(OAlk).sub.3wherein Alk is alkyl of 1 to 6 carbon atoms to form a compound of the formula ##STR3## reacting the latter with a reagent capable of introducing a hydroxy protective group and reacting the latter with a hydrolysis agent for the oxygen-boron bond to obtain the corresponding compound of Formula I.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: March 30, 1993
    Assignee: Roussel Uclaf
    Inventors: Jean-Louis Brayer, Daniel Calvo, Francois Ottello
  • Patent number: 5171878
    Abstract: Process for the preparation of .beta.-resorcylic acid derivatives of the general formula ##STR1## in which R, R.sup.2 and R.sup.3 can be identical or different and denote a hydrogen atom or an alkyl radical and R.sup.1 and R.sup.4 can be identical or different and denote an alkyl radical, by reaction of a diketone with .beta.-ketocarboxylic acid derivatives in the presence of an alkaline earth metal compound. The derivatives are useful as fragrances, or in perfumes.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: December 15, 1992
    Assignee: Consortium for elektrochemische Industrie GmbH
    Inventor: Rolf Hirsenkorn
  • Patent number: 5155244
    Abstract: A method of solubilizing a first compound in a second medium where the first compound has a limited solubility in the second medium. In particular, the method comprises reacting the first compound with the second medium. By this reaction, a product is formed whereby an active component of the first compound is covalently incorporated into the second medium.The first compound and second medium each contain at least one reactive group which will react with a reactive group of the other. In addition, the first compound comprises at least one antioxidant which will be covalently bonded to and thus effectively solubilized in the second medium by the reaction.The second medium comprises glyceride derivatives, silicones, fluorocarbons and alkoxylates containing reactive groups such as hydroxy, amino, carboxyl, ester, or amides.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: October 13, 1992
    Assignee: Karlshamns AB
    Inventors: George H. Greene, James C. Phillips, Jerry F. Stults, Jan P. E. Tellings