Lactic Acid Per Se Or Salt Thereof Patents (Class 562/589)
  • Patent number: 10683254
    Abstract: Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 ?m and less than 1 ?m with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
    Type: Grant
    Filed: December 25, 2009
    Date of Patent: June 16, 2020
    Assignee: Toray Industries, Inc.
    Inventors: Kenji Sawai, Hideki Sawai, Takashi Mimitsuka, Ito Masateru, Katsushige Yamada, Kenji Kawamura, Shin-ichi Minegishi, Izumi Nakagawa, Tatsuya Nagano
  • Patent number: 10640445
    Abstract: A method of producing lactic acid includes filtering a lactic acid-containing aqueous solution through a nanofiltration membrane to recover an aqueous lactic acid solution from the permeate side (Step A); distilling the aqueous lactic acid solution to recover lactic acid from the vapor side (Step B); and crystallizing the lactic acid obtain in Step B, and performing solid-liquid separation to recover a lactic acid crystal(s) (Step C).
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: May 5, 2020
    Assignee: Toray Industries, Inc.
    Inventors: Kenji Kawamura, Miyuki Horiguchi, Satoshi Sakami, Katsushige Yamada
  • Patent number: 9850224
    Abstract: Process for increasingly producing D-Lactide and meso lactide by depolymerizing by back biting polylactide (PLA) said process which comprises: (i) Depolymerizing polylactide into its corresponding dimeric cyclic esters by heating the polylactide in the presence of a catalyst system comprising a catalyst and a co-catalyst in a reaction zone at temperature and pressure at which the polylactide is molten; (ii) Forming a vapor product stream from the reaction zone; (iii) Removing the vapor product stream and optionally condense it; (iv) Recovering, either together or separately meso-lactide, D-lactide and L-lactide.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: December 26, 2017
    Assignee: Futerro S.A.
    Inventors: Christian Penu, Benjamine Belloncle
  • Patent number: 9758463
    Abstract: The method for producing a vapor composition containing lactic acid of the present invention is capable of suppressing the generation of by-products such as acetaldehyde and carbon monoxide due to pyrolysis of a lactic acid species during vaporization. Furthermore, a lactic acid oligomer generated can be effectively used without loss, and a vapor composition containing lactic acid can be industrially efficiently produced stably for a long time. The present invention relates to a method for producing a vapor composition containing lactic acid including: feeding a liquid composition containing lactic acid to a vaporizer; mixing the liquid composition with a liquid composition containing a lactic acid oligomer contained in the vaporizer to prepare a liquid mixture; and heating the liquid mixture to vaporize part of the liquid mixture, whereby a vapor composition containing lactic acid is produced.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 12, 2017
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hisashi Kamei, Hiroshi Yoshida
  • Patent number: 9012685
    Abstract: A method for recovery of highly pure alkyl lactate and lactic acid is provided, which includes a step 1 for producing source liquid comprising lactic acid or ammonium lactate; a step 2 for dehydrating the source liquid product of step 1; a step 3 for producing liquid mixture by sequentially adding and stirring alcohol and acid solution to the dehydrated source liquid; a step 4 for separating and removing ammonium salt precipitation from the liquid mixture of step 3; a step 5 for producing alkyl lactate from ammonium salt-free liquid mixture by esterification reaction; and a step 6 for separating alcohol and alkyl lactate by distillation from the mixture of step 5.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 21, 2015
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Dong Won Hwang, Jong-San Chang, Young Kyu Hwang, U-Hwang Lee, HyoJin Gwak
  • Patent number: 9012682
    Abstract: The invention relates to a process for transformation of lignocellulosic biomass or cellulose using stable non-zeolitic heterogeneous catalysts that are based on tin and/or antimony, preferably dispersed on a substrate. The use of these catalysts makes it possible to obtain directly lactic acid with high selectivity while limiting the production of oligosaccharides and soluble polymers.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: April 21, 2015
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Flora Chambon, Nadine Essayem, Franck Rataboul, Catherine Pinel, Amandine Cabiac, Emmanuelle Guillon
  • Publication number: 20150105533
    Abstract: The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 16, 2015
    Inventors: Joel S. Goldberg, Joe Brice Weinberg
  • Patent number: 8987510
    Abstract: The invention relates to a method for the removal of the cyclic diester of a 2-hydroxy alkanoic acid from a vapor containing said diester, wherein the vapor is contacted with an aqueous solution so that the diester dissolves in said solution. According to the invention, the method is characterized in that the solution is an alkaline solution, preferably having a pH above 10. The problem of the formation of slurries of the diester in the aqueous solutions can be prevented by the present invention. The method can be applied with great advantage in the production or conversion of lactide.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 24, 2015
    Assignee: Purac Biochem BV
    Inventors: Jan Van Krieken, Siebe Cornelis De Vos, Johannes Adrianus Kamp
  • Patent number: 8940934
    Abstract: An object of the present invention is to provide a production process of an ?-hydroxy acid having a sufficient quality as a polymer raw material, which process does not produce a large amount of waste as a byproduct and is economical. The present invention provides a production process of an ?-hydroxy acid having a step of adding a basic metal to an ?-hydroxy acid ammonium salt to yield an ?-hydroxy acid metal salt and a step of desalting the ?-hydroxy acid metal salt to yield the ?-hydroxy acid.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 27, 2015
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Makoto Okamoto, Hideki Date
  • Publication number: 20140356477
    Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.
    Type: Application
    Filed: October 1, 2013
    Publication date: December 4, 2014
    Applicant: Run Them Sweet, LLC
    Inventors: Michael A Horning, George A Brooks
  • Patent number: 8895778
    Abstract: The invention provides energy efficient depolymerization of polyesters such as post-consumer polylactic acid. Ultrasonic induced implosions can be used to facilitate the depolymerization. The expanding market of polylactic acid-based plastic products, such as water bottles and packaging materials, has raised concerns of contaminating the recycling stream, which is largely filled with petroleum-based plastics. Thus the development of an energy efficient and economically viable PLA recycling process is urgently needed. Post consumer PLA was exposed to methanol as the suspension media in the presence of organic or ionic salts of alkali metals such a potassium carbonate and sodium hydroxide as depolymerization catalysts to provide high quality lactic acid monomers in high yield.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: November 25, 2014
    Assignee: Iowa State University Research Foundation
    Inventors: Gowrishankar Srinivasan, David Grewell
  • Publication number: 20140316162
    Abstract: Methods of producing clean (e.g., low sulfur and metal ion content, and free of fermentation inhibitors) sugar and lignin-rich streams, and downstream conversion products, from lignocellulosic biomass, may include obtaining non-chemically pretreated, milled lignocellulosic biomass, reacting the milled lignocellulosic biomass with an enzymatic agent to produce a slurry that includes converted monomeric lignocellulosic sugars and lignin-rich residuals, and separating the slurry into a sugar stream that includes the converted monomeric lignocellulosic sugars and a lignin-rich stream that includes the lignin-rich residuals. The sugar stream, not including water, includes at least 75% monomeric lignocellulosic sugar, less than 0.20% sulfur, and less than 3.0% metal ion content, and the lignin-rich stream includes at least 35% lignin and less than 0.50% sulfur.
    Type: Application
    Filed: April 23, 2013
    Publication date: October 23, 2014
    Applicant: WEYERHAEUSER NR COMPANY
    Inventors: Johnway Gao, Amar N. Neogi
  • Patent number: 8759045
    Abstract: A method of producing lactic acid by separating lactic acid produced in a culture solution by microbial fermentation, comprising: a step (A) of filtering the culture solution through a nano-filtration membrane; and a step (B) of distilling a lactic-acid-containing solution produced in step (A) under a pressure of 1 Pa to atmospheric pressure (inclusive) at a temperature of 25 to 200° C. (inclusive) to recover lactic acid.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 24, 2014
    Assignee: Toray Industries, Inc.
    Inventors: Masateru Ito, Shin-ichi Minegishi, Eri Shimizu, Kenji Sawai, Yohito Ito, Hideki Sawai, Katsushige Yamada
  • Publication number: 20140128635
    Abstract: Disclosed is the biological production of lactic acid using a microorganism. A transformant capable of producing lactic acid of high optical purity at high yield, a method for the preparation thereof, and a method for producing lactic acid in a convenient and economically beneficial manner using the same are provided. The Zymomonas mobilis transformant can produce lactic acid of high optical purity at high yield without a stringent limitation to production conditions and a regulation of the intracellular metabolism pathway. Because it requires no additional separation and purification steps, the use of the transformant allows the production of lactic acid in a short process, resulting in a significant reduction in production cost, and avoiding the environment problems caused by precipitate wastes, which brings about environmental issues.
    Type: Application
    Filed: February 23, 2011
    Publication date: May 8, 2014
    Applicant: MACROGEN INC.
    Inventors: Jae-Young Kim, Sang-Heum Shin, Hyon-Yong Chong, Kap-Seok Yang, Jeong-Sun Seo
  • Publication number: 20140121269
    Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 1, 2014
    Applicant: Run Them Sweet, LLC
    Inventors: Michael A. Horning, George A. Brooks
  • Publication number: 20140121270
    Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.
    Type: Application
    Filed: August 2, 2013
    Publication date: May 1, 2014
    Applicant: Run Them Sweet, LLC
    Inventors: Michael A. Horning, George A. Brooks
  • Publication number: 20140087978
    Abstract: A method of converting an inactive biocide into an active biocide comprises: contacting the inactive biocide with an activating agent, wherein the activating agent is capable of chemically reacting with the inactive biocide; and causing or allowing a chemical reaction to take place between the inactive biocide and the activating agent, wherein the chemical reaction produces the active biocide. The methods can also include deactivating the active biocide via a chemical reaction between the active biocide and a deactivating agent.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: HALLIBURTON ENERGY SERVICES, INC
    Inventor: Jay P. DEVILLE
  • Patent number: 8680146
    Abstract: The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: March 25, 2014
    Assignee: Novartis AG
    Inventors: Guido Jordine, Michael Mutz
  • Patent number: 8664435
    Abstract: A method of preparing a liquid lactic acid composition that has a total acid content of at least 94% (w/w) and that does not crystallize at a temperature above 10° C. includes obtaining a starting liquid lactic acid composition that has a total acid content of at least 94% (w/w) and that crystallizes at a temperature above 10° C. and incubating said starting liquid lactic acid composition at a temperature above the crystallization point of the starting liquid lactic acid composition for a time period to obtain the liquid lactic acid composition that does not crystallize at a temperature above 10° C.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: March 4, 2014
    Assignee: Purac Biochem B.V.
    Inventor: Jan Van Breugel
  • Patent number: 8664436
    Abstract: The present invention relates to a solid bed adsorptive separation of organic acid and/or amino acids from fermentation broths containing organic acid and/or amino acid.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: March 4, 2014
    Assignee: Rohm and Haas Company
    Inventor: Areski Rezkallah
  • Publication number: 20140012043
    Abstract: The invention relates to a method for the removal of the cyclic diester of a 2-hydroxy alkanoic acid from a vapor containing said diester, wherein the vapor is contacted with an aqueous solution so that the diester dissolves in said solution. According to the invention, the method is characterized in that the solution is an alkaline solution, preferably having a pH above 10. The problem of the formation of slurries of the diester in the aqueous solutions can be prevented by the present invention. The method can be applied with great advantage in the production or conversion of lactide.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 9, 2014
    Applicant: PURAC BIOCHEM BV
    Inventors: Jan Van krieken, Siebe Cornelis De Vos, Johannes Adrianus Kamp
  • Patent number: 8624058
    Abstract: The invention relates to a process for transformation of lignocellulosic biomass or cellulose that uses tungsten-based heterogeneous catalysts that are dispersed on an oxide-based substrate, preferably with a base of oxide(s) of aluminum and/or zirconium and/or titanium and/or niobium. The use of these catalysts makes it possible to obtain directly lactic acid with high selectivity while limiting the production of oligosaccharides and soluble polymers.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: January 7, 2014
    Assignees: Centre National de la Recherche Scientifique, IFP Energies nouvelles
    Inventors: Flora Chambon, Nadine Essayem, Franck Rataboul, Catherine Pinel, Amandine Cabiac, Emmanuelle Guillon
  • Publication number: 20130289112
    Abstract: Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
    Type: Application
    Filed: March 21, 2011
    Publication date: October 31, 2013
    Applicant: TIANJIN CHASESUN PHARMACEUTICAL CO., LTD
    Inventors: Jiang Zheng, Xinchuan Zheng, Xin Liu, Hong Zhou, Ning Wang, Hongwei Cao, Yan Li, Yongling Lu, Kecen Zhao, Jingcheng Yang, Yang Yang, Yuanfeng Zhu, Guo Wei, Min Huang
  • Patent number: 8519185
    Abstract: Glycolic acid having a high purity is obtained by subjecting glycolic acid or a glycolic acid solution containing contaminants to double-chamber electrodialysis combined with one or more treatments selected from among treatment with an activated carbon, treatment with an ion exchange resin, concentration treatment and cooling crystallization.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: August 27, 2013
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Shinya Okazaki, Kaori Matoishi, Kiyoshi Itou
  • Patent number: 8481675
    Abstract: A process for recycling a polymer blend necessarily containing PLA, comprising grinding, compacting, dissolving in a solvent of PLA, removing the undissolved contamining polymers, alcoholysis depolymerisation reaction and purification steps.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: July 9, 2013
    Assignee: Galactic S.A.
    Inventors: Philippe Coszach, Jean-Christophe Bogaert, Jonathan Willocq
  • Patent number: 8471062
    Abstract: Method for purifying lactic acid by crystallization in one or a plurality of steps, characterized in that crystals are formed from an impure aqueous lactic acid solution having a color of >500 Hazen, at a concentration between 85 and 95% by controlling the lactic acid oligomer content expressed in terms of a relative monomer content greater than 80% and controlling the degree of supersaturation of the solution between 1 and 60% in order to obtain lactic acid crystals having a specific surface area by mass of <0.05 m2/g.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: June 25, 2013
    Assignee: Galactic S.A.
    Inventors: Philippe Coszach, Jean-Christophe Bogaert, Pierre-Antoine Mariage, Angelo Chianese, Maria-Paola Parisi
  • Patent number: 8431677
    Abstract: Method for purifying a conventional polymer stream (PE, PP, PET, PVC, etc.) contaminated with not more than 50% PLA, comprising steps for the suspension of the polymer with solubilisation of the PLA fraction and the recovery of the purified polymer after separation.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: April 30, 2013
    Assignee: Galactic S. A.
    Inventors: Philippe Coszach, Jonathan Willocq
  • Publication number: 20130095545
    Abstract: A primary object of the present invention is to provide a polylactic acid decomposition method that efficiently decomposes polylactic acid so that the polylactic acid can readily undergo degradation by a biological treatment such as methane fermentation. Specifically, the present invention provides a polylactic acid decomposition method involving a step of impregnating a polylactic acid-containing organic material with a treatment solution containing an organic acid salt and/or inorganic acid salt of an amine compound.
    Type: Application
    Filed: June 30, 2010
    Publication date: April 18, 2013
    Applicant: OSAKA GAS CO., LTD.
    Inventor: Jun Tsubota
  • Publication number: 20130096342
    Abstract: The invention provides energy efficient depolymerization of polyesters such as post-consumer polylactic acid. Ultrasonic induced implosions can be used to facilitate the depolymerization. The expanding market of polylactic acid-based plastic products, such as water bottles and packaging materials, has raised concerns of contaminating the recycling stream, which is largely filled with petroleum-based plastics. Thus the development of an energy efficient and economically viable PLA recycling process is urgently needed. Post consumer PLA was exposed to methanol as the suspension media in the presence of organic or ionic salts of alkali metals such a potassium carbonate and sodium hydroxide as depolymerization catalysts to provide high quality lactic acid monomers in high yield.
    Type: Application
    Filed: January 24, 2012
    Publication date: April 18, 2013
    Inventors: Gowrishankar Srinivasan, David Grewell
  • Publication number: 20130078704
    Abstract: Methods of processing chemicals change their structure, and in particular increase their solubility and/or rate of dissolution, for intermediates and products made from the structurally changed materials. Many of the methods provide materials that can be more readily utilized in reactions or other processes to produce useful intermediates and products, e.g., energy, fuels, foods or materials. Chemicals that are treated using the processes described herein can be used to form highly concentrated solutions. Treatment can change the functionality of the chemical, and thus the polarity of the chemical, which may render the treated chemical soluble in solvents in which the untreated chemical is insoluble or only sparingly or partially soluble. Methods may in some cases increase the solubility of the chemical in water or aqueous media. The chemical may be, for example, a solid, liquid, or gel, or mixtures thereof.
    Type: Application
    Filed: November 20, 2012
    Publication date: March 28, 2013
    Applicant: Xyleco, Inc.
    Inventor: Xyleco, Inc.
  • Publication number: 20130053601
    Abstract: The invention relates to a process for transformation of lignocellulosic biomass or cellulose that uses tungsten-based heterogeneous catalysts that are dispersed on an oxide-based substrate, preferably with a base of oxide(s) of aluminum and/or zirconium and/or titanium and/or niobium. The use of these catalysts makes it possible to obtain directly lactic acid with high selectivity while limiting the production of oligosaccharides and soluble polymers.
    Type: Application
    Filed: February 1, 2011
    Publication date: February 28, 2013
    Inventors: Flora Chambon, Nadine Essayem, Franck Rataboul, Catherine Pinel, Amandine Cabiac, Emmanuelle Guillon
  • Publication number: 20130052141
    Abstract: A hyperpolarized MR imaging medium and a method of 13C-MR detection using a hyperpolarized MR imaging medium for the determination of lactate dehydrogenase (LDH) activity. The contrast media comprises hyperpolarised [13C, 2H]lactate.
    Type: Application
    Filed: May 2, 2011
    Publication date: February 28, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Kevin Brindle, Mikko Iivari Kettunen, Brett W.C. Kennedy
  • Patent number: 8349597
    Abstract: A method of producing lactic acid by separating lactic acid produced in a culture solution by microbial fermentation, comprising: a step (A) of filtering the culture solution through a nano-filtration membrane; and a step (B) of distilling a lactic-acid-containing solution produced in step (A) under a pressure of 1 Pa to atmospheric pressure at a temperature of 25 to 200° C. to recover lactic acid.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: January 8, 2013
    Assignee: Toray Industries, Inc.
    Inventors: Masateru Ito, Shin-ichi Minegishi, Eri Shimizu, Kenji Sawai, Yohito Ito, Hideki Sawai, Katsushige Yamada
  • Publication number: 20120328708
    Abstract: The present invention concerns a disinfectant or antimicrobial composition for use in dental treatment, such as treatment and/or prevention of periodontitis, gingivitis or other forms of oral infection. The present Inventor found that microorganisms that infect the dental tissues and cause inflammation thereof, are susceptible to osmotic stress, to such extent that the application of a hypertonic composition is effective in curing or preventing infection and/or inflammations. It was furthermore found that these microorganisms are also susceptible to acidic stress. The present invention therefore provides compositions that induce osmotic stress in microorganisms causing infection of dental tissue when topically applied thereto, preferably osmotic as well as acidic stress. The present invention also concerns the methods and uses involving the compositions of the invention.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 27, 2012
    Applicant: Nikinc Pharma B.V.
    Inventors: Suzette Veronica Van Der Waal, Stanley Brul, Johannes Jacob De Soet, Lucas Wilhelmus Maria Van Der Sluis
  • Publication number: 20120277465
    Abstract: Methods and systems for electrochemical conversion of carbon dioxide to carboxylic acids, glycols, and carboxylates are disclosed. A method may include, but is not limited to, steps (A) to (D). Step (A) may introduce water to a first compartment of an electrochemical cell. The first compartment may include an anode. Step (B) may introduce carbon dioxide to a second compartment of the electrochemical cell. The second compartment may include a solution of an electrolyte and a cathode. Step (C) may apply an electrical potential between the anode and the cathode in the electrochemical cell sufficient to reduce the carbon dioxide to a carboxylic acid intermediate. Step (D) may contact the carboxylic acid intermediate with hydrogen to produce a reaction product.
    Type: Application
    Filed: July 5, 2012
    Publication date: November 1, 2012
    Applicant: LIQUID LIGHT, INC.
    Inventors: Emily Barton Cole, Kyle Teamey, Andrew B. Bocarsly, Narayanappa Sivasankar
  • Patent number: 8293940
    Abstract: The present invention relates to a process for recovery and purification of lactic acid from a fermentation broth containing lactic acid. The process comprises subjecting the fermentation broth to ultrafiltration and/or microfiltration to form a first permeate, concentrating the first permeate to form concentrated broth, subjecting the concentrated broth to supported liquid membrane for extraction of lactic acid into a separate stream, subjecting the extracted lactic acid solution to activated carbon for removal of color, subjecting the extracted lactic acid solution to cation exchange resin for deminerization, subjecting the extracted lactic acid solution to anion exchange resin for removal of anionic impurities and concentrating the extracted lactic acid solution to desired concentration. The supported liquid membrane of the present invention contains an organic layer that comprises a earner, a co-extractant, a diluent and a stabilizer.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: October 23, 2012
    Assignee: Hyflux IP Resources Pte, Ltd.
    Inventors: Ooi Lin Lum, Govindharaju Venkidachalam, Yew Chin Neo
  • Publication number: 20120203032
    Abstract: The present disclosure relates to a process for preparing a lactic salt from a lactide starting material. In particular, the present disclosure is directed to the production of potassium lactate, wherein the potassium lactate has a desirable neutral odor and a concentration greater than 75%, and wherein the potassium lactate possesses desirable properties for food applications.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 9, 2012
    Applicant: GALACTIC S.A.
    Inventors: Aurelie Bernard, Nicolas Delmotte, Jean-Christophe Bogaert, Pierre-Antoine Mariage
  • Publication number: 20120190891
    Abstract: Embodiments of the invention include processing lipid feedstocks into various products. In an embodiment, the invention includes a method of processing a lipid feedstock including combining the lipid feedstock with water to form a reaction mixture; and contacting the reaction mixture with a catalyst, the catalyst including a metal oxide. Methods can be used to form polyols, diols, and carboxylic acids, amongst others. Other embodiments are also included herein.
    Type: Application
    Filed: November 21, 2011
    Publication date: July 26, 2012
    Inventors: Clayton V. McNeff, Bingwen Yan, Daniel Thomas Nowlan
  • Publication number: 20120165568
    Abstract: A method of preparing a liquid lactic acid composition that has a total acid content of at least 94% (w/w) and that does not crystallise at a temperature above 10° C. includes obtaining a starting liquid lactic acid composition that has a total acid content of at least 94% (w/w) and that crystallises at a temperature above 10° C. and incubating said starting liquid lactic acid composition at a temperature above the crystallisation point of the starting liquid lactic acid composition for a time period to obtain the liquid lactic acid composition that does not crystallise at a temperature above 10° C.
    Type: Application
    Filed: July 15, 2010
    Publication date: June 28, 2012
    Applicant: Purac Biochem BV
    Inventor: Jan Van Breugel
  • Publication number: 20120142945
    Abstract: A method for recovery of highly pure alkyl lactate and lactic acid is provided, which includes a step 1 for producing source liquid comprising lactic acid or ammonium lactate; a step 2 for dehydrating the source liquid product of step 1; a step 3 for producing liquid mixture by sequentially adding and stirring alcohol and acid solution to the dehydrated source liquid; a step 4 for separating and removing ammonium salt precipitation from the liquid mixture of step 3; a step 5 for producing alkyl lactate from ammonium salt-free liquid mixture by esterification reaction; and a step 6 for separating alcohol and alkyl lactate by distillation from the mixture of step 5.
    Type: Application
    Filed: December 2, 2011
    Publication date: June 7, 2012
    Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Dong Won HWANG, Jong-San CHANG, Young Kyu HWANG, U-Hwang LEE, HyoJin GWAK
  • Publication number: 20120142958
    Abstract: A process for recycling a polymer blend necessarily containing PLA, comprising grinding, compacting, dissolving in a solvent of PLA, removing the undissolved contamining polymers, alcoholysis depolymerisation reaction and purification steps.
    Type: Application
    Filed: March 31, 2010
    Publication date: June 7, 2012
    Applicant: GALACTIC S.A.
    Inventors: Philippe Coszach, Jean-Christophe Bogaert, Jonathan Willocq
  • Patent number: 8192589
    Abstract: The invention relates to a method and a device for the purification of an aqueous solution of an organic acid having a boiling point at atmospheric pressure of less than 450° C., which further has approximately 275 g carboxylate ions/l or less, preferably 250 g carboxylate ions/l or less, and preferably less than 1% by weight ionic impurities, calculated on the basis of the total solution. In particular, the invention relates to a method and a device for the continuous purification and concentration, on an industrial scale, of an aqueous solution of an organic acid having a boiling point at atmospheric pressure of less than 450° C. According to the method, this solution is subjected to two or more distillation steps, the first distillation step being carried out at a temperature of from 80° to 150° C. and a pressure of from 50 to 250 mbar, and the second distillation step being carried out at a temperature of from 80° to 200° C. and a pressure of from 0.01 to 50 mbar.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: June 5, 2012
    Assignee: Purac Biochem B.V.
    Inventors: Hendrik Martinus Winkelaar, Jan Van Breugel, Margarita Camprubi Vilá, José Maria Vidal Lancis
  • Publication number: 20120083531
    Abstract: The present invention relates to pharmaceutical compositions suitable for inhalation, comprising as an active ingredient calcium lactate or calcium citrate. The invention also relates to methods of treating, preventing, and reducing the spread of an infection of the respiratory tract, comprising administering a pharmaceutical composition that comprises calcium lactate or calcium citrate as an active ingredient.
    Type: Application
    Filed: March 26, 2010
    Publication date: April 5, 2012
    Inventors: Robert W. Clarke, Richard Batycky, David L. Hava, Michal M. Lipp
  • Patent number: 8143439
    Abstract: A process for the production of lactic acid and 2-hydroxy-3-butenoic acid or esters thereof by conversion of glucose, fructose, sucrose, xylose and glycolaldehyde dissolved in a solvent in presence of a solid Lewis acidic catalyst.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: March 27, 2012
    Assignee: Haldor Topsøe A/S
    Inventors: Esben Taarning, Saravanamurugan Shunmugavel, Martin Spangsberg Holm
  • Publication number: 20120029228
    Abstract: A process for recycling a polymer blend necessarily containing PLA, comprising grinding, compacting, dissolving in a solvent of PLA, removing the undissolved contamining polymers, alcoholysis depolymerisation reaction and purification steps.
    Type: Application
    Filed: March 31, 2010
    Publication date: February 2, 2012
    Applicant: GALACTIC S.A.
    Inventors: Philippe Coszach, Jean-Christophe Bogaert, Jonathan Willocq
  • Patent number: 8048655
    Abstract: A method is disclosed for the recovery of an organic acid from a dilute salt solution in which the cation of the salt forms an insoluble carbonate salt. A tertiary amine and CO2 are introduced to the solution to form the insoluble carbonate salt and a complex between the acid and an amine. A water immiscible solvent, such as an alcohol, is added to extract the acid/amine complex from the dilute salt solution to a reaction phase. The reaction phase is continuously dried and a product between the acid and the solvent, such as an ester, is formed.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: November 1, 2011
    Assignee: ZeaChem, Inc.
    Inventors: Dan W. Verser, Timothy J. Eggeman
  • Publication number: 20110257429
    Abstract: The invention relates to an improved method for releasing an organic acid, preferably a carbon, sulfone or phosphone acid, particularly an alpha or beta hydroxycarbon acid, from the ammonia salt thereof by releasing and removing ammoniac and simultaneous extraction of the released acid, having an amine as a suitable extraction means from the aqueous phase. This method corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonia salt solution thereof can be significantly improved by the use of a strip medium or carrier gas, such as nitrogen, air, water vapor or inert gases such as argon. The released ammoniac is removed from the aqueous solution by the continuous gas flow and can be resupplied into a production process. The free acid can be obtained by a method such as distillation, rectification, crystallization, reextraction, chromatography, adsorption or by a membrane method from the extraction means.
    Type: Application
    Filed: February 1, 2010
    Publication date: October 20, 2011
    Applicant: Evonik Degussa GmbH
    Inventors: Alexander Schraven, Thomas Tacke, Thomas Haas, Christoph Kobler, Dieter Buss, Axel Ronneburg, Olivier Zehnacker
  • Publication number: 20110252507
    Abstract: The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins, pharmaceuticals and nutraceuticals. More particularly, the present invention contemplates the use of grasses, and even more particularly C4 grasses, such as sugarcane, for the production of a range of compounds such as, for example, polyhydroxyalkanoates, pHBA, vanillin, indigo, adipic acid, 2-phenylethanol, 1,3-propanediol, sorbitol, fructan polymers and lactic acid as well as other products including, inter alia, other plastics, silks, carbohydrates, therapeutic and nutraceutic proteins and antibodies. The present invention further extends to transgenic plants and, in particular, transgenic C4 grass plants, capable of producing the compounds noted above and other products, and to methods for generating such plants.
    Type: Application
    Filed: July 13, 2010
    Publication date: October 13, 2011
    Applicants: The University of Queensland, BSES Limited
    Inventors: Stevens Michael Brumbley, Matthew Peter Purnell, Barrie Fong Chong, Lars Arved Petrasovits, Lars Keld Nielsen, Richard Bruce McQualter
  • Publication number: 20110229403
    Abstract: A system and method for passive capture of ammonia in an enclosure containing material that gives off ammonia. The invention allows for the passage of gaseous NH3 through microporous hydrophobic gas-permeable membranes and its capture in a circulated acidic solution with concomitant production of a concentrated non-volatile ammonium salt.
    Type: Application
    Filed: March 15, 2011
    Publication date: September 22, 2011
    Inventors: Ariel A. Szogi, Matias B. Vanotti, Michael J. Rothrock
  • Publication number: 20110218248
    Abstract: The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
    Type: Application
    Filed: November 10, 2009
    Publication date: September 8, 2011
    Inventors: Guido Jordine, Michael Mutz