Abstract: Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Camitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.

Abstract: The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction.

Abstract: A process for the preparation of arylaminonitrophenyl hydroxyethyl sulfones of the formula (1) ##STR1## in which Z denotes the radical ##STR2## in which R.sub.1 denotes a hydrogen atom or an --NH.sub.2, --NH--R or --N(R).sub.2 group, R representing a C.sub.1 -C.sub.4 -alkyl group, R.sub.2 denotes a hydrogen atom, a C.sub.1 -C.sub.4 -alkyl group or a C.sub.1 -C.sub.4 -alkoxy group, R.sub.3 represents a hydrogen, chlorine or bromine atom or a sulfonic acid, sulfonamide, carboxylic acid, carboxamide, hydroxyl, carbomethoxy, carboethoxy or hydroxyethylsulfonyl group, R.sub.4 denotes a hydrogen, chlorine or bromine atom or a sulfonic acid, carboxylic acid, hydroxy or C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkyl group, it being possible for 1-3 different R.sub.1 -R.sub.3 substituents, not more than two of which may, however, be identical, to be present in the radical Z.sub.a, and for 1-4 different R.sub.1 -R.sub.