Plural Naphthalene Ring Systems Attached Indirectly To The -nhc(=x)nh- Group By Nonionic Bonding Patents (Class 562/50)
  • ACTIVATION AND ACTIVATORS OF SIRT6
    Publication number: 20130029930
    Abstract: The invention provides a method of increasing a deacetylated activity of SIRT6 by contacting SIRT6 with an agent that binds SIRT6 and reduces the Km of SIRT6 for a substrate, thereby increasing the deacetylase activity of SIRT6. The invention also provides compounds of the formulas (II) and (III).
    Type: Application
    Filed: December 14, 2010
    Publication date: January 31, 2013
    Applicant: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Ping Xu
  • USE OF DRUGS THAT ACTIVATE P2Y RECEPTORS TO ENHANCE SYNAPTOGENESIS
    Publication number: 20110257109
    Abstract: The present invention encompasses compositions and methods that activate P2Y receptors for the increased production of new synapses in the central nervous system. The formulations of the invention may be administered to a healthy subject or to a subject in need thereof to restore synapses.
    Type: Application
    Filed: April 19, 2011
    Publication date: October 20, 2011
    Inventor: Richard WURTMAN
  • AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT VESICLE-FUSING ATPASE ACTIVITY
    Publication number: 20110207775
    Abstract: The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect vesicle-fusing ATPase; a method for assaying pesticidal activity of a test substance, which comprises measuring the activity of a vesicle-fusing ATPase in a reaction system in which the vesicle-fusing ATPase contacts with a test substance, and the like.
    Type: Application
    Filed: November 19, 2007
    Publication date: August 25, 2011
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yasutaka Shimokawatoko, Marc Van De Craen, Irene Nooren, Bert Oosthuyse, Bert Demey, Wendy Maddelein, Geraldine Drevon
  • Urea derivatives as inhibitors for CCR-3 receptor
    Patent number: 6875884
    Abstract: Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synthesized using liquid and solid phase synthesis protocols.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: April 5, 2005
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Janak Padia, Michael Hocker, Tsuyoshi Nishitoba, Hirohi Ohashi, Eiji Sawa