Oxy, Not Bonded Directly To A Ring, In Same Side Chain As Carboxyl, Or Salt Thereof Patents (Class 562/470)
  • Patent number: 9133099
    Abstract: The present invention relates to compounds comprising the general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms, Y and Z, which may be identical or different, are selected from the group comprising —H, OH, —COOH, —OR3, —CH(OR3)COOH, in which R3 is selected from H, phenyl, benzyl, CF, or CF3 or CF2CF3, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: September 15, 2015
    Assignee: Nogra Pharma Limited
    Inventors: Giancarlo Naccari, Sergio Baroni
  • Publication number: 20150119587
    Abstract: Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I [Formula should be inserted here], wherein R1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R2 is C1-C6 alkyl. 2,4-Dihydroxy-3-methylbenzal-dehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry.
    Type: Application
    Filed: June 19, 2013
    Publication date: April 30, 2015
    Inventors: Pulla Reddy Muddasani, Manikumar Chintalapudi, Venkaiah Chowdary Nannapaneni
  • Patent number: 8969554
    Abstract: Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides. The compounds are triazine derivatives represented by following Formula 1 or salts thereof, and the herbicides containing them: [Chem. 28] wherein in the formula, R1 represents a hydrogen atom; a C1-C12 alkyl group; a C2-C6 alkenyl group, etc., R2 represents a C1-C12 alkyl group, etc., Y and Z represent an oxygen atom or a sulfur atom, and A represents a 5- or 6-membered cyclic group which may contain a nitrogen atom, an oxygen atom, or a sulfur atom.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 3, 2015
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Atsushi Shibayama, Ryu Kajiki, Masami Kobayashi, Takashi Mitsunari, Atsushi Nagamatsu
  • Publication number: 20150011630
    Abstract: The present invention relates to new dihydroxyphenyl modulators of neurotransmitter levels, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 8, 2014
    Publication date: January 8, 2015
    Inventors: David S. Goldstein, Courtney Holmes, Rudolf-Geisbert Alken, Frank Schneider, Chengzhi Zhang
  • Publication number: 20140378692
    Abstract: As shown by the following formula (1), after methyl laurate (2 mmol) and water (8 mL) are added to an ammonium pyrosulfate catalyst (5 mol %), a hydrolysis reaction of methyl laurate is carried out by heating for 24 hours at 60° C. while stirring is performed, so that lauric acid can be obtained with a yield of 86%.
    Type: Application
    Filed: December 13, 2012
    Publication date: December 25, 2014
    Inventors: Kazuaki Ishihara, Akira Sakakura, Yoshiki Koshikari
  • Patent number: 8759573
    Abstract: The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: June 24, 2014
    Assignee: Rhodia Operations
    Inventors: Bruno Heinisch, Pascal Pitiot, Jean-Louis Grieneisen
  • Publication number: 20140171444
    Abstract: The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl- naphthyl-, or thienyl-substituted diketo acids and carboxylate derivatives thereof. Also provided are methods of treating tuberculosis or other pathophysiological conditions associated with a malate synthase enzyme with the inhibitory compounds and methods of in silico design of the inhibitory compounds. In addition, the present invention provides the inhibitory compounds designed by this method. Furthermore, three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds are provided. Further still a method for stabilizing an aromatic or heteroaromatic diketo acid or its prodrug or close analog in solution by derivatizing at least the ortho position on the aromatic ring is provided.
    Type: Application
    Filed: March 3, 2014
    Publication date: June 19, 2014
    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Joel S. Freundlich, James C. Sacchettini, Inna V. Kriger, Thomas R. Ioerger, Vijay Gawandi
  • Patent number: 8735626
    Abstract: A method of producing an aromatic amino compound using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively. A primary or secondary amine compound having an aromatic ring group and a halogenated aromatic compound as starting materials, are reacted with the halogenated aromatic compound in the presence of copper catalyst and base to produce the aromatic amino compound having a structure in which an aromatic ring group derived from the halogenated aromatic compound is coupled to the amino group of the amine compound, wherein the amine compound and the halogenated aromatic compound are reacted together such that an aromatic oxycarboxylic acid having a hydroxyl group and a hydroxycarbonyl group bonded to neighboring carbon atoms, is present together with the copper catalyst and the base.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: May 27, 2014
    Assignee: Hodogaya Chemical Co., Ltd.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi
  • Patent number: 8703821
    Abstract: The present invention provides dialkyl ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: April 22, 2014
    Assignee: Emisphere Technologies Inc.
    Inventor: Jianfeng Song
  • Patent number: 8586607
    Abstract: There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 19, 2013
    Assignee: Syddansk Universitet
    Inventors: Trond Ulven, Elisabeth Christiansen
  • Publication number: 20130296599
    Abstract: The invention provides novel phenylglyoxylic acid derivatives, which may be useful as intermediates for preparing stereoisomerically enriched drug compounds. The invention also provides methods of making phenylglyoxylic acid derivatives, and uses of phenylglyoxylic acid derivatives.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 7, 2013
    Inventors: Dharma Rao Polisetti, Kalpathy Santhosh, Muralidhar Bondlela, Robert Carl Andrews, Thomas Scott Yokum, Eugene Campian, Rajashaker Kache
  • Patent number: 8552062
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: October 8, 2013
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel, Kirvin L. Hodge
  • Publication number: 20130109710
    Abstract: The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof
    Type: Application
    Filed: September 14, 2012
    Publication date: May 2, 2013
    Applicant: JAPAN TOBACCO INC.
    Inventors: Takashi Shimada, Hiroshi Ueno, Kazuhiro Tsutsumi, Kouichi Aoyagi, Tomoyuki Manabe, Shin-Ya Sasaki, Susumu Katoh
  • Patent number: 8383852
    Abstract: Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: February 26, 2013
    Assignee: Emisphere Technologies, Inc.
    Inventors: Pingwah Tang, Steven Dinh
  • Publication number: 20120295858
    Abstract: The present invention relates to a new use of traditional Chinese drug products of Danshensu (DLA), Notoginsenoside R1 (R1) and their combination, in particular to the therapeutic and preventive effects of DLA, R1 and their combination on the diseases caused by microcirculation disorder.
    Type: Application
    Filed: November 4, 2010
    Publication date: November 22, 2012
    Inventors: Jingyan Han, Jun Guo, Jiying Yang, Kai Sun, Mingxia Wang, Yu Zhang, Yuying Liu
  • Publication number: 20120130097
    Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 24, 2012
    Applicant: AstraZeneca AB
    Inventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
  • Publication number: 20120116118
    Abstract: The present invention relates to a novel process for preparing substituted and unsubstituted (2,4-dimethylbiphenyl-3-yl)acetic acids and their esters of the formula (I) using homogeneous and heterogeneous palladium catalysts, and also the intermediates 4-tert-butyl-2,6-dimethylphenylacetic acid and 4-tert-butyl-2,6-dimethylmandelic acid, and to processes for their preparation.
    Type: Application
    Filed: June 25, 2010
    Publication date: May 10, 2012
    Applicant: Bayer Cropscience AG
    Inventor: Reiner FISCHER
  • Publication number: 20120088784
    Abstract: The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
    Type: Application
    Filed: November 4, 2011
    Publication date: April 12, 2012
    Inventors: Boulos Zacharie, Christopher Penney, Lyne Gagnon, Jean-François Bienvenu, Valérie Perron, Brigitte Grouix
  • Patent number: 8153841
    Abstract: The present invention relates to compounds comprising the general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising —H, —OH, —COOH, —OR3, —CH(OR3)COOH, in which R3 is selected from H, phenyl, benzyl, —CF3 or —CF2CF3, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: April 10, 2012
    Assignee: Giuliani International Limited
    Inventors: Giancarlo Naccari, Sergio Baroni
  • Publication number: 20120053362
    Abstract: There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-1-naphthylethylamine or a salt of (R)-1-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.
    Type: Application
    Filed: March 4, 2010
    Publication date: March 1, 2012
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
  • Patent number: 8101804
    Abstract: A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: January 24, 2012
    Assignee: Clariant Specialty Fine Chemicals (France)
    Inventors: Alain Schouteeten, Sébastien Jus, Jean-Claude Vallejos
  • Patent number: 8058471
    Abstract: The present invention has its object to provide a method for producing an optically active hydroxycarboxylic acid derivative which is an intermediate important for production of medicines, agrochemicals, chemical products, and so on. The production method of the present invention comprises: carrying out a hydrogen-transfer reduction of a ketocarboxylic acid or a salt thereof by the reaction of an optically active diamine complex to produce an optically active hydroxycarboxylic acid derivative. According to the present invention, it is possible to safely and efficiently produce an industrially-useful optically active hydroxycarboxylic acid derivative.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: November 15, 2011
    Assignee: Kaneka Corporation
    Inventors: Susumu Amano, Akio Fujii, Shohei Yamamoto, Masaru Mitsuda
  • Publication number: 20110245528
    Abstract: The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.
    Type: Application
    Filed: September 23, 2009
    Publication date: October 6, 2011
    Inventor: C. Eric Schwartz
  • Publication number: 20110218353
    Abstract: Disclosed are fluorovinyl ether functionalized aromatic diesters and derivatives thereof. The compounds disclosed have utility as functionalized monomers and comonomers in polyesters, polyamides, and the like. It has been found that incorporation of the monomers into polymers provides improved soil resistance to shaped articles produced from the polymers.
    Type: Application
    Filed: September 1, 2010
    Publication date: September 8, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, Surbhi Mahajan, Kenneth Gene Moloy, Fredrik Nederberg, Joel M. Pollino, Joachim C. Ritter
  • Patent number: 8008523
    Abstract: A process for preparing monocarboxylic perfluoropolyethers of formula: A-O—(RF)z—(CFY)t—C(O)OX (I) wherein: X is H, C1-C10 alkyl, or an aryl group; Y=F, CF3; t=1, 2 or 3; A is a C1-C4 perfluoroalkyl end group; z=0 or 1; RF is a perfluorooxyalkylene chain; having a number average molecular weight in the range 180-8,000; comprising the following steps: a) one or more distillations of perfluoropolyethers (PFPE) of formula T-O—(RF)z-T? (II) wherein: z and RF are as above defined; T, T?, equal to or different from each other, are selected from acyl fluoride or carbonyl-containing functional end groups and non functional end groups to obtain one PFPE fraction of formula (II) wherein the difference between the minimum and the maximum molecular weight of the components is lower than or equal to 600; b) partial fluorination of the fraction obtained in a); c) esterification c1) and/or hydrolysis c2) of the mixture obtained in b); d) distillation of the product obtained in c2) or in c1).
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: August 30, 2011
    Assignee: Solvay Solexis S.p.A.
    Inventors: Giuseppe Marchionni, Ugo De Patto, Pier Antonio Guarda
  • Patent number: 8008525
    Abstract: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: August 30, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Kohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
  • Publication number: 20110190520
    Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 4, 2011
    Applicant: AstraZeneca AB
    Inventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
  • Publication number: 20110178043
    Abstract: Compounds and related methods as can be used for selective mevalonate pathway inhibitors.
    Type: Application
    Filed: November 9, 2007
    Publication date: July 21, 2011
    Inventors: Richard B. Silverman, Takashi Kudoh
  • Publication number: 20110172435
    Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
    Type: Application
    Filed: November 12, 2010
    Publication date: July 14, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Karen M. Kedzie, Daniel W. Gil, John E. Donello, Wha-Bin Im
  • Publication number: 20110152315
    Abstract: There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type I1 diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.
    Type: Application
    Filed: July 23, 2009
    Publication date: June 23, 2011
    Inventors: Trond Ulven, Elisabeth Christiansen
  • Patent number: 7960582
    Abstract: The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: June 14, 2011
    Assignee: AstraZeneca AB
    Inventors: Hans Jorgen Blixt, Bo Lars Gustaf Bosson, Roberto Guiseppe Paolo Gatti, Simone Zaramella, Michael William Senior, Kurt Vogtli, Andrea Zistler
  • Publication number: 20110124910
    Abstract: This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.
    Type: Application
    Filed: February 7, 2011
    Publication date: May 26, 2011
    Inventors: Tilo HAAG, Danja Grossbach, Gabriele Winter, Michael Sander, Wolfgang Beckmann, Klaus Bartel, Christian Dinter
  • Publication number: 20110112200
    Abstract: The present invention provides crystalline and amorphous salts of O-desmethylvenlafaxine and processes for preparing said salts of O-desmethylvenlafaxine. The present invention further provides pharmaceutical compositions comprising said salts of O-desmethylvenlafaxine.
    Type: Application
    Filed: June 16, 2009
    Publication date: May 12, 2011
    Inventors: Valerie Niddam-Hildesheim, Tamar Nidam, Eli Lancry
  • Patent number: 7906662
    Abstract: The compounds trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl azide and trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaminium (2R)-2-hydroxy-2-phenylethanoate.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: March 15, 2011
    Assignee: Astrazeneca AB
    Inventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
  • Publication number: 20110053974
    Abstract: To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X represents ?C(R5)- or ?N—; Y represents —O— or —NH—; L represents a bond or a substitutable C1-C3 alkylene group; M represents a substitutable C3-C10 cycloalkyl group, a substitutable C6-C10 aryl group, or a substitutable heterocyclic group; R1 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 aliphatic acyl group, a C1-C6 alkoxy C1-C6 alkyl group, or a C6-C10 aryl group; and R2, R3, R4, and R5 may be the same or different and each represent a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C1-C3 alkoxy group, or a nitro group.
    Type: Application
    Filed: September 29, 2010
    Publication date: March 3, 2011
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Narihiro TODA, Masao YOSHIDA, Rieko TAKANO, Masahiro INOUE, Takeshi HONDA, Koji MATSUMOTO, Ryutaro NAKASHIMA
  • Patent number: 7875744
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: January 25, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
  • Publication number: 20110009664
    Abstract: The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor.
    Type: Application
    Filed: December 9, 2008
    Publication date: January 13, 2011
    Applicant: Rhodia Pperations
    Inventors: Bruno Heinisch, Pascal Pitiot, Jean-Louis Grieneisen
  • Publication number: 20100288004
    Abstract: The invention relates to the use of metal complexes comprising a ligand derived from 2-aryl-2-hydroxyacetic acid and a divalent or trivalent metal cation and to the use of the said ligands in dissolving divalent or trivalent metal cations in aqueous phase. The said complexes can be used to treat metal deficiencies in plants.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 18, 2010
    Applicant: CLARIANT SPECIALTY FINE CHEMICALS (FRANCE)
    Inventors: Alain Schouteeten, Sébastien Jus, Claude Cathelineu
  • Patent number: 7829051
    Abstract: Methods for the reduction of gaseous carbon dioxide emissions from combustion or oxidation reactions are provided. The various methods involve the formation of carbon suboxides and/or polymerized carbon suboxides (PCS), preferentially over gaseous carbon oxides to thereby reduce gaseous carbon dioxide emissions. The various methods can be employed for efficient generation of energy and/or hydrogen. In addition, various methods for the use of polymerized carbon suboxide are disclosed.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: November 9, 2010
    Assignee: Drexel University
    Inventors: Alexander Fridman, Alexander F. Gutsol, Young L. Cho
  • Patent number: 7820847
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: October 26, 2010
    Assignee: Merck Patent GmbH
    Inventors: Jean-Jacques Zeiller, Hervé Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Patent number: 7816385
    Abstract: A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator -Activated Receptors (PPAR).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 19, 2010
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Per Sauerberg, Lone Jeppesen, Zdenek Polivka, Karel Sindelar
  • Publication number: 20100261789
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Application
    Filed: June 23, 2010
    Publication date: October 14, 2010
    Inventors: Jean-Jacques Zeiller, Hervé Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Patent number: 7767811
    Abstract: One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomeric mixture of a chiral substrate, e.g., a cyclic carbonate or cyclic carbamate; and a nucleophile, e.g., an alcohol, amine or thiol. A preferred embodiment of the present invention relates to a method for achieving the kinetic resolution of racemic and diastereomeric mixtures of derivatives of ?- and ?-amino, hydroxy, and thio carboxylic acids. In certain embodiments, the methods of the present invention achieve dynamic kinetic resolution of a racemic or diastereomeric mixture of a substrate, i.e.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: August 3, 2010
    Assignee: Brandeis University
    Inventors: Li Deng, Jianfeng Hang, Liang Tang
  • Publication number: 20100191011
    Abstract: The present invention has its object to provide a method for producing an optically active hydroxycarboxylic acid derivative which is an intermediate important for production of medicines, agrochemicals, chemical products, and so on. The production method of the present invention comprises: carrying out a hydrogen-transfer reduction of a ketocarboxylic acid or a salt thereof by the reaction of an optically active diamine complex to produce an optically active hydroxycarboxylic acid derivative. According to the present invention, it is possible to safely and efficiently produce an industrially-useful optically active hydroxycarboxylic acid derivative.
    Type: Application
    Filed: August 8, 2007
    Publication date: July 29, 2010
    Applicant: Kaneka Corporation
    Inventors: Susumu Amano, Akio Fujii, Shohei Yamamoto, Masaru Mitsuda
  • Publication number: 20100185012
    Abstract: A method of producing optically active trans-2-aminocyclohexanol includes allowing racemic trans-2-aminocyclohexanol to react with optically active 2-methoxyphenylacetic acid to produce an optically active 2-methoxyphenylacetic acid salt of optically active trans-2-aminocyclohexanol and separating the salt. An optically active 2-methoxyphenylacetic acid salt of optically active trans-2-aminocyclohexanol is also provided. The method makes it possible to produce optically active trans-2-aminocyclohexanol with ease and a high yield from an industrially-advantageous, inexpensive raw material.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 22, 2010
    Applicant: TORAY FINE CHEMICALS CO., LTD
    Inventors: Ryuji Ogawa, Toshihiro Fujino, Kenichi Sakai
  • Publication number: 20100152439
    Abstract: The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein R1 is defined as in claim 1.
    Type: Application
    Filed: February 23, 2010
    Publication date: June 17, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Guenther HUCHLER, Werner RALL, Uwe RIES
  • Publication number: 20100112701
    Abstract: The present invention relates to a protein which can asymmetrically reduce an ortho-substituted phenylglyoxalic acid compound to produce an aide or ester compound of corresponding optically-active ortho-substituted mandelic acid compound with a good optical yield, a DNA encoding the protein, a process for producing the protein from the DNA, and a process for asymmetrically reducing an ortho-substituted phenylglyoxalic acid compound to produce a corresponding optically-active ortho-substituted mandelic acid compound.
    Type: Application
    Filed: March 24, 2008
    Publication date: May 6, 2010
    Applicant: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Asako
  • Patent number: 7683193
    Abstract: Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: March 23, 2010
    Assignee: University of Southern California
    Inventor: Nicos A. Petasis
  • Publication number: 20100004483
    Abstract: A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.
    Type: Application
    Filed: July 25, 2007
    Publication date: January 7, 2010
    Applicant: CLARIANT SPECIALTY FINE CHEMICALS (FRANCE)
    Inventors: Alain Schouteeten, Sébastien Jus, Jean-Claude Vallejos
  • Patent number: RE43372
    Abstract: Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: May 8, 2012
    Assignee: Duke University
    Inventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De