Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
Type:
Grant
Filed:
October 22, 2009
Date of Patent:
May 7, 2013
Assignee:
Actelion Pharmaceuticals Ltd.
Inventors:
Kurt Hilpert, Francis Hubler, Dorte Renneberg
Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
April 16, 2013
Assignee:
AnaSpec Incorporated
Inventors:
Jianjun He, Anita Hong, Qingheng Wang, Raman Khosrow Afshar, Ming Zhu, Vera Rakhmanova
Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
December 30, 1997
Assignee:
G. D. Searle & Co.
Inventors:
John J. Talley, Daniel P. Getman, Ko-Chung Lin, Gary A. DeCrescenzo, Donald J. Rogier, Jr., John N. Freskos
Abstract: J-Acid urea of the formula ##STR1## is prepared by reacting 7-amino-4-hydroxynaphthalene-2-sulfonic acid (J-acid) with urea at from 100.degree. to 140.degree. C. under a pressure ranging from atmospheric pressure to 10 bar in an inert solvent to a partial extent, precipitating unconverted J-acid in an acidic medium and separating it off, and, if desired, isolating J-acid urea from the resulting neutralized solution by salting out.
Abstract: This invention is directed to new water-soluble, monoazo dyes having the following general formula: ##STR1## in which: X and Y are independently selected from the group consisting of: ##STR2## R, R.sub.1, R.sub.2 are independently selected from H, lower alkyl of one to four carbons and sulfonated lower alkyl;A is a phenyl or napthyl radical optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy, carboxylic acid or sulfonic acid;W is a phenyl or naphthyl radical optionally substituted by carboxylic acid, sulfonic acid, amino, amido, lower alkyl, lower alkoxy, hydroxy or halogen groups;Z is a phenyl radical optionally substituted with halogen, lower alkoxy or lower alkyl groups; andcopper, chromium, cobalt and nickel metallized complexes of said dyestuffs.The dyes of this invention on cellulose textiles have high tinctorial strength, purity of shade, light and wash fastness particularly chlorine wash fastness.
Type:
Grant
Filed:
March 17, 1988
Date of Patent:
August 8, 1989
Assignees:
Hugh C. Crall, Hoechst Celanese Corp.
Inventors:
Glenn A. Thompson, Anthony J. Corso, Hans H. Steuernagel