Halogen, Bonded Directly To Carbon, In Substituent Q Patents (Class 564/209)
  • Patent number: 9199930
    Abstract: Disclosed herein a novel, process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: December 1, 2015
    Assignee: Council of Scientific and Industrial Research
    Inventors: Muthukrishnan Murugan, Prashant Pramod Mujumdar
  • Patent number: 8981151
    Abstract: Fluorocarbon- and urethane-(meth)acryl-containing additives and hardcoats. The hardcoats are particularly useful as a surface layer on an optical device.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: March 17, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas P. Klun, Naiyong Jing, Richard J. Pokorny, Zai-Ming Qiu, Mark J. Pellerite, William D. Coggio, Christopher B. Walker, Jr.
  • Publication number: 20140221689
    Abstract: Fluorocarbon- and urethane-(meth)acryl-containing additives and hardcoats. The hardcoats are particularly useful as a surface layer on an optical device.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Thomas P. Klun, Naiyong Jing, Richard J. Pokorny, Zai-Ming Qiu, Mark J. Pellerite, William D. Coggio, Christopher B. Walker, Jr.
  • Publication number: 20140148603
    Abstract: A method for preparing a fluorinated organic compound (II) from an organic compound (I) comprising at least one nucleofugal group Nu, and also a preparation of different specific organic compounds, in particular a fluoro-methylpyrazole compound. The method comprises: a reaction, in the presence of water, of the organic compound (I) and at least one salt providing at least one fluoride anion; and a replacement of at least one nucleofugal group Nu of the compound (I) with a fluorine atom, in order to obtain the fluorinated organic compound (II).
    Type: Application
    Filed: May 29, 2012
    Publication date: May 29, 2014
    Applicant: RHODIA OPERATIONS
    Inventors: Olivier Buisine, Michael Dejoux
  • Patent number: 8710257
    Abstract: A method for preparing highly fluorinated carboxylic acids and theirs salts and the precursors thereof.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: April 29, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Klaus Hintzer, Tilman C. Zipplies, Oleg Shyshkov
  • Publication number: 20140012027
    Abstract: A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicants: Taiyo Nippon Sanso Corporation, Kyoto University
    Inventors: Junichi YOSHIDA, Aiichiro NAGAKI
  • Patent number: 8609857
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: December 17, 2013
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin Sill, Habib Skaff
  • Patent number: 8461386
    Abstract: The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: June 11, 2013
    Assignee: United Phosphorus Limited
    Inventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Birja Shanker
  • Publication number: 20120226050
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 6, 2012
    Applicant: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
  • Patent number: 8247612
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: August 21, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20120190879
    Abstract: The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH2, and CN. Specific alkenes discussed include acrylic acid, crotonic acid, methacrylic acid, acrylonitrile, acrylamide, and methacrylonitrile. The alkene is combined with a primary or secondary alcohol (e.g., isopropanol) and an acid chloride (e.g., acetyl chloride) under conditions suitable to chlorinate the alkene. Products formed by the invention include 3-chorosubstituted carbonyl compounds such as 3-chlorpropionic acid (3-CPA), 3-chloropropionamide (3-CPAD), and 3-chloropropionitrile among other products.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 26, 2012
    Inventor: Michael Todd Coleman
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Publication number: 20120101287
    Abstract: The invention related to an optically active compound of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use as herbicides or plant growth regulators. The invention also relates to novel intermediates of formula (III), (V) and (XIII) as defined in the description.
    Type: Application
    Filed: December 28, 2011
    Publication date: April 26, 2012
    Applicant: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Hansjöerg Dietrich, Klemens Minn, Thomas Auler, Hermann Bieringer, Martin Hills, Heinz Kehne, Hubert Menne
  • Patent number: 8158829
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 17, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Patent number: 8084643
    Abstract: The present invention discloses certain novel prodrugs of florfenicol and/or of florfenicol analogs, including prodrugs of salts pharmaceutically acceptable salts of florfenicol and its analogs, including nitrogen-containing esters of the secondary alcohol group of florfenicol and of its analogs, and pharmaceutically acceptable salts thereof, compositions containing them, and methods of administering them to subjects. In particular embodiments the prodrugs are sufficiently water-soluble to serve the functions needed of a water-soluble prodrug of florfenicol or of a water-soluble prodrug of a florfenicol analog. A certain subclass of the compounds also possesses the hydrolytic stability needed to maintain the prodrug in solution in the subject's system until appropriate conditions exist when the prodrug can hydrolyze, releasing florfenicol or the florfenicol analog in question.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: December 27, 2011
    Assignee: Intervet Inc.
    Inventors: Tomasz W. Glinka, Jason Z. Zhang
  • Publication number: 20110060144
    Abstract: A method for manufacturing amidomagnesium halogenides and admixtures thereof with alkali metal salts in aparotic, organic solvents, compounds obtained according to the method and use thereof in synthesis chemistry, for example for deprotonizing enolizable systems, functionalized aromatics and heteroaromatics.
    Type: Application
    Filed: May 18, 2009
    Publication date: March 10, 2011
    Inventors: Alexander Murso, Christopher Kurth, Peter Rittmeyer
  • Publication number: 20110054217
    Abstract: The present invention relates to a process for the asymmetric hydrogenation of imines with hydrogen under elevated pressure in the presence of a catalyst system. In particular the present invention relates to the use of the said catalytic system for the enantioselective hydrogenation of prochiral ketimines to asymmetric amines leading to the formation of herbicides.
    Type: Application
    Filed: April 16, 2009
    Publication date: March 3, 2011
    Applicant: UNITED PHOSPHORUS LIMITED
    Inventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Birja Shanker
  • Publication number: 20100286073
    Abstract: The present invention relates to compounds, as well as to compositions, methods and kits comprising such compounds, for use in the treatment or prophylaxis of fibromyalgia, chronic fatigue syndrome, myofascial pain syndrome, Gulf War syndrome and related conditions, wherein the compound is a fatty acid oxidation inhibitor and/or a carbohydrate oxidation activator.
    Type: Application
    Filed: October 3, 2008
    Publication date: November 11, 2010
    Inventor: Paul JENKINS
  • Publication number: 20100209780
    Abstract: A battery that includes a cathode, anode and an electrolytic solution containing an organic electrolyte solvent including a compound of the formula: R1—CO—NR2—OR3 wherein R1 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives and perfluorinated analogues; R2 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives; R3 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives wherein the electrolyte is stable at voltages of greater than 4.0 volts.
    Type: Application
    Filed: February 17, 2009
    Publication date: August 19, 2010
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Synthonix Corporation, Toyota Motor Corporation
    Inventors: John Muldoon, Gary Allred, Scott Ankeney, Masaki Matsui, Anthony Dotse, Tsuyoshi Sugimoto
  • Publication number: 20100160430
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.
    Type: Application
    Filed: May 16, 2008
    Publication date: June 24, 2010
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20100152289
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.
    Type: Application
    Filed: May 18, 2008
    Publication date: June 17, 2010
    Inventor: Hiroyuki Miyazaki
  • Patent number: 7638650
    Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 29, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Publication number: 20090186941
    Abstract: A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.
    Type: Application
    Filed: November 1, 2006
    Publication date: July 23, 2009
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20090143621
    Abstract: A method of forming an alkoxylated fluoroalcohol is accomplished by providing a boron compound having or providing at least one boron-oxygen bond and an iodine source. The boron compound and iodine source are combined with reactants of a fluoroalcohol and an alkylene oxide in the presence of a base. The reactants are allowed to react to form an alkoxylated fluoroalcohol reaction product.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 4, 2009
    Inventor: Thomas Joseph Martin
  • Publication number: 20090074673
    Abstract: The disclosure provides, in part, compositions and methods for producing cellular labels for tracking cells by MRI. The disclosure provides, in part, methods for labeling, detecting and quantifying cell numbers in vivo.
    Type: Application
    Filed: July 10, 2008
    Publication date: March 19, 2009
    Applicant: Carnegie Mellon University
    Inventors: Jelena Janjic, Eric T. Ahrens
  • Publication number: 20090043130
    Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a divalent radical selected from the group consisting of a covalent bond, —O— and —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated linear or branched alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is a linear or branched alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups selected from the group consisting of —O—, —OH, —NR—, —N(R)2, and —C(O)NR—, wherein a) the ratio of hydrophilic groups to carbon atoms is from about 1:2 to about 1:10; b) each carbon atom has at most one hydrophilic group bonded to it, and c) covalent bonding between hydrophilic groups is absent; R is hydrogen or a C1 to C4 linear or branched alkyl; and Ro1 is a linear or branched aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 e
    Type: Application
    Filed: August 6, 2007
    Publication date: February 12, 2009
    Inventor: Weiming Qiu
  • Publication number: 20080113172
    Abstract: Partially fluorinated amino acid derivatives are provided that are useful as organogelators and surface treatment materials to provide oil- and water-repellency properties to substrates. Also provided are composite materials comprising a porous support and a porous nanoweb. The porous nanoweb contains fibrous structures of about 10 nm to about 1000 nm effective average fiber diameter.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 15, 2008
    Inventors: Erick Jose Acosta, Anilkumar Raghavanpillai, Sheng Peng, Stefan Reinartz
  • Patent number: 7361689
    Abstract: Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2 is H, CH3 or CH2OH, and X1 and X2 are independently selected halogens; and R3 is CH2Cl, CH2F, CHF2, CHCl2 or CH2OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: April 22, 2008
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Dale E. Shuster, Scott Hecker, Tomasz W. Glinka, Rajeshwar Singh, Zhuoyi Su
  • Patent number: 6924397
    Abstract: The present invention relates to a process for the preparation of ?-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: August 2, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: William Aloysius Nugent, Dengjin Wang
  • Patent number: 6689910
    Abstract: Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination compounds of nickel or palladium. The resulting polymers are useful as molding resins, elastomers, in adhesives and for films.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: February 10, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Lin Wang, Samuel David Arthur, Elizabeth Forrester McCord, Yueli Wang, Peter Arnold Morken, Lynda Kaye Johnson
  • Publication number: 20040024243
    Abstract: The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.
    Type: Application
    Filed: February 5, 2003
    Publication date: February 5, 2004
    Inventors: Veronique Mathieu, Francine Janssens, James Franklin
  • Patent number: 6649719
    Abstract: Described is a compound having at least one acrylate monomer, said monomer including at least one pendant group of the structure —O—CH(Rf)(Rf′), wherein Rf is a straight chain or branched perfluoroalkyl group with five or less carbon atoms, and Rf′ is a branched perfluoroalkyl group with three to five carbon atoms; and a method of reducing the surface tension of a liquid by adding a compound of the invention to the liquid. Also described is a composition that includes a compound of the invention in an aqueous solution or dispersion; a method of treating a substrate to render it oil- and/or water-repellent that includes treating a substrate with a composition of the invention; a method of coating an electrical device that includes applying a composition of the invention; a method of coating optical fibers that includes applying a composition of the invention; and an article that includes a substrate treated with a composition of the invention.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: November 18, 2003
    Assignee: 3M Innovative Properties Company
    Inventors: George G. I. Moore, Michael A. Yandrasits, Jay F. Schulz, Richard M. Flynn
  • Patent number: 6388133
    Abstract: A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR2″ comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CONR2″ with elemental fluorine. The groups R, R′ and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R′ may also be nitro or chlorine.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: May 14, 2002
    Assignee: F2 Chemicals Limited
    Inventors: Richard Dickinson Chambers, John Hutchinson, Julie Thomson
  • Patent number: 6376705
    Abstract: Esters and other carboxylic acid derivatives of 3,3,4,4-tetrahydroperfluoroalkylcarboxylic acids are made by the iron promoted reaction of an ester of bromodifluoroacetic acid or other carboxylic acid derivatives and a (perfluoroalkyl)ethylene. The resulting products may be converted to the corresponding alkali metal or ammonium carboxylate slits which are useful as surfactants in fluoroolefin polymerizations.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: April 23, 2002
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Patent number: 6365769
    Abstract: Novel mixtures of perfluoroalkyl halides and derivatives thereof are described. These mixtures contain some compounds with a straight perfluoroalkyl group and some with a branched perfluoroalkyl group. Methods of preparation and use are also described.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: April 2, 2002
    Assignee: 3M Innovative Properties Company
    Inventors: Frederick E. Behr, Rudolf J. Dams, Johan E. DeWitte, Donald F. Hagen
  • Patent number: 6353012
    Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: March 5, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
  • Patent number: 6251882
    Abstract: Novel alkyl ketone compounds having potent cytotoxic activity are described as anti-tumor agents and are particularly effective against leukemia and breast tumor cells.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: June 26, 2001
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Rama Krishna Narla, David Alan Perry
  • Patent number: 6197987
    Abstract: The present invention relates to chemically stable, polyfunctional, perfluorinated polyorganosiloxanes (POS) comprising on the one hand fluorinated lateral grafts resulting from the hydrosilylation of perfluorinated olefins with SiH units and having alkyl and/or alkyl ester linkages but not ether linkages, and on the other hand other, non-perfluorinated functional units E capable of giving them diverse and varied physical and chemical properties and opening up avenues in numerous applications. Examples of these POS according to the invention are those of the following formula: According to another of its features, the invention relates to a process for the preparation of these polyfunctional perfluorinated POS. Applications: antifoams, agents for lowering surface tension, dirt repellents, antiadhesives, lubricants, oleophobic and/or hydrophobic agents, coatings etc.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: March 6, 2001
    Assignee: Rhone-Bouling Chimie
    Inventors: Philippe Jost, Philippe Karrer, Gérard Mignani, Philippe Olier
  • Patent number: 6096762
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 1, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Vivekananda M. Vrudhula, Gene M. Dubowchik, Bireshwar Dasgupta, Dolatrai M. Vyas
  • Patent number: 6054615
    Abstract: Selected quaternary ammonium salts containing fluoroalkyl, preferably perfluoroalkyl, groups that are stable to bases are described. They are useful as phase transfer reaction catalysts, especially in basic media.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: April 25, 2000
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Patent number: 6013795
    Abstract: Briefly, in one aspect, the present invention provides compositions of open-chain, .alpha.-branched fluoroalkylcarbonyl fluorides, and derivatives thereof.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: January 11, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: Anthony P. Manzara, Wei-Qiang Fan, Richard M. Stern, George G. I. Moore
  • Patent number: 5968963
    Abstract: Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
    Type: Grant
    Filed: March 4, 1996
    Date of Patent: October 19, 1999
    Assignee: Warner-Lambert Company
    Inventor: Reynold Homan
  • Patent number: 5932595
    Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: August 3, 1999
    Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Steven Lee Bender, Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Lawrence Emerson Fisher, Robert Than Hendricks, Keshab Sarma
  • Patent number: 5880160
    Abstract: The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic, antiinflammatory and muscle relaxant activities; said derivatives include novel colchine nitrogen amides for use either as such or after derivatization of the hydroxyl at C.sub.3 of the aromatic ring and at C.sub.10 of the tropolone ring. These novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine but, in comparison with the latter, they are much more active on cells resistant to the usual antiblastics. The compounds can be included in pharmaceutical formulations useful for the intravenous, oral and topical administrations.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: March 9, 1999
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta
  • Patent number: 5820665
    Abstract: An object of the present invention is to provide a compound which imparts a sufficient water repellency and a suitable oil repellency to substrates such as a fiber, a paper, a wood material, a hide, a leather, a resin, a glass, a metal, etc. The compound of the present invention is a fluoroalkylcarboxylic acid of the general formula (I), and its derivative of the general formula (II) (e.g. fluoroalkyl alcohol, fluoroalkyl carboxylic acid chloride, fluoroalkylcarboxylic acid amide and fluoroalkylamine).
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: October 13, 1998
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventor: Yoshiaki Kai
  • Patent number: 5786515
    Abstract: A simple, high yielding synthesis of a-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: July 28, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Lisa F. Frey, Richard D. Tillyer, David M. Tschaen
  • Patent number: 5756728
    Abstract: An improved process for preparing 1,1'-?1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-?1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: May 26, 1998
    Assignee: Johnson Matthey Public Limited Company
    Inventors: David Xu, Prasad Kapa, Oljan Repic, Thomas J. Blacklock
  • Patent number: 5753709
    Abstract: Certain N-acyl 2-aryl cyclopropylmethylamine derivatives are useful as melatonergic agents.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: May 19, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel J. Keavy, Michael F. Parker, Ronald J. Mattson, Graham Johnson
  • Patent number: 5736578
    Abstract: Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ;Z=C.sub.1-6 alkyl; --(CH.sub.2).sub.m --CF.sub.3 (m=0-2); CD.sub.3 ; or ##STR2## n=1 or 2; and R=C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.2-4 alkenyl, halogen substituted C.sub.1-6 alkyl, or C.sub.1-6 alkoxy substituted C.sub.1-6 alkyl.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: April 7, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Brett T. Watson, Katherine S. Takaki, Joseph P. Yevich, James R. Epperson, George N. Karageorge, Karen L. Leboulluec
  • Patent number: RE38506
    Abstract: The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1=R3—N—R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: April 20, 2004
    Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York
    Inventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic