Carbon To Carbon Unsaturation In Substituent Q Patents (Class 564/204)
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Patent number: 8236987Abstract: The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.Type: GrantFiled: November 9, 2007Date of Patent: August 7, 2012Assignees: The Regents of the University of California, Oregon Health & Science UniversityInventors: Thomas S. Scanlan, Toru Iijima
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Publication number: 20120165572Abstract: The invention is directed to a compound represented by the Formula (1) as defined herein, and a method for preparing a compound represented by the Formula (1) which includes: reacting a diamine compound represented by the Formula (2) as defined herein with a methacrylic anhydride or an acrylic anhydride under a condition where an organic acid having a pKa of 2.0 or more is present in an amount of 0.5 to 5.0 moles based on 1 mole of the diamine compound to obtain a reaction mixture; adding phosphoric acid to the reaction mixture; and purifying the reaction mixture by extraction with an organic solvent.Type: ApplicationFiled: December 21, 2011Publication date: June 28, 2012Applicant: FUJIFILM CORPORATIONInventors: Yu IWAI, Takafumi NAKAYAMA, Junya ABE, Ichiro KOYAMA
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Patent number: 8153756Abstract: Disclosed is a fluorine-containing polymer having: (A) a repeating unit derived from a fluorine-containing monomer which is represented by the following formula: CH2?C(—X)—C(?O)—Y—[—(CH2)m—Z—]p—(CH2)n—Rf??(I) (B) a repeating unit derived from a monomer containing no fluorine atom, and if necessary (C) a repeating unit derived from a crosslinkable monomer. This fluorine containing polymer has excellent water repellency, oil repellency and antifouling property.Type: GrantFiled: September 23, 2008Date of Patent: April 10, 2012Assignee: Daikin Industries, Ltd.Inventors: Ikuo Yamamoto, Yutaka Ohira, Yoshio Funakoshi, Shinichi Minami, Ginjiro Tomizawa
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Patent number: 8083973Abstract: A compound which undergoes a color change upon irradiation, and which has the general structure: X—C?C—C?C—Y—(CO)n-QZ wherein X is H, alkyl or —Y—(CO)n-QW; each Y is the same or a different divalent alkylene group; Q is O, S or NR; R is H or alkyl; W is H, alkyl or Z; each Z is the same or a different unsaturated alkyl group; and each n is 0 or 1.Type: GrantFiled: January 22, 2009Date of Patent: December 27, 2011Assignee: DataLase Ltd.Inventor: Anthony N Jarvis
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Publication number: 20110290418Abstract: Provided is a complex of hydrogen peroxide and at least one compound represented by Formula I: wherein X is: —C(R3)3, —C?C(R3), —O(R3), —N(R3)2, or —S(R3); and R1, R2, and R3 are each independently selected from H, alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl heteroarylalkyl, heterocyclyl, and cycloalkyl, or R2 and an R3 are optionally taken together to form an alicyclic ring. Also provided are anaerobic cure systems and curable compositions employing the complexes described herein.Type: ApplicationFiled: July 7, 2011Publication date: December 1, 2011Applicants: Loctite ( R&D) Limited, Henkel CorporationInventors: Philip T. Klemarczyk, David Birkett, David Farrell, Peter Wrobel, Ciaran McArdle, Greg Clarke
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Patent number: 7932303Abstract: A material contains at least a polymerizable N,O-functionalized acrylic acid hydroxyamide of the Formula (I) in which A is an n+m-valent linear or branched aliphatic C1 to C50 radical, in which the carbon chain can be interrupted by O, S, —CO—O—, CO—NH, O—CO—NH or NH—CO—NH, an n+m-valent aromatic C6 to C18 radical or an n+m-valent cycloaliphatic or heterocyclic C3 to C18 radical, wherein the radicals can carry one or more substituents, Y is not present, or is O, S, an ester, amide or urethane group, R1 is hydrogen, an aliphatic C1 to C20 alkyl or C3 to C8 cycloalkyl radical which can carry one or more substituents, R2 is H or a C1 to C10 alkyl radical, R3 is not present or is a C1 to C16 alkylene radical which can be interrupted by O, HG is not present, is —COOH, —P?O(OH)2; —P?O(OH)(OR4); —O—P?O(OH)2, —SO2OH or —O—P?O(OH)(OR4), R4 is a C1 to C15 alkyl radical, phenyl or benzyl radical and n is a number from 1 to 5 and m a number from 0 to 3.Type: GrantFiled: September 11, 2007Date of Patent: April 26, 2011Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Iris Lamparth, Urs Karl Fischer, Frank Zeuner, Armin de Meijere, Volker M. Rheinberger
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Patent number: 7928134Abstract: The invention is directed to 5-(hetero)aryl-4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor agonists, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, methods for preparing novel intermediates useful for their syntheses, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, administered to patients to achieve a therapeutic effect in disorders in which CB1 receptors are involved, or that can be treated via manipulation of those receptors. Compounds of the present invention include compounds of formula (I): wherein the substituents have the definitions given in the specification.Type: GrantFiled: September 19, 2008Date of Patent: April 19, 2011Assignee: Solvay Pharmaceuticals B.V.Inventors: Josephus H. M. Lange, Hicham Zilaout, Bernard J. Van Vliet
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Publication number: 20110033633Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: ApplicationFiled: May 26, 2009Publication date: February 10, 2011Inventors: Catherine A. Bothof, Yi He, Jerald K. Rasmussen, Kannan Seshadri, Clinton P. Waller, JR., Douglas E. Weiss
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Publication number: 20110017961Abstract: A compound which undergoes a colour change upon irradiation, and which has the general structure: X—C?C—C?C—Y—(CO)n-QZ wherein X is H, alkyl or —Y—(CO)n-QW; each Y is the same or a different divalent alkylene group; Q is O, S or NR; R is H or alkyl; W is H, alkyl or Z; each Z is the same or a different unsaturated alkyl group; and each n is 0 or 1.Type: ApplicationFiled: January 22, 2009Publication date: January 27, 2011Inventor: Anthony N. Jarvis
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Publication number: 20100317884Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.Type: ApplicationFiled: August 24, 2010Publication date: December 16, 2010Applicant: The Government of the US, as represented by the Secretary of the NavyInventors: Holly L. Ricks-Laskoski, Arthur W. Snow
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Publication number: 20100280204Abstract: The present invention relates to a method for producing N-methyl-N-vinylacetamide, which comprises a step for controlling the N-1,3-butadienyl-N-methylacetamide content in N-methyl-N-vinylacetamide to 0.01-150 ppm. This method enables production of N-methyl-N-vinylacetamide having a stable quality, which can be controlled in stability and polymerizability as a monomer. N-methyl-N-vinylacetamide produced by the method enables production of an N-methyl-N-vinylacetamide polymer having stable physical properties such as a molecular weight.Type: ApplicationFiled: December 24, 2008Publication date: November 4, 2010Applicant: SHOWA DENKO K.K.Inventor: Tetsuya Ishii
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Publication number: 20100184863Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E, 6E, 8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E, 6Z, 8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.Type: ApplicationFiled: July 17, 2009Publication date: July 22, 2010Applicant: Takasago International CorporationInventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Mei, Carter B. Green, Amrit S. Mankoo
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Patent number: 7705136Abstract: New modifiers were synthesized for incorporation of a methacrylic function in 3?-, 5?- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5?-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.Type: GrantFiled: February 25, 2005Date of Patent: April 27, 2010Assignee: UChicago Argonne, LLCInventors: Julia B. Golova, Boris K. Chernov
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Publication number: 20100015076Abstract: Novel (co)polymeric structures having functional groups making possible, under conditions that are safe for human use, the formation of chemical bonds with human keratin, and in particular with the keratin present in hair, eyelashes and eyebrows, skin, nails, lips, the oral mucosa and tissues of the external genital organs are disclosed; the invention also relates to the synthesis of such (co)polymeric structures and the use thereof in the fields of cosmetics and medicine.Type: ApplicationFiled: December 23, 2005Publication date: January 21, 2010Applicant: EUDERMIC S.R.L.Inventors: Matteo Zanotti Russo, Nicola Barbini
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Publication number: 20090311402Abstract: Alkyldienamides compounds suitable for use as flavoring agents are disclosed. The compounds are used as flavors since they possess umami characteristics or other desirable organoleptic properties. The disclosed compounds are defined by the structure set forth below: wherein R is ethyl or cyclopropyl; and wherein R? is methyl or butyl, with the proviso that when R is ethyl, R? is not methyl.Type: ApplicationFiled: August 20, 2009Publication date: December 17, 2009Inventors: Mark L. Dewis, Michelle E, Huber, Michael V. Cossette, David O. Agyemang, Garry Conklin, Tao Pei
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Publication number: 20090149674Abstract: The invention relates to a method for the continuous production of alkyl amino acryl amides by reacting alkyl acrylates with high-boiling amines. A specific preparation technique is used in order to achieve hitherto unobtainable product qualities. Very high spatial, temporal and overall yields can also be obtained.Type: ApplicationFiled: November 18, 2005Publication date: June 11, 2009Applicant: ROEHM GMBHInventors: Volker Schleep, Thomas Mertz
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Publication number: 20090074709Abstract: A method of applying a biocidal polymer to a surface including applying a solution of the biocidal polymer to the surface, wherein the biocidal polymer includes biocidal groups and the biocidal polymer is insoluble in water. The biocidal groups can be selected from the group consisting of quaternary salt groups or haloamino groups.Type: ApplicationFiled: September 12, 2008Publication date: March 19, 2009Inventors: RICHARD R. KOEPSEL, ALAN J. RUSSELL, THANGAPPAN RAVIKUMAR
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Publication number: 20080315147Abstract: Fluoroalkyl amidoalkyl alcohols of the formula are disclosed and their corresponding (meth)acrylate esters. These fluoroalkyl amidoalkyl (meth)acrylate monomers can be copolymerized with a wide variety of conventional ethylenically unsaturated monomers. The resulting copolymers are useful as water, oil- and grease-proofing agents for paper, textiles and hard surfaces such as masonry and wood.Type: ApplicationFiled: June 18, 2007Publication date: December 25, 2008Applicant: Huntsman International LLCInventor: Shobha Kantamneni
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Patent number: 7452487Abstract: A phosphorus-acid-group-containing (meth)acrylamide polymer having high electrolytic group density and excellent conductivity is obtained by introducing a phosphorus acid group into a (meth)acrylamide monomer which may be N-substituted, and polymerizing the resultant monomer. This polymer is usable for conductive resins, proton-conductive polymer electrolyte membranes and coating agents.Type: GrantFiled: February 23, 2005Date of Patent: November 18, 2008Assignee: Uni-Chemical Co., Ltd.Inventor: Yoshio Kanzaki
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Publication number: 20080269324Abstract: A drag may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inhibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photoreceptor cell.Type: ApplicationFiled: August 7, 2006Publication date: October 30, 2008Inventor: Robert R. Rando
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Patent number: 7442829Abstract: Disclosed is a fluorine-containing polymer having: (A) a repeating unit derived from a fluorine-containing monomer which is represented by the following formula: CH2?C(—X)—C(?O)—Y—[—(CH2)m-Z-]p—(CH2)n—Rf ??(I) (B) a repeating unit derived from a monomer containing no fluorine atom, and if necessary (C) a repeating unit derived from a crosslinkable monomer. This fluorine containing polymer has excellent water repellency, oil repellency and antifouling property.Type: GrantFiled: March 25, 2005Date of Patent: October 28, 2008Assignee: Daikin Industries, Ltd.Inventors: Ikuo Yamamoto, Yutaka Ohira, Yoshio Funakoshi, Shinichi Minami, Ginjiro Tomizawa
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Publication number: 20080234405Abstract: A material contains at least a polymerizable N,O-functionalized acrylic acid hydroxyamide of the Formula (I) in which A is an n+m-valent linear or branched aliphatic C1 to C50 radical, in which the carbon chain can be interrupted by O, S, —CO—O—, CO—NH, O—CO—NH or NH—CO—NH, an n+m-valent aromatic C6 to C18 radical or an n+m-valent cycloaliphatic or heterocyclic C3 to C18 radical, wherein the radicals can carry one or more substituents, Y is not present, or is O, S, an ester, amide or urethane group, R1 is hydrogen, an aliphatic C1 to C20 alkyl or C3 to C8 cycloalkyl radical which can carry one or more substituents, R2 is H or a C1 to C10 alkyl radical, R3 is not present or is a C1 to C16 alkylene radical which can be interrupted by O, HG is not present, is —COOH, —P?O(OH)2; —P?O(OH)(OR4); —O—P?O(OH)2, —SO2OH or —O—P?O(OH)(OR4), R4 is a C1 to C15 alkyl radical, phenyl or benzyl radical and n is a number from 1 to 5 and m a number from 0 to 3.Type: ApplicationFiled: September 11, 2007Publication date: September 25, 2008Applicant: Ivoclar Vivadent AGInventors: Norbert Moszner, Iris Lamparth, Urs Karl Fischer, Frank Zeuner, Armin de Meijere, Volker M. Rheinberger
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Process for making an acrylic monomer having one or more quaternary ammonium groups and its polymers
Publication number: 20080234432Abstract: A method for making a monomer having an ethylenically unsaturated group and two or more quaternary ammonium groups per molecule, comprising: (a) reacting an excess of a monomeric reactant having at least one ethylenically unsaturated group and at least one tertiary amino group per molecule with a halohydroxyalkyl(trialkyl)quaternary ammonium salt, in an aqueous medium, (b) monitoring the pH of the aqueous medium from at least as early as the time when all reactants have been added to aqueous medium until completion of the reaction, and (c) adjusting the pH of the aqueous medium to and maintaining the pH of the aqueous medium at a value greater than or equal to 9, from the time, after all reactants have been added to aqueous medium, that the reaction mixture exhibits an apparent pH minimum until completion of the reaction.Type: ApplicationFiled: March 19, 2008Publication date: September 25, 2008Inventors: Leo Zhaoqing Liu, Jon D. Kiplinger, Douglas Radtke -
Publication number: 20080193377Abstract: Nanohybrid polymer conjugates that provide a “platform” delivery system is disclosed. The delivery platform provides a multi-focused therapeutic regimen that may be tailored to combat a host of cancers, including advanced-stage, therapy-resistant tumors. The nanohybrids of the instant invention incorporate a configurable polymeric backbone, are multivalent (e.g., may incorporate several targeting ligands), and have the capacity to carry multiple classes of “payloads” (e.g., alpha-, beta-, gamma- and positron-emitting isotopes). The polymer conjugates comprise a single molecular species that can be useful not only in diagnostic assessment, but also in tailoring therapies to suit a variety of cancers.Type: ApplicationFiled: June 28, 2005Publication date: August 14, 2008Inventors: Bruce R. Line, Beth Line, Hamidreza Ghandehari, Sergey Baklanov
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Patent number: 7348457Abstract: ?-Ketol unsaturated fatty acid derivatives represented by the following formula (1), ?-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these derivatives: wherein R1 represents linear C1-5 alkyl; R represents hydrogen, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, etc.; R5 represents hydrogen, etc.; n is an integer from 3 to 15; and the carbon atoms at the A- and B-positions may be in either (R)- or (S)-configuration; and wherein R7 represents C1-17 alkyl, etc; R8 represents hydrogen, etc.; R9 represents ?-ketolalkylene; and R10 represents specific divalent linear hydrocarbyl.Type: GrantFiled: March 14, 2005Date of Patent: March 25, 2008Assignee: Shiseido Company, Ltd.Inventors: Toshii Iida, Shoko Yamaguchi, Mineyuki Yokoyama, Yoshihiro Yokokawa, Koji Kobayashi
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Patent number: 7294743Abstract: The present invention relates to a method for synthesis of an acrylamide derivative, starting with dissolving a salt of a nucleophilic amine in water to form an aqueous solution and desalting said solution with a base, comprising the following steps: a) addition of dissolved activated acrylic acid derivative to said solution; b) acidification of aqueous phase; and c) extraction of said aqueous phase.Type: GrantFiled: October 18, 2004Date of Patent: November 13, 2007Assignee: GE Healthcare Bio-Sciences ABInventors: Mattias Algotsson, Philippe Busson, Nicolas Thevenin
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Patent number: 7196119Abstract: The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.Type: GrantFiled: October 20, 2004Date of Patent: March 27, 2007Assignees: The Regents of the University of California, Oregon Health & Science UniversityInventors: Thomas S. Scanlan, Martin J. Kelly, Jian Qiu, Sandra Tobias, Oline K. Ronnekleiv
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Patent number: 7183432Abstract: A method of synthesizing diacetylenic amides is described. The key steps of the invention include the reaction of an aldehyde with the monoanion of a diacetylene and the reductive removal of a propargylic alcohol. The invention offers the first known method of synthesizing diacetylenic amides that are naturally isolated from Echinacea through a direct and flexible route.Type: GrantFiled: March 29, 2005Date of Patent: February 27, 2007Assignee: Iowa State University Research Foundation, Inc.Inventors: George A. Kraus, Jaehoon Bae
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Patent number: 7157603Abstract: The method of separating reversibly thermally precipitable oligomeric N-substituted (meth)acrylamides and conjugates thereof from aqueous solution includes thermally precipitating the oligomeric N-substituted (meth)acrylamides and the conjugates thereof from an aqueous solution in the presence of at least one salt and then filtering in the presence of at least one filter aid. The filter aid has a wet density of 0.2–0.3 g/cc and comprises?99% cellulose with fiber lengths<75 ?m (99%) and=?m (65%). The salt can be a potassium, sodium, ammonium, calcium and/or magnesium chloride, acetate and/or sulfate salt and can be present in the aqueous solution in a concentration between 0.01 M and 3 M.Type: GrantFiled: May 6, 2002Date of Patent: January 2, 2007Assignee: Polytag Technology SAInventor: Frank Hilbrig
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Patent number: 7067471Abstract: A refined product of a polyoxypropylene fatty acid isopropanolamide surfactant, having a high stability in storage and a very small change in smell thereof, is obtained by heat-treating an addition-reaction mixture prepared from a compound of the formula (III) and propylene oxide in a molar amount of 0.5 to 10 times that of the compound of the formula (III), and containing the target compound of the formula (I) and an oxazoline compound of the formula (II) produced as a by-product with water or an alkaline aqueous solution at 50 to 100° C., to hydrolyze the oxyazoline compound and to control the content of the oxyazoline compound to 0.1% by mass or less; and a detergent composition containing the refined product in a content of 1 to 50% by mass, exhibits enhanced thickening, foaming, emulsifying, dispersing and dissolving properties. [R1?C1–C19alkyl or alkenyl group, X=oxypropylene group, n=average number of addition-reacted X groups of 0.Type: GrantFiled: April 5, 2005Date of Patent: June 27, 2006Assignee: Kawaken Fine Chemicals Co., Ltd.Inventors: Toyofumi Ito, Hiroshi Higuchi
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Patent number: 7002041Abstract: An amide composition containing an unsaturated amide, a sulfur-containing compound, and a weak acid salt. The composition can include an amide in crystalline form or the composition can be in form of aqueous solution. The composition can exhibit improved stability whereby polymerization of the amide is inhibited.Type: GrantFiled: November 4, 2002Date of Patent: February 21, 2006Assignee: Mitsui Chemicals, Inc.Inventors: Takeya Abe, Kenju Sasaki
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Patent number: 6960690Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.Type: GrantFiled: December 5, 2001Date of Patent: November 1, 2005Assignee: Mirns Bio CorporationInventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
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Patent number: 6956014Abstract: A thickener which is superior in handling characteristics and blending stability and has a high thickening action is provided, comprising a fatty acid alkanolamide represented by the general formula (1) and a surfactant composition comprising the thickener and at least one surfactant: wherein R1 represents a straight-chain or branched alkyl or alkenyl group having 5 to 21 carbon atoms which may be substituted with at least one hydroxy group, R2 and R3 independently represent an alkyl group having 1 to 2 carbon atoms, AO represents an oxyalkylene group having 2 to 4 carbon atoms and n denotes a number of 0 to 10 in average.Type: GrantFiled: October 29, 2003Date of Patent: October 18, 2005Assignee: Kao CorporationInventors: Makoto Kubo, Yohei Kaneko
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Patent number: 6916457Abstract: A non-chrome, copper-containing catalyst, Cu—Al—O and method of preparing the same are provided wherein the Cu—Al—O catalyst is prepared by the co-precipitation of copper nitrate (Cu(NO3)2) and sodium aluminate (Na2Al2O4) solutions using sodium carbonate (Na2CO3) as a precipitant. The precipitate is filtered, washed to removed excess sodium, and dried. The dried product, to be used in a powder form, is calcined at a preferred temperature of approximately 700° to 900° C. for approximately 1 to 4 hours. The dry powder, to be tableted or extruded, is calcined at a temperature of approximately 400° to 700° C. The activity of the Cu—Al—O catalyst can be promoted in hydrogenolysis applications by the addition of various agents. The Cu—Al—O catalyst can be employed in applications in place of Cu/Cr, or other copper based catalysts.Type: GrantFiled: July 16, 2002Date of Patent: July 12, 2005Assignee: Engelhard CorporationInventor: Jianping Chen
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Patent number: 6891049Abstract: The method for producing N-alkoxy-N-alkylamides of general formula (I): wherein R1 represents C1-10-alkyl, cyclo-C5-7-alkyl, cyclo-C5-7-alkenyl, C2-10-alkenyl, aryl, aryl-C1-3-alkyl, heteroaryl, heteroaryl-C1-3-alkyl or heterocyclyl; and R2 represents C1-6 alkyl. In the process, an ester of general formula (II): R1COOR3, wherein R1 has the above-mentioned meaning, and R3 represents C1-6-alkyl, 4-nitrophenyl, 2,4-dinitrophenyl, succinimido or benzotriazole-1-yl, is reacted with hydroxylamine, a hydroxylamine derivative or with a hydroxylammonium salt, and the reaction product is alkylated in the presence of a phase transfer catalyst.Type: GrantFiled: January 24, 2001Date of Patent: May 10, 2005Assignee: Lonza AGInventors: Paul Hanselmann, Stefan Hildbrand, Etienne Sterren
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Patent number: 6753449Abstract: Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.Type: GrantFiled: October 9, 2001Date of Patent: June 22, 2004Assignee: ArQule, Inc.Inventor: MaoJun Guo
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Patent number: 6750368Abstract: The present invention relates to a process for preparing sulphuric methacrylamide. The process can include adding sulphur trioxide and a second part of acetone cyanohydrin without sulfuric add to a reaction medium, after a first part of acetone cyanohydrin with sulphuric acid free of sulfur trioxide is mixed and dehydrated by heating.Type: GrantFiled: July 12, 2002Date of Patent: June 15, 2004Assignee: AtofinaInventors: Jean-François Croisy, Michel Tosi
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Publication number: 20040010106Abstract: Monomer compounds comprising several cationic groups are provided. The invention also relates to a process for making these monomer compounds. The process is highly selective and prevents unwanted reactions leading to undesired structures. The invention relates also to polymers, including copolymers, comprising units deriving from said monomer compounds. The monomer compounds comprise several cationic groups, e.g.Type: ApplicationFiled: June 3, 2003Publication date: January 15, 2004Inventor: Leo Zhaoqing Liu
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Patent number: 6667406Abstract: Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.Type: GrantFiled: March 7, 2000Date of Patent: December 23, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Sengen Sun, William V. Murray
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Publication number: 20030109626Abstract: Provided are fluorine-containing compounds, and polymers derived therefrom, for use in compositions used for treating textile substrates. Also provided are methods of making fluorine-containing compounds and polymers derived therefrom, compositions comprising the compounds and/or polymers of the present invention, methods of treating substrates, and the treated products derived therefrom.Type: ApplicationFiled: June 18, 2002Publication date: June 12, 2003Inventors: David Bradley, Jing Ji Ma, Haridasan K. Nair, David Nalewajek, Leonard M. Stachura, George Samuels, Michael Van Der Puy
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Patent number: 6562995Abstract: Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, sulfur or nitrogen attached to a methylene group, to which is further attached a sulfur, nitrogen or CH2 group. Methods of treating illnesses and conditions, such as cancer, hemological disorders, inherited metabolic disorders and others, using these compounds are also disclosed.Type: GrantFiled: December 21, 2000Date of Patent: May 13, 2003Assignee: Beacon Laboratories, Inc.Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
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Patent number: 6521790Abstract: Compounds of formula (I) are novel and useful for treating seizure, migraine and psychiatric disorders.Type: GrantFiled: November 1, 2001Date of Patent: February 18, 2003Assignee: Abbott LaboratoriesInventor: Youssef L. Bennani
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Patent number: 6506710Abstract: A method for controlling the rheology of aqueous systems, particularly for those intended for underground use, includes injecting an aqueous viscoelastic fluid containing a surfactant gelling agent into the system. The viscoelastic surfactant composition of the invention comprises, as a gelling agent, at least one fatty aliphatic amidoamine oxide in a glycol solvent. The composition also maintains the levels of free fatty acid and free amine within critical parameters in order to achieve superior performance. The additives may be incorporated in the viscoelastic fluid to tailor its use in stimulation fluids, drilling muds, fracture fluids, and in applications such as permeability modification, gravel packing, cementing, and the like.Type: GrantFiled: April 20, 2000Date of Patent: January 14, 2003Assignee: Akzo Nobel N.V.Inventors: Michael D. Hoey, Ralph Franklin, Douglas M. Lucas, Maurice Dery, Randy E. Dobson, Michael Engel, James F. Gadberry, Ramanair S. Premachandran, Glenda Del Carmen Vale
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Patent number: 6369249Abstract: The present invention relates to a process for the preparation of N-substituted acrylamides of the general formula CH2═CH—CONHR, wherein, R is alkyl group having carbon 1 to 22 or acyl group having carbon 1 to 18. The process for the preparation of the N-substituted acrylamides comprises reacting acrylamide with alkyl acyl chloride in the presence of Lewis acid catalyst in an organic solvent at a temperature ranging between room temperature to 50° C. for a period ranging between 1 hour to 24 hours.Type: GrantFiled: February 2, 2000Date of Patent: April 9, 2002Assignee: Council of Scientific & Industrial ResearchInventors: Bhalchandra Shripad Lele, Mohan Gopalkrishna Kulkarni
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Patent number: 6353012Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.Type: GrantFiled: October 23, 2000Date of Patent: March 5, 2002Assignee: Alcon Universal Ltd.Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
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Patent number: 6348629Abstract: An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either be an N-hydroxylamine or an N-nitrosonamine, the hydrophilic tail can be a polyhydric alcohol tail and the inhibitor can be a concentrate in a liquid medium such as water, alcohol and mixture thereof.Type: GrantFiled: August 9, 2001Date of Patent: February 19, 2002Assignee: Sun Drilling Products Corp.Inventor: Robert Albright
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Patent number: 6312481Abstract: Monoamide-containing polyether alcohol compounds of the formula: wherein R1, R2 and R3 are each independently selected from hydrogen, hydrocarbyl of 1 to 100 carbon atoms, substituted hydrocarbyl of 1 to 100 carbon atoms and polyoxyalkylene alcohol of 2 to 200 carbon atoms or R2 and R3 taken together form a heterocyclic group of 2 to 100 carbon atoms or a substituted heterocyclic group of 2 to 100 carbon atoms with the proviso that at least one of R1, R2 or R3 must be polyoxyalkylene alcohol have been found to decrease intake valve deposits, control octane requirement increases and reduce octane requirement when used as gasoline additives.Type: GrantFiled: October 9, 1997Date of Patent: November 6, 2001Assignee: Shell Oil CompanyInventors: Jiang-Jen Lin, James R. Macias, Sarah Louise Weaver
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Patent number: 6235789Abstract: A compound of the formula wherein R1 and R2 are H, a hydrocarbon group or a heterocyclic group, or R1 and R2 are combinedly a spiro ring; R3 is a hydrocarbon group, a substituted amino group, a substituted hydroxyl group or a heterocyclic group; R4 is H or alkyl; ring A is a substituted benzene ring; m and n denote 1 to 4; {overscore (.........)} means a single or double bond or a salt, a process of producing thereof and a composition having a binding affinity for melatonin receptor.Type: GrantFiled: May 28, 1997Date of Patent: May 22, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigenori Ohkawa, Osamu Uchikawa, Masaomi Miyamoto
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Patent number: RE37555Abstract: The invention relates to a method of producing a mixture of a quaternary ammonium compound, fatty acid, fatty acid ester and tertiary amine salt in situ which is a highly functional mixture that is manufactured in a single step reaction whereby quaternization is completed without the aid of solvents, especially flammable solvents. The single step reaction process eliminates separate blending of individual components. The compositions obtained can be used as fabric softeners, in modified clays, as hair treating compounds and as disinfectants.Type: GrantFiled: June 11, 1999Date of Patent: February 19, 2002Assignee: Goldschmidt Chemical CompanyInventors: Jeannene A. Ackerman, Michael Miller, David E. Whittlinger
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Patent number: RE38506Abstract: The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1=R3—N—R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells.Type: GrantFiled: November 2, 2001Date of Patent: April 20, 2004Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic