Phosphorus Attached Indirectly To Amino Nitrogen By Nonionic Bonding Patents (Class 564/15)
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Patent number: 6043363Abstract: Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.Type: GrantFiled: March 8, 1999Date of Patent: March 28, 2000Assignee: Symyx Technologies, Inc.Inventors: Anne Marie LaPointe, Anil Guram, Timothy S. Powers, Bernd Jandeleit, Thomas Boussie, Cheryl Lund
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Patent number: 6034240Abstract: Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.Type: GrantFiled: March 9, 1998Date of Patent: March 7, 2000Assignee: Symyx Technologies, Inc.Inventor: Anne Marie La Pointe
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Patent number: 5990318Abstract: Novel soluble polyester-supported chiral phosphines have been prepared and have been used in the preparation of rhodium and ruthenium catalysts. Such polymer-supported catalysts show high catalytic activities and enantioselectivities. In the case of Ru(BINAP) catalyst supported on soluble polyester, the resulting catalysts were found to be more active than those of the corresponding homogeneous Ru(BINAP) catalysts in the asymmetric hydrogenation of 2-arylpropenoic acids. These soluble polyester-supported catalysts can be easily separated from the reaction mixture and then be reused without loss of activity and selectivity.Type: GrantFiled: March 6, 1998Date of Patent: November 23, 1999Assignee: The Hong Kong Polytechnic UniversityInventors: Albert Sun-Chi Chan, Qing-Hua Fan
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Patent number: 5958971Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.Type: GrantFiled: October 22, 1997Date of Patent: September 28, 1999Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
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Patent number: 5929232Abstract: The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a stereoisomerically or regioselectively enriched product.Type: GrantFiled: March 25, 1996Date of Patent: July 27, 1999Assignee: President and Fellows of Harvard CollegeInventors: Eric N. Jacobsen, James L. Leighton, Luis E. Martinez
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Patent number: 5914319Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.Type: GrantFiled: September 1, 1995Date of Patent: June 22, 1999Assignee: Eli Lilly and CompanyInventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
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Patent number: 5902904Abstract: The invention is an improved method for the preparation of tertiary phosphines by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate esters with chlorophosphines in the presence of a catalyst and a reductant. The general reaction scheme is shown below: ##STR1## wherein R.sup.1 is aryl, alkenyl, cycloalkenyl or aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl, or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; R.sup.2 and R.sup.3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CONR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen, alkyl, aryl or aralkyl; and n is 2 where R.Type: GrantFiled: August 21, 1998Date of Patent: May 11, 1999Assignee: Monsanto CompanyInventors: Scott A. Laneman, David J. Ager, Amihia Eisenstadt
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Patent number: 5891714Abstract: Cationic phospholipids and their use in treating pathogen-associated disease are disclosed. The class of phospholipids comprises the phosphotriester derivatives of phosphoglycerides and sphingolipids. Liposomes comprising one or more of the cationic phospholipids are effective in the lipofection of nuclidic acids and are therefore useful in methods of treating disease.Type: GrantFiled: June 6, 1995Date of Patent: April 6, 1999Assignee: Northwestern UniversityInventors: Gary W. Ashley, Robert C. MacDonald, Miho Shida
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Patent number: 5866087Abstract: The invention relates to novel calixarenes of formula: ##STR1## in which m is equal to 0 or 1, n is an integer from 2 to 8, with 4.ltoreq.n(m+1).ltoreq.8,R.sup.1 and R.sup.2, which can be the same or different, are alkyl or O-nitrophenoxyalkyl groups andR.sup.3 and R.sup.4, which can be the same or different, are alkyl or aryl groups.The calixarenes can be used for extracting actinides and lanthanides from aqueous solutions from spent fuel reprocessing.Type: GrantFiled: October 14, 1997Date of Patent: February 2, 1999Assignee: Commissariat a l'Energie AtomiqueInventors: Jean-Fran.cedilla.ois Dozol, Helene Rouquette, Volker Bohmer, Cordula Gruttner, Ralf A. Jakobi, Dagmar Kraft, Walter Vogt
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Patent number: 5847209Abstract: A process for recovery of solid and reusable urea from the urea adduction process. Refinery streams are subjected to a step of urea adduction for removal of unwanted branched products, aromatics and sulphur. The adduct is purified, dried and then subjected to the step of mechanical shearing.Type: GrantFiled: December 3, 1997Date of Patent: December 8, 1998Inventors: Anurag Ateet Gupta, Krishan Kumar Swamy, Shanti Prakash, Madan Mohan Rai, Akhilesh Kumar Bhatnagar
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Patent number: 5811290Abstract: A method and composition for enhancing the biodegradation of hydrocarbon contaminated soil, water, and/or sludge are disclosed. The composition comprises an adduct of urea with a non-ionic surfactant and a phosphorous source. The disclosed method provides for the application of a degradation effective amount of a composition which comprises a N:P ratio which ranges from 10:2 to about 10:0.5 and the urea and non-ionic surfactant are present in the adduct in a weight ratio ranging from 98:2 to 75:25. Further, the method of biodegradation is carried out by the application of the composition to provide for a C:N:P ratio of 100:10:1 to 100:1:001. The C:N:P ratio is based on the weight percent of the hydrocarbon contaminate in the soil, water and/or sludge sites to be treated.Type: GrantFiled: October 7, 1997Date of Patent: September 22, 1998Assignee: Exxon Research and Engineering CompanyInventors: Ramesh Varadaraj, Cornelius Hendrick Brons
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Patent number: 5780498Abstract: The present invention provides novel compounds represented by the general formula I: ##STR1## wherein R.sub.1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl;R.sub.2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl;R.sub.3 and R.sub.3 ' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; orR.sub.3 and R.sub.3 ' together form a ring structure;R.sub.3 " is hydrogen, lower alkyl or an aryl; orR.sub.2 and R.sub.3 " together form a lower alkylene group --(CH.sub.2).sub.n -- wherein n is an integer of 1, 2 or 3; orR.sub.2 and R.sub.3 " together form a group represented by the formula: --(CH.sub.2).sub.p --Ar-- or --Ar--(CH.sub.2).sub.p --, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene;C(.dbd.X) is C(.dbd.Type: GrantFiled: April 30, 1996Date of Patent: July 14, 1998Assignee: Ciba-Geigy Japan LimitedInventors: Hideyuki Saika, Toshiki Murata, Thomas Pitterna, Thomas Fruh, Lene D. Svensson, Yoshihiro Urade, Takaki Yamamura, Toshikazu Okada
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Patent number: 5739396Abstract: Ligands useful for transition metal catalyzed bond forming reactions are provided with a metal binding portion having at least one metal binding moiety ##STR1## wherein Ar and Ar' each is an aryl or a heteroaryl. These ligands may be prepared by providing an aromatic carboxylic acid having a diarylphosphino or diheteroarylphosphino substituent on the aromatic ring, and forming an ester or an amide derivative of the carboxylic acid by coupling with a chiral diol or a chiral diamine. The ligands facilitate, for example, flexible strategies for enantiocontrolled construction of five membered carbocyclic rings with varying substitution patterns and high enantioselectivity.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignee: Stanford UniversityInventors: Barry M. Trost, David L. Van Vranken, Richard C. Bunt
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Patent number: 5726159Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.Type: GrantFiled: September 1, 1995Date of Patent: March 10, 1998Assignee: Eli Lilly and CompanyInventors: Aaron L. Schacht, Robert T. Shuman, Gerald F. Smith, Michael R. Wiley
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Patent number: 5714148Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.Type: GrantFiled: September 30, 1996Date of Patent: February 3, 1998Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
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Patent number: 5710130Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.Type: GrantFiled: September 1, 1995Date of Patent: January 20, 1998Assignee: Eli Lilly and CompanyInventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
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Patent number: 5707966Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.Type: GrantFiled: September 1, 1995Date of Patent: January 13, 1998Assignee: Eli Lilly and CompanyInventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
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Patent number: 5705690Abstract: One embodiment of the present invention provides compounds comprising an adduct of urea with a non-ionic surfactant. Another embodiment of the present invention, there is provided a composition suitable for enhancing the bioremediation of contaminated soils and water which comprises at least one adduct of urea with a non-ionic surfactant, preferably in combination with a phosphorous source.Type: GrantFiled: September 2, 1994Date of Patent: January 6, 1998Assignee: Exxon Research and Engineering CompanyInventors: Ramesh Varadaraj, Cornelius Hendrick Brons
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Patent number: 5705487Abstract: This invention relates to thrombin inhibiting compounds having the Formula IX--Y--NH--(CH.sub.2).sub.r --G Iwhere X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.Type: GrantFiled: September 1, 1995Date of Patent: January 6, 1998Assignee: Eli Lilly and CompanyInventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
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Patent number: 5698003Abstract: Improved solvent systems for the formulation of N-alkyl thiophosphoric triamide urease inhibitors. These formulations enable the preparation of stable concentrated solutions of N-alkyl thiophosphoric triamides for storage, transportation, and eventual impregnation onto solid urea containing fertilizers and incorporation into liquid urea containing fertilizer compositions. These formulations are comprised primarily of a solvent selected from the group consisting of glycols and glycol derivatives. Optionally, in addition to the glycol base solvent, the formulations can contain a co-solvent selected from the group consisting of liquid amides, 2-pyrrolidone and N-alkyl 2-pyrrolidones, and/or a nonionic surfactant selected from the group consisting of alkylaryl polyether alcohols. The presence of the co-solvent and/or surfactant has been found to impart desirable properties to the formulations under certain conditions.Type: GrantFiled: December 19, 1995Date of Patent: December 16, 1997Assignee: IMC-Agrico CompanyInventors: Barry A. Omilinsky, Alexander D. Lindsay, Allen R. Sutton, Willis L. Thornsberry, Jr.
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Patent number: 5693868Abstract: The present invention provides a method for producing novel optically active diphosphine compounds ?2,2'-bis(di-substituted phosphino)-1,1'-binaphthyl compounds! having a selectivity (chemoselectivity or enantioselectivity) and catalytic activity different from those of conventional BINAP compounds. In a method of the present invention for producing an optically active diphosphine compound (i.e., 2,2-bis(di-substituted phosphino)-1,1'-binaphthyl), 2,2'-bis(trifluoromethanesulfonyloxy)-1,1'-binaphthyl is reacted, in the presence of a transition metal-phosphine complex, with a phosphineoxide compound represented by the following general formula:A.sub.Type: GrantFiled: October 30, 1996Date of Patent: December 2, 1997Assignee: Takasago International CorporationInventors: Noboru Sayo, Xiaoyong Zhang, Tatsuya Ohmoto, Akifumi Yoshida, Tohru Yokozawa
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Patent number: 5686633Abstract: Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.3 ' and R.sub.4 ' are as defined in claim 1. The compounds are in part novel and are suitable for use as light stabilizers for organic materials.Type: GrantFiled: December 31, 1991Date of Patent: November 11, 1997Assignee: Ciba Specialty Chemicals CorporationInventors: Eric Vieira, Hugh Stephen Laver
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Patent number: 5679863Abstract: The preparation of .alpha.-carbonylphosphine oxides by oxidizing an .alpha.-hydroxyalkyl phosphine oxide with an organic hydroperoxide or of an organic peroxy acid in the presence of a compound of a Group IV to Group VIII metal in the periodic table, and novel .alpha.-hydroxybenzyl phosphine oxides. .alpha.-Carbonylphosphine oxides are used as photoinitiators for polymerizable compositions.Type: GrantFiled: October 16, 1995Date of Patent: October 21, 1997Assignee: BASF AktiengesellschaftInventors: Martin Fischer, Eckhard Hickmann, Rudolf Kropp, Jochen Schroeder, Beate Trentmann
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Patent number: 5661018Abstract: A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to make.Type: GrantFiled: June 6, 1995Date of Patent: August 26, 1997Assignee: Northwestern UniversityInventors: Gary W. Ashley, Robert C. MacDonald, Miho Shida
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Patent number: 5650099Abstract: A dicationic surfactant for enhancing the chemiluminescence of chemiluminescent compounds particularly dioxetanes which are triggerable is described. The surfactant has the formulaX.sup.- (R.sub.1).sub.3 A.sup.+ CH.sub.2 -Link-CH.sub.2 A.sup.+ (R.sub.2).sub.3 X.sup.-wherein A is selected from the group consisting of phosphorus and nitrogen atoms separately or together, wherein X is an anionic counterion and R.sub.1 and R.sub.2 are selected from the group consisting of unsubstituted and substituted alkyl and aralkyl groups containing 1 to 20 carbon atoms and R.sub.1 and R.sub.2 can be the same or different, and wherein Link is a carbon chain group selected from the group consisting of dialkylenearyl, aryl, alkylene, alkenylene and alkynylene groups containing 4 to 20 carbon atoms. The surfactants are particularly useful in Western and Southern blot assays.Type: GrantFiled: May 16, 1995Date of Patent: July 22, 1997Assignee: Lumigen, Inc.Inventors: M. Hashem Akhavan-Tafti, Zahra Arghavani
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Patent number: 5616745Abstract: New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.Type: GrantFiled: June 7, 1995Date of Patent: April 1, 1997Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-Paul Behr, Jean-Philippe Loeffler
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Patent number: 5612295Abstract: Multifunctional additives having a variety of advantageous properties are described. They are formed by a process which comprises heating concurrently or in any sequence a) an oil-soluble ashless dispersant containing basic nitrogen with b) an alkoxylated alcohol of at least 8 carbon atoms c) a borating agent and optionally d) an inorganic oxyacid or anhydride of phosphorous. The reactants are in proportions on an active ingredient basis of about 0.03 to about 0.35 part by weight of b) per part by weight of a), and about 0.005 to about 0.06 part by weight of boron as c) per part by weight of a). The reaction temperature can range from about 50.degree. to about 150.degree. C. Water and/or solids present in the resultant mixture can be removed. Preferably, the optional phosphorous component is used in the formation of these additives. This phosphorous component can be an inorganic oxyacid or anhydride of phosphorous.Type: GrantFiled: March 27, 1996Date of Patent: March 18, 1997Assignee: Ethyl CorporationInventors: Donald R. Bell, Rolfe J. Hartley, Andrew G. Papay
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Patent number: 5587161Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT).Type: GrantFiled: December 21, 1994Date of Patent: December 24, 1996Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer
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Patent number: 5548032Abstract: A crosslinking agent suitable for acrylic rubbers, particularly for acrylic rubbers containing units of a cyanoacetic acid comonomer or a malonic acid comonomer for imparting a crosslinkability, which comprises a reaction product of formaldehyde or a polymerized formaldehyde with urea or thiourea in the presence of an acidic catalyst.Type: GrantFiled: May 5, 1995Date of Patent: August 20, 1996Assignee: Toyo Seal Kogyo Kabushiki KaishaInventors: Terumitsu Tokunaga, Michinori Kuraya
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Patent number: 5541289Abstract: A method for incorporating novel phosphine containing amino acids into peptide sequences is provided. The resulting phosphine-containing peptides can be used to bind a transition metal between two phosphine moieties presented on an amino acid in a peptide. The resulting phosphine-containing peptide metal complex is useful as a stereoselective catalyst of a chemical reaction or as a means for delivering a metal selectively to a target tissue or organ for medical uses.Type: GrantFiled: March 30, 1994Date of Patent: July 30, 1996Assignee: Washington UniversityInventor: Scott R. Gilbertson
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Patent number: 5532226Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.Type: GrantFiled: December 9, 1993Date of Patent: July 2, 1996Assignee: Ortho Pharmaceutical CorporationInventors: Keith Demarest, Charles Schwender, David Wustrow
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Patent number: 5527829Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.Type: GrantFiled: May 23, 1994Date of Patent: June 18, 1996Assignee: Agouron Pharmaceuticals, Inc.Inventor: Vincent J. Kalish
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Patent number: 5405990Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.Type: GrantFiled: July 22, 1993Date of Patent: April 11, 1995Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip J. Burke, Robert I. Dowell, Anthony B. Mauger, Caroline J. Springer
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Patent number: 5403955Abstract: Novel mordants based upon a polyethyleneimine backbone and either pendant phosphonium or quaternized-nitrogen compounds are disclosed. The mordants find use in stopping or controlling ink-bleeding into ink-jet receptors and photographic films.Type: GrantFiled: April 28, 1994Date of Patent: April 4, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventor: Omar Farooq
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Patent number: 5380892Abstract: A process for separation of aliphatic straight-chain compounds having terminal functional groups from mixtures containing isomers thereof branched in the .alpha.-position by precipitating the aliphatic, straight-chain compounds as their clathrates.Type: GrantFiled: July 6, 1992Date of Patent: January 10, 1995Assignee: Hoechst AktiengesellschaftInventors: Gregor Deckers, Dieter Frohning
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Patent number: 5324857Abstract: Reaction of amine-containing substrates with hydrogen peroxide can suffer from certain problems, especially in the presence of transition metals. These problems include both in situ generation of impurities and particularly nitrosamines, which are allegedly carcinogenic, and also impaired product formation. The problems can be ameliorated by employing in the reaction mixture free radical scavengers, including in particular phenols and polyhydroxy-substituted aromatic compounds. The scavengers are advantageously employed in conjunction with a metal chelating agent such as polycarboxylic acid or an organopolyphosphonic acid.Type: GrantFiled: April 28, 1992Date of Patent: June 28, 1994Assignee: Solvay InteroxInventor: Noel S. Shehad
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Patent number: 5300686Abstract: Organophosphorus dihalides can have one of their halogen substituents substituted with an alkyl group from a trialkylaluminum by gradual addition of the latter reagent to the former.Type: GrantFiled: January 19, 1990Date of Patent: April 5, 1994Assignee: Akzo nvInventor: Jeffrey E. Telschow
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Patent number: 5300687Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.Type: GrantFiled: July 18, 1991Date of Patent: April 5, 1994Assignee: Ortho Pharmaceutical CorporationInventors: Charles Schwender, Keith Demarest, David Wustrow
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Patent number: 5243073Abstract: The present invention relates to novel preorganized hexadentate ligands suitable for complexing with a radionuclide to form imaging agents for diagnostic purposes. The ligands have the formula: ##STR1## wherein a) R.sub.2 is hydrogen and R.sub.3 is methyl; or R.sub.2 and R.sub.3 together form a methoxy benzene ring.Type: GrantFiled: December 14, 1990Date of Patent: September 7, 1993Assignee: Mallinckrodt Medical, Inc.Inventors: William L. Neumann, Raghavan Rajagopalan
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Patent number: 5210202Abstract: Chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphinoxy radical of the formula W=OP (R).sub.Type: GrantFiled: December 23, 1991Date of Patent: May 11, 1993Assignee: Societe Chimique des Charbonnages S.A.Inventors: Michele Petit, Andre Mortreux, Francis Petit, Gerard Buono, Gilbert Peiffer
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Patent number: 5166385Abstract: Process for the preparation of phosphino compounds Phosphorus-containing compounds of the formula (I)(R.sup.1)(R.sup.2)P(O)--CR.sup.3 R.sup.4 --CHR.sup.5 R.sup.6 (I)in whichR.sup.1 and R.sup.2 are alkyl, alkoxy or optionally substituted phenyl,R.sup.3 and R.sup.5 are H, R, optionally substituted phenyl, ROCO--, RO--CO--RO--, halogen, CN, RO--, RO--RO--R-CO--, H.sub.2 NCO--, RNHCO-- or RRNCO--, in which R is alkyl,R.sup.4 and R.sup.6 have the same meaning as defined for R.sup.1 and R.sup.2 or are a divalent radical--CO--R.sup.7 --COin whichR.sup.7 is oxygen, NR* or sulfur, and R* is H, optionally substituted phenyl or alkyl,are precursors for plant protection agents and fire retardants. According to the invention they can be prepared in high yields and high purity by reacting a compound (R.sup.1)(R.sup.2)P--OR.sup.8, in which R.sup.8 is alkyl or optionally substituted phenyl, with an alkene of the formula R.sup.3 R.sup.4 C.dbd.CR.sup.5 R.sup.Type: GrantFiled: November 25, 1991Date of Patent: November 24, 1992Assignee: Hoechst AktiengesellschaftInventors: Gunter Scheffel, Stephen Lachhein
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Patent number: 5132448Abstract: .alpha.-Chloro phosphorus ylides of the formula I ##STR1## where the Ar radicals are identical or different aryl groups, and E is a substituent which stabilizes the ylide (I), are prepared by reacting a phosphonium salt of the formula II ##STR2## where Hal is chlorine, bromine or iodine, with a chlorinating agent, using bleaching powder as chlorinating agent.Type: GrantFiled: September 11, 1990Date of Patent: July 21, 1992Assignee: BASF AktiengesellschaftInventor: Bernd Schaeffer
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Patent number: 5130036Abstract: Lubricant additives are producd by reacting an alkoxplated amine with phosphorous acid. The additives preferably also contain a boron moiety which is reacted with the phosphorous acid and amine, preferably in a one step reaction. More preferably, a mono-functional alcohol or a long-chain aliphatic carboxylic acid is added to this mixture. The additives are particularly useful in metalworking oils and particularly as extreme pressure additives to replace the currently used chlorinated paraffin additives.Type: GrantFiled: May 18, 1990Date of Patent: July 14, 1992Assignee: The Elco CorporationInventors: Gerald D. Burt, Randolph A. McDonald
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Patent number: 5068426Abstract: Crude organic solutions of N,N-dialkylcarbamoylmethylphosphine oxide compounds can be purified by treatment with a first row transition metal salt to form a complex which can be treated to regenerate a purified solution of the compound. The first row transition metal can be selected from the monobasic acid salts of zinc, for example.Type: GrantFiled: January 19, 1990Date of Patent: November 26, 1991Assignee: Akzo N.V.Inventor: Jeffrey E. Telschow
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Patent number: 5026886Abstract: A process is disclosed for preparing biaryl, bidentate ligands comprising:(1) contacting a biaryl compound having the structural formula: ##STR1## with a proton abstracting agent under conditions suitable to form a biaryl dianion, which is then(2) contacted with a Group V compound of the formula: ##STR2## where X' is halogen or a suitable leaving group.Type: GrantFiled: January 25, 1988Date of Patent: June 25, 1991Assignee: Eastman Kodak CompanyInventors: Jerome L. Stavinoha, Gerald W. Phillips, Thomas A. Puckette, Thomas J. Devon
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Patent number: 5023376Abstract: Reaction of amine-containing substrates with hydrogen peroxide can suffer from the problems of in situ generation of nitrosamines, which are allegedly carcinogens, as impurities and impaired product formation, especially in the presence of transition metals.The problems can be ameliorated by employing a selected range of alkyleneaminopoly(methylenephosphonic acid) compounds such as cyclohexane-1,2-diaminotetra(methylenephosphonic acid).Type: GrantFiled: July 17, 1989Date of Patent: June 11, 1991Assignee: Interox AmericaInventors: Noel S. Shehad, Laurie L. Dussack, Dirk van Hemelrijk
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Patent number: 5008015Abstract: The content of hydrogen chloride and phosphorous acid of crude amino organic phosphonic acids, especially diethylenetriaminepentakis (methylene phosphonic acid) is reduced by solvent extraction into an alcoholic phase leaving purified phosphonic acid behind.Type: GrantFiled: October 31, 1989Date of Patent: April 16, 1991Assignee: Albright & Wilson LimitedInventors: Paul M. Davies, Raymond A. Smith
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Patent number: 5001250Abstract: Crude N,N-dialkylcarbamoylmethylphosphonates and phosphine oxide extractants, and particularly crude dihexyl N,N-diethylcarbamoylmethylphosphonate and octylphenyl N,N-diisobutylcarbamoyl phosphine oxide, are purified by distilling the crude materials in a thin film evaporator. Preferably, the crude dihexyl N,N-diethylcarbamoylmethylphosphonate is reacted with concentrated hydrochloric acid and subsequently reacted with aqueous sodium hydroxide prior to distillation in the thin film evaporator to hydrolyze impurities contained in the crude product. The purified extractants are useful for extracting actinides and lanthanides from liquid waste streams.Type: GrantFiled: May 30, 1989Date of Patent: March 19, 1991Assignee: Occidental Chemical CorporationInventor: Mohan S. Saran
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Patent number: 4956467Abstract: Novel nucleophilic tertiary organophosphines and the specific cleavage of peptide bonds by nucleophilic tertiary organophosphines. This invention is of particular utility in providing chemical agents for use in the cleavage of proteins and the determination of the amino acid sequence of proteins.Type: GrantFiled: April 5, 1989Date of Patent: September 11, 1990Assignee: American Cyanamid CompanyInventors: Lois M. Hinman, Libby S. Miller
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Patent number: 4925974Abstract: A process for the production of a blocked urea group-containing polyisocyanate from a partially blocked polyisocyanate and polyamine, comprising the steps of:(i) reacting a partially blocked polyisocyanate, said polyisocyanate being made substantially free of monomeric polyisocyanate, by vacuum thin layer evaporation with a primary polyamine, secondary polyamine, or mixtures thereof, in relative proportions such that the ratio of isocyanate groups to amino groups is in the range from about 1:1 to 1.3:1, and(ii) isolating said urea group-containing polyisocyanate by wherein the vacuum boiling point of said polyisocyanate is lower than the deblocking temperature of said urea group-containing polyisocyanate.Type: GrantFiled: September 16, 1988Date of Patent: May 15, 1990Assignee: Huels AktiengesellschaftInventor: Rainer Gras