Alicyclic Ring Or Ring System, Having Plural Amino Nitrogens Attached Directly Or Indirectly Thereto By Acyclic Nonionic Bonding, Attached Indirectly To An Aryl Ring Or Ring System By Acyclic Nonionic Bonding Patents (Class 564/306)
  • Patent number: 9586943
    Abstract: The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein ?-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of ?-helical proteins in interaction with other biomolecules.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: March 7, 2017
    Assignees: UNIVERSITAT DE VALÈNCIA, INSTITUTO DE SALUD CARLOS III, UNIVERSIDAD CATÓLICA DE VALENCIA “SAN VINCENTE MÁRTIR”
    Inventors: José Gallego Sala, Santos Fustero Lardiés, José Alcamí Pertejo, Luis González Bulnes, Ignacio Ibañez Sánchez, Silvia Catalán Muñoz, Ángel Cantero Camacho, Pablo Barrio Fernández, Silvia Prado Martín
  • Publication number: 20150094437
    Abstract: Arylamine compounds comprising an arylamine core and at least one addition-polymerizable group X selected from the group consisting of formula (A); said addition polymerizable group attached to one ring of the arylamine core through a spacer of general formula (1): C(R1R2)—(C(R3R4))m; wherein, R1 and R2, independent of one another, each represent a C1-C8 alkyl group or an aryl group of from 5 to 30 carbon atoms, R3 and R4, independent of one another, are hydrogen, a C1 to C8 alkyl group or an aryl group of from 5 to 30 carbon atoms and m is an integer of from 0 to 6, or through a fluorene subunit of general formulae (2) or (3); wherein R5 represents hydrogen, C1 to C8-alkyl, or C5 to C30 aryl, and R6 and R7, independently of one another represent C1 alkylene or a C5 to C30 arylene group, provided that R6 and R7 both carry an addition-polymerizable group X and R5 is not hydrogen if R6 is methylene.
    Type: Application
    Filed: December 20, 2012
    Publication date: April 2, 2015
    Inventors: Jean Raphael Caille, Jonathan Maunoury
  • Patent number: 8927756
    Abstract: The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 6, 2015
    Assignee: Asahi Glass Company, Limited
    Inventors: Takashi Okazoe, Yuko Nagasaki, Hidekazu Okamoto
  • Patent number: 8859817
    Abstract: Provided are a process for the preparation of phenyl carbamate derivatives, useful in the treatment of CNS (central nervous system) disorders, an intermediate in the synthesis of the phenyl carbamate derivatives, and a process for preparation of the intermediate.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: October 14, 2014
    Assignee: Bio-Pharm Solutions Co., Ltd.
    Inventor: Yong Moon Choi
  • Publication number: 20140288040
    Abstract: The invention provides compounds of the formula (6): or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF or nitrogen; and R0 is hydrogen or C1-2 alkyl; R1a is selected from CONH2; CO2H; an optionally substituted acyclic C1-8 hydrocarbon group; and an optionally substituted monocyclic carbocyclic or heterocyclic group of 3 to 7 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S; R2 is selected from hydrogen and a group R2a; R2a is selected from an optionally substituted acyclic C1-8 hydrocarbon group; an optionally substituted monocyclic carbocyclic or heterocyclic group of 3 to 7 ring members, of which 0, 1 or 2 ring members are heteroatom ring members selected from O, N and S; and an optionally substituted bicyclic heterocyclic group of 9 or 10 ring members, of which 1 or 2 ring members are nitrogen atoms; wherein at least one of R1 and R2 is other than hydrogen; R3 is an optionally substituted 3- to 10-membered monocyclic or bicyc
    Type: Application
    Filed: October 31, 2012
    Publication date: September 25, 2014
    Applicant: ASTEX THERAPEUTICS LIMITED
    Inventors: Andrew James Woodhead, Gianni Chessari, Gilbert Ebai Besong, Maria Grazia Carr, Steven Douglas Hiscock, Michael Alistair O'Brien, David Charles Rees, Susanne Maria Saalau-Bethell, Hendrika Maria Gerarda Willems, Neil Thomas Thompson
  • Patent number: 8772543
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Medarex, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong, Qian Zhang
  • Publication number: 20140128614
    Abstract: To provide pesticidal allylAryl heterocycle derivatives that are useful as a pesticidal compound. Pesticidal allylAryl heterocycle derivatives that are expressed by the Formula (I), and pesticides and an agent for controlling animal parasites which include the allylAryl heterocycle derivatives as an effective component.
    Type: Application
    Filed: April 24, 2012
    Publication date: May 8, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Mamoru Hatazawa, Tetsuya Murata, Peter Bruechner, Daiei Yamazaki, Eiichi Shimojo, Teruyuki Ichihara, Katsuhiko Shibuya, Tadashi Ishikawa
  • Patent number: 8703682
    Abstract: Tetra-alkylated phenylenediamine compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials and meet copper corrosion requirements, and lubricating oil compositions containing such phenylenediamine compounds.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: April 22, 2014
    Assignee: Infineum International Limited
    Inventors: Joseph P. Hartley, Robert G. Rowland, Jie Cheng, Jacob Emert, Joseph Stieber
  • Publication number: 20140088319
    Abstract: The present invention discloses a catalytic system for preparing highly branched alkane from olefin, which contains novel nickel or palladium complexes. In the presence of the catalytic system, highly branched oily alkane mixture can be efficiently obtained from olefins (such as ethylene) under mild conditions. The alkane mixture has a low bromine number, and can be used as a processing aid(s) and lubricant base oil with high-performance. Provides also was a method for preparing the catalyst and a method for preparing an oily olefin polymer.
    Type: Application
    Filed: April 23, 2012
    Publication date: March 27, 2014
    Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    Inventors: Yong Tang, Wenjie Tao, Xiuli Sun, Junfang Li, Zheng Wang
  • Patent number: 8624064
    Abstract: The present invention relates to a compound represented by the following general formula (I): wherein R1 and R2 independently represent a monovalent hydrocarbon group; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X represents a divalent hydrocarbon group; and R4, R5 and R6 independently represent a monovalent organic group or a group represented by the following general formula (II): in which R7 and R8 independently represent a monovalent hydrocarbon group; and R9 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, with the proviso that R5 and R6 may combine together to form a divalent hydrocarbon group. The aforementioned compounds are useful as a polymerization inhibitor and the like.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 7, 2014
    Assignee: Dow Corning Toray Company, Ltd.
    Inventors: Takeaki Saiki, Keiji Wakita, Yasushi Sugiura, Yoshinori Taniguchi
  • Patent number: 8492508
    Abstract: A polyimide represented by formula (6) is provided. The polyimide is fabricated by performing a polycondensation reaction with a amine compound shown in formula (4) and a dianhydride compound shown in formula (5) as monomers. In formulas (5) and (6), Ar represents aromatic group, and n represents a positive integer.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: July 23, 2013
    Assignee: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8476426
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: July 2, 2013
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Louis Peglion, Aimee Dessinges
  • Patent number: 8465848
    Abstract: This invention relates to electroluminescent benzofluorenes that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a benzofluorene composition.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: June 18, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventor: Eric Maurice Smith
  • Patent number: 8461146
    Abstract: The present invention provides an oral pharmaceutical composition for the treatment of premature ejaculation, and the composition provides the effective and excellent treatment of premature ejaculation as well as reduced side effects like nausea, vomiting, drowsiness, sedation effect, awakening effect, and weight-loss etc.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: June 11, 2013
    Assignees: Yuhan Corporation, Hyun Uk SEOL
    Inventors: Hyun Uk Seol, Young Sung Lee, Young Hun Kim, Kyeong Bae Kim, Jeong Min Seo, Kyoung Kyu Ahn
  • Patent number: 8420861
    Abstract: Compounds for utilization as anti-tumor agents against cancer and certain inflammatory and arthritic conditions designed with multiple active sites to cause inhibition and cell death synthesized from the starting compound 1,4,5,8-tetrachloroanthraquinone. Included are anti-tumor compounds of the class 1,4,5,8-tetrakis-alkylaminoalkyl, 1,4,5,8-tetrakis-hydroxyalkylaminoalkyl, 1,4,5,8-tetrakis-chloroethylamino, 1,2-bischloroethylamino-1,4,5,8-tetrakis-aminoethylamino derivatives of Anthraquinone. Also includes mixtures of groupings such as 1-aminoalkylamino-4,5,8-tris-(1,2-dimethyl)aminoalkylamino anthraquinone, 1,2-dichloroethyl 1-aminoalkyl amino-4,5,8-tris-aminoethylamino anthraquinone, bis-1,4aminoalkylamino bis-5,8-alkylaminoanthraquinone, 1,4-bis-chloroalkylamino-5,8-bisaminoalkylamino anthraquinone and others.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: April 16, 2013
    Inventor: D. Richard Ishmael
  • Patent number: 8420862
    Abstract: Highly pure 2,3,5,6-tetraaminotoluene species are produced by chemically reducing undesirable oxidation byproducts. The 2,3,5,6-tetraaminotoluene species are then used in the manufacture of superior high-performance polybenzimidazole polymers.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: April 16, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Publication number: 20130090471
    Abstract: The present invention relates to a method for identifying compounds that modulate cholesterol metabolism by detecting enzyme activities involved in the synthesis or catabolism of cholesterol. Said method enables the lethal risk for mammalian cells when the cholesterol level decreases to be avoided, due to the use of genetically modified yeasts, the survival of which is not strictly dependent upon the cholesterol production.
    Type: Application
    Filed: June 9, 2011
    Publication date: April 11, 2013
    Applicant: SANOFI
    Inventors: Bruno Dumas, Isabelle Maury
  • Patent number: 8410312
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: April 2, 2013
    Assignees: GE Healthcare Limited, GE Healthcare AS
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Patent number: 8367797
    Abstract: A polyamide represented by formula (6) is provided. The polyamide is fabricated by performing a polycondensation reaction with amine compound shown in formula (4) and an acid or derivative thereof shown in formula (5) as monomers. In formulas (5) and (6), X represents aromatic groups or aliphatic groups. In formula (5), R represents OH group or halogen.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: February 5, 2013
    Assignee: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8318980
    Abstract: The invention relates to new, highly efficient UV-absorbing compounds, a process for their manufacturing and to uses of these UV-absorbing compounds. The UV-absorbing compounds are in particular UV-A-absorbing compounds according to Formula (VI) or (VII): R2CH2—N(R17)—(CR12)m—N(R17)—CH2R2??(VI) N{(R17)3-n[(CR12)m-N(R17)—CH2R2]n}??(VII).
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: November 27, 2012
    Assignee: Fujifilm Manufacturing Europe B.V.
    Inventors: Sebastianus Gerardus Johannes Maria Kluijtmans, Jan Bastiaan Bouwstra
  • Patent number: 8304514
    Abstract: The invention provides a conjugated polymer, a method for preparing the same, and optoelectronic devices employing the same. The conjugated polymer includes a structure represented by Formula (I), wherein, R1 is independently an octyl or dodecyl group, R2 is independently an H or 1,1,3,3-tetramethylbutyl, and, n is an integer larger than 1.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: November 6, 2012
    Assignee: National Taiwan University of Science & Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8299304
    Abstract: This invention provides alignment materials for liquid crystal display device of vertical alignment mode and methods for the preparation of the same, and more particularly, it provides diaminobenzene derivatives represented by the following formula 1 (shown in description), capable of aligning liquid crystal in uniform and vertical way and remarkably improving clarity and solubility against organic solvents, methods for the preparation of the same and liquid crystal alignment films using the same.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: October 30, 2012
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jin wook Choi, Dal bong Seo, Jae cheol Park, Yong bae Kim
  • Patent number: 8217390
    Abstract: Polymers that enable the use of high work-function metals as a cathode in optoelectronic devices and optoelectronic devices incorporating the polymers as an electron transport layer.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: July 10, 2012
    Assignee: University of Washington
    Inventors: Kwan-Yue Jen, Fei Huang, Yuhua Niu, Yong Zhang
  • Patent number: 8212078
    Abstract: This invention provides aromatic diimines where the diimines have imino groups with at least two carbon atoms, and either are in the form of one benzene ring having two imino groups on the ring, which imino groups are meta or para relative to each other, and in which each position ortho to an imino group bears a hydrocarbyl group, or are in the form of two benzene rings connected by an alkylene bridge and having one imino group on each ring, and in which each position ortho to an imino group bears a hydrocarbyl group.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: July 3, 2012
    Assignee: Albemarle Corporation
    Inventors: John Y. Lee, Paul L. Wiggins, Judit Orgad, Mahmood Sabahi, Vernon O. Brandt, David W. Owens
  • Patent number: 8188316
    Abstract: Processes are provided for preparing complexes of 2,3,5,6-tetraaminotoluene with an aromatic diacid where the aromatic diacid is insoluble in water under ambient conditions. An integrated process design starting with nitration of 2,6-dihalotoluene eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 29, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8188317
    Abstract: An integrated process is provided for preparing complexes of 2,3,5,6-tetraminotoluene with an aromatic diacid starting with nitration of 2,6-dihalotoluene. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 29, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8168829
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: May 1, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: David C. Palmer, Sergio Casco-Cancian, Tong Xiao, Kirk L. Sorgi, Armin Roessler, Anita Vladislavic, Roger Faessler
  • Patent number: 8163961
    Abstract: Complexes of 2,3,5,6-tetraaminotoluene with an aromatic diacid are prepared by reaction with a divalent salt of the aromatic diacid while maintaining the pH of the reaction solution between 3 and 10. The resulting complexes are suitable for making high molecular weight polybenzimidazole polymers for high-performance fibers.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: April 24, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8163955
    Abstract: An improved process is provided for the preparation of 2,6-diamino-3,5-dinitrotoluene by amination of 2,6-dichloro-3,5-dinitrotoluene. The presence of water unexpectedly results in a highly pure product, free of glycol ether impurities. This product can be used to make highly pure 2,3,5,6-tetraaminotoluene, which in turn can be used to make high molecular weight polybenzimidazoles for high strength fibers.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: April 24, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8158830
    Abstract: An integrated process is provided for preparing 1,2,4,5-tetraminobenzene and salts thereof, starting in certain embodiments with nitration of 1,3-dihalobenzene. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: April 17, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Joachim C. Ritter, Ekaterini Korovessi, Rajiv Dhawan
  • Patent number: 8143450
    Abstract: A process is provided for preparing complexes of 1,2,4,5-tetraminobenzene with an aromatic diacid. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: March 27, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Joachim C. Ritter, Ekaterini Korovessi, Rajiv Dhawan
  • Patent number: 8115007
    Abstract: A process for the preparation of diaminodinitropyridine or diaminodinitrobenzene by contacting an aminopyridine or aminobenzene with oleum and nitric acid, wherein the improvement comprises adding at least about 1% molar excess of nitric acid, based upon the aminopyridine or aminobenzene with stirring for at least two hours to form first the intermediate sulfonic acid, and then diaminodinitropyridine or diaminodinitrobenzene, and use of such products in the preparation of rigid rod polymers is disclosed.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: February 14, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Hasan Dindi, James Arnold Schultz
  • Patent number: 8101666
    Abstract: The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative stress, degeneration and/or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: January 24, 2012
    Assignee: Aposense Ltd.
    Inventors: Ilan Ziv, Anat Shirvan
  • Patent number: 8093428
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: January 10, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventor: Xun Li
  • Publication number: 20110319446
    Abstract: Compounds of formula (I) have muscarinic M3 receptor modulating activity; wherein A is an oxygen atom or group —N(R12)—; (i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group —R5, —Z—Y—R5, —Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H; and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a hydrogen atom; or a group —R5, —Z—Y—R5, —Z—NR9R10, —Z—CO—NR9R10, —Z—NR9—CO—R5, or —Z—CO2H, in which cases the nitrogen atom to which it is attached is a quaternary nitrogen and carries a positive charge; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group —Y—R5, —Z—Y—R5, —Z—NR9R10; —Z—CO—NR9R10; —Z—NR9—CO—R5; or —Z—CO2H and R3 is a lone pair, or C1-C6-alkyl in which case the nitrogen atom to whi
    Type: Application
    Filed: June 20, 2011
    Publication date: December 29, 2011
    Applicant: Argenta Discovery Ltd.
    Inventors: Harry Finch, Nicholas Charles Ray, Richard James Bull, Monique Bodil van Niel, Andrew Stephen Robert Jennings
  • Patent number: 8080551
    Abstract: HIV replication inhibitors having formula (I) defined herein are disclosed. Pharmaceutical compositions containing the HIV replication inhibitors; the use of the HIV replication inhibitors in the treatment of HIV; and processes for preparing the HIV replication inhibitors are also disclosed.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: December 20, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jérôme Emile Georges Guillemont, Patrice Palandijian, Marc René De Jonge, Lucien Maria Henricus Koymans, Hendrik Maarten Vinkers, Frederik Frans Desiré Daeyaert, Jan Heeres, Koen Jeanne Alfons Van Aken, Paulus Joannes Lewi, Paul Adriaan Jan Janssen, Frank Xavier Jozef Herwig Arts, legal representative
  • Patent number: 8071812
    Abstract: A process is provided for the preparation of 1,3-diamino-4,6-dinitrobenzene by amination of 1,3-dihalo-4,6-dinitrobenzene. The presence of water advantageously results in a highly pure product, free or essentially free of glycol ether impurities.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: December 6, 2011
    Assignee: E.I du Pont de Nemours & Company
    Inventors: Joachim C. Ritter, Annalisa Hargis
  • Publication number: 20110275783
    Abstract: A polyamide represented by formula (6) is provided. The polyamide is fabricated by performing a polycondensation reaction with amine compound shown in formula (4) and an acid or derivative thereof shown in formula (5) as monomers. In formulas (5) and (6), X represents aromatic groups or aliphatic groups. In formula (5), R represents OH group or halogen.
    Type: Application
    Filed: August 23, 2010
    Publication date: November 10, 2011
    Applicant: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8048926
    Abstract: L-DOPA amide derivatives, pharmaceutical compositions containing same and their use in the treatment of conditions associated with impaired dopaminergic activity/signaling (e.g., Parkinson disease) are disclosed.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: November 1, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Daphne Atlas
  • Publication number: 20110257404
    Abstract: [Problem] To provide a method of producing an aromatic amino compound by using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively.
    Type: Application
    Filed: January 25, 2010
    Publication date: October 20, 2011
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi
  • Publication number: 20110172239
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Application
    Filed: July 16, 2010
    Publication date: July 14, 2011
    Inventors: Alan D. SNOW, Beth NGUYEN, Gerardo CASTILLO, Virginia SANDERS, Thomas LAKE, Lesley LARSEN, Rex T. WEAVERS, Stephen LORIMER, David LARSEN, David L. COFFEN, Charlotte COFFEN
  • Patent number: 7964730
    Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: June 21, 2011
    Assignee: Theravance, Inc.
    Inventors: Martin S. Linsell, John R. Jacobsen, Daisuke Roland Saito
  • Publication number: 20110105374
    Abstract: Monoaryltrialkyl phenylenediamine compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials and meet copper corrosion requirements, and lubricating oil compositions containing such phenylenediamine compounds.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 5, 2011
    Inventors: Jie Cheng, Jacob Emert, Joseph P. Hartley, Robert G. Rowland, Joseph Stieber
  • Publication number: 20110105372
    Abstract: Tetra-alkylated phenylenediamine compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials and meet copper corrosion requirements, and lubricating oil compositions containing such phenylenediamine compounds.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 5, 2011
    Inventors: Joseph P. Hartley, Robert G. Rowland, Jie Cheng, Jacob Emert, Joseph Stieber
  • Publication number: 20100298328
    Abstract: 1-Heterocyclylamino-2-hydroxy-3-amino-?-arylalkanes of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.
    Type: Application
    Filed: March 30, 2007
    Publication date: November 25, 2010
    Inventors: John J. Baldwin, David A. Claremon, Lawrence W. Dillard, Alexey V. Ishchenko, Jing Yuan, Zhenrong Xu, Gerard McGeehan, Wenguang Zeng
  • Patent number: 7825211
    Abstract: A process for synthesizing formulations for polyimides suitable for use in high-temperature composites in which all reactions other than chain-extension have already taken place prior to making a composite is described, wherein the resulting oligomers comprise a backbone and at least one difunctional endcap. The resulting resin systems have only the single step of endcap-to-endcap reactions during composite processing. Prior to the initiation temperature of these endcap-to-endcap reactions, the resins are stable affording the composite manufacturer a very large processing window.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: November 2, 2010
    Assignee: The Boeing Company
    Inventors: Hyman Ralph Lubowitz, Thomas Karl Tsotsis
  • Publication number: 20100189623
    Abstract: The invention relates to a process for recovering acids from product streams of organic syntheses, which comprises the steps a) neutralization of the acid with a base, b) removal of the base by means of adsorption, c) recovery of the acid.
    Type: Application
    Filed: June 9, 2008
    Publication date: July 29, 2010
    Applicant: BASF SE
    Inventors: Veronika Wloka, Torsten Mattke, Carsten Knoesche, Daniel Breuninger, Nils Bottke
  • Publication number: 20100072888
    Abstract: Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same as an electroluminescent material.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 25, 2010
    Applicant: Gracel Display Inc.
    Inventors: Young Gil Kim, Young Jun Cho, Chi Sik Kim, Sung Jin Eum, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
  • Patent number: 7597726
    Abstract: New, highly effective Mannich detergents for use in hydrocarbon fuels are described which reduce engine deposits in spark and compression ignition internal combustion engines. They are Mannich condensation reaction products obtained from reacting: (i) a polyamine having a sterically-hindered primary amino group, (ii) a hydrocarbyl-substituted hydroxyaromatic compound, and (iii) an aldehyde. These Mannich detergent compounds may be dispersed in a liquid carrier to provide a fuel additive concentrate for hydrocarbon engine fuels which effectively control engine deposit formation in intake valves and also other engine regions such as port fuel injectors and combustion chambers.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: October 6, 2009
    Assignee: Afton Chemical Corporation
    Inventors: Peter W. Hou, Dennis J. Malfer, May Duffield Thomas, William J. Colucci
  • Patent number: 7572877
    Abstract: An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improved workability without adding solvent or diluent and an excellent property of epoxy resin cure product. The above modified cyclic aliphatic polyamine is obtained by addition reaction of a cyclic aliphatic polyamine such as isophoronediamine and norbornanediamine and an alkenyl compound such as styrene. The modified cyclic aliphatic polyamine thus obtained is added in epoxy resin to be used as a curing agent for epoxy resin.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: August 11, 2009
    Assignee: Mitsubishi Gaschemical Company, Inc.
    Inventors: Takeshi Koyama, Tetsushi Ichikawa, Hisayuki Kuwahara, Masatoshi Echigo