Abstract: Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post-translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.
Type:
Grant
Filed:
June 11, 2014
Date of Patent:
January 30, 2018
Assignee:
UVic Industry Partnerships
Inventors:
Fraser Hof, Samuel Minaker, Kevin Daze, Sara Tabet, Manuel Ma
Abstract: According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes an arylsulfonium salt that when exposed to actinic rays or radiation, generates an acid, the arylsulfonium salt containing at least one aryl ring on which there are a total of one or more electron donating groups, the acid generated upon exposure to actinic rays or radiation having a volume of 240 ?3 or greater.
Type:
Grant
Filed:
January 28, 2011
Date of Patent:
February 24, 2015
Assignee:
FUJIFILM Corporation
Inventors:
Takeshi Kawabata, Tomotaka Tsuchimura, Takayuki Ito
Abstract: The present invention provides a compound that has high solubility in a highly polar solvent and is usefully usable for an application method using a highly polar solvent, the compound that can manufacture an electroluminescent device having high light-emitting efficiency. Specifically, the present invention provides a compound containing a structure represented by Formula (1): wherein: Ar1, Ar2, Ar3, and Ar4 each independently represent a divalent aromatic group optionally having substituent(s); Ar5 represents a monovalent aromatic group optionally having substituent(s); p and q each independently represent an integer of 0 or more; and R1 represents a given monovalent group.
Type:
Application
Filed:
October 11, 2012
Publication date:
August 21, 2014
Applicant:
SUMITOMO CHEMICAL COMPANY, LIMITED
Inventors:
Ken Sakakibara, Masanobu Tanaka, Rui Ishikawa, Hideyuki Higashimura
Abstract: The present invention relates to sulfonic acid containing compounds of formula IB, in which G, R1, R3 and T are as defined in the claims, that bind to thyroid receptors in the liver. Activation of these receptors results in modulation of gene expression of genes regulated by thyroid hormones. The compounds can be used to treat diseases and disorders including metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome X and diabetes.
Type:
Application
Filed:
February 9, 2010
Publication date:
February 23, 2012
Applicant:
METABASIS THERAPEUTICS, INC.
Inventors:
Serge H. Boyer, Scott J. Hecker, Mali Venkat Reddy
Abstract: There is provided a reaction accelerator for polymerizing a conductive polymer, comprising: a salt of an anion derived from a sulfonic acid having a skeleton of benzene or naphthalene having at least one OH group, and at least one divalent or more cation other than a transition metal cation. There is also provided a conductive polymer including the salt concerning the reaction accelerator. There is also provided a solid electrolyte capacitor including the conductive polymer as a solid electrolyte. The conductive polymer has a high electric conductivity and good heat-resistance. The solid electrolyte capacitor is reliable for an extended period of time.
Abstract: A method for producing isolatable and dispersible graphene sheets, wherein the graphene sheets may be tailored to be soluble in aqueous, non-aqueous or semi-aqueous solutions. The water soluble graphene sheets may be used to produce a metal nanoparticle-graphene composite having a specific surface area that is 20 times greater than aggregated graphene sheets. Graphene sheets that are soluble in organic solvents may be used to make graphene-polymer composites.
Type:
Application
Filed:
May 22, 2009
Publication date:
August 4, 2011
Applicant:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors:
Edward T. Samulski, Yongchao Si, Theo Dingemans
Abstract: Ink jet inks comprising a modified pigment, wherein the modified pigment is a pigment having attached organic groups of substituted or unsubstituted 1,2-benzenedicarboxylic acids and/or salts thereof.
Type:
Application
Filed:
May 30, 2009
Publication date:
December 10, 2009
Applicant:
EVONIK DEGUSSA GMBH
Inventors:
Ralph McIntosh, Gerd Tauber, Werner Kalbitz, Stephan Lüdtke, Jutta Zimmermann, Alfons Karl, Frank Forster
Abstract: The invention relates to a redispersible polymer powder including a polymer to be redispersed and an ortho-cresol based condensation polymer or salt thereof and methods for manufacturing same. More particularly, the invention relates to the use of an ortho-cresol based condensation polymer as a redispersing aid in a redispersible polymer powder.
Abstract: Strontium salts of the sulphonic acids of formula (I): A-B—SO3H , ??(I) wherein: A represents a group selected from OH, NH2, SO3H and CO2H, B represents an arylene group or an optionally substituted linear or branched C1-C12alkylene chain wherein one or more carbon atoms of the alkylene chain may be optionally replaced by an oxygen atom, by a nitrogen atom or by an SO2 group. Medicinal products containing the same which are useful in the treatment of osteoarthritis and osteoporosis.
Abstract: The present invention includes a method for making a formulation for treating mucosal discontinuities, comprising: providing phenolic compounds and treating the purified phenolic compounds with sulfuric acid to make sulfonic acids and sulfonate salts. The present invention also includes formulations prepared by the method.
Abstract: The present invention relates to certain alkylated 2-(2-hydroxyphenyl) benzenesulfinic acid and 2-(2-hydroxyphenyl)benzenesulfonic acid compounds and compositions which consist essentially of 2-(2-hydroxyphenyl) benzenesulfinic acid, 2-(2-hydroxyphenyl)benzenesulfonic acid and/or substituted derivatives thereof. The compositions of the invention are useful as hydrotropes and are also of use as, or as starting materials for, surfactants, and as starting materials for the synthesis of other useful chemicals such as, polymers and resins, solvents, adhesives and biocides.
Abstract: The present invention provides compounds having the formula:
in which R is hydrogen or C1-C4alkyl, preferably hydrogen and Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, CF3, halogen (F, Cl, Br or I) or SO3M in which M is H, Na, K, Ca, Mg, ammonium, mono-, di-, tri- or tetra-C1-C4alkylammonium, mono-, di- or tri-hydroxyalkylammonium or ammonium that is di- or tri-substituted with a mixture of C1-C4alkyl and C1-C4hydroxyalkyl groups; a process for their production; and their use as intermediates in the production of asymmetric or symmetric fluorescent whitening agents.
Type:
Grant
Filed:
September 22, 1998
Date of Patent:
February 27, 2001
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Bernd Siebenhaar, Bruno Casagrande, Victor Eliu
Abstract: A process for the production of a fluorescent whitening agent of formula: ##STR1## in which X and Z are as defined herein, comprising A) rearranging a hydrazobenzene compound having the formula: ##STR2## in which Z is as defined herein, to produce in situ a compound having the formula: ##STR3## B) diazotising the compound of formula (3) to produce a compound having the formula: ##STR4## in which Z has its previous significance and G.sub.1 is a counter ion; and C) reacting the compound of formula (4) with 2 moles of a compound having the formula: ##STR5## in which X and n have their previous significance, in the presence of an inorganic or organic palladium salt, or a mixture thereof, as catalyst-precursor, to produce a compound having the formula (1).
Type:
Grant
Filed:
April 23, 1998
Date of Patent:
February 29, 2000
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Victor Eliu, Werner Kanert, Adriano Indolese, Philipp Wyser, Anita Schnyder
Abstract: Para sulfonated calixarenes are obtained in a one-step reaction directly from para blocked calixarenes by treating same with a sulfonating agent, such as concentrated sulfuric acid, to perform an ipso-electrophilic substitution.
Type:
Grant
Filed:
June 26, 1996
Date of Patent:
September 14, 1999
Assignee:
Transdiffusia S.A.
Inventors:
Roger Lamartine, Jean-Bernard Regnouf de Vains, Philippe Choquard, Arnold Marcillac
Abstract: An process for forming a product which may be in a liquid phase is disclosed wherein a first reactant, preferably a liquid reactant, is directly fed into a reaction zone containing mixing elements and which comprises a first compartment of a reactor. A second reactant, which is maintained at a higher pressure, is fed into a second compartment of the reactor separated from the first compartment by a porous wall. The second reactant passes through this porous wall into the reaction zone to react with the first reactant. The process thereby controls rates of the reactions and the exothermic heats generated by the reactions. Pulsatile flow in one or both reaction compartments improves mixing. An evaporator for a portion of the product improves product quality and permits higher reaction temperatures in the reactor.
Type:
Grant
Filed:
December 6, 1996
Date of Patent:
August 10, 1999
Assignee:
SRI International
Inventors:
William J. Asher, Daryl L. Roberts, Jerry L. Jones, Douglas E. Gottschlich
Abstract: The present invention provides compounds having the formula: ##STR1## in which R is hydrogen or C.sub.1 -C.sub.4 alkyl, preferably hydrogen and Y is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, CF.sub.3, halogen (F, Cl, Br or I) or SO.sub.3 M in which M is H, Na, K, Ca, Mg, ammonium, mono-, di-, tri- or tetra-C.sub.1 -C.sub.4 alkylammonium, mono-, di- or tri-hydroxyalkylammonium or ammonium that is di- or tri-substituted with a mixture of C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 hydroxyalkyl groups; a process for their production; and their use as intermediates in the production of asymmetric or symmetric fluorescent whitening agents.
Type:
Grant
Filed:
December 19, 1997
Date of Patent:
May 11, 1999
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Bernd Siebenhaar, Bruno Casagrande, Victor Eliu
Abstract: Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.
Abstract: An exothermic process for forming a product which may be in a liquid phase is disclosed wherein a first reactant, preferably a liquid reactant, is directly fed into a reaction zone containing mixing elements and which comprises a first compartment of a reactor. A second reactant, which is maintained at a higher pressure, is fed into a second compartment of the reactor separated from the first compartment by a porous wall. The second reactant passes through this porous wall into the reaction zone to react with the first reactant. The process thereby controls rates of the reactions and the exothermic heats generated by the reactions. Pulsatile flow in one or both reaction compartments improves mixing. An evaporator for a portion of the product improves product quality and permits higher reaction temperatures in the reactor.
Type:
Grant
Filed:
March 2, 1994
Date of Patent:
December 10, 1996
Assignee:
SRI International
Inventors:
William J. Asher, Daryl L. Roberts, Jerry L. Jones, Douglas E. Gottschlich
Abstract: Subterranean oil-bearing formations are treated with aqueous acid solutions which include an effective amount of an alkoxylated alkyl substituted phenol sulfonate which exhibits both antisludge and demulsification properties.
Type:
Grant
Filed:
February 13, 1995
Date of Patent:
August 6, 1996
Assignees:
Nalco/Exxon Energy Chemicals, L.P, Exxon Production Research Co.
Inventors:
Anita R. Mokadam, Charles E. Strubelt, Dennis A. Williams, Kenneth M. Webber
Abstract: Compounds useful as polymer stabilizers which are polymerizable into condensation polymer systems are disclosed and claimed. A particularly preferred embodiment is 1-(3'-(benzotriazol-2"-yl)-4'-hydroxyphenyl)-1,1-bis(4-hydroxyphenyl)ethan e.
Type:
Grant
Filed:
August 10, 1993
Date of Patent:
August 1, 1995
Assignee:
Hoechst Celanese Corp.
Inventors:
John R. Fritsch, Olan S. Fruchey, Debasish Kuila, George Kvakovszky, Mark A. Murphy, Michael T. Sheehan, James R Sounik, Richard Vicari
Abstract: There is disclosed a multi-step process for the preparation of benzenesulfonamides of general formula ##STR1## wherein R is 3,3-difluorobutyl or 3,3-difluorobuten-1-yl. The benzenesulfonamides obtainable by the process of the invention are intermediates for the synthesis of herbicidally active sulfonyl ureas.
Abstract: A process for preparing 2,6-di-t-butyl-4-mercapto-phenol. This is accomplished by sulfonation of the phenol with a silylated sulfonating agent (e.g., trimethylsilyl-chlorosulfonate). The sulfonic acid is then reduced directly or is converted to the sulfonyl halide intermediate which is then reduced to yield the 2,6-di-t-butyl-4-mercapto-phenol.
Abstract: Oxidized diphenylheteroalkanes of the formula I ##STR1## where R.sup.1 to R.sup.6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosmetic agents.
Abstract: A process for dehydrating phenol sulfonate salts by azeotropic distillation of water wherein a surfactant such as sodium dodecylbenzene sulfonate is used to prevent the salts from agglomerating and plating out on the walls of the reaction vessel.
Abstract: A process for manufacturing monosulfonated alkylphenol polyalkylene oxide sulfonates is disclosed. The process produces the monosulfonated alkylphenol polyalkylene oxide sulfonates by a combination of sulfonation to produce a sulfate/sulfonate dianion, followed by a displacement of the sulfate to produce a disulfonate. The process produces a commercially viable disulfonate, which has a wide variety of commercial uses.
Type:
Grant
Filed:
November 14, 1988
Date of Patent:
September 25, 1990
Assignee:
Exxon Production Research Company
Inventors:
Margaret B. Parnell, Thomas L. Ashcraft, Jr., Kenneth M. Webber
Abstract: Divalent ion tolerant aromatic sulfonate suitable for enhanced oil recovery characterized by the formula: ##STR1## where x=0 to 4R'=H or Ch.sub.3R=CH.sub.3 (CH.sub.2)y and y=1 to 15. Preferably, the compositioncomprises of second compound characterized by the formula ##STR2## wherein R, x, y, and R' are the same as defined in claim 1.
Type:
Grant
Filed:
November 14, 1988
Date of Patent:
January 16, 1990
Assignee:
The Standard Oil Company
Inventors:
Roman Loza, Arthur J. Cooper, Gerald P. Coffey
Abstract: A new process for the preparation of aromatic sulphonic acids, in which the sulphonation of the aromatic compounds is carried out with sulphur trioxide in organic solvents in the presence of hydrogen halide.
Type:
Grant
Filed:
January 6, 1989
Date of Patent:
August 22, 1989
Assignee:
Bayer Aktiengesellschaft
Inventors:
Horst Behre, Heinz U. Blnak, Wilfried Kohler, Nikolaus Muller, Peter Schnegg