Plural Rings Patents (Class 562/435)
  • Patent number: 4695648
    Abstract: A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or substituted or unsubstituted phenyl;R.sub.4, R.sub.5, and R.sub.6 are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R.sub.4 to R.sub.6 being hydrogen;R.sub.7 to R.sub.11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R.sub.8 and R.sub.10 may in addition be carboxy; at least two of R.sub.7 to R.sub.11 always being hydrogen; and--A-- is --CO--, --CH.sub.2 --CO--, --CH.dbd.CH--, --CH.dbd.CH--CO-- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group.The invention comprises also lactones of those compounds in which R.sub.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: September 22, 1987
    Assignee: Pharmacia AB
    Inventors: Karl H. Agback, Tamara Agback, Alf S. Nygren
  • Patent number: 4689432
    Abstract: The present invention discloses a group of calcium chelating compounds which have a descreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca.sup.2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical prcursors of the related 2-nitrosobenzophenones.The present invention also discloses a novel method for preparing 1-hydroxy- or 1-alkoxy-1-(2-nitroaryl)-1-aryl methanes. Methanes of this type are critical to the preparation of, or actually constitute, the photolabile Ca.sup.2+ chelating compounds disclosed and claimed herein.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: August 25, 1987
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Grzegorz Grynkiewicz, Akwasi Minta
  • Patent number: 4663465
    Abstract: 2,2-Dimethyl-3-arylcyclopropanecarboxylic acids and esters, suitable as insecticide intermediates, of the formula ##STR1## in which Ar is naphthyl or substituted furyl, thienyl or phenyl, andR.sup.1 is hydrogen or alkyl, are produced by subjecting ##STR2## to radical polymerization to produce ##STR3## reacting that with chlorine or bromine to produce ##STR4## and reacting that with an alkali metal or alkaline earth metal hydroxide or carbonate. Various intermediates II and III are new.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: May 5, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhard Lantzsch, Dieter Arlt, Manfred Jautelat
  • Patent number: 4657580
    Abstract: This invention relates to certain herbicidally active substituted diphenyl ether oxime derivatives, herbicidal compositions of the same and the use thereof for preemergence and postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: April 14, 1987
    Assignee: PPG Industries, Inc.
    Inventor: Dennis K. Krass
  • Patent number: 4649156
    Abstract: The present invention provides a novel 6-nitroprostaglandin derivatives of the formula (I) ##STR1## wherein A, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in claim 1.The 6-nitroprostaglandin derivatives is useful as medicines because of its excellent pharmacological activities including platelet aggregation inhibiting activity, blood pressure lowering activity and anti-ulcerous activity, and useful as intermediate for other pharmaceutically active compounds such as 6-oxoprostaglandin derivatives, prostaglandin E.sub.1 derivatives, etc.
    Type: Grant
    Filed: July 19, 1985
    Date of Patent: March 10, 1987
    Assignee: Teijin Limited
    Inventors: Toshio Tanaka, Atsuo Hazato, Seizi Kurozumi
  • Patent number: 4638078
    Abstract: The invention is a compound which comprises an amido alkenoic acid or a water-soluble salt thereof and and arylcyclobutene moiety, wherein the cyclobutene moiety is fused to the aryl radical, and wherein the amide nitrogen is connected to the aryl radical of the arylcyclobutenyl moiety by a direct bond or a bridging member.
    Type: Grant
    Filed: April 25, 1985
    Date of Patent: January 20, 1987
    Assignee: The Dow Chemical Company
    Inventor: Robert A. Kirchhoff
  • Patent number: 4634777
    Abstract: Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond,R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, andR.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen,and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: January 6, 1987
    Assignee: Sawai Pharmaceutical Co., Ltd.
    Inventors: Toshio Satoh, Hitoshi Matsumoto, Hisao Kakegawa, Yoshiko Kato, Juichi Riku, Junji Yoshinaga, Yoshifumi Kanamoto
  • Patent number: 4607116
    Abstract: Provided is a process for preparing a diaryl or a mixture of diaryls represented by any or a combination of the following formulae (II), (III) and (V), characterized in that a diaryliodonium salt represented by the following formula (I) is reacted in a solvent in the presence of a transition metal catalyst and a reducing metal at a temperature in the range of room temperature to 100.degree. C.:[Ar.sub.1 -I.sup..sym. -Ar.sub.2 ]X.sup..crclbar. (I)Ar.sub.1 -Ar.sub.1 (II)Ar.sub.1 -Ar.sub.2 (III)Ar.sub.2 -Ar.sub.2 (IV)wherein Ar.sub.1 and Ar.sub.2, which may be alike or different, are each an aryl group which may have a substituent group or groups and X.sup..crclbar. is a counter ion which is inert to said reaction.
    Type: Grant
    Filed: March 8, 1984
    Date of Patent: August 19, 1986
    Assignee: Nippon Petrochemicals Company Limited
    Inventors: Yasuo Yamazaki, Takehiko Suzuki, Masaharu Uchiyama
  • Patent number: 4605759
    Abstract: In the production of a .beta.-phenylserine by reacting glycine with a benzaldehyde in the presence of an alkali and treating the product with an acid, a novel process which comprises carrying out the reaction in a mixed solvent composed of water and a hydrophobic organic solvent. The presence of a phase transfer catalyst or a surface-active agent in this reaction system promotes the reaction and the .beta.-phenylserine can be obtained in a high yield.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: August 12, 1986
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Ryuichi Mita, Toshio Katoh, Chojiro Higuchi, Akihiro Yamaguchi
  • Patent number: 4605758
    Abstract: Pharmaceutically useful optically active .alpha.-arylalkanoic acids or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting an aryl magnesium Grignard reagent with an optically active .alpha.-substituted acyl halide to form the optically active aryl .alpha.-substituted alkyl ketone, which is ketalized and rearranged to the desired optically active .alpha.-arylalkanoic acid or the corresponding ester, ortho ester or amide. In an alternate embodiment, the aryl .alpha.-substituted alkyl ketone is reduced to the corresponding alkanol, which is rearranged to the .alpha.-arylalkanal. The alkanal so produced is converted to the desired optically active .alpha.-arylalkanoic acid by conventional methods.
    Type: Grant
    Filed: April 23, 1984
    Date of Patent: August 12, 1986
    Assignee: Syntex Pharmaceuticals International Ltd.
    Inventor: George C. Schloemer
  • Patent number: 4603222
    Abstract: Diphenyl ethers of the formula ##STR1## wherein m is 1-3, n is 1 or 2, R is hydrogen, carboxy, carboxylate salt or ester, formyl oxime, cyano, alkyl, alkoxy, chloro, bromo, or N, N-dialkyl amino, are prepared by reacting a chloro-fluoro-benzotrifluoride of the formula ##STR2## wherein m and n are as defined above with a nitro-phenoxide of the formula ##STR3## where R is defined above, and M is a cation of an alkali metal or an alkaline earth metal.
    Type: Grant
    Filed: August 30, 1984
    Date of Patent: July 29, 1986
    Assignee: Occidental Chemical Corporation
    Inventors: David Y. Tang, Byron R. Cotter, Frederick J. Goetz
  • Patent number: 4598077
    Abstract: Amidine derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R.sub.1 and R.sub.2 together with an intermediary carbon atom and/or hetero atom may form a ring; X represents ##STR2## (wherein R.sub.8 represents a hydrogen atom, a lower alkyl group, or --CH.sub.2 COOR.sub.9, where R.sub.9 represents a hydrogen atom or a lower alkyl group; Z represents a single bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, or --CH.dbd.CH--); R.sub.3 represents a hydrogen or chlorine atom, methoxy group, nitro group, or amino group; Y represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O--, or --OCH.sub.2 --; R.sub.4 represents a hydrogen atom, methoxy group, benzoyl group, nitro group, or amino group; and R.sub.5, R.sub.6 and R.sub.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: July 1, 1986
    Assignee: Torii & Co. Ltd.
    Inventors: Setsuro Fujii, Takuo Sato, Hiroyuki Kawamura, Takashi Yaegashi, Masateru Kurumi, Takuo Aoyama
  • Patent number: 4596883
    Abstract: The invention relates to certain herbicidally active substituted diphenyl ether derivatives, herbicidal compositions of the same and the use thereof for preemergence and postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: July 5, 1984
    Date of Patent: June 24, 1986
    Assignee: PPG Industries, Inc.
    Inventors: James A. Schwindeman, Horng-Jau Lin
  • Patent number: 4594440
    Abstract: Crude phenoxybenzoic acid herbicide, e.g., acifluorfen, having one or more undesirable isomer/by-product impurities associated therewith is separated therefrom employing an inert solvent which is selective for the isomers/other by-products.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: June 10, 1986
    Assignee: Rhone:Pulenc, Inc.
    Inventors: Thomas J. Giacobbe, Grace Tsien
  • Patent number: 4589907
    Abstract: Compounds having the formula ##STR1## in which Z is ##STR2## wherein X is hydrogen or halogen and Y is --CH or N; R is alkyl, phenyl, trihalomethylphenyl, cyanomethyl, carboalkoxymethyl, ##STR3## alkenyl; and R.sub.1 is hydrogen, lower alkyl, halo-(lower alkyl), or Z; and intermediate alkyl onium salts of the type ##STR4## in which R.sub.3 is C.sub.1 -C.sub.8 alkyl, G is nitrogen or phosphorus and Z' is ##STR5## wherein X is hydrogen or halogen and Y is --CH or N; are herbicides.
    Type: Grant
    Filed: September 17, 1985
    Date of Patent: May 20, 1986
    Assignee: Stauffer Chemical Company
    Inventor: Raymond A. Felix
  • Patent number: 4585876
    Abstract: Novel xanthones and thioxanthones of the formula I ##STR1## in which A, X, Y, Z, E and E' are as defined in patent claim 1, are described. A is preferably --S-- and E and E' are preferably bonded in the ortho-position relative to one another. The compounds (I) are suitable, for example, as sensitizers for photocrosslinkable polymers or photocurable compositions, or for use in mixtures with polymers with H donor groups for image formation, in particular electrically conductive coatings and patterns, by means of electroless deposition of metals.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: April 29, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Fischer, Jurgen Finter, Hans Zweifel
  • Patent number: 4564385
    Abstract: This invention relates to certain herbicidally active substituted diphenyl ether oxime derivatives, herbicidal compositions of the same and the use thereof for preemergence and postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: January 14, 1986
    Assignee: PPG Industries, Inc.
    Inventor: Dennis K. Krass
  • Patent number: 4552977
    Abstract: Process for the preparation of (phenoxy- or benzyl-)-phenoxypropionic acids and the alkali metal salts thereof by adding a double molar amount of an aqueous alkali hydroxide to a boiling mixture of a (benzyl- or phenoxy-)-phenol and 2-chloropropionic acid (ester), with simultaneous azeotropic distillation of the water introduced or formed in the reaction.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: November 12, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Koch, Peter Herbrechtsmeier
  • Patent number: 4550205
    Abstract: The invention relates to new diphenyl ethers of the general formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a nitro group, an optionally halogenated alkyl, alkoxy or alkylthio group having 1-6 carbon atoms, or an alkanoyl group having 1-4 carbon atoms;Y is a nitrogen atom or a group of the formula CH or CCl;Z is a hydrogen atom, a halogen atom, a nitro group, an optionally halogenated alkyl group having 1-4 carbon atoms, or an alkanoyl group having 1-4 carbon atoms; n is 0-2;R.sub.1 is a hydrogen atom, or an alkyl or alkanoyl group having 1-4 carbon atoms;R.sub.2 and R.sub.3 are equal or different and represent hydrogen atoms or alkyl groups having 1-4 carbon atoms; andA is a group of the general formula ##STR2## wherein R.sub.4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, or a cation of an alkali metal, alkaline earth metal or an alkylated or non-alkylated ammonium group, andR.sub.5 and R.sub.
    Type: Grant
    Filed: November 4, 1982
    Date of Patent: October 29, 1985
    Assignee: Duphar International Research B.V.
    Inventors: Gerard B. Paerels, Cornelis W. Raven
  • Patent number: 4542233
    Abstract: Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.
    Type: Grant
    Filed: July 20, 1983
    Date of Patent: September 17, 1985
    Assignee: Biaschim S.p.A.
    Inventors: Oreste Piccolo, Aldo Belli, Giovanni Villa, Enrico Zen, Attilio Citterio
  • Patent number: 4536346
    Abstract: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: August 20, 1985
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Janis Upeslacis
  • Patent number: 4531969
    Abstract: Optically active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R.sub.1 and R.sub.2, among others, are halogen or CF.sub.3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates.
    Type: Grant
    Filed: December 20, 1978
    Date of Patent: July 30, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans J. Nestler, Gerhard Horlein, Reinhard Handte, Hermann Bieringer, Friedhelm Schwerdtle, Peter Langeluddeke
  • Patent number: 4526608
    Abstract: Substituted phenoxyphenylhydroxyamines and pyridyloxyphenylhydroxyamines, and the use thereof for the control of weeds.
    Type: Grant
    Filed: March 31, 1983
    Date of Patent: July 2, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4515628
    Abstract: Novel diphenyl ether hydrazine derivatives, particularly 2-nitro-5 (nucleus-substituted phenoxy) phenylhydrazine derivatives are provided. They are useful as a selective herbicide having a high herbicidal acitivity and residual efficacy.
    Type: Grant
    Filed: July 28, 1981
    Date of Patent: May 7, 1985
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Takeo Yoshimoto, Akira Hosono, Joh Miki, Kengo Oda, Masaaki Ura, Naoki Sato, Teruhiko Toyama, Hajime Tachibana, Yuji Enomoto, Yasunobu Funakoshi, Takashi Fujita, Yoshikata Hojo
  • Patent number: 4511729
    Abstract: Nitrophenoxy- or nitrophenylthiobenzeneacetic acid esters are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.
    Type: Grant
    Filed: March 10, 1983
    Date of Patent: April 16, 1985
    Assignee: Ethyl Corporation
    Inventors: G. Patrick Stahly, Barbara C. Stahly
  • Patent number: 4509970
    Abstract: Novel substituted phenylphosphinyloxy- and phenylphosphinylthio-iminocarboxylates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: April 9, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4504671
    Abstract: Aldoxime or ketoxime-O-alkanoic acid is prepared by transoximation of an aldehyde or ketone, the reaction being conducted in a liquid phase at a pressure below one atmosphere. Conversion of the aldoxime or ketoxime-O-alkanoic acid to the ester or salt form is also described.
    Type: Grant
    Filed: October 15, 1982
    Date of Patent: March 12, 1985
    Assignee: PPG Industries, Inc.
    Inventors: Dennis K. Krass, John C. Crano, Melvin S. Newman
  • Patent number: 4492683
    Abstract: New compounds and a method for inhibiting the growth of fungus is disclosed which comprises contacting said fungus with a fungicidal amount of a phenyl glycine compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, phenyl, substituted phenyl, halogen, amino or hydroxy groups; R.sub.3 is a hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl, benzoyl, halo or nitro substituted benzoyl, substituted cycloalkyl, methylcarbamoyl, cyclohexylcarbamoyl, phenylcarbamoyl, halophenylcarbamoyl, methylphenylcarbamoyl, methylthiocarbamoyl, phenyl, substituted phenyl, napthyl group or --SO.sub.2 R.sub.7 where R.sub.7 is a hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl or amino group; R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl or substituted lower alkyl groups and R.sub.6 is a hydrogen, lower alkyl or substituted lower alkyl, alkenyl or substituted alkenyl group.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: January 8, 1985
    Assignee: Buffalo Color Corporation
    Inventor: Krishen L. Nagpal
  • Patent number: 4484008
    Abstract: This invention relates to an improvement in the process of isolating certain diphenyl ethers from an aprotic organic solvent by the addition of a diphenyl ether phase forming amount of water to a reaction mixture comprising a liquid phase of the diphenyl ether dissolved in the solvent.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: November 20, 1984
    Assignee: PPG Industries, Inc.
    Inventors: James A. Cook, Jr., James A. Manner
  • Patent number: 4482736
    Abstract: Herbicidally active compounds of the formula ##STR1## in which R.sup.1 represents a hydrogen or chlorine atom,R.sup.2 represents a hydrogen atom, a cyano group, an optionally substituted radical selected from alkyl, aryl, alkanoyl, benzoyl, alkoxycarbonyl, alkenoxycarbonyl, alkinoxycarbonyl, aralkoxycarbonyl and aryloxycarbonyl, or a radical of the general formula--COOM,in whichM represents a hydrogen atom, one equivalent of an alkali metal ion or alkaline earth metal ion or optionally substituted ammonium, andR.sup.3 represents a cyano group or a radical of the general formula ##STR2## wherein Y represents an oxygen or sulphur atom or an imino (NH) or alkylimino (Nalkyl) group,R.sup.4 and R.sup.5 independently of each other represent a hydrogen atom or a methyl group,n is 0 or 1 andZ represents an optionally substituted radical,Novel intermediates therefor are also shown.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: November 13, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Ludwig Eue, Robert Schmidt
  • Patent number: 4477556
    Abstract: A photopolymerizable coating composition comprising(1) a nongaseous, ethylenically unsaturated, polymerizable compound,(2) a specified acidic o-nitroaromatic compound, and(3) an organic, radiation-sensitive, free-radical generating system which is useful for making a positive or negative polymeric image on a substrate.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 16, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Thomas E. Dueber, William J. Nebe
  • Patent number: 4469893
    Abstract: Diphenyl esters of the formula ##STR1## wherein R is hydrogen, carboxy, carboxylate salt or ester, formyl, cyano, alkyl, alkoxy, chloro, bromo, or N, N-dialkyl amino, are prepared by reacting a chloro-fluoro-benzotrifluoride with a nitro-phenoxide of the formula ##STR2## where R is defined above, and M is a cation of an alkali metal or an alkaline earth metal.
    Type: Grant
    Filed: March 22, 1982
    Date of Patent: September 4, 1984
    Assignee: Occidental Chemical Corporation
    Inventors: David Y. Tang, Byron R. Cotter, Frederick J. Goetz
  • Patent number: 4450173
    Abstract: A short-acting .beta.-blocking compound of the formula ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: May 22, 1984
    Assignee: American Hospital Supply Corporation
    Inventors: Paul W. Erhardt, Robert J. Borgman
  • Patent number: 4442117
    Abstract: There are described novel homoserine derivatives of the formula (I) ##STR1## which possess valuable microbicidal properties. In the formula: Ar is substituted phenyl or naphthyl; R.sub.1 is C.sub.2 -C.sub.6 alkyl optionally interrupted by oxygen or sulfur, 2-furyl, 2-tetrahydrofuryl, 1H-1,2,4-triazolylmethyl, 1-imidazolylmethyl, 1-pyrazolylmethyl, C.sub.2 -C.sub.4 alkenyl or cyclopropyl, each of which is optionally substituted by halogen; R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; and B is halogen or an ester, thioester, sulfonic acid ester or sulfonic acid amide group. Additionally, where B is halogen, R.sub.1 may be halomethyl. The novel derivatives can be used for combating microorganisms harmful to plants, particularly for combating phytopathogenic fungi, and they have for practical requirements a very favorable curative and protective action for protecting cultivating plants, without the plants being impaired as a result of undesirable secondary effects.
    Type: Grant
    Filed: October 23, 1980
    Date of Patent: April 10, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Kunz, Wolfgang Eckhardt, Adolf Hubele, Peter Riebli
  • Patent number: 4439617
    Abstract: Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.
    Type: Grant
    Filed: November 13, 1981
    Date of Patent: March 27, 1984
    Assignee: Ayerst, McKenna & Harrison Inc.
    Inventors: Kazimir Sestanj, Nedumparambil A. Abraham, Francesco Bellini, Adi Treasurywala
  • Patent number: 4438136
    Abstract: Novel bicyclo [2,2,1] heptanes and hept-2-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by a grouping --C(R).dbd.N--NHCO--(NH).sub.a --R' in which R is hydrogen, an aliphatic hydrocarbon residue, an aromatic residue or an aliphatic hydrocarbon residue substituted by an aromatic residue, a is 0 or 1 and R' is an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: March 20, 1984
    Assignee: National Research Development Corporation
    Inventors: Robert L. Jones, Norman H. Wilson
  • Patent number: 4435208
    Abstract: Herbicidally active compounds of the formula ##STR1## in which R.sup.1 represents a hydrogen or chlorine atom,R.sup.2 represents a hydrogen atom, a cyano group, an optionally substituted radical selected from alkyl, aryl, alkanoyl, benzoyl, alkoxycarbonyl, alkenoxycarbonyl, alkinoxycarbonyl, aralkoxycarbonyl and aryloxycarbonyl, or a radical of the general formula --COOM,in whichM represents a hydrogen atom, one equivalent of an alkali metal ion or alkaline earth metal ion or optionally substituted ammonium, andR.sup.3 represents a cyano group or a radical of the general formula ##STR2## wherein Y represents an oxygen or sulphur atom or an imino (NH) or alkylimino (N-alkyl) group,R.sup.4 and R.sup.5 independently of each other represent a hydrogen atom or a methyl group,n is 0 or 1 andZ represents an optionally substituted radical.
    Type: Grant
    Filed: November 6, 1981
    Date of Patent: March 6, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Ludwig Eue, Robert Schmidt
  • Patent number: 4435589
    Abstract: Process for the preparation of dimethyl succinylosuccinate, or the disodium salt thereof, by condensation of dimethyl succinate in a 35-45 percent by weight solution of sodium methylate in methanol, and a process for the preparation of dianilinodihydroterephthalic acids, the dimethyl esters and salts thereof, and of dianilinoterephthalic acids, and the dimethyl esters and salts thereof, starting from the disodium salt of dimethyl succinylosuccinate prepared according to the new process, without intermediate isolation.
    Type: Grant
    Filed: January 21, 1982
    Date of Patent: March 6, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Meinhard Rolf, Detlef-Ingo Schutze, Rutger Neeff, Hans-Volker Runzheimer
  • Patent number: 4426220
    Abstract: Diphenyl ethers of the formula ##STR1## where Z.sup.1, Z.sup.2 and Z.sup.3 independently of one another are each hyrogen, halogen, nitro, cyano, carboxyl, alkyl of 1 to 4 carbon atoms, or haloalkyl, alkoxy, haloalkoxy, alkylmercapto, haloalkylmercapto, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or haloalkylsulfonyl where alkyl is in each case of 1 to 4 carbon atoms, Y is hydrogen, halogen, cyano or nitro and Q is --CO--NA--OR.sup.1, where A is hydrogen, alkyl of 1 to 4 carbon atoms, a metal ion or an unsubstituted or substituted ammonium ion and R.sup.1 is carboxyalkyl, alkoxycarbonylalkyl or carbamylalkyl of not more than 10 carbon atoms, herbicides which contain these diphenyl ethers as active ingredients, and methods of controlling undesirable plant growth using these active ingredients.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: January 17, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Adolf Parg, Gerhard Hamprecht, Bruno Wuerzer
  • Patent number: 4424166
    Abstract: In the preparation of a 1,1-dihalogenoalkene of the formula ##STR1## in which R.sup.1 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain, andX.sup.1 and X.sup.2 each independently is a halogen atom,wherein a carbonyl compound of the formula ##STR2## is reacted with a trihalogenoacetate of the formula ##STR3## in which X.sup.3 is a halogen atom, andM.sup..sym. is an alkali metal ion or one equivalent of an alkaline earth metal ion,in the presence of an approximately equimolar amount of a phosphorus-containing compound, the improvement which comprises employing as said phosphorus-containing compound a phosphorous acid trialkyl ester or a phosphorous acid triamide and effecting the reaction at a temperature between about 0.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: January 3, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fritz Maurer, Uwe Priesnitz, Hans-Jochem Riebel
  • Patent number: 4396627
    Abstract: Compounds having the formula: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Y and X are as defined hereinbelow, are useful for the reduction of abnormally high blood glucose and lipid levels in the treatment of obesity or hyperglycaemia.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: August 2, 1983
    Assignee: Beecham Group Limited
    Inventors: Anthony T. Ainsworth, David G. Smith
  • Patent number: 4395570
    Abstract: A process for preparing a substantially pure, isomer free 5-(2-halo-4-trifluoromethylphenoxy)-2-nitrobenzoic acid or its esters, salts and amides by the basic condensation of a 4-trifluoromethylphenol and a 1-chloro-3-substituted-4-nitrobenzene followed by halogenation. All known previous routes afforded, in addition to the desired product, a number of inactive isomers.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: July 26, 1983
    Assignee: Rohm and Haas Company
    Inventor: Colin Swithenbank
  • Patent number: 4388472
    Abstract: A compound of the formula: ##STR1## and salts and esters thereof, useful as intermediates for the preparation of compounds of the formula ##STR2## wherein R.sup.1 is an alkyl group optionally substituted by one or more fluorine atoms or by an optionally substituted phenyl group R.sup.2 is No.sub.2 or Cl and R.sup.6 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms.
    Type: Grant
    Filed: January 13, 1981
    Date of Patent: June 14, 1983
    Assignee: Imperial Chemical Industries PLC
    Inventors: David Cartwright, David J. Collins
  • Patent number: 4386954
    Abstract: This invention is directed to diphenyl ethers having in the 3' position a radical of the formula: ##STR1## The products are prepared by reacting a 3'-halocarbonyl compound with an appropriately substituted oxime. These compounds and their agronomically acceptable salts and compositions containing these compounds as active ingredients are selective herbicides.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: June 7, 1983
    Assignee: Rohm and Haas Company
    Inventors: John W. Ashmore, Ted T. Fujimoto
  • Patent number: RE31455
    Abstract: Salts of compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group, andY is a hydrogen atom, a halogen atom, or a trihalomethyl group,and compositions containing these salts exhibit herbicidal activity.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: December 6, 1983
    Assignee: Rohm and Haas Company
    Inventors: Horst O. Bayer, Colin Swithenbank, Roy Y. Yih
  • Patent number: RE31731
    Abstract: Compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group,Y is a hydrogen atom, or a trihalomethyl group, andZ is an alkoxy group, an alkoxyalkoxy group, a hydroxyalkoxy group, an alkyl group, a halogen atom, an alkylamino group, a dialkylamino group, an alkylthio group, a carboxy group, a carbalkoxy group, a carboxyalkoxy group, a carbalkoxyalkoxy group, a carboxyalkyl group, a carbalkoxyalkyl group, a dialkylureido group, an alkanoylamino group, or carbalkoxyamino group,and compositions containing these compounds exhibit herbicidal activity.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: November 13, 1984
    Inventors: Horst O. Bayer, Colin Swithenbank, Roy Y. Yih
  • Patent number: RE31831
    Abstract: 2-nitro-5-(substituted-phenoxy)benzoic acids and esters salts, amides and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: June 25, 1981
    Date of Patent: February 12, 1985
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen
  • Patent number: RE32215
    Abstract: 2-nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: July 22, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen
  • Patent number: RE32216
    Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: July 29, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen
  • Patent number: RE32243
    Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: February 23, 1983
    Date of Patent: September 9, 1986
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Robert J. Theissen