Nitrogen Attached Directly To The Sulfonate Sulfur By Nonionic Bonding (e.g., Sulfamic Acids, Etc.) Patents (Class 562/37)
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Patent number: 8962663Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.Type: GrantFiled: March 7, 2013Date of Patent: February 24, 2015Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of ArizonaInventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
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Patent number: 8932797Abstract: A photoacid generator compound has formula (I): G+Z???(I) wherein G has formula (II): In formula (II), X is S or I, each R0 is commonly attached to X and is independently C1-30 alkyl; polycyclic or monocyclic C3-30 cycloalkyl; polycyclic or monocyclic C6-30 aryl; or a combination comprising at least one of the foregoing groups. G has a molecular weight greater than 263.4 g/mol, or less than 263.4 g/mol. One or more R0 groups are further attached to an adjacent R0 group, a is 2 or 3, wherein when X is I, a is 2, or when X is S, a is 2 or 3. Z in formula (I) comprises the anion of a sulfonic acid, a sulfonimide, or a sulfonamide. A photoresist and coated film also includes the photoacid generator, and a method of forming an electronic device uses the photoresist.Type: GrantFiled: November 30, 2011Date of Patent: January 13, 2015Assignees: Dow Global Technologies LLC, Rohm and Haas Electronic Materials LLCInventors: James W. Thackeray, Suzanne M. Coley, James F. Cameron, Paul J. LaBeaume, Ahmad E. Madkour, Owendi Ongayi, Vipul Jain
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Publication number: 20150011790Abstract: An emulsifier for emulsion polymerization contains a compound represented by the following general formula (I).Type: ApplicationFiled: January 9, 2013Publication date: January 8, 2015Inventors: Asako Ogasawara, Masayuki Hashimoto
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Patent number: 8569348Abstract: Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.Type: GrantFiled: January 12, 2010Date of Patent: October 29, 2013Assignee: Aerpio Therapeutics Inc.Inventors: Robert Shalwitz, Kevin G. Peters
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Patent number: 8530137Abstract: The present invention provides a photoresist composition having a sulfonium salt comprising an anion represented by the formula (IA): wherein R1 and R2 independently represent a hydrogen atom, a C1-C12 aliphatic hydrocarbon group, a C3-C20 saturated cyclic hydrocarbon group, a C6-C20 aromatic hydrocarbon group or a C7-C21 aralkyl group, and the aliphatic hydrocarbon group, the saturated cyclic hydrocarbon group, the aromatic hydrocarbon group and the aralkyl group can have one or more substituents selected from the group consisting of a hydroxyl group, a cyano group, a fluorine atom, a trifluoromethyl group and a nitro group, and one or more —CH2— in the aliphatic hydrocarbon group can be replaced by —O— or —CO—, or R1 and R2 are bonded each other to form a C4-C20 nitrogen-containing ring together with the nitrogen atom to which they are bonded, an acrylic resin having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solutioType: GrantFiled: February 11, 2011Date of Patent: September 10, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Tatsuro Masuyama, Satoshi Yamaguchi
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Publication number: 20130041142Abstract: [Object] An object of the present invention is to provide a human sweet taste receptor-acting sweet taste regulating substance to a sweet taste substance by which the advantageous effects such as improvement in a taste, saving of a sweetener, reduction in calorie, low caries etc. can be obtained by applying to various foods and beverages. [Solution] The sweet taste receptor-acting sweet taste regulating substance of the present invention is identified by measurement of a physiological response by a sweet taste substance, using a cultured cell strain which is allowed to express hT1R2 and hT1R3, and a G protein ? subunit, by transferring an expression construct obtained by inserting respective cDNAs encoding the hT1R2 and the hT1R3, and the G protein ? subunit into the same plasmid, into a 293 cell in which an FRT (Flippase Recognition Target) site has been incorporated into one place in a genome DNA.Type: ApplicationFiled: September 8, 2010Publication date: February 14, 2013Inventors: Keiko Abe, Takumi Misaka, Satoshi Fujiwara
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Publication number: 20130030059Abstract: The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T11 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Type: ApplicationFiled: March 12, 2012Publication date: January 31, 2013Inventors: Xiaodong Li, Lena Staszewski, Hong Xu
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Patent number: 8232421Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.Type: GrantFiled: September 21, 2010Date of Patent: July 31, 2012Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
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Patent number: 8202731Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: GrantFiled: June 3, 2010Date of Patent: June 19, 2012Assignee: Glumetrics, Inc.Inventor: Jeff T. Suri
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Patent number: 8110333Abstract: A resist composition includes (A) a compound represented by the following formula (I): wherein each of R1 to R13 independently represents a hydrogen atom or a substituent, provided that at least one of R1 to R13 is a substituent containing an alcoholic hydroxyl group; Z represents a single bond or a divalent linking group; and X? represents an anion containing a proton acceptor functional group.Type: GrantFiled: August 1, 2008Date of Patent: February 7, 2012Assignee: Fujifilm CorporationInventors: Sou Kamimura, Yasutomo Kawanishi, Kenji Wada, Tomotaka Tsuchimura
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Publication number: 20120015841Abstract: The invention relates to novel cells and cell lines, and methods for making and using them.Type: ApplicationFiled: February 1, 2010Publication date: January 19, 2012Applicant: CHROMOCELL CORPORATIONInventors: Kambiz Shekdar, Dennis Sawchuk, Purvi Manoj Shah
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Publication number: 20110251289Abstract: The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.Type: ApplicationFiled: June 3, 2009Publication date: October 13, 2011Applicants: CSIR, AGRICULTURAL RESEARCH COUNCIL, UNIVERSITY OF PRETORIAInventors: Moira Bode, Robert Vleggaar, Paul J. Gates, R. Anitra Schultz, Dharmaral Naicker, Nel Fourie
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Publication number: 20110200935Abstract: The present invention provides a photoresist composition having a sulfonium salt comprising an anion represented by the formula (IA): wherein R1 and R2 independently represent a hydrogen atom, a C1-C12 aliphatic hydrocarbon group, a C3-C20 saturated cyclic hydrocarbon group, a C6-C20 aromatic hydrocarbon group or a C7-C21 aralkyl group, and the aliphatic hydrocarbon group, the saturated cyclic hydrocarbon group, the aromatic hydrocarbon group and the aralkyl group can have one or more substituents selected from the group consisting of a hydroxyl group, a cyano group, a fluorine atom, a trifluoromethyl group and a nitro group, and one or more —CH2— in the aliphatic hydrocarbon group can be replaced by —O— or —CO—, or R1 and R2 are bonded each other to form a C4-C20 nitrogen-containing ring together with the nitrogen atom to which they are bonded, an acrylic resin having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solutioType: ApplicationFiled: February 11, 2011Publication date: August 18, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tatsuro MASUYAMA, Satoshi YAMAGUCHI
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Publication number: 20110105543Abstract: This invention relates to novel triaryl derivatives, formula (I), a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein all of X, Y and Z represent CH; or one or two of X, Y and Z represent N; and the others of X, Y and Z represent CH; and R1, R2, R3, R4 and R5. independently of each other, represent hydrogen, halo, tri-fluoromethyl, trifluoromethoxy, cyano, hydroxyl, alkoxy, alkyl, amino or sulfamoyl; or R1 and R2, together with the phenyl ring to which they are attached form an indolyl ring or a benzo-dioxolyl ring; and R3, R4 and R5 are as defined above; and R6 represents amino or nitro, which are found to be modulators of the nicotinic acetylcholine receptors.Type: ApplicationFiled: March 9, 2009Publication date: May 5, 2011Applicant: NeuroSearch A/SInventors: Antonio Nardi, Jeppe Kejser Christensen, Dan Peters
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Publication number: 20110009640Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.Type: ApplicationFiled: September 21, 2010Publication date: January 13, 2011Applicant: BASF AKTIENGESELLSCHAFTInventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
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Publication number: 20110008261Abstract: The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures thereof is used.Type: ApplicationFiled: February 3, 2009Publication date: January 13, 2011Applicant: GE HEALTHCARE LIMITEDInventors: Mathilde H. Lerche, Magnus Karlsson, Pernille R. Jensen
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Patent number: 7824918Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: GrantFiled: August 6, 2008Date of Patent: November 2, 2010Assignee: Glumetrics, Inc.Inventor: Jeff T. Suri
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Publication number: 20100222586Abstract: The present invention relates to a process for preparing sulfuric diamides of the general formula I R1R2N—S(O)2—NH2??(I) in which R1 and R2 are each independently a primary alkyl radical having from 1 to 8 carbon atoms, a secondary alkyl radical having from 3 to 8 carbon atoms or a cycloalkyl radical having from 5 to 8 carbon atoms, or, together with the nitrogen atom, form a 5- to 8-membered, saturated nitrogen heterocycle which, as well as the nitrogen atom, may have a further heteroatom selected from O and S as a ring member, where the nitrogen heterocycle is unsubstituted or may have 1, 2, 3 or 4 alkyl groups having in each case from 1 to 4 carbon atoms as substituents.Type: ApplicationFiled: October 10, 2008Publication date: September 2, 2010Inventors: Axel Pleschke, Thomas Schmidt, Joachim Gebhardt, Sandra Loehr, Michael Keil, Jan Hendrik Wevers
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Publication number: 20100197852Abstract: The invention provides a compound which is useful in production of a fluoropolymer and easy to be removed from the produced fluoropolymer, a method of producing the compound, and a method of producing a fluoropolymer using the compound. The invention provides a compound which is represented by Rf1—CH2O—CF2—CHF—Rf2—X, wherein Rf1 represents a fluoroalkyl group containing 1 to 5 carbon atoms, Rf2 represents a fluoroalkylene group containing 1 to 3 carbon atoms, X represents —COOM or —SO3M, and M represents one of H, K, Na, and NH4.Type: ApplicationFiled: July 24, 2008Publication date: August 5, 2010Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Nobuhiko Tsuda, Akinari Sugiyama
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Publication number: 20100190753Abstract: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.Type: ApplicationFiled: August 27, 2009Publication date: July 29, 2010Applicant: BELLUS Health (International) LimitedInventors: Xianqi KONG, Walter A. Szarek, Francine Gervais
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Publication number: 20100063317Abstract: Optically active 2-sulfonyloxy-1-phenylethanol derivative of formula (II) can be prepared easily and selectively by the method of the present invention using an asymmetric reduction of an ?-sulfonyloxy acetophenone compound with a rhodium catalyst having petamethylcyclopentadienyl group and a hydrogen donor, and the compound of formula (II) obtained in the inventive method exhibits a higher e.e. (enantiomer excess) value than that of the products in the conventional methods.Type: ApplicationFiled: November 1, 2007Publication date: March 11, 2010Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Kee-In Lee, Do-Min Lee
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Patent number: 7659426Abstract: The present invention provides a pharmaceutical composition containing, as an active ingredient, a compound that specifically binds to KSRP or a functional fragment thereof, and a screening method for the compound. KSRP is a novel target protein for anticancer agents; a compound capable of regulating the expression and activity of such a protein and a pharmaceutical composition containing it are highly useful for proliferative diseases, particularly as anticancer agents. By providing the novel target protein, the mechanism behind the anticancer effect that has conventionally been unexplainable can be elucidated.Type: GrantFiled: November 30, 2004Date of Patent: February 9, 2010Assignee: Reverse Proteomics Research Institute Co., Ltd.Inventors: Akito Tanaka, Akira Yamazaki, Takeshi Tsutsumi, Tomohiro Terada, Masayuki Haramura
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SOLVENTS AND NOVEL ELECTROLYTIC COMPOSITIONS HAVING A LARGE RANGE OF STABILITY AND HIGH CONDUCTIVITY
Publication number: 20090206299Abstract: The present invention is concerned with novel polar solvents and novel electrolytic compositions comprising such solvents, and having a high range of stability, as required for applications in the field of electrochemistry. The present solvents have a highly polar amide function, and preferably combine with a salt soluble in the solvent and having an anion with a delocalized charge, and at least one polymer, to form an electrolytic composition.Type: ApplicationFiled: April 23, 2009Publication date: August 20, 2009Applicants: ACEP inc., Centre National De La Recherche Scient., Universite de MontrealInventors: Christophe MICHOT, Dany BROUILLETTE, Daniel BARIL, Jean-Yves BERGERON, Michel ARMAND -
Patent number: 7220914Abstract: Zwitterionic compounds, photovoltaic cell charge carrier layers containing such compounds, photovoltaic cells including such charge carrier layers, and related methods are disclosed.Type: GrantFiled: November 30, 2004Date of Patent: May 22, 2007Assignee: Konarka Technologies, Inc.Inventors: Kethinni G. Chittibabu, Savvas Hadjikyriacou, David Waller
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Publication number: 20040167183Abstract: Compounds of formula (I): 1Type: ApplicationFiled: August 4, 2003Publication date: August 26, 2004Applicant: The Procter & Gamble CompanyInventors: Sean Rees Klopfenstein, Matthew Brian Maier, David Robert Jones, Jeffrey Lyle Gray, Matthew Eugene Pokross, Kevin Gene Peters, Artem Gennady Evdokimov
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Patent number: 6762205Abstract: Phenyl sulfamate derivatives represented by the following formula or salts thereof have a powerful inhibitory effect on steroid sulfatase and are hence useful for the prophylaxis or treatment of diseases associated with steroids such as estrogens, such as breast cancer, corpus uteri cancer, endometrial hyperplasia, infertility, endometriosis, adenomyosis uteri, autoimmune disease, dementia or Alzheimer's disease. wherein R1 and R2 each independently represent a hydrogen atom or a lower alkyl group; R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, —OSO2NR1R2, a lower alkanoylamino group, a nitro group or a cyano group; and A represents a substituted or unsubstituted phenyl group, a group of the formula —X—NR4R5, or the like.Type: GrantFiled: January 3, 2002Date of Patent: July 13, 2004Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Naoyuki Koizumi, Makoto Okada, Shigeki Iwashita, Shigehiro Takegawa, Takayoshi Nakagawa, Hiroo Takahashi, Tomohito Fujii
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Patent number: 6657086Abstract: Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.Type: GrantFiled: August 30, 2002Date of Patent: December 2, 2003Assignee: Aventis Pharma Deutschland GmbHInventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
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Patent number: 6583172Abstract: Anticonvulsant derivatives useful in treating chronic neurodegenerative conditions are disclosed.Type: GrantFiled: March 30, 2000Date of Patent: June 24, 2003Inventor: Richard P. Shank
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Patent number: 6482860Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents.Type: GrantFiled: July 18, 1997Date of Patent: November 19, 2002Assignee: Tularik Inc.Inventors: John A. Flygare, Julio Cesar Medina, Bei Shan, David Louis Clark, Terry J. Rosen
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Publication number: 20020134124Abstract: The present invention relates to the use of diureides of dicarboxylic acids of the formula I 1Type: ApplicationFiled: December 3, 2001Publication date: September 26, 2002Inventors: Klaus Horchler von Locquenghien, Klaus Erhardt, Wolfgang Weigelt, Jurgen Dressel, Alexander Wissemeier, Frank Boerner, Gerhard Kossmehl
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Patent number: 6448435Abstract: A process that can be used for sulfonating, sulfating, or sulfamating an organic compound is disclosed. The process can comprise, consist essentially of, or consist of, contacting the organic compound with sulfur trioxide under a condition sufficient to effect the sulfonation, sulfation, or sulfamation of the organic compound. The organic compound can be an aromatic compound, alcohol, carbohydrate, amine, amide, protein, or combinations of two or more thereof. The sulfur trioxide can be present in a complex comprising an inorganic support such as zeolite, silicalite, silica, titanosilicate, borosilicate, clay, aluminophosphate, and combinations of two or more thereof.Type: GrantFiled: February 4, 2002Date of Patent: September 10, 2002Assignee: E. I. du Pont de Nemours and CompanyInventors: Stephen Ernest Jacobson, David Richard Corbin
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Patent number: 5804595Abstract: The invention provides certain amino acid conjugates of substituted 2-phenyl-N-?1-(phenyl)-2-(1-heterocycloalkyl- or heterocycloaryl-)ethyl!acetamides useful for selectively agonizing kappa opioid receptors in mammalian tissue.Type: GrantFiled: December 5, 1995Date of Patent: September 8, 1998Assignee: Regents of the University of MinnesotaInventors: Philip S. Portoghese, An-Chih Chang
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Patent number: 5731459Abstract: The invention relates to a process for removing amino acids and/or aminosulphonic acids from preferably aqueous solutions which contain these as impurities by adsorbing the amino acids on zeolites. Solutions to which the process according to the invention can be applied are produced, for example, from the industrial synthesis of oligopeptides in which the amino acids serving as starting materials are always present in solution, sometimes to a not inconsiderable residual concentration, together with the desired end product.Type: GrantFiled: August 28, 1996Date of Patent: March 24, 1998Assignee: Degussa AktiengesellschaftInventors: Stefan Stockhammer, Wiltrud Schafer-Treffenfeldt, Gunter Knaup, Karlheinz Drauz, Elfriede Sextl
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Patent number: 5686492Abstract: Described herein are disubstituted p-fluorobenzenesulfonamides, containing a CF.sub.3 group, of general formula I ##STR1## which are suitable as NMR diagnostic agents.Type: GrantFiled: June 6, 1995Date of Patent: November 11, 1997Assignee: Schering AktiengesellschaftInventors: Ulrich Niedballa, Johannes Platzek, Bernd Raduchel
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Patent number: 5587505Abstract: Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 -R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.Type: GrantFiled: July 26, 1995Date of Patent: December 24, 1996Assignee: Shionogi & Co., Ltd.Inventors: Toshiro Konoike, Yoshitaka Araki, Tetsuyoshi Hayashi, Kensuke Sakurai, Takehiko Tozyo
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Patent number: 5510510Abstract: Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein:x is --ONR.sup.1 C(O)--, --N(OR.sup.1)C(O)--, --NR.sup.1 C(O)--, --C(O)NR.sup.1 --, --NR.sup.1 S(O.sub.2)--, --C(O)O--, --OC(O)--, --C(O)--, --O--, --NR.sup.1 -- or --(S).sub.q --;Y is --CO.sub.2 R.sup.2, --SO.sub.3 R.sup.2 or --P(O) (OR.sup.2) (R.sup.3);R is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkenylene or aryl;R.sup.3 is --(O).sub.t R.sup.4 ;R.sup.1, R.sup.2 and R.sup.4 are each independently hydrogen, alkyl, aryl or aralkyl;m and n are each independently 0 or an integer from 1 to 5;p and t are each independently 0 or 1; andq is an integer from 1 to 2.Type: GrantFiled: June 28, 1994Date of Patent: April 23, 1996Assignee: Bristol-Meyers Squibb CompanyInventors: Dinesh V. Patel, Scott A. Biller
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Patent number: 5364417Abstract: A process for dyeing nylon with acid or premetallized acid dyes is provided wherein the dye bath is brought to a temperature of 160.degree.-230.degree. F. and a pH of 5.5-4.0, followed by the gradual addition of sulfamic acid to lower the pH to 3.75-2.25, thereby improving dye exhaustion.Type: GrantFiled: November 16, 1992Date of Patent: November 15, 1994Assignee: Milliken Research CorporationInventors: David E. Wenstrup, Sammy L. Roe
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Patent number: 5126481Abstract: The preparation is described of compounds of the structure ##STR1## in which the substituents have the meanings indicated in the description. The compounds, which are in part new, are used as intermediate products for dyestuffs.Type: GrantFiled: April 26, 1991Date of Patent: June 30, 1992Assignee: Bayer AktiengesellschaftInventors: Karl J. Herd, Wolfgang Harms
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Patent number: 5103046Abstract: 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared bya) reacting, an inert organic solvent, a salt of sulfamic acid, which is at least partially soluble therein, with at least approximately the equimolar amount of an acetoacetylating agent, in the presence of an amine or phosphine catalyst, and by cyclizing the acetoacetamide-N-sulfonate which is formed in this reaction, or the free sulfonic acid,b) by the action of at least approximately the equimolar amount of SO.sub.3, where appropriate in an inert inorganic or organic solvent, to give 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide, which is produced in the form of the acid in this reaction;it is possible, if desired, to obtain from the acid formc) the appropriate salts by neutralization with bases.The non-toxic salts-- in particular the potassium salt-- are valuable synthetic sweeteners.Type: GrantFiled: January 29, 1991Date of Patent: April 7, 1992Assignee: Hoechst AktiengesellschaftInventors: Karl Clauss, Adolf Linkies, Dieter Reuschling
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Patent number: 5041629Abstract: The preparation is described of compounds of the structure ##STR1## in which the substituents have the meanings indicated in the descripion. The compounds, which are in part new, are used as intermediate products for dyestuffs.Type: GrantFiled: August 21, 1989Date of Patent: August 20, 1991Assignee: Bayer AktiengesellschaftInventors: Karl J. Herd, Wolfgang Harms
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Patent number: 5026905Abstract: The present invention describes a class of dyes for use in staining cell samples and methods of making such dyes. A preferred class of dyes known as detergent dyes which possess the ability to stain cells in whole blood and are only slowly leached or lost from the stained cells over time are described. The present invention has application, for example, to blood typing for the determination of the presence of blood group antigens A, B, AB, O, and D (Rh.sub.o) and antibodies to such antigens.Type: GrantFiled: August 19, 1988Date of Patent: June 25, 1991Assignee: Syntex (U.S.A.) Inc.Inventors: Thomas L. Tarnowski, Mae W. Hu, Maureen Laney, John S. Pease, Vartan Ghazarossian
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Patent number: 4992589Abstract: Compounds of the formula (1) ##STR1## in which X denotes a sulfur atom or the group ##STR2## in which R denotes a hydrogen atom, an alkylene-C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.6 - or alkyl-C.sub.1 -C.sub.6 - group, each of which can be substituted by hydroxyl, sulfo, carboxyl or cyano groups, R.sub.1 denotes a hydrogen atom or an alkyl-C.sub.1 -C.sub.6 -group which can be substituted by --SO.sub.3 M or COOM groups (where M denotes an H, Li, Na, K or Ca atom), hydroxyl, amino, methylamino, acetylamino, alkyl-C.sub.1 -C.sub.4 -sulfonylamino, methoxy, ethoxy, .beta.-hydroxyethylsulfonyl, phenyl, monosulfophenyl, disulfophenyl, or 4-[.beta.-hydroxyethylsulfonyl]-2-sulfophenyl groups, or represents a phenyl or naphthyl group, each of which can be substituted by --SO.sub.3 M or COOM groups (where M denotes an H, Li, Na, K or Ca atom), alkyl-C.sub.1 -C.sub.4 -, alkoxy-C.sub.1 -C.sub.4 -, amino, methylamino, alkyl-C.sub.1 -C.sub.4 -sulfonylamino or acetylamino groups, and R.sub.Type: GrantFiled: August 10, 1988Date of Patent: February 12, 1991Assignee: Hoechst AktiengesellschaftInventors: Hermann Fuchs, Theodor Papenfuhs, Werner Brodt, Folker Kohlhaas
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Patent number: 4973732Abstract: Polymers, such as polysiobutylene or ethylene-propylene copolymers, are functionalized by reaction with an activated imine to yield novel polymers.Type: GrantFiled: February 9, 1987Date of Patent: November 27, 1990Assignee: Texaco Inc.Inventors: Phillip B. Valkovich, Kechia J. Chou
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Patent number: 4973733Abstract: Polymers, such as polyisobutylene or ethylene-propylene copolymers, are functionalized by reaction with an activated imine to yield novel polymers.Type: GrantFiled: February 9, 1987Date of Patent: November 27, 1990Assignee: Texaco Inc.Inventors: Phillip B. Valkovich, Kechia J. Chou
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Patent number: 4895977Abstract: The removal of oxidizable organic impurities which include alkylthiolsulfonate from alkanesulfonic acids by treatment with an ozone containing gas is disclosed. The treated products have improved color and odor and exhibit improved long-term color stability.Type: GrantFiled: December 12, 1988Date of Patent: January 23, 1990Assignee: Pennwalt CorporationInventor: Martin Nosowitz
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Patent number: 4328202Abstract: Ionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --CH.sub.2 NH.multidot.Acyl or --CH.sub.2 OH; Y is --NR.sub.3 R.sub.4, --NH.multidot.Acyl or OR.sub.5 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 can be identical or different, and each is hydrogen, C.sub.1-6 - alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, R.sub.5 is C.sub.1-6 alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, and Acyl, which can be the same or different in X and Y, is C.sub.2-6 -alkanoyl or C.sub.2-6 -alkanoyl substituted by 1-4 OH groups and/or by one C.sub.1-3 -alkoxy group, or a physiologically compatible salt thereof with an inorganic or organic base, have valuable properties as X-ray contrast agents.Type: GrantFiled: January 9, 1981Date of Patent: May 4, 1982Assignee: Schering, A.G.Inventors: Heinz Gries, Heinrich Pfeiffer, Ulrich Speck, Wolfgang Muetzel