Carboxyl, Or Salt Thereof, In Side Chain Having Sulfur Bonded Directly To A Ring Patents (Class 562/431)
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Patent number: 4535176Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.Type: GrantFiled: May 29, 1984Date of Patent: August 13, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Sesha I. Natarajan, Eric M. Gordon
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Patent number: 4511729Abstract: Nitrophenoxy- or nitrophenylthiobenzeneacetic acid esters are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.Type: GrantFiled: March 10, 1983Date of Patent: April 16, 1985Assignee: Ethyl CorporationInventors: G. Patrick Stahly, Barbara C. Stahly
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Patent number: 4497959Abstract: Substituted succinic anhydride or succinate stabilizers of the formula I or II ##STR1## where R.sub.1 and R.sub.2 are independently alkyl, cycloalkyl, phenyl or aralkyl, R.sub.3 is hydrogen or methyl, R.sub.4 is hydrogen, lower alkyl or phenyl, R.sub.5 is hydrogen, alkyl, alkylthio, arylthio or the structure ##STR2## and R.sub.6 and R.sub.7 are independently hydrogen, alkyl; aryl or substituted aryl are useful as stabilizers for polymeric substrates, particularly polyolefins and rubber.Type: GrantFiled: February 3, 1983Date of Patent: February 5, 1985Assignee: Ciba-Geigy CorporationInventors: John D. Spivack, Stephen D. Pastor
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Patent number: 4492799Abstract: Novel halo-4-alkenoic acid compounds which are useful intermediates for the synthesis of insecticides and miticides.Type: GrantFiled: July 2, 1979Date of Patent: January 8, 1985Assignee: Union Carbide CorporationInventor: Thomas N. Wheeler
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Patent number: 4481148Abstract: Hydroxyl-containing liquid polymers having an aliphatic polymeric backbone and sulfide linkages near the terminal portions of the polymer molecule are prepared by polymerizing (1) at least one of selected vinylidene monomers having at least one terminal CH.sub.2 .dbd.C< group per monomer molecule, together with (2) at least one hydroxyl-containing disulfide in the presence of (3) ultraviolet radiation.Type: GrantFiled: March 16, 1981Date of Patent: November 6, 1984Assignee: The B. F. Goodrich CompanyInventor: Changkiu K. Riew
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Patent number: 4461911Abstract: Process for the preparation of S-arylthioglycolic acids of the formula ##STR1## in which A designates a benzene ring, which can be substituted by 1, 2, 3, 4 or 5 substituents from the series halogen, nitro, hydroxyl, mercapto, trifluoromethyl, alkyl, aryl, alkoxy, aryloxy, acylamino, alkylamino, arylamino, alkylmercapto, arylmercapto, cyano, carboxyl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl or optionally substituted aminocarbonyl, or represents a benzene ring, which optionally carries 1 or 2 of the previously mentioned substituents, to which a carbocyclic or heterocyclic aromatic ring is attached, characterized in that aryldiazonium salts of the formula ##STR2## in which A has the meanings given for the formula (I) andX designates the radical of an acid capable of forming a salt with the diazonium cation,are reacted with thioglycolic acid in an aqueous acid medium in the presence of Cu(I) or Cu(II) salts and the reaction mixture is worked up to compounds of the formula (I) or their salts.Type: GrantFiled: May 26, 1982Date of Patent: July 24, 1984Assignee: Bayer AktiengesellschaftInventors: Detlef-Ingo Schutze, Anton Adams
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Patent number: 4456766Abstract: The subject matter of the invention is a process for the production of N-acetyl-2,3-dehydroaminocarboxylic acid esters by reaction of the corresponding 2-azido-carboxylic acid esters with a mixture of one part by volume of acetic anhydride and 1.5 to 5 parts by volume of acetic acid in the presence of rhenium VII sulfide and/or oxide and at a temperature between 50.degree. and 150.degree. C., in a given case, in the simultaneous presence of dry hydrogen chloride.Type: GrantFiled: September 16, 1982Date of Patent: June 26, 1984Assignee: Degussa AktiengesellschaftInventors: Franz Effenberger, Thomas Beisswenger
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Patent number: 4425360Abstract: The present invention provides pyruvic acid oximes of the general formula: ##STR1## wherein R is a hydrogen atom, a C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, cinnamyloxy, phenylamino, phenyl-N-alkylamino or phenylthio radical or an aryl or aryloxy radical, the aryl moiety of which can be substituted one or more times by C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen, hydroxyl, trifluoromethyl, amino, acetylamino, nitrile, nitro or methylenedioxy, A is a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon chain containing up to 10 carbon atoms, which can be substituted one or more times by halogen or hydroxyl, and R.sub.1 is a C.sub.1 -C.sub.8 alkyl radical, which can be substituted one or more times by halogen, hydroxyl, nitrile, phenyl or carboxyl, or is a nitrile or formyl group, with the proviso that when R--A-- is a methyl or ethyl radical, R.sub.1 is not a methyl radical or a nitrile group and when R--A-- is a benzyl radical, R.sub.Type: GrantFiled: September 8, 1981Date of Patent: January 10, 1984Assignee: Boehringer Mannheim GmbHInventors: Hans P. Wolff, Ruth Heerdt, Manfred Hubner, deceased, Hans Kuhnle, Felix H. Schmidt
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Patent number: 4406902Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclo-propanecarboxamido)-.omega.-pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs).Type: GrantFiled: July 23, 1981Date of Patent: September 27, 1983Assignee: Merck & Co., Inc.Inventors: Wallace T. Ashton, Louis Barash, Jeannette E. Brown, Donald W. Graham
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Patent number: 4389416Abstract: Described are compounds of the formula ##STR1## wherein R is hydrogen, loweralkyl, aminomethyl or halo; R.sub.1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or aminomethyl; A is oxygen, CH.sub.2, Sulfur or a single bond; X is oxygen, CH.sub.2, sulfur or sulfoxide; and Y is hydrogen, loweralkyl or halo and may be the same or different, and pharmaceutically acceptable salts thereof.The compounds are effective as diuretic agents.Type: GrantFiled: October 9, 1981Date of Patent: June 21, 1983Assignee: Abbott LaboratoriesInventor: Jacob J. Plattner
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Patent number: 4386954Abstract: This invention is directed to diphenyl ethers having in the 3' position a radical of the formula: ##STR1## The products are prepared by reacting a 3'-halocarbonyl compound with an appropriately substituted oxime. These compounds and their agronomically acceptable salts and compositions containing these compounds as active ingredients are selective herbicides.Type: GrantFiled: August 17, 1981Date of Patent: June 7, 1983Assignee: Rohm and Haas CompanyInventors: John W. Ashmore, Ted T. Fujimoto
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Patent number: 4386031Abstract: The present invention refers to N-Benzoyl-.omega.Type: GrantFiled: November 6, 1981Date of Patent: May 31, 1983Assignee: A. Nattermann & Cie GmbHInventors: Gerd Hilboll, Hans-Heiner Lautenschlager, Brigitte Stoll, Manfred Probst
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Patent number: 4360688Abstract: Novel compounds are disclosed of the classes: ##STR1## wherein the subscript n is an integer from 3-5, inclusive, R.sub.1 is hydrogen or R.sub.2 ; R.sub.2 and R.sub.3 consist essentially of C.sub.1 -C.sub.6 alkyl and R.sub.2 may be the same as or different from R.sub.3, and wherein Aryl consists essentially of phenyl and phenyl substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, and trifluoromethyl;(b) derivatives of furan having the formula ##STR2## wherein R.sub.4 consists essentially of hydrogen and C.sub.1 -C.sub.6 alkyl, and W is either carbonyl or carbinol; and(c) cyclopentenonyl compounds having the formulas ##STR3## wherein R.sub.5 consists essentially of hydrogen and C.sub.1 -C.sub.6 alkyl, P.sub.1 is hydrogen or a protective group, Y is either ##STR4## A new process is disclosed for preparing 1-(methyl)-16,16-(dimethyl)-11-alpha-15-alpha-dihydroxy-9-oxo-2,13,trans, trans-prostadienoate, and congeners thereof, including racemic mixtures.Type: GrantFiled: May 21, 1981Date of Patent: November 23, 1982Assignee: American Cyanamid CompanyInventor: Middleton B. Floyd, Jr.
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Patent number: 4351950Abstract: Novel substituted arylene compounds and methods for their preparation and use are disclosed. These new compounds are useful as anti-arteriosclerotic agents.Type: GrantFiled: January 2, 1980Date of Patent: September 28, 1982Assignee: Warner-Lambert CompanyInventor: Ila Sircar
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Patent number: 4347379Abstract: Numerous alpha-carboxylic acids are prepared in a liquid medium by the reaction of an organic compound having at least one reactive hydroxyl or thiol group, with a monoketone, and a haloform, in the presence of a phase transfer catalyst and an alkali metal hydroxide. The term "alpha-alkoxycarboxylic acids" includes alpha-phenoxycarboxylic acids, alpha-thioalkoxycarboxylic acids and alpha-thiophenoxycarboxylic acids. Specific substituents on the beta carbon atom of an alpha-alkoxycarboxylic (or "2-alkoxycarboxylic") acid reaction product formed in this novel synthesis, are introduced by appropriate choice of the ketone reactant; alkoxy and phenoxy substituents on the alpha carbon atom of a 2-alkoxycarboxylic acid are introduced by appropriate choice of the organic compound having a hydroxyl or thiol group. De-alkoxylation of the 2-alkoxycarboxylic acid yields alpha-beta monoolefinically unsaturated carboxylic acids which are necessarily alpha substituted, and may also be beta-substituted.Type: GrantFiled: March 10, 1980Date of Patent: August 31, 1982Assignee: The B. F. Goodrich CompanyInventor: John T. Lai
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Patent number: 4342694Abstract: Processes for producing a (1.alpha., 4.alpha., 5.alpha.)-6,6-dimethyl-4-halo-substituted-methyl-3-oxabicyclo[3.1.0]hexan- 2-one and its novel intermediates from known and inexpensive starting materials are described and exemplified. The halomethyl bicyclic lactone is a useful intermediate for the preparation of insecticidal cis-3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropanecarboxylates or cis-3-(2-halo-2-trihalomethylethenyl)-2,2-dimethylcyclopropanecarboxylates .Type: GrantFiled: June 23, 1980Date of Patent: August 3, 1982Assignee: FMC CorporationInventors: Kiyoshi Kondo, Toshiyuki Takashima, Minoru Suda
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Patent number: 4330677Abstract: The invention relates to polyethers having an an average molecule weight of 3000 to 5000 and having a propylene oxide proportion of 60 to 80% and an ethylene oxide proportion of 20 to 40%. Also included in the invention are compositions containing said polyethers and methods for the use of said polyethers and compositions, particularly for their anti-lipidaemic effect.Type: GrantFiled: October 31, 1979Date of Patent: May 18, 1982Assignee: Bayer AktiengesellschaftInventors: Siegfried Linke, Mithat Mardin, Hans P. Krause, Rudiger Sitt
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Patent number: 4323691Abstract: Described are compounds of the formula ##STR1## wherein ##STR2## wherein Z is hydrogen or loweralkyl, R.sub.5 and R.sub.6 may be the same or different and are hydrogen, loweralkyl or together are alkylene of 4 or 5 carbon atoms,R.sub.2 is hydrogen, halo, haloloweralkyl, loweralkyl, loweralkoxy, loweralkylthio or ##STR3## wherein R.sub.5 and R.sub.6 are previously defined, R.sub.3 is hydroxy, alkoxy, branched alkoxy, adamantyloxy, morpholino, amino or amino substituted by loweralkyl or alkylene of 4 or 5 carbon atoms,R.sub.4 is hydrogen or loweralkyl, andX.sub.1 and X.sub.2 are hydrogen, loweralkyl, halo or when substituted on adjacent carbon atoms of the benzene ring form a 1,3-butadienylene linkage, Y is oxygen or sulfur, and pharmaceutically acceptable salts thereof. The compounds are effective as diuretic agents in increasing urinary excretion.Type: GrantFiled: December 1, 1980Date of Patent: April 6, 1982Assignee: Abbott LaboratoriesInventors: Carroll W. Ours, Cheuk M. Lee
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Patent number: 4322439Abstract: The invention relates to .omega.-[2-(N-lower alkyl-benzamido)-phenyl]-alkanoic acids, their use and preparation, and medicaments containing them.Type: GrantFiled: September 21, 1979Date of Patent: March 30, 1982Assignee: BYK Gulden Lomberg Chemische Fabrik GmbHInventors: Kurt Klemm, Uwe Kruger, Erich Rapp, Horst Wolf, Ekkehard Kraas
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Patent number: 4301186Abstract: This invention relates to new ammonium salts of .alpha.-ketocarboxylic acids, to their use for the production of amines in situ by photochemical decomposition and to photochemically hardenable coating compositions containing these ammonium salts.Type: GrantFiled: June 28, 1979Date of Patent: November 17, 1981Assignee: Bayer AktiengesellschaftInventors: Wolfram Mayer, Hans Rudolph, Eckhard De Cleur, Manfred Schonfelder
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Patent number: 4296128Abstract: New carboxylic acid hydrazides of the formula ##STR1## in which R represents an optionally esterified carboxy group,and salts of the compound of the formula I, in which R represents carboxy, possess antithrombotic properties and can be used as medicinal active substances in pharmaceutical preparations.Type: GrantFiled: May 7, 1980Date of Patent: October 20, 1981Assignee: Ciba-Geigy CorporationInventors: Alfred Sallmann, Richard Goschke
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Patent number: 4266074Abstract: Substituted acetate compounds represented by the formula ##STR1## which are useful as pesticides and pesticidal composition containing the substituted acetate compounds as active ingredients, as well as processes for preparing the compounds and the compositions are disclosed.Type: GrantFiled: July 16, 1975Date of Patent: May 5, 1981Assignee: Sumitomo Chemical Company LimitedInventors: Keimei Fujimoto, Nobuo Ohno, Yoshitoshi Okuno, Toshio Mizutani, Isao Ohno, Masachika Hirano, Nobushige Itaya, Takashi Matsuo
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Patent number: 4261924Abstract: New 4-nitro-2-trichloromethylphenylsulfenamides having a fungicidal and bactericidal action, processes for their manufacture, fungicides containing these compounds as active ingredients, and a process for combating fungi with these compounds.Type: GrantFiled: September 25, 1979Date of Patent: April 14, 1981Assignee: BASF AktiengesellschaftInventors: Helmut Hagen, Ernst-Heinrich Pommer, Wolfgang Reuther, Hans Ziegler
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Patent number: 4235780Abstract: Processes for producing a (1.alpha., 4.alpha., 5.alpha.)-6,6-dimethyl-4-halo-substituted-methyl-3-oxabicyclo[3.1.0]hexan- 2-one and its novel intermediates from known and inexpensive starting materials are described and exemplified.Type: GrantFiled: November 1, 1979Date of Patent: November 25, 1980Assignee: FMC CorporationInventors: Kiyoshi Kondo, Toshiyuki Takashima, Minoru Suda
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Patent number: 4233054Abstract: New phenoxy-alkanecarboxylic acid derivatives which have a herbicidal action and which are effective in regulating plant growth are described. They correspond to the formula ##STR1## in which A is the cyano group, a carboxylic acid, a salt, ester, thioester or amide thereof,Q is a mono- to trisubstituted phenyl or pyrid-2-yl radical,R.sub.3 is hydrogen, halogen, cyano, nitro, alkyl or carbamoyl,R.sub.4 is alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, phenyl or benzyl, andX, Y and Z are each oxygen or sulfur.They can be used as selective herbicides in cereal and rice crops, or for reducing the vegetative growth, for example in soya-bean crops, and also for defoliation and desiccation in cotton or potato crops shortly before the harvesting thereof.Type: GrantFiled: March 12, 1979Date of Patent: November 11, 1980Assignee: Ciba-Geigy CorporationInventors: Henry Szczepanski, Otto Rohr, Georg Pissiotas, Beat Bohner, Hermann Rempfler
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Patent number: 4223155Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is an optionally halo-substituted hydrocarbyl group, and X is --C(O)Cl, --C(O)Br or C(O)OR in which R is H, a salt-forming cation, an alkyl group or the residue of a pyrethroid alcohol are new pesticides or intermediates therefore. The compounds are prepared using a multi-step synthesis starting from the neutral terpene, 3-carene.Type: GrantFiled: July 26, 1979Date of Patent: September 16, 1980Assignee: Shell Oil CompanyInventor: Steven A. Roman
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Patent number: 4199597Abstract: Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with an alkyl ester of a bromoalkanoic acid, followed by hydrolysis to the free acid.Type: GrantFiled: May 4, 1979Date of Patent: April 22, 1980Assignee: Schering CorporationInventors: Bernard R. Neustadt, Elijah H. Gold
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Patent number: 4198527Abstract: Novel esters of ether and thioether substituted cyclopropanecarboxylic acids, synthesis thereof, and intermediates therefor, such esters being useful as pesticides.Type: GrantFiled: September 15, 1978Date of Patent: April 15, 1980Assignee: Zoecon CorporationInventor: Clive A. Henrick
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Patent number: 4175201Abstract: This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans--CH.dbd.CH, C.tbd.C; or CH.sub.2 --CH.sub.2 ;M is H or lower alkyl;n is an integer of from 2 to 5;X is alkyl;W is H or OR, wherein R is H, acyl, or alkyl;each Y is H, OH or alkoxy;and to novel intermediates and processes useful in the production thereof.Type: GrantFiled: April 18, 1977Date of Patent: November 20, 1979Assignee: University of ChicagoInventor: Josef Fried
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Patent number: 4172211Abstract: A process for preparing thioethers of mercaptocarboxylic acids by contacting glycolic acid or bromoacetic acid and a mercaptan in the presence of aqueous hydrogen bromide.Type: GrantFiled: March 31, 1978Date of Patent: October 23, 1979Assignee: Chevron Research CompanyInventor: Shigeto Suzuki
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Patent number: 4168385Abstract: This invention discloses .alpha.-aryloxy or .alpha.-arylthio para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.Type: GrantFiled: February 17, 1977Date of Patent: September 18, 1979Assignee: American Cyanamid CompanyInventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
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Patent number: 4165334Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each straight chain, branched chain or cyclic alkyl, alkenyl, aryl, aralkyl or alkaryl moieties having from 1-30 carbon atoms; R.sub.3 is a C.sub.2 -C.sub.8 alkylene, alkenylene, arylene or alkarylene moiety; R.sub.4 is a C.sub.1 -C.sub.8 alkylene, alkenylene, arylene or alkarylene moiety; A is a water-solubilizing anionic moiety; and n is from 1 to about 100 are useful as surfactants. Compounds wherein groups R.sub.1, R.sub.2 and R.sub.3 and integer n are selectively chosen provide good clay soil detergency performance even in the absence of builders. The compounds are usefully combined with other organic surfactants to provide detergent compositions having good clay and oily soil removal performance.Type: GrantFiled: June 7, 1977Date of Patent: August 21, 1979Assignee: The Procter & Gamble CompanyInventors: Eugene P. Gosselink, James M. Richmond, George E. Wentler
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Patent number: 4163060Abstract: Novel substituted aromatic aliphatic amino carboxylic acids containing a tertiary nitrogen atom such as 3-[N-ethyl-[1-methyl-2-(4-methoxyphenyl)] ethylamino] -1-propane carboxylic acid ethyl ester or 7-[N-ethyl-[1-methyl-2-(4-methoxyphenyl)] ethylamino] -1-heptane carboxylic acid ethyl ester have been found to be useful spasmolytic agents.Type: GrantFiled: January 17, 1977Date of Patent: July 31, 1979Assignee: U.S. Philips CorporationInventors: Jan Hartog, Johannes M. A. Zwagemakers
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Patent number: 4156011Abstract: The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2,Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.Type: GrantFiled: April 5, 1977Date of Patent: May 22, 1979Assignee: Societe Anonyme dite: Laboratoire L. LafonInventors: Victor Lafon, Louis Lafon
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Patent number: 4153803Abstract: Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.Type: GrantFiled: March 1, 1977Date of Patent: May 8, 1979Assignee: Siegfried AktiengesellschaftInventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
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Patent number: 4134753Abstract: Compounds of the formula ##STR1## exhibit, in the pre-emergence process and in the post-emergence process, a good herbicidal action against a number of dicotyledonous weeds, they are well tolerated in monocotyledonous crops, such as wheat, barley, rice, sorghum and maize, and are also selectively active in some dicotyledonous crops such as soy beans, groundnuts and the like.Type: GrantFiled: July 18, 1977Date of Patent: January 16, 1979Assignee: Hoechst AktiengesellschaftInventors: Gerhard Horlein, Hubert Schonowsky, Hermann Bieringer, Peter Langeluddeke
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Patent number: 4133814Abstract: Derivatives of 2-phenyl-3-aroylbenzothiophenes and 2-phenyl-3-aroylbenzothiophene-1-oxides are useful as antifertility agents. Certain of these compounds also are useful in suppressing the growth of mammary tumors.Type: GrantFiled: September 17, 1976Date of Patent: January 9, 1979Assignee: Eli Lilly and CompanyInventors: C. David Jones, Tulio Suarez
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Patent number: 4123611Abstract: 6-Aminoacylamidopenicillanic acid or 7-amino-acylamidocephalosporanic acids are produced in high yields by acylating 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an amino acid, or a functional equivalent thereof, having its amino group protected with N,N-disubstituted .beta.-keto acid amide, and then removing the protecting group from the resulting protected 6-aminoacylamidopenicillanic acid or protected 7-aminoacylamidocephalosporanic acid by hydrolysis.Type: GrantFiled: January 6, 1975Date of Patent: October 31, 1978Assignee: President of Osaka UniversityInventors: Toshiyasu Ishimaru, Yasutsugu Shimonishi, Hisayuki Sakurai, Minoru Hatanaka