Ester Function Attached Directly To A Ring Patents (Class 560/64)
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Patent number: 10913729Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body. Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.Type: GrantFiled: November 6, 2018Date of Patent: February 9, 2021Assignee: SYMRISE AGInventors: Oskar Koch, Marcus Rudolf Götz
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Patent number: 9505907Abstract: An ester composition including terephthalate compounds substituted with a non-hybrid and non-branched alkyl group, a hybrid and branched alkyl group, and a non-hybrid and branched alkyl group, respectively by 0.5 wt % to 9.5 wt %, by 14.5 wt % to 43.8 wt %, and 46.7 wt % to 85 wt % based on the total weight of the ester composition, a method of preparing the same, and a resin composition including the same are provided. The ester composition has a short absorption time with respect to the resin and short fusion time and improves the processability of the resin composition. In addition, good physical properties may be provided when manufacturing a sheet and a compound such as a cable, an interior of a car, a film, a sheet, a tube, a wallpaper, a toy, a flooring material, and the like.Type: GrantFiled: April 23, 2015Date of Patent: November 29, 2016Assignee: LG Chem, Ltd.Inventors: Hyun Kyu Kim, Mi Yeon Lee, Dong Hyun Ko, Chil Eui Hong, Gyu Il Lee
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Patent number: 9328050Abstract: This invention relates to hydrogenation processes for making hydroxymethylbenzoic acid compounds. More specifically, this invention relates to hydrogenation processes in the presence of tertiary amide solvent compounds, as well as compositions that can result from such processes. The invention thus provides processes for making hydroxymethylbenzoic acid compounds.Type: GrantFiled: December 23, 2014Date of Patent: May 3, 2016Assignee: Eastman Chemical CompanyInventors: Venkata Bharat Ram Boppana, Robert Thomas Hembre, Scott Donald Barnicki, Shane Kipley Kirk
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Patent number: 9187401Abstract: The invention relates to a process for preparing a compound represented by the formula 1 which compound may optionally be further mono- or di- substituted with halogen atoms, alkyl groups having 1 to 4 C— atoms and/or alkoxy groups having 1 to 4 C— atoms, wherein R is methyl or ethyl group, comprising the step of: contacting a corresponding compound represented by the formula 2 which compound is not further substituted or further mono- or di- substituted in corresponding positions with halogen atoms, alkyl groups having 1 to 4 C— atoms and/or alkoxy groups having a to 4 C-atoms, with an alkylating agent, wherein the alkylating agent is a compound of the formula (RO)2SO2 or RX, wherein R has the above meaning and X is halogen, in the presence of a bis-quaternary ammonium salt or a polymeric quaternary ammonium salt, in a two-phase system of an aqueous solution of a base and an organic solvent.Type: GrantFiled: October 8, 2012Date of Patent: November 17, 2015Assignee: SAUDI BASIC INDUSTRIES CORPORATIONInventors: Syed Azhar Hashmi, Flaiyh Al-Anazi
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Patent number: 9000209Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.Type: GrantFiled: June 21, 2012Date of Patent: April 7, 2015Assignee: Iowa State University Research Foundation, Inc.Inventor: George A. Kraus
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Patent number: 8962541Abstract: The present invention relates to alcohols and in particular to C4 to C15 alcohols that are used in the production of esters.Type: GrantFiled: December 3, 2009Date of Patent: February 24, 2015Assignee: ExxonMobil Chemical Patents Inc.Inventors: Allen D. Godwin, Philippe L. Buess, Raphael F. Caers, Arie Van Vliet, Eddy T. A. Van Driessche, Alfons Cuyckens
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Patent number: 8920524Abstract: Disclosed are polyisobutenyl alcohols and substituted polyisobuentyl alcohols of the formula: wherein n is an integer from 5 to 90, R is selected from the group consisting of hydrogen, haloalkyl, alkoxycarbonyl and substituted aryl wherein at least one substituent group of the substituted aryl is selected from cyano, nitro and alkoxycarbonyl.Type: GrantFiled: December 15, 2010Date of Patent: December 30, 2014Assignee: Chevron Oronite Company LLCInventors: Richard E. Cherpeck, Ruth Smocha
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Patent number: 8846292Abstract: A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.Type: GrantFiled: December 29, 2011Date of Patent: September 30, 2014Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Masatoshi Echigo, Dai Oguro
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Patent number: 8846972Abstract: The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylated salicylate derivative.Type: GrantFiled: February 26, 2010Date of Patent: September 30, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Chi B. Vu, Jean E. Bemis, Michael R. Jirousek, Jill C. Milne, Jesse J. Smith
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Publication number: 20140288324Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.Type: ApplicationFiled: June 21, 2012Publication date: September 25, 2014Inventor: George A. Kraus
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Publication number: 20140275604Abstract: The invention relates to a process for preparing a compound represented by the formula 1 which compound may optionally be further mono- or di- substituted with halogen atoms, alkyl groups having 1 to 4 C- atoms and/or alkoxy groups having 1 to 4 C- atoms, wherein R is methyl or ethyl group, comprising the step of: contacting a corresponding compound represented by the formula 2 which compound is not further substituted or further mono- or di- substituted in corresponding positions with halogen atoms, alkyl groups having 1 to 4 C- atoms and/or alkoxy groups having a to 4 C- atoms, with an alkylating agent, wherein the alkylating agent is a compound of the formula (RO)2SO2 or RX, wherein R has the above meaning and X is halogen, in the presence of a bis-quaternary ammonium salt or a polymeric quaternary ammonium salt, in a two-phase system of an aqueous solution of a base and an organic solvent.Type: ApplicationFiled: October 8, 2012Publication date: September 18, 2014Inventors: Syed Azhar Hashmi, Flaiyh Al-Anazi
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Publication number: 20140221394Abstract: The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue.Type: ApplicationFiled: January 7, 2014Publication date: August 7, 2014Applicant: Astex Therapeutic Ltd.Inventors: Martyn Frederickson, John Francis Lyons, Neil Thomas Thompson, Mladen Vinkovic, Brian John Williams, Andrew James Woodhead, Alison Jo-Anne Woolford
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Patent number: 8722846Abstract: The composition of a homopolymer of (phosphonyl) aromatic diester compound using a catalyst and a glycol is provided. Further, the composition of a copolymer of the (phosphonyl) aromatic diester compound using a catalyst, a glycol and a second diester is provided. These polymers find application as flame retardants during synthesis of various polymeric materials.Type: GrantFiled: December 8, 2011Date of Patent: May 13, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Neville Everton Drysdale, Fredrik Nederberg
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Patent number: 8633244Abstract: The invention relates to the use of esters of 2-propylheptanol with benzoic acid and/or benzoic acid derivatives in cosmetic and/or pharmaceutical preparations. The compounds are distinguished by their particularly light sensory impression.Type: GrantFiled: September 12, 2012Date of Patent: January 21, 2014Assignee: Cognis IP Management GmbHInventor: Markus Dierker
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Patent number: 8613868Abstract: The present invention relates to compounds represented by the following Formula I, In Formula I, R1 and R2 are each independently selected from hydrogen, and optionally substituted hydrocarbyl, provided that at least one of R1 and R2 is selected from optionally substituted hydrocarbyl (e.g., tertiary butyl); n is 0, 1 or 2, and each R3 is independently selected from optionally substituted hydrocarbyl; L1 is a divalent linking group, such as a bond or —C(O)O—; each L2 independently represents a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 independently represents a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t is from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; and E can be, for example, C5-C18 aryl.Type: GrantFiled: August 8, 2011Date of Patent: December 24, 2013Assignee: Transitions Optical, IncInventors: Xiao-Man Dai, Ruisong Xu, Meng He, Anil Kumar, Rachael L. Yoest, Chenguang Li
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Publication number: 20130310595Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2?): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.Type: ApplicationFiled: November 21, 2012Publication date: November 21, 2013Applicant: JAPAN TOBACCO INC.Inventor: Japan Tobacco Inc.
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Patent number: 8580480Abstract: A radiation-sensitive resin composition includes (A) a fluorine-containing compound that includes a group shown by the following formula (1), and (B) a photoacid generator. wherein RC represents a (p+1)-valent aromatic ring group, Q represents a linking group obtained by removing one hydrogen atom from a monovalent hydrophilic group, RE represents a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms, p is an integer from 1 to 5, provided that a plurality of Q and a plurality of RE may respectively be either the same or different when p is an integer from 2 to 5, and “*” indicates a bonding hand.Type: GrantFiled: July 26, 2011Date of Patent: November 12, 2013Assignee: JSR CorporationInventors: Yusuke Asano, Mitsuo Sato
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Publication number: 20130296323Abstract: This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.Type: ApplicationFiled: February 27, 2013Publication date: November 7, 2013Applicant: COYOTE PHARMACEUTICALS, INC.Inventors: Hiroaki Serizawa, Ankush B. Argade, Akash Datwani, Natalie Spencer, Yonghua Pan, Florian Ermini
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Publication number: 20130225822Abstract: The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.Type: ApplicationFiled: November 18, 2011Publication date: August 29, 2013Inventors: Qilin Zhou, Jianhua Xie, Xiaoyan Liu, Jianbo Xie, Lixin Wang
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Patent number: 8513454Abstract: The composition of a (phosphonyl) aromatic compound represented by is provided. In this composition, R1(a) and R1(b) are each independently H, CnH2n+1, phenyl or benzyl; R2(a) and R2(b) are each independently H, CnH2n+1, phenyl or benzyl with the proviso that no more than one R2(a) and no more than one R2(b) can be phenyl or benzyl; R3(a) and R3(b) are each independently CnH2n+1, phenyl or benzyl; and, n is an integer of 1-10; and p is an integer of 1-10. The disclosed composition can find utility in improving flame retardancy of polyesters, aramids and nylons.Type: GrantFiled: December 8, 2011Date of Patent: August 20, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Neville Everton Drysdale, Fredrik Nederberg
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Publication number: 20130150612Abstract: The composition of a (phosphonyl) aromatic compound represented by is provided. In this composition, R1(a) and R1(b) are each independently H, CnH2n+1, phenyl or benzyl; R2(a) and R2(b) are each independently H, CnH2n+1, phenyl or benzyl with the proviso that no more than one R2(a) and no more than one R2(b) can be phenyl or benzyl; R3(a) and R3(b) are each independently CnH2n+1, phenyl or benzyl; and, n is an integer of 1-10; and p is an integer of 1-10. The disclosed composition can find utility in improving flame retardancy of polyesters, aramids and nylons.Type: ApplicationFiled: December 8, 2011Publication date: June 13, 2013Applicant: E.I. DUPONT DE NEMOURS AND COMPANYInventors: Neville Everton Drysdale, Fredrik Nederberg
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Publication number: 20130143964Abstract: Disclosed are a sympathetic inhibitor allowing more effective inhibition of activity of a sympathetic nerve, as well as a cosmetic composition, a food, and a sundry article containing the same. Ethyl 4-methoxybenzoate is efficacious for quieting down the activity of the sympathetic nerve. The sympathetic inhibitor, the cosmetic composition, the food and the sundry article containing the same enable more effective inhibition of the activity of the sympathetic nerve.Type: ApplicationFiled: May 26, 2011Publication date: June 6, 2013Inventors: Keiko Mori, Shinichiro Haze, Yoko Gozu, Atsushi Joichi
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Patent number: 8454857Abstract: A polymerizable liquid crystal compound shown by the following formula, a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optically anisotropic article that includes the liquid crystalline polymer, are disclosed.Type: GrantFiled: June 17, 2009Date of Patent: June 4, 2013Assignee: Zeon CorporationInventors: Kei Sakamoto, Yasushi Nakano
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Publication number: 20130115653Abstract: A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.Type: ApplicationFiled: November 9, 2011Publication date: May 9, 2013Applicant: Thesis Chemistry, LLCInventors: John R. Peterson, Christopher M. Yost, Jian Wu
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Publication number: 20130115654Abstract: A method for utilizing agricultural biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from agricultural biomass for producing derivative products while minimizing waste products.Type: ApplicationFiled: November 9, 2011Publication date: May 9, 2013Applicant: Thesis Chemistry, LLCInventors: John R. Peterson, Christopher M. Yost, Jian Wu
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Publication number: 20130053566Abstract: Cationic palladium catalysts comprising diamino carbene ligands, wherein the catalysts are of the formula [Pd(X)q(LBX)t(DC)]r+[Ym-]p or [Pd(X)q(LB)n(LBX)t(DC)]2a+[V?]u[Z2?]y, wherein DC is a diamino carbene ligand, X is an anionic ligand, LBX is a combined anionic and neutral ligand, and Y, V, and Z are non-coordinating anions. The compounds are useful in catalytic reactions, including cross-coupling reactions and hydroamination reactions. In particular, the catalysts are used in the following reactions: Suzuki-Miyaura coupling, Kumada coupling, Negishi coupling, Sonogashira coupling, Hartwig-Buchwald amination, and Heck-Mizoroki coupling.Type: ApplicationFiled: April 14, 2011Publication date: February 28, 2013Inventors: Kamaluddin Abdur-Rashid, Dino Amoroso, Chi-Wing Tsang, Wenli Jia
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Publication number: 20130040926Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.Type: ApplicationFiled: July 11, 2012Publication date: February 14, 2013Inventors: Stephen CONNOLLY, Mark Richard EBDEN, Iain Alastair Stewart WALTERS, Thomas LANGER, Alan Robert STEVEN, Craig Robert STEWART, Paula Margaret TOMLIN, Andrew John WILLIAMS
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Publication number: 20130035467Abstract: A process for preparing a hybrid polyester-polyether polyol comprises contacting a carboxyl group-containing component and an epoxide, optionally in the presence of one or more of a double metal cyanide catalyst, a superacid catalyst, a metal salt of a superacid catalyst and/or a tertiary amine catalyst, under conditions such that a hybrid polyester-polyether polyol is formed. The hybrid polyester-polyether polyol offers the advantages of both ester and ether functionalities when used in a polyurethane formulation, thus enhancing physical properties. The process results in products having narrow polydispersity, a low acid number and unsaturation, and reduced byproduct formation, particularly when the double metal cyanide catalyst is employed.Type: ApplicationFiled: April 21, 2011Publication date: February 7, 2013Inventors: Pavel L. Shutov, Jorge Jimenez, Hanno R. Van der Wal, Francois M. Casati
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Patent number: 8318969Abstract: This invention provides alignment materials for liquid crystal display device of vertical alignment mode and methods for the preparation of the same, and more particularly, it provides diaminobenzene derivatives represented by the following formula 1: wherein n is an integer of 1 to 5 and R is an alkyl or alkoxy group of 3 to 5 carbon atoms, which align liquid crystal in uniform and vertical way, have not only excellent mechanical properties such as heat resistance and surface strength but also high pretilt angles of liquid crystal and in particular, can make response rate of liquid crystal fast, methods for the preparation of the same and liquid crystal alignment films using the same.Type: GrantFiled: February 9, 2007Date of Patent: November 27, 2012Assignee: Dongjin Semichem Co., Ltd.Inventors: Jin wook Choi, Eung jae Park, Jae cheol Park, Yong bae Kim
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Publication number: 20120289695Abstract: Methods of producing organic materials, and in particular methods of producing petroleum materials and organic compounds such as aromatic acids, phenols, and aliphatic poly-carboxylic acids using an oxidative hydrothermal dissolution (OHD) process are disclosed.Type: ApplicationFiled: June 4, 2012Publication date: November 15, 2012Applicant: SOUTHERN ILLINOIS UNIVERSITY CARBONDALEInventors: Kenneth B. Anderson, John C. Crelling, William W. Huggett, Derek M. Perry
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Patent number: 8293134Abstract: An optically anisotropic material having a good durability against light is provided. Further, an optical element having a good durability against light and an optical information writing/reading device employing such an element are provided. The optically anisotropic material is obtainable by polymerizing a polymerizable liquid crystal composition containing at least 5 mol % of at least one type of polymerizable compound represented by a general formula CH2?CR1—COO—K-Cy-Cy-L-OCO—CR2?CH2. A phase difference plate 4 produced by employing the optically anisotropic material has a good durability against light, and accordingly, the phase difference plate 4 can realize an optical heat device suitable for large capacity writing/reading by employing a blue laser as a light source 1.Type: GrantFiled: December 28, 2010Date of Patent: October 23, 2012Assignee: Asahi Glass Company, LimitedInventors: Satoshi Okada, Hiroshi Kumai, Makota Hasegawa
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Patent number: 8288436Abstract: The invention relates to the use of esters of 2-propylheptanol with benzoic acid and/or benzoic acid derivatives in cosmetic and/or pharmaceutical preparations. The compounds are distinguished by their particularly light sensory impression.Type: GrantFiled: April 17, 2008Date of Patent: October 16, 2012Assignee: Cognis IP Management GmbHInventor: Markus Dierker
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Publication number: 20120258249Abstract: Certain ether-esters compounds and certain ether ester coalescents are provided. Also provided are an aqueous coating composition including an aqueous polymeric dispersion and from 0.1% to 40% by weight, based on the weight of the aqueous polymeric dispersion solids, of the glycol ether-ester coalescents and a method for forming a coating from the aqueous coating composition.Type: ApplicationFiled: March 30, 2012Publication date: October 11, 2012Inventors: Linda A. ADAMSON, Michael C. BECKER, Felipe A. DONATE, David M. FASANO, Sarah E. ITTNER, Rebecca J. WACHOWICZ, Thomas R. TEPE
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Patent number: 8262932Abstract: A polymerizable liquid crystal compound represented by formula (I) is disclosed. R0 and R1 represent a hydrogen atom, or a C1-4 alkyl group, provided that at least one of R0 and R1 represent a C1-4 alkyl group; A0, A1, B0 and B1 represent a single bond, or a divalent linking group having a cyclic structure; X0, X1, Y0 and Y1 represent a single bond, —O—, —S—, —OCO—, —COO—, —OCOO—, —NR2CO—, —CONR2—, —OCONR2—, —NR2COO—, —NR2CONR2—, —C?N— or —N?C—; Q0 and Q1 a single bond or a divalent aliphatic group; Z0 and Z1 represent a hydrogen atom, cyano, halogen atom or polymerizable group; and n and m each independently represent an integer of from 0 to 2.Type: GrantFiled: March 28, 2011Date of Patent: September 11, 2012Assignee: FUJIFILM CorporationInventors: Shunya Katoh, Mitsuyoshi Ichihashi
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Publication number: 20120223270Abstract: A method comprises forming a reaction mixture comprising a terephthalate polyester, a glycol comprising 2 to 5 carbons, and an amidine organocatalyst; and heating the reaction mixture at a temperature of about 120° C. or more to depolymerize the terephthalate polyester, thereby forming a terephthalate reaction product comprising a monomeric dihydroxy terephthalate diester; wherein the terephthalate reaction product contains terephthalate oligomers in an amount less than the amount of terephthalate oligomers that would result from i) substituting the amidine organocatalyst with an equimolar amount of a guanidine catalyst and ii) depolymerizing the terephthalate polyester under otherwise identical reaction conditions.Type: ApplicationFiled: March 4, 2011Publication date: September 6, 2012Applicants: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Abdullah M. Alabdulrahman, Hamid A. Almegren, Fares D. Alsewailem, Phillip Joe Brock, Daniel Joseph Coady, Kazuki Fukushima, James Lupton Hedrick, Hans Werner Horn, Julia Elizabeth Rice
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Publication number: 20120205578Abstract: A polishing composition, comprising a compound having structure I or salts thereof: wherein R1 is selected from the group consisting of —O?Mx+ wherein x is selected from the group consisting of 1, 2, and 3, —O—R3 wherein R3 is selected from the group consisting of alkyl, allyl, and phenyl, —N(R3R4) wherein R4 is selected from the group consisting of —H, alkyl, allyl, and phenyl, and —S—R3, and wherein R2 is selected from the group consisting of —CH2—CO2—CH3, —CO—NH—R5, —CH2—CH(OH)—CH2—OH, —CH2—CH(OH)—CH2—R3, and —CH2-substituted phenyl, wherein R5 is selected from the group consisting of alkyl and substituted phenyl.Type: ApplicationFiled: November 15, 2011Publication date: August 16, 2012Inventor: John L. Lombardi
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Publication number: 20120178704Abstract: Stilbene compounds for the prevention and treatment of colon cancer or colon inflammation and methods of using same are provided.Type: ApplicationFiled: December 7, 2007Publication date: July 12, 2012Inventors: Agnes M. Rimando, Nanjoo Suh, Cassia Mizuno, Bandaru s. Reddy, Sada L. Reddy
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Patent number: 8217075Abstract: 2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a —CO—R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2 is a —CO—Y—R4 radical for which Y is —O—, —S—, —NH—, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO— in which R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2 is alkyl (2 to 4C) substituted by OH, alkType: GrantFiled: January 27, 2009Date of Patent: July 10, 2012Assignee: OroxcellInventors: Jean Pachot, Christophe Dini, Alexis Denis
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Publication number: 20120172337Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Applicant: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Publication number: 20120148690Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.Type: ApplicationFiled: December 10, 2010Publication date: June 14, 2012Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
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Patent number: 8188306Abstract: Novel compounds useful for inhibiting the 90kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.Type: GrantFiled: September 30, 2009Date of Patent: May 29, 2012Assignee: University of KansasInventors: Brian S. J. Blagg, Gang Shen
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Patent number: 8143436Abstract: Process for preparing a compound of the formula by contacting, in an organic solvent in the presence of an aqueous solution of a base, hydroxy benzoic acid with a compound of the formula RnX, wherein R is an alkyl group having 1 to 6 C-atoms and X is an acid rest group having a valence n, wherein the organic solvent is an alkyl substituted aromatic hydrocarbon and the reaction is carried out at a pH of 8-10.Type: GrantFiled: April 23, 2008Date of Patent: March 27, 2012Assignee: Saudi Basic Industries CorporationInventor: Jaiprakash Brijlal Sainani
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Publication number: 20120040984Abstract: The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method for preparing same and to the therapeutic applications thereof.Type: ApplicationFiled: January 27, 2010Publication date: February 16, 2012Applicant: SANOFIInventors: Eykmar Fett, Patrick Mougenot, Claudie Namane, Eric Nicolai, Christophe Philippo
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Patent number: 8101095Abstract: The racemic and chiral compounds expressed by common formula 1 and formula 2: wherein the lateral substituents X1, X2, X3, X4, X5, X6, X7 and X8 in the benzene rings represent independently hydrogen and fluorine atoms, bridge group Z represent independently the single bond or COO, CH2CH2, CH2O and OCH2 group, substituent Y represents CH3, or CH2F, CHF2, CF3, C2H5 group, symbols n, m, r and t are independently integers of 1 to 8; symbols p and s signify independently number of 0 to 1 and its orthoconic antiferroelectric long helical pitch mixtures prepared by the methods 1) to the racemic components selected from compounds 1 are added chiral components selected from the compound of formula 1 and/or chiral components selected from the compounds of formula 2 and/or another optically active compounds with high helical twisting power, 2) to chiral compound 1 which helical pitches increases with the temperature increase is added chiral compound 1 which helical pitch decreases with temperature increase.Type: GrantFiled: April 13, 2010Date of Patent: January 24, 2012Assignee: Wojskowa Akademia Techniczna IM. Jaroslawa DabrowskiegoInventors: Roman Slawomir Dabrowski, Krzysztof Ludwik Czuprynski, Przemyslaw Kula, Magdalena Zurowska, Wojciech Rejmer, Wiktor Piecek, Zbigniew Raszewski
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Publication number: 20110312864Abstract: The present invention relates to alcohols and in particular to C4 to C15 alcohols that are used in the production of esters.Type: ApplicationFiled: December 3, 2009Publication date: December 22, 2011Inventors: Allen D. Godwin, Philippe L. Buess, Raphael F. Caers, Arie Van Vliet, Eddy T.A. Van Driessche, Alfons Cuyckens
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Publication number: 20110280940Abstract: The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.Type: ApplicationFiled: October 13, 2009Publication date: November 17, 2011Inventors: Robert Kiss, Jacques Dubois, Jean Neve, Delphine Lamoral-Theys, Francois Dufrasne, Laurent Pottier
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Patent number: 8043789Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.Type: GrantFiled: December 17, 2008Date of Patent: October 25, 2011Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
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Patent number: 8034967Abstract: A method of producing a purified ester-substituted phenol stream is provided. The method includes a first step of obtaining from a melt transesterification reaction a byproduct stream containing a residual ester-substituted diaryl carbonate, an ester-substituted phenol, a residual melt transesterification catalyst, and a catalyst degradation product. A second step includes treating the reaction byproduct stream to separate ester-substituted phenol and catalyst degradation product from residual ester-substituted diaryl carbonate and residual melt transesterification catalyst to create a light recycle stream containing ester-substituted phenol and catalyst degradation product and a heavy recycle stream containing residual ester-substituted diaryl carbonate and residual melt transesterification catalyst. A third step includes treating the light recycle stream to reduce catalyst degradation product concentration thereby producing a purified ester-substituted phenol stream.Type: GrantFiled: November 30, 2007Date of Patent: October 11, 2011Assignee: Sabic Innnovative Plastics IP B.V.Inventors: Hatem Belfadhel, Stephan Bouwens, Martin Herke Oyevaar
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Publication number: 20110230532Abstract: A compound having the structure wherein Y is selected from the group consisting of —C(O)OR2, —C(O)NHR8, —C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.Type: ApplicationFiled: July 27, 2009Publication date: September 22, 2011Inventors: Amjad Ali, Robert K. Baker, Kathleen M. Rupprecht, Michael Man-Chu Lo, Brent Whitehead
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Publication number: 20110201716Abstract: Polyester polyol comprising the esterification product of a) from 10 to 70 mol % of a dicarboxylic acid composition comprising a1) from 50 to 100 mol % of a material based on terephthalic acid, selected from among terephthalic acid, dimethyl terephthalate, polyalkylene terephthalate and mixtures thereof, a2) from 0 to 50 mol % of phthalic acid, phthalic anhydride or isophthalic acid, a3) from 0 to 50 mol % of one or more dicarboxylic acids, b) from 2 to 30 mol % of one or more fatty acids and/or fatty acid derivatives and/or benzoic acid, c) from 10 to 70 mol % of one or more aliphatic or cycloaliphatic diols having from 2 to 18 carbon atoms or alkoxylates thereof, d) from 2 to 50 mol % of a higher-functional polyol selected from the group consisting of glycerol, alkoxylated glycerol, trimethylolpropane, alkoxylated trimethylolpropane, pentaerythritol and alkoxylated pentaerythritol, wherein at least 200 mmol, preferably at least 500 mmol and particularly preferably at least 800 mmol, of polyols d) havinType: ApplicationFiled: October 13, 2009Publication date: August 18, 2011Applicant: BASF SEInventors: Lionel Gehinger, Gunnar Kampf, Gerlinde Tischer