Unsaturated Patents (Class 562/598)
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Publication number: 20030204106Abstract: A method for the decomposition of a Michael type adduct of an acrylic acid and/or an acrylic ester represented by the following formula [I] or [II] is disclosed, wherein decomposing the Michael type adduct in the presence of at least one copper salt and at least one metal salt selected from the group consisting of an alkali metal salt and an alkaline earth metal salt into an acrylic acid and/or an acrylic ester and/or an alcohol.Type: ApplicationFiled: March 10, 2003Publication date: October 30, 2003Inventors: Fumio Shibusawa, Naoki Serata, Kazuhiko Sakamoto
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Patent number: 6617470Abstract: In a process for esterifying (meth)acrylic acid with an alkanol in the presence of an esterification catalyst, in which unconverted starting compounds and (meth)acrylic ester to be formed are separated off by distillation and an oxyester-containing bottom product is formed, the bottom product is first separated off and then the oxyesters contained in it are cleaved in the presence of a relatively long-chain alkylbenzenesulfonic acid at elevated temperatures.Type: GrantFiled: May 11, 2001Date of Patent: September 9, 2003Assignee: BASF AktiengesellschaftInventors: Heinrich Aichinger, Holger Herbst, Gerhard Nestler, Jürgen Schröder, Stefan Beckmann
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Patent number: 6608221Abstract: A process for the preparation of (2R)-2-propyloctanoic acid which is characterized by subjecting (2S)-2-(2-propynyl)octanoic acid or (2S)-2-(2-propenyl)octanoic acid to reduction using platinum on carbon. This process gives (2R)-2-propyloctanoic acid having high optical purity without isomerization.Type: GrantFiled: September 10, 2001Date of Patent: August 19, 2003Assignees: Ono Pharmaceutical Co., Ltd., Tokyo Kasei Kogyo Co., Ltd.Inventors: Norikazu Toda, Kaoru Yamaguchi, Youichi Iguchi
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Patent number: 6599397Abstract: This method of preventing polymerization of methacrylic acid inn the process of its production is characterized by comprising using, in a refining column, a combination of N-nitrosophenylhydroxylamine or salt thereof with an N-oxyl compound, an N-hydroxy-,2,2,6,6-tetramethylpiperidine compound and a 2,2,6,6-tetramethylpiperidine compound. In this method, N-nitrosophenylhydroxylamine or a salt thereof rises inside a refining column under splitting part thereof to effectively inhibit polymerization of (meth)acrylic acid or the like. The above polymerization in both vapor and liquid phases can be inhibited more effectively by the combined use of the compounds mentioned above.Type: GrantFiled: June 6, 2001Date of Patent: July 29, 2003Assignee: Nippon Shokubai Co., Ltd.Inventors: Kazuhiko Sakamoto, Tomohiro Nakae, Kazuo Okochi, Masahiro Uemura, Sei Nakahara
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Patent number: 6582943Abstract: The present invention relates to a method for producing 2-hydroxyisobutyric acid where acetone cyanohydrin is converted to 2-hydroxyisobutyric acid using an enzyme catalyst having nitrilase activity, or having a combination of nitrile hydratase and amidase activities. The invention also encompasses production of methacrylic acid wherein the 2-hydroxyisobutyric acid produced with the catalyst described is dehydrated to produce methacrylic acid.Type: GrantFiled: February 5, 2002Date of Patent: June 24, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Sarita Chauhan, Robert DiCosimo, Robert Fallon, John Gavagan, Leo Ernest Manzer, Mark S. Payne
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Publication number: 20030032832Abstract: It has been discovered that the polymerization of unsaturated compounds, such as butadiene, may be inhibited by the addition of a diene and/or alkanolamine inhibitor. The inhibitor is believed to catalytically destroy peroxides present, such as hydrogen peroxide, which may be present in trace amounts. Particularly useful inhibitors include, but are not limited to, ethylenediamine (EDA) and monoethanolamine (MEA).Type: ApplicationFiled: June 20, 2001Publication date: February 13, 2003Inventor: Muslim D. Shahid
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Patent number: 6518453Abstract: In a process for stabilizing chemical compounds having at least one ethylenically unsaturated bond to undesired free radical polymerization, a nitroxyl radical and a chemical compound containing phosphorus in chemically bonded form are added to the unsaturated compound present as pure substance or as a component of a mixture.Type: GrantFiled: July 3, 2001Date of Patent: February 11, 2003Assignee: BASF AktiengesellschaftInventors: Heinz Friedrich Sutoris, Gerhard Wagenblast, Volker Schliephake, Jürgen Schröder, Klaus Joachim Müller-Engel, Harald Keller, Thomas Jaworek
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Patent number: 6518452Abstract: A method is described of stabilizing (meth)acrylic esters against unwanted free-radical polymerization, in which the mixture to be stabilized has added to it a polymerization inhibitor mixture comprising at least one nitroxyl radical and/or at least one organic compound having at least one nitroso group, and at least one p-phenylenediamine.Type: GrantFiled: February 7, 2000Date of Patent: February 11, 2003Assignee: BASF AktiengesellschaftInventors: Heinrich Aichinger, Holger Herbst, Gerhard Nestler
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Publication number: 20030028051Abstract: A method for the decomposition of a Michael type adduct, characterized by causing a Michael type adduct to react in the presence of an N-oxyl compound thereby decomposing the Michael type adduct into acrylic acid and/or the acrylic ester and/or the alcohol and a method for the production of acrylic acid and/or the acrylic ester, characterized by comprising a step of recovering a Michael type adduct formed in the process for the production of acrylic acid or acrylic ester and a step of decomposing the recovered Michael type adduct by the method of decomposition mentioned above. This invention, therefore, allows promotion of efficient utilization of the raw materials.Type: ApplicationFiled: June 27, 2002Publication date: February 6, 2003Inventors: Fumio Shibusawa, Naoki Serata, Kazuhiko Sakamoto
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Patent number: 6504056Abstract: A method of transporting and/or storing pure acrylic acid comprises ensuring by means of appropriate measures that the pure acrylic acid is partly crystalline during the entire duration of transport and/or storage.Type: GrantFiled: May 1, 2001Date of Patent: January 7, 2003Assignee: BASF AktiengesellschaftInventors: Heinrich Aichinger, Gerhard Nestler, Paul Leon Kageler
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Patent number: 6504055Abstract: Processes for producing citraconic anhydride and citraconic acid using porous materials with specific surface acidities and surface areas are described. The preferred catalyst is a porous gamma alumina. Itaconic acid is produced from citraconic acid. Itaconic acid is an intermediate to a variety of compounds including polymers.Type: GrantFiled: September 21, 2000Date of Patent: January 7, 2003Assignee: Board of Trustees of Michigan State UniversityInventors: Dennis J Miller, Dushyant Shekhawat, Kirthivasan Nagarajan, James E. Jackson
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Patent number: 6498272Abstract: In a process for the preparation of acrylic acid, a product gas mixture obtained by catalytic gas-phase oxidation of a C3-precursor of acrylic acid and containing acrylic acid is directly cooled with a quench liquid and then subjected to fractional condensation in a separation column provided with baffles, said product gas mixture ascending into itself and a crude acrylic acid being removed via a side take-off, and the acrylic acid oligomers formed are cleaved and recycled.Type: GrantFiled: August 30, 2001Date of Patent: December 24, 2002Assignee: BASF AktiengesellschaftInventors: Jürgen Schröder, Gerhard Nestler, Klaus Joachim Müller-Engel
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Patent number: 6489509Abstract: An aqueous potassium sorbate solution has a dissolved oxygen concentration of not more than 3.0 mg/l. The aqueous potassium sorbate solution can be obtained (i) by degassing an aqueous potassium sorbate solution to thereby control the dissolved oxygen concentration to 3.0 mg/l or less, or (ii) by performing a reaction in a system, in which the oxygen concentrations of the gas phase and of materials to be reacted are reduced, in the production of an aqueous potassium sorbate solution by a reaction of sorbic acid and potassium hydroxide in the presence of water. The resulting aqueous potassium sorbate solution exhibits successively stable hue.Type: GrantFiled: May 3, 2001Date of Patent: December 3, 2002Assignee: Daicel Chemical Industries, Ltd.Inventors: Mitsuhiro Kouno, Noboru Kamei
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Publication number: 20020165410Abstract: A method of transporting and/or storing pure acrylic acid comprises ensuring by means of appropriate measures that the pure acrylic acid is partly crystalline during the entire duration of transport and/or storage.Type: ApplicationFiled: May 1, 2001Publication date: November 7, 2002Applicant: BASF AktiengesellschaftInventors: Heinrich Aichinger, Gerhard Nestler, Paul Leon Kageler
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Patent number: 6455732Abstract: Pure acrylic acid is stored and/or transported by a process in which the pure acrylic acid is stored and/or transported as liquid aqueous solution at ≦15° C.Type: GrantFiled: April 21, 2000Date of Patent: September 24, 2002Assignee: BASF AktiengesellschaftInventors: Heinrich Aichinger, Klaus Joachim Müller-Engel, Gerhard Nestler, Jürgen Schröder
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Patent number: 6399811Abstract: The present invention provides compounds of formula I wherein R1 and R3 are independently H or C1-3 alkyl, and R2 is H, C1-3 alkyl, methylene or ethylidene, with the proviso that R1 and R2 are not simultaneously H; n is 0 or 1; and - - - is a single or a double bond, wherein a maximum of two double bonds are present in the compound. Compounds of formula II are also provided: wherein A is selected from the group of CR4R5OH, CR4R5OC(O)R6, CO2R6, CN and C(O)R4; R1, R3, R4, and R5 are independently H or C1-3-alkyl; R2 is H, C1-3-alkyl, methylene, or ethylidene; R6 is H, C1-3 alkyl, C2-4 alkenyl, or alkinyl; n is 0 or 1; and - - - is a single or a double bond, wherein a maximum of two double bonds are present. Compositions containing compounds of formulae I and II, as well as methods for imparting fragrance to substrates using such compounds are also provided.Type: GrantFiled: December 31, 2001Date of Patent: June 4, 2002Assignee: Givaudan SAInventors: Jerzy A. Bajgrowicz, Bernadette Bourdin Trunz, Peter Gygax
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Patent number: 6353012Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.Type: GrantFiled: October 23, 2000Date of Patent: March 5, 2002Assignee: Alcon Universal Ltd.Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
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Patent number: 6348598Abstract: Disclosed are novel N-oxyl compounds of the following formula (1). wherein n is an integer of 1 to 18; R1 and R2 are each hydrogen or methyl, but at least one of them is hydrogen; R3, R4, R5 and R6 are each a straight-chain or branched alkyl group; and R7 is hydrogen or (meth)acryloyl. When these compounds are added to vinyl monomers such as &agr;,&bgr;-unsaturated carboxylic acids and esters thereof, they exhibit a satisfactory polymerization-inhibiting effect even at low contents and even at elevated temperatures.Type: GrantFiled: May 11, 2000Date of Patent: February 19, 2002Assignees: Mitsubishi Rayon Co., Ltd., Osaka Organic Chemical Ind. Co., Ltd.Inventors: Junichi Doi, Hiroshi Sonobe, Akio Tani, Shinji Suzuki, Masafumi Akehi
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Publication number: 20010044468Abstract: A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.Type: ApplicationFiled: January 12, 2001Publication date: November 22, 2001Inventors: James E. Hall, Richard R. Tidwell, David W. Boykin
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Patent number: 6300513Abstract: It intends to prevent the reduction in quantity with time of an oxyl compound in vinyl compounds. The quantity reduction of the N-oxyl compound is suppressed by causing an N-oxyl compound, N-hydroxy-2,2,6,6-tetramethylpiperidine compound and a 2,2,6,6-tetramethylpiperidine compound to co-exist in vinyl compounds.Type: GrantFiled: December 5, 2000Date of Patent: October 9, 2001Assignee: Nippon Shokubai Co., Ltd.Inventors: Kazuhiko Sakamoto, Naoki Serata, Kouji Ueno, Sei Nakahara, Masatoshi Ueoka
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Patent number: 6274624Abstract: Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.Type: GrantFiled: May 11, 1998Date of Patent: August 14, 2001Assignee: American Biogenetic Sciences Inc.Inventors: Heinz Nau, Ciaran M. Regan
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Patent number: 6274385Abstract: The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.Type: GrantFiled: August 9, 1999Date of Patent: August 14, 2001Assignee: Abbott LaboratoriesInventors: Jill Edie Hochlowski, Thomas J. Sowin, Daniel W. Norbeck, Anne-Laure Marie Grillot, Rolf E. Swenson
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Publication number: 20010005763Abstract: The present invention provides an apparatus for producing (meth)acrylic acid and a process for producing (meth)acrylic acid with this apparatus wherein the apparatus enables to produce (meth)acrylic acid stably for a long period of time by effectively inhibiting the polymerization of (meth)acrylic acid in its production process (for example, in a reboiler). At least a part of the apparatus is made of a nickel-chromium-iron alloy with a molybdenum content of 3 to 20 mass %, but not including 3 mass %, or with a molybdenum content of 1 to 4 mass % and a copper content of 0.5 to 7 mass %.Type: ApplicationFiled: December 12, 2000Publication date: June 28, 2001Applicant: Nippon Shokubai Co., Ltd.Inventors: Sei Nakahara, Kazuhiko Sakamoto, Yukihiro Matsumoto, Kenji Sanada, Masatoshi Ueoka
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Patent number: 6252110Abstract: A method for recovering acrylic acid from high boiling impurities containing acrylic acid dimer, acrylic acid and maleic acid at high efficiency with stability which includes the steps of (1) introducing said high boiling impurities containing acrylic acid dimer, acrylic acid and maleic acid into an acrylic acid recovery column, distilling acrylic acid from the column top and recovering the same, (2) introducing bottom liquid A from said acrylic acid recovery column into a pyrolyzing tank to decompose the acrylic acid dimer in the bottom liquid A, and (3) recirculating at least a part of bottom liquid B from said pyrolyzing tank into the acrylic acid recovery column.Type: GrantFiled: June 25, 1998Date of Patent: June 26, 2001Assignee: Nippon Shokubai Co LTDInventors: Masahiro Uemura, Takahiro Takeda, Masatoshi Ueoka
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Patent number: 6207859Abstract: A process for inhibiting free-radical polymerization of an alpha,beta-unsaturated (&agr;,&bgr;-unsaturated) carboxylic acid, and for providing desired grade &agr;,&bgr;-unsaturated carboxylic acid for use following storage and transport is described herein. In particular, bulk storage and shipment such as with overseas transport is described. The process comprises combining the &agr;,&bgr;-unsaturated carboxylic acid with a phenolic inhibitor and a coinhibitor to form an inhibited mixture, storing the inhibited mixture, transporting the inhibited mixture, and removing the coinhibitor to provide the desired grade &agr;,&bgr;-unsaturated carboxylic acid for use. In preferred embodiments, the &agr;,&bgr;-unsaturated carboxylic acid is acrylic acid, the phenolic inhibitor is p-methoxyphenol, the coinhibitor is manganese cation, and removal of the coinhibitor is carried out using an ion exchange resin.Type: GrantFiled: September 23, 1999Date of Patent: March 27, 2001Assignee: Celanese International CorporationInventors: Leon B. Levy, Edward F. Dougherty, Charles C. Hobbs, Jr., Jerome F. Perez, Mark O. Scates, Madan Singh
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Patent number: 6172131Abstract: Hydrolysis-stable and polymerizable acrylphosphonic acids are described which are particularly suitable as a component of dental adhesives owing to their adhesion-promoting properties.Type: GrantFiled: October 9, 1998Date of Patent: January 9, 2001Assignee: Ivoclar AGInventors: Norbert Moszner, Frank Zeuner, Volker Rheinberger
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Patent number: 6156694Abstract: The present invention relates to a Raney catalyst comprising iron, cobalt, a third metal wherein the third metal is selected from the group consisting of nickel, rhodium, ruthenium, palladium, platinum, osmium, iridium and mixtures of any of the metals of this group.Type: GrantFiled: November 5, 1998Date of Patent: December 5, 2000Assignee: E. I. Dupont De Nemours & CompanyInventor: Mark Jay Harper
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Patent number: 6153783Abstract: A two-step process for producing a difunctional organic compound is provided which comprises:a) reacting a cycloalkanone with a 2-substituted-1-alkene in the presence of an enamine catalyst to produce the corresponding substituted cycloalkanone intermediate and,b) subjecting the intermediate reaction product to ultraviolet radiation in the presence of a solvent to form the difunctional organic compound of the general formula: ##STR1## wherein R4 is derived from the solvent and is hydroxyl, --NH.sub.2 or OR.sup.5, andwherein R, R1, R2, R4, R.sup.5, and x are as defined in the specification.Type: GrantFiled: January 6, 2000Date of Patent: November 28, 2000Assignee: Cognis CorporationInventors: Louis Rebrovic, Michael Staley
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Patent number: 6087296Abstract: The present invention relates to a Raney catalyst comprising iron, cobalt, a third metal wherein the third metal is selected from the group consisting of nickel, rhodium, ruthenium, palladium, platinum, osmium, iridium and mixtures of any of these metals.Type: GrantFiled: November 5, 1998Date of Patent: July 11, 2000Assignee: E. I. du Pont de Nemours & Co.Inventor: Mark Jay Harper
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Patent number: 6063959Abstract: 1,4-Dibenzothiazine-comprising crude acrylic acid is purified by crystallization by raising its diacrylic acid content to at least 1% by weight prior to the crystallization step.Type: GrantFiled: December 30, 1998Date of Patent: May 16, 2000Assignee: BASF AktiengesellschaftInventors: Klaus Lehnert, Klaus Joachim Muller-Engel, Gerhard Nestler, Bernd Eck
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Patent number: 6054483Abstract: The invention relates to fatty acids conjugated to amino acids and their derivatives that elicit the production and/or release of plant volatiles compounds which attract and/or retain beneficial insects and deter herbivorous insect feeding. These conjugates also induce plants to increase production of pharmacologically important compounds such as taxol, increase fragrance of flowers, and increase production of plant essential oil. The invention also relates to methods for isolating the compounds from herbivorous insect oral secretions and to chemically synthesizing the compounds and their active derivatives.Type: GrantFiled: December 3, 1996Date of Patent: April 25, 2000Assignees: The United States of America as represented by the Secretary of Agriculture, Virginia Military Institute Research Laboratories, Inc.Inventors: James H. Tumlinson, III, Hans T. Alborn, John H. Loughrin, Theodoor C. J. Turlings, Tappey H. Jones
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Patent number: 6051735Abstract: There is disclosed a process for prevention the polymerization of a vinyl compound selected from acrylic acid and methacrylic acid which comprises allowing at least one corrosion inhibitive substance selected from an alcohol and inorganic acid or salt thereof, an aromatic carboxylic acid or salt thereof and a zinc-containing salt to coexist with a metallic salt of dithiocarbamic acid, in prevention the polymerization of the vinyl compound with the metallic salt of dithiocarbamic acid.Type: GrantFiled: December 15, 1998Date of Patent: April 18, 2000Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Kenji Okamoto, Takashi Nakagawa, Hideaki Mimaki, Kouji Tomita
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Patent number: 6048897Abstract: Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.Type: GrantFiled: September 13, 1996Date of Patent: April 11, 2000Assignee: Brigham and Women's HospitalInventor: Charles N. Serhan
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Patent number: 6046278Abstract: High temperature polymerization process and products obtained therefrom are provided. The polymerization is conducted at above 225.degree. C. to produce polymers having a degree of polymerization below 50. The products are useful as detergent additives and for subsequent polymerization.Type: GrantFiled: March 5, 1998Date of Patent: April 4, 2000Assignee: Rohm and Haas CompanyInventors: Michael Bennett Freeman, Gary Robert Larson, Richard Foster Merritt, Yi Hyon Paik, Jan Edward Shulman, Graham Swift, Robert Wilczynski
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Patent number: 6046357Abstract: A process for inhibiting free-radical polymerization of an alpha,beta-unsaturated (.alpha.,.beta.-unsaturated) carboxylic acid, and for providing desired grade .alpha.,.beta.-unsaturated carboxylic acid for use following storage and transport is described herein. In particular, bulk storage and shipment such as with overseas transport is described. The process comprises combining the .alpha.,.beta.-unsaturated carboxylic acid with a phenolic inhibitor and a coinhibitor to form an inhibited mixture, storing the inhibited mixture, transporting the inhibited mixture, and removing the coinhibitor to provide the desired grade .alpha.,.beta.-unsaturated carboxylic acid for use. In preferred embodiments, the .alpha.,.beta.-unsaturated carboxylic acid is acrylic acid, the phenolic inhibitor is .rho.-methoxyphenol, the coinhibitor is manganese cation, and removal of the coinhibitor is carried out using an ion exchange resin.Type: GrantFiled: October 2, 1998Date of Patent: April 4, 2000Assignee: Celanese International CorporationInventors: Leon B. Levy, Edward F. Dougherty
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Patent number: 6034268Abstract: Compounds of the formula ##STR1## in which one of the radicals R.sup.1 and R.sup.2 is methyl and the other is vinyl and one of the radicals R.sup.3 and R.sup.4 is methyl and the other is ##STR2## in which R.sup.5 is hydrogen, alkyl or alkenyl, in particular C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.6 -alkenyl, are particularly suitable as fragrances and flavors.Type: GrantFiled: November 4, 1998Date of Patent: March 7, 2000Assignee: Haarmann & Reimer GmbHInventors: Horst Surburg, Horst Sommer, Stefan Lambrecht, Peter Worner, Matthias Guntert, Gunter Kindel, Volkmar Koppe
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Patent number: 6025523Abstract: Solid mixed oxides composition of formula (I):Mo.sub.12 V.sub.a Sr.sub.b W.sub.c Cu.sub.d Si.sub.e O.sub.x(I)2.ltoreq.a.ltoreq.14, 0.1.ltoreq.B.ltoreq.6, 0.ltoreq.c.ltoreq.12, 0.ltoreq.d.ltoreq.6, 0.ltoreq.e.ltoreq.15; x is the quantity of oxygen bonded to the other elements and depends on their oxidation states, are used in the manufacture of acrylic acid by oxidation of acrolein, the said solid composition reacting with acrolein according to the redox reaction (1):SOLID.sub.oxidized +ACROLEIN.fwdarw.SOLID.sub.reduced +ACRYLIC ACID(1).To manufacture acrylic acid, a gaseous mixture of acrolein and of water vapor and, if appropriate, of an inert gas is passed over a solid composition of formula (I), to conduct the redox reaction (1) by operating at a temperature of 200 to 500.degree. C., at a pressure of 1.01.times.10.sup.4 to 1.01.times.10.sup.6 Pa (0.1 to 10 atmospheres), and with a residence time of 0.01 second to 90 seconds, in the absence of molecular oxygen.Type: GrantFiled: February 27, 1998Date of Patent: February 15, 2000Assignee: ELF Atochem S.A.Inventors: Gerard Hecquet, Jean-Pierre Schirmann, Michel Simon, Charlotte Pham
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Patent number: 6011176Abstract: The use of organic, polymeric, anionic water-soluble flocculants for the phase separation of an organic-aqueous system which essentially comprises monomeric acrylates, diacrylates, (poly)ester acrylates or (poly)ether acrylates and unreacted residues of the carboxylic anhydrides, carboxylic acids or alcohols used for preparing the acrylates.Type: GrantFiled: January 29, 1999Date of Patent: January 4, 2000Assignee: BASF AktiengesellschaftInventors: Wolfgang Paulus, Matthias Geisendorfer
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Patent number: 5977151Abstract: A compound of the formula ##STR1## where R.sup.1 is the radical of the formula II or III ##STR2## is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV ##STR3## is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.Type: GrantFiled: January 23, 1998Date of Patent: November 2, 1999Assignee: Hoechst AktiengesellschaftInventors: Stefan Mullner, Bernd Kirschbaum, Wilfried Schwab
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Patent number: 5945451Abstract: The present invention relates to new fluorobutenyl (thio)ethers of the formula (I) ##STR1## in which R.sup.1 represents hydrogen or halogen,R.sup.2 and R.sup.3 independently of one another represent hydrogen or in each case optionally substituted alkyl, cycloalkyl, aryl, aralkyl or hetaryl,R.sup.4 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, cycloalkyl, aryl, aralkyl, hetaryl and additionally represent a metal ion equivalent or an ammonium ion if Z represents oxygen,X represents oxygen or sulphur,Y represents oxygen or sulphur,Z represents oxygen, sulphur or the radical NR.sup.5 in whichR.sup.5 represents hydrogen, in each case optionally substituted alkyl, aryl, aralkyl, hetaryl or the radical ##STR2## in which R.sup.6 and R.sup.7 independently of one another represent hydrogen, in each case optionally substituted alkyl, aryl, aralkyl, or together represent optionally substituted alkanediyl andR.sup.Type: GrantFiled: June 16, 1997Date of Patent: August 31, 1999Assignees: Bayer Aktiengesellschaft, Monsanto CompanyInventors: Udo Kraatz, Jurgen Hartwig, Wolfram Andersch, Christoph Erdelen, Andreas Turberg, Norbert Mencke, Peter Gerrard Ruminski
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Patent number: 5908803Abstract: The present invention relates to the isolation of a palladium-based catalyst from a mixture in which it is dissolved. More specifically, the invention relates to the isolation of a palladium-based catalyst from a mixture originating from the reaction of hydroxycarbonylation of butadiene to pentenoic acids. It therefore consists of a process for the isolation of at least a portion of the palladium dissolved in a solution also containing at least 3-pentenoic acid, characterized in that the said solution is acidified and stirred with an aqueous solution of hydrochloric acid, so as to obtain two liquid phases including an aqueous phase containing at least a portion of the palladium.Type: GrantFiled: April 9, 1997Date of Patent: June 1, 1999Assignee: Rhone-Poulenc Fiber & Resin IntermediatesInventors: Philippe Leconte, Carl Patois
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Patent number: 5902889Abstract: A process for hydrogenating carbon-carbon double bonds of a water-soluble olefinically unsaturated carboxylic acid salt which comprises(a) combining an aqueous solution of an olefinically unsaturated carboxylic acid salt with(1) an oxidant selected from the group consisting of oxygen, air and hydroperoxides;(2) a reducing agent selected from hydrazine and hydrates thereof; and(3) a metal ion activator;(b) heating the mixture to a temperature from 0.degree. C. to the reflux temperature of the reaction mixture; and(c) neutralizing the pH of the reaction mixture.Type: GrantFiled: September 18, 1997Date of Patent: May 11, 1999Assignee: The Goodyear Tire & Rubber CompanyInventors: Lawson Gibson Wideman, Denise Jeannette Keith
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Patent number: 5891921Abstract: Wood preservative systems comprising (a) a biocidal effective amount of (i) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium carboxylate having the formula ##STR1## wherein R.sup.1 and R.sup.2 are a C.sub.8 -C.sub.12 alkyl group; R.sup.3 is a substituted or unsubstituted, interrupted or uninterrupted C.sub.1 -C.sub.100 group; l and q independently are 1, 2 or 3 and (l) (q) is 1, 2, or 3; and n is 0 or an integer from 1 to 50; (ii) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium borate having the formula ##STR2## wherein R.sup.1 and R.sup.2 are defined as above, and a is 2 or 3, but when a is 2, b is 0 or 1, and when a is 3, b is 0, 1, or 2; or (iii) a combination of (i) and (ii); and (b) a solvent are provided. These carboxylate quats as well as carboxylate quats wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is a C.sub.8 -C.sub.20 alkyl group are preferably prepared by an indirect or a direct synthesis.Type: GrantFiled: April 18, 1996Date of Patent: April 6, 1999Assignee: Lonza Inc.Inventor: Leigh E. Walker
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Patent number: 5886220Abstract: There is disclosed a process for preventing the polymerization of a vinyl compound which comprises allowing water in an amount of 0.05 to 5% by weight based on the vinyl compound or a corrosion inhibitive substance selected from an alcohol, an inorganic acid or its salt, an aromatic carboxylic acid or its salt and a zinc-containing salt in an amount of preferably 0.01 to 5% by weight based on the same, to coexist with a metallic salt of dithiocarbamic acid, in preventing the polymerization of the vinyl compound with the metallic salt of dithiocarbamic acid. The above process makes it possible to effectively inhibit the polymerization of acrylic acid, methacrylic acid, etc. in the distillation system, etc. of the production process for the above acids as well as the corrosion of the equipment and machinery to be used therein and also to assure long-term stable continuous operation of the equipment and machinery.Type: GrantFiled: March 5, 1997Date of Patent: March 23, 1999Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Kenji Okamoto, Takashi Nakagawa, Hideaki Mimaki, Kouji Tomita
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Patent number: 5856562Abstract: In a method for inhibiting the polymerization of (meth)acrylic acid or esters thereof, the improvement comprising using as a polymerization inhibitor a N-oxyl compound represented by the general formula (1): ##STR1## wherein X represents CH.sub.2, CHOH, C=O, CHCOCH.sub.3 or CHNHCOCH.sub.2, in combination with phosphine compound or a cobalt compound.Type: GrantFiled: May 27, 1997Date of Patent: January 5, 1999Assignee: Mitsubishi Chemical CorporationInventors: Norioki Mine, Tooru Segi
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Patent number: 5856568Abstract: A process for inhibiting polymerization of a vinyl compound comprising using (A) one or both of N-nitrosophenylhydroxylamine and a salt thereof in combination with (B) a salt of copper or in combination with (B') a metal salt of a dialkyldithiocarbamic acid and (C) at least one selected from the group consisting of inorganic acids, salts of inorganic acids, and water.In accordance with the above process, stable continuous operation of a process for producing a vinyl compound, particularly acrylic acid or methacrylic acid, such as a distillation process of the vinyl compound, for a long time is enabled by effectively suppressing polymerization of the vinyl compound in the process or by effectively suppressing polymerization of the vinyl compound in the process while corrosion of the apparatus for the production is prevented.Type: GrantFiled: May 30, 1997Date of Patent: January 5, 1999Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Kenji Okamoto, Takashi Nakagawa, Kouji Tomita
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Patent number: 5830966Abstract: Compounds of general formula (I) ##STR1## characterised in that R.sup.1 and R.sup.2 are independently selected from the group consisting of COOR, CN, aryl, substituted aryl, COOH, halogen, C(O)NHR.sup.4, C(O)NR.sup.5 R.sup.6 ;X and Y are independently selected from the group consisting of H, COOH, COOR, CN, R.sup.3 CO--, C(O)NHR.sup.4, C(O)NR.sup.5 R.sup.6, P(O)(OR.sup.7).sub.2 and SO.sub.2 R.sup.8 ; with the proviso that X and Y are not both H; or X and Y together with the carbon atom to which they are attached form a carbocyclic or heterocyclic ring system which can contain oxygen, sulfur or nitrogen atoms; and R, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are various groups;and polymers and copolymers derived from such compounds.Type: GrantFiled: January 26, 1996Date of Patent: November 3, 1998Assignees: E. I. du Pont de Nemours and Company, Commonwealth Scientific & Industrial Research OrganisationInventors: San Hoa Thang, Ezio Rizzardo, Graeme Moad
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Patent number: 5789616Abstract: A method is provided for the production of zinc acrylate which possesses an essentially fine constitution, permits easy pulverization into a fine powder, and, when kneaded with a rubber composition, attains uniform diffusion in a state very rarely inducing fast adhesion or formation of cluster. The fine zinc acrylate powder is obtained by a method which comprises causing acrylic acid and a higher fatty acid of 12-30 carbon atoms to react with zinc oxide in an organic solvent while continuing dispersion of the zinc oxide in the organic solvent in the presence of an anionic surfactant.Type: GrantFiled: June 12, 1997Date of Patent: August 4, 1998Assignees: Bridgestone Sports Co., Ltd, Nippon Shokubai Co., Ltd, Nihon Joyu Kogyo Co., Ltd.Inventors: Keiji Kobayashi, Yukihisa Kodama, Minoru Saotome, Yoshinori Saito
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Patent number: 5786380Abstract: The invention provides compounds which are effective antiepileptics and at the same time display only a slight sedative and teratogenic effect and have the formula ##STR1## where the compounds of the formulae (I) and (II) can also be mono- or polyunsaturated, in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each, independently of one another, hydrogen or a C.sub.1 -C.sub.6 -alkyl group, R.sup.5 is hydrogen or a C.sub.1 -C.sub.2 -alkyl group, and at least one of the radicals R.sup.1 to R.sup.4 in the compounds of the formulae (I) and (II) is different from hydrogen, where the compounds of the formula (I), in the case where a center of asymmetry is present on the carbon atom in position 2, and the compounds of the formulae (II), (III) and (IV) are in the form of their racemate, their pure enantiomers or a mixture of their enantiomers which differs from the racemate, and pharmaceutically compatible salts thereof.Type: GrantFiled: November 23, 1994Date of Patent: July 28, 1998Inventors: Heinz Nau, Ursula Bojic, Ralf-Siegbert Hauck, Mohamed Mohey Eldin Elmazar
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Patent number: RE37670Abstract: Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.Type: GrantFiled: February 8, 1999Date of Patent: April 23, 2002Assignee: American Biogenetics Inc.Inventors: Heinz Nau, Ciaran M. Regan